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MKLRGATALVTGANRGIGHHFAVELLQRGAKVYATARRPELVSVPGAEVIRLDITDQSSVDAVAAVAGDV DVLINNAADTAGGNLVTGDLDAIRSTMDSNYYGTLAMIRAFAPILGRNGGGAILNVLSAAAWTTVDGNTA YAAAKSAQWGLTNGVRIELAPQGTQVVALVPGLVGTQTLFDFAERHGIEFPDGAVMDPADLVRLALDGLE RGEIEILDPMGVDAKTSLAGPPRAFAPSAFDAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1493 | - | - | 100% (243) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0234 | - | 5e-51 | 48.90% (227) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1212 | - | 1e-24 | 33.49% (215) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3199 | - | 6e-38 | 41.56% (231) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5243 | - | 1e-21 | 33.15% (184) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3174 | - | 2e-37 | 41.13% (231) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 8e-18 | 28.86% (246) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4428 | - | 3e-35 | 37.82% (238) | short chain dehydrogenase |
| M. marinum M | MMAR_3561 | - | 2e-22 | 31.46% (213) | oxidoreductase |
| M. avium 104 | MAV_4667 | - | 2e-21 | 38.29% (175) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3805 | - | 1e-100 | 78.02% (232) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3427 | - | 7e-20 | 29.92% (254) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2794 | - | 2e-22 | 33.33% (174) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1493|M.vanbaalenii_PYR-1 ---------------------MKLRGATALVTGANRGIGHHFAVELLQRG
MSMEG_3805|M.smegmatis_MC2_155 MPSLATESDHSVIFVGFEGEIMKLHGATALVTGANRGLGHHLAVELIRRG
Mb3199|M.bovis_AF2122/97 --------------------MTSLAERTALVTGANRGMGREYVAQLLGRK
Rv3174|M.tuberculosis_H37Rv --------------------MTSLAERTVLVTGANRGMGREYVAQLLGRK
MAB_4428|M.abscessus_ATCC_1997 ----------------------MIKDTVVLVTGGRRGLGAAIVDEVLNRG
MMAR_3561|M.marinum_M ---------------------MTSTPPVALITGVSSGIGAAIAVRLASAG
MUL_2794|M.ulcerans_Agy99 ---------------------MTSTPPVALITGVSSGIGAAIAVRLASAG
Mflv_5243|M.gilvum_PYR-GCK ---------------------MAT----VLITGCSSGYGRATALKFLAEG
MAV_4667|M.avium_104 ------------------MVGTGRNERVAVVTGASSGIGEATARTLAAQG
TH_3427|M.thermoresistible__bu --------------------MDNIRGKTIAITGAARGIGYATATALLARG
MLBr_01094|M.leprae_Br4923 --------------------MEGFAGKVAVVTGAGSGIGQALAIELARSG
:** * * . .
Mvan_1493|M.vanbaalenii_PYR-1 -AKVYA------TARRPELVSVPG--AEVI--RLDITDQSSVDAVAAVAG
MSMEG_3805|M.smegmatis_MC2_155 -AKVYA------TARRPELVDVPG--AHVL--RLDITDQWSVEAAAAAAD
Mb3199|M.bovis_AF2122/97 VAKVYA------ATRNPLAIDVSD--PRVIPLQLDVTDAVSVAEAADLAT
Rv3174|M.tuberculosis_H37Rv VAKVYA------ATRNPLAIDVSD--PRVIPLQLDVTDAVSVAEAADLAT
MAB_4428|M.abscessus_ATCC_1997 ARKVYS------TARAP--FEDPR--AQVVTKQLEVTSAESVDALARDLT
MMAR_3561|M.marinum_M -FRVVG------TSRAPQRLAPIPGVETLALDVTDDTAVRSVVSEVIDRT
MUL_2794|M.ulcerans_Agy99 -FRVVG------TSRAPQRLAPIPGVETLALDVTDDTAVRSVVSEVIDRT
Mflv_5243|M.gilvum_PYR-GCK -WNVVA------TMRNP-RPDVLPASDRLRVSALDVTDPESIAS-AVEAA
MAV_4667|M.avium_104 -FHVVA------VARRAKRIHALANEIGGTAIVADVTDDAAVAALASKLS
TH_3427|M.thermoresistible__bu ARVVIGDRD---VALQESAVAQLGRLGPVSGYPLDVTDRESFATFLDKAR
MLBr_01094|M.leprae_Br4923 AKLAISDVDGEGLAQTEGQLKAIG--ASARTDRLDVTEREAFLTYADVVH
. . : * :.
Mvan_1493|M.vanbaalenii_PYR-1 -----DVDVLINNAADTA-GGNLVTGDLDAIRSTMDSNYYGTLAMIRAFA
MSMEG_3805|M.smegmatis_MC2_155 -----DVDVLINNAAFTD-GGNLVTGDLAKIRATMDSNYYGTLAMIRAFA
Mb3199|M.bovis_AF2122/97 -----DVGILINNAGISR-ASSVLDKDTSALRGELETNLFGPLALASAFA
Rv3174|M.tuberculosis_H37Rv -----DVGILINNAGISR-ASSVLDKDTSALRGELETNLFGPLALASAFA
MAB_4428|M.abscessus_ATCC_1997 -----DVEIVVNNAGVLH-PDPLLTGDFDRIDATFQTNVFGPLRIARAFA
MMAR_3561|M.marinum_M G----RIDVLVNNAGLGI-AGAAEESSIDQARSLFDTNFFGLIRLTNEVL
MUL_2794|M.ulcerans_Agy99 G----HIDVLVNNAGLGI-AGAAEESSIDQARSLFDTNFFGLIRLTNEVL
Mflv_5243|M.gilvum_PYR-GCK G----PLDAVVNNAGIGA-VGAFEATPMSTIRELFDTNTFGVMAMTQAVV
MAV_4667|M.avium_104 -----RVDVLVNNAGGARGLEPVAEADLEHWRWMWETNVIGTLRVTRALL
TH_3427|M.thermoresistible__bu TDGGGHIDVLINNAGVMP-IGPFLEQSEQAIRSSIEVNLYGVLTGCQLAL
MLBr_01094|M.leprae_Br4923 ENFG-KVNQIYNNAGIAF-TGDVEVSHFKDIERVMDVDYWGVVNGTKAFL
: : ***. : : * :
Mvan_1493|M.vanbaalenii_PYR-1 PILGRNGGGAILNVLSAAAWTTVDGNTAYAAAKSAQWGLTNGVRIELAPQ
MSMEG_3805|M.smegmatis_MC2_155 PILARNGGGAILNVLSVAAWRTVDGNTSYAAAKSAEWGLTNGVRVELARQ
Mb3199|M.bovis_AF2122/97 DRIAERSG-AIVNVSSVLAWLPLG--MSYGVSKAAMWSATESMRIELAPR
Rv3174|M.tuberculosis_H37Rv DRIAERSG-AIVNVSSVLAWLPLG--MSYGVSKAAMWSATESMRIELAPR
MAB_4428|M.abscessus_ATCC_1997 PILKANGGGAIVNIHSVLSWLGGAG--AYGASKAAIWSVSNTLRLELEAQ
MMAR_3561|M.marinum_M PHMRRRGSGRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELREY
MUL_2794|M.ulcerans_Agy99 PHMRRRGSGRIINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELREY
Mflv_5243|M.gilvum_PYR-GCK PQMRERRSGVVVNVTSSTTLAPMPLAAAYTASKSAIEGFTGSLALELGFF
MAV_4667|M.avium_104 PKLVDSGDGLIVTVTSVAALEVYDGGAGYTAAKHGQGALHRTLRGELLGK
TH_3427|M.thermoresistible__bu PDMVRRRSGHIINIASMSGLIPVPGQVPYNAAKFGVVGLSVALADEMAPY
MLBr_01094|M.leprae_Br4923 PYLISSGDGHVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALA
: . ::.: * * :* . . : *:
Mvan_1493|M.vanbaalenii_PYR-1 G--TQVVALVPGLVGTQTL--------FDFAERHGIEFPDGAVMDPADLV
MSMEG_3805|M.smegmatis_MC2_155 G--THVAALVPGLIRTDTL--------LEFARGNGIELPEEHMNEPADLA
Mb3199|M.bovis_AF2122/97 G--VQVVGVYVGLVDT------------DMGR-----FADAPKSDPADVV
Rv3174|M.tuberculosis_H37Rv G--VQVVGVYVGLVDT------------DMGR-----FADAPKSDPADVV
MAB_4428|M.abscessus_ATCC_1997 H--THVLGVHAAFIDT------------DMVS-----ALPVPKTPPSAIA
MMAR_3561|M.marinum_M G--VRALLVEPSYTR------------TDFESN--MWEADTPQAAYADNR
MUL_2794|M.ulcerans_Agy99 G--VRALLVEPSYTR------------TDFESN--MWEADTPQAAYADNR
Mflv_5243|M.gilvum_PYR-GCK G--VRAKLVEPGYGPG-----------TQFTSNGVERMAGLIPAEYQDFA
MAV_4667|M.avium_104 P--VRLTEIAPGAVET------------EFSLVRFDGDQQRADAVYTGIT
TH_3427|M.thermoresistible__bu G--VEVSVVMPPFTRT------------ELISG-TKETAATKPAEPEDIA
MLBr_01094|M.leprae_Br4923 GRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAA
.. : :.
Mvan_1493|M.vanbaalenii_PYR-1 RLALDGLERG-EIEILD---PMGVDAKTSLAGPPRAFAPSAFDAG-----
MSMEG_3805|M.smegmatis_MC2_155 RMALDGLEAG-EVEIID---RMSVDAKAALAGPPVTLSL-----------
Mb3199|M.bovis_AF2122/97 RQVLDGIEAGKEDVLAD---EMSRQVRASLNVPARERIARLMGN------
Rv3174|M.tuberculosis_H37Rv RQVLDGIEAGKEDVLAD---EMSRQVRASLNVPARERIARLMGN------
MAB_4428|M.abscessus_ATCC_1997 ARIIDALDKGDNEVLTD---DLTVQIKSQLAGPVEKLAYRPGH-------
MMAR_3561|M.marinum_M AAVRAVVADKIRNAELP---AVVADATYAAATDKRIKLRYPAGRHARQLA
MUL_2794|M.ulcerans_Agy99 AAVRAVVANKIRNAELP---AVVADATYAAAIDKRIKLRYPAGRHARQLA
Mflv_5243|M.gilvum_PYR-GCK APVFEEFR-SPGMVTTP---DEVADVVFQAATDTSGRLRFAAGADAVALA
MAV_4667|M.avium_104 PLVAADVAEVIGFVASR---PAHVNLDLIVMKPRDQASASRFNRRG----
TH_3427|M.thermoresistible__bu AAIVKTLDKPKTHVSVPGPLRFIAQAAQTLGPRGRRWLNKRLGLDTVFLE
MLBr_01094|M.leprae_Br4923 RIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQ
.
Mvan_1493|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_3805|M.smegmatis_MC2_155 ----------------------------------
Mb3199|M.bovis_AF2122/97 ----------------------------------
Rv3174|M.tuberculosis_H37Rv ----------------------------------
MAB_4428|M.abscessus_ATCC_1997 ----------------------------------
MMAR_3561|M.marinum_M LLKRIAPAAVLDNGIRKQTGLNSPRPTPVLAER-
MUL_2794|M.ulcerans_Agy99 LLKRIAPAAVLDNGIRKQTGLNSPRPTPVLAER-
Mflv_5243|M.gilvum_PYR-GCK Q---------------------------------
MAV_4667|M.avium_104 ----------------------------------
TH_3427|M.thermoresistible__bu FDQQARQGYEQRAQQALGVLEGGNKQQDRSGQKS
MLBr_01094|M.leprae_Br4923 R---------------------------------