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TATISGATSLTGQMLIAGAPVRGTGKEVRAFDPAAGQPLEPVYQHGDNTHVDAACAAAADAFAQYRATTS EQRAAFLDTIATNIEAVGEALIARAVAESGLPQARITGELGRTTGQLRLFASVLREGSWNGARIDTALPD RTPLPRPDLRQRHIPLGPVAVFSASNFPLAFSVAGGDTASALAAGCPVVVKGHDAHPGTSELVARAVTDA VTTSGLPAGTFSLLFGSGPGLGIALVTDPRIKAVGFTGSRSGGMALVSAAAARPEPIPVYAEMSSINPVF VLDGALKTRGAELGRAFVASLTMGSGQFCTNPGLVIAVDGPGLDTFAAAARDALAGSPATPMLTPTIARS YASGVEALSGAAQLVGRGAPGTSETACHAALFSTDAQTFLASEALQAEVFGSSSLIVRCADFEQMRAVAE GIEGQLTATVHADDSDLDDAGRLLPLLELKAGRILFGGWPTGVEVCHAMVHGGPFPATSDSRSTSVGSQA IERYLRPVCYQDVPAPLLPSAIAEGNPEKLWRRVDGRLTQD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1031 | - | - | 100% (532) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1328 | - | 2e-25 | 27.97% (497) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1856 | - | 4e-25 | 28.87% (433) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0239c | gabD1 | 1e-14 | 24.58% (415) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4860 | - | 2e-20 | 27.68% (401) | gamma-aminobutyraldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0234c | gabD1 | 1e-14 | 24.58% (415) | succinic semialdehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-12 | 26.14% (352) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 2e-22 | 27.22% (496) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2610 | - | 2e-22 | 27.67% (477) | aldehyde dehydrogenase |
| M. avium 104 | MAV_5202 | - | 3e-20 | 25.79% (442) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6134 | - | 0.0 | 71.67% (533) | NADP-dependent fatty aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4531 | - | 5e-26 | 29.24% (472) | PUTATIVE putative betaine aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 2e-19 | 27.93% (426) | gamma-aminobutyraldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0239c|M.bovis_AF2122/97 MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
Rv0234c|M.tuberculosis_H37Rv MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRFVQTHPA
MLBr_02573|M.leprae_Br4923 --------------------------------------------------
Mflv_4860|M.gilvum_PYR-GCK ------------------------------------MTVASSWIDGAPVK
MAB_3328|M.abscessus_ATCC_1997 ------------------------------------MSVPSSWINGRPVA
MUL_2789|M.ulcerans_Agy99 --------------------------------MTTTVSVAGSWINGAAHS
MMAR_2610|M.marinum_M ---------------------------------MVEKKVFHNIIGGEIQA
MAV_5202|M.avium_104 -----------------------------------MREYLKFYIDGQWVD
TH_4531|M.thermoresistible__bu ------------------------------VTTTENRLVSEIHLAGRRLA
Mvan_1031|M.vanbaalenii_PYR-1 ----------------------------MTATISGATSLTGQMLIAGAPV
MSMEG_6134|M.smegmatis_MC2_155 ----------------------------MTSMVQ-TTDLTGQMLIAGTPV
Mb0239c|M.bovis_AF2122/97 KDVSVPIATINPATGETVK-TFTAATDDEVDAAIARAHRRFADYRQTSFA
Rv0234c|M.tuberculosis_H37Rv KDVSVPIATINPATGETVK-TFTAATDDEVDAAIARAHRRFADYRQTSFA
MLBr_02573|M.leprae_Br4923 ----MSIATINPATGETVK-TFTPTTQDEVEDAIARAYARFDNYRHTTFT
Mflv_4860|M.gilvum_PYR-GCK TG-GAQHTVINPATGESVA-EFALAQPGDVDRAVVSARAALPGWKGATPA
MAB_3328|M.abscessus_ATCC_1997 TH-GDTHRVINPATGEAVA-DLKLATTADVDAAVAAARAAGPAWASSTPV
MUL_2789|M.ulcerans_Agy99 TG-GRQHAVINPATQETIA-ELALATPADVDHAVVAARRALPQWAGVTTA
MMAR_2610|M.marinum_M TPDGNTMDIVNPSTGEVYA-SAPNSSGKDVDDAFTAAAKAFESWRWSTPS
MAV_5202|M.avium_104 PVRPNTFDVENPATEQVCG-KISLGSAADVDVAVGAARRAFGRWSQSSRE
TH_4531|M.thermoresistible__bu EGSAGVYEHVNPATGKVQG-EVPLAGPAEVDEAVAAAQEAFKEWRKWRPE
Mvan_1031|M.vanbaalenii_PYR-1 RGTGKEVRAFDPAAGQPLEPVYQHGDNTHVDAACAAAADAFAQYRATTSE
MSMEG_6134|M.smegmatis_MC2_155 RGAGREIRGIDPQTGSFLEPAYPYGDTSHVEAACAAAADAFGPYRNAPVE
:* : . .*: * * :
Mb0239c|M.bovis_AF2122/97 QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
Rv0234c|M.tuberculosis_H37Rv QRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYA
MLBr_02573|M.leprae_Br4923 QRAKWANATADLLEAEANQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYA
Mflv_4860|M.gilvum_PYR-GCK ERSAVLAKLAKLADDATADLVAEEVSQTGKPVRLATEFDVPGSVDNIDFF
MAB_3328|M.abscessus_ATCC_1997 DRSSVLAKLAAVLSANADTLVADEVAQTGKPVRLASEFDVPGSIDNVEFF
MUL_2789|M.ulcerans_Agy99 ERSAVLAELADLLEQRAPELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFF
MMAR_2610|M.marinum_M ERQRALLRLADLIEDNAEELVALECENTGKPISLTMSEEIPPMVDQIRFF
MAV_5202|M.avium_104 DRLDLLQAILAEYQKRADDLAAAVTEEIGAPPSLAAGPQVFLGIGHLTTA
TH_4531|M.thermoresistible__bu DRRRLLTRIAERIRAHEDELAVLQARENGLPVSQGKAVLVPHGAGWFEAA
Mvan_1031|M.vanbaalenii_PYR-1 QRAAFLDTIATNIEAVGEALIARAVAESGLPQAR-ITGELGRTTGQLRLF
MSMEG_6134|M.smegmatis_MC2_155 QRARFLEAIADNLDSSRDVLVERAHAESGLPVAR-LTGEVGRTSGQLRLF
:* : * . : .
Mb0239c|M.bovis_AF2122/97 ENAEA-------LLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLW
Rv0234c|M.tuberculosis_H37Rv ENAEA-------LLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLW
MLBr_02573|M.leprae_Br4923 EKAET-------LLADEPAEAAAVGASKALARYQPLGVVLAVMPWNFPLW
Mflv_4860|M.gilvum_PYR-GCK AGAAR-------HLEGK-ASAEYSGDHTSSIRREAVGVVATITPWNYPLQ
MAB_3328|M.abscessus_ATCC_1997 AGAAR-------HLEGK-ATAEYSADHTSSIRREAAGVVATITPWNYPLQ
MUL_2789|M.ulcerans_Agy99 AGAAR-------RLPGQ-ATAEYSADHTSSIRREAIGVVATITPWNYPLQ
MMAR_2610|M.marinum_M AGAAR-------VLEGR-SQGEYMRGHTSSIRREPVGPVAQVAPWNYPMM
MAV_5202|M.avium_104 IEVLK-------NFAFT------EQRGATLIAREPIGVCGLITPWNWPIN
TH_4531|M.thermoresistible__bu AGWAD-------KLEGA-VVPTTPGETVDLTLLEPIGVVAVILTWNAPIG
Mvan_1031|M.vanbaalenii_PYR-1 ASVLREGSWNGARIDTALPDRTPLPRPDLRQRHIPLGPVAVFSASNFPLA
MSMEG_6134|M.smegmatis_MC2_155 AGVLREGSWNQARIDPALPDREPLPRPDIRQRSVPLGPVAVFGASNFPLA
: . * . . * *:
Mb0239c|M.bovis_AF2122/97 QAVR--FAAPALMAGNVGLLKHASNVP----QCALYLADVIARGGFPDGC
Rv0234c|M.tuberculosis_H37Rv QAVR--FAAPALMAGNVGLLKHASNVP----QCALYLADVIARGGFPDGC
MLBr_02573|M.leprae_Br4923 QTVR--FAAPALMAGNVGLLKHASNVP----QCALYLADVIARGGFPEDC
Mflv_4860|M.gilvum_PYR-GCK MAVW--KVIPALAAGCSVVIKPAEITP----LTTLTLARLASEAGLPDGV
MAB_3328|M.abscessus_ATCC_1997 MAVW--KVLPALAAGCTVVIKPSELTP----LTTLTLARLAAEAGLPEGV
MUL_2789|M.ulcerans_Agy99 MAVW--KVMPALAAGCTVVIKPSELTP----LTTLTLARLAAEAGLPDGV
MMAR_2610|M.marinum_M MAVW--KFAPALAAGCTVVLKPSDTTP----ASSYWMVEKMQEI-FPPGV
MAV_5202|M.avium_104 QVAV--KVYPALATGCTVVLKPSEVAP----FSSYIFAEILAAAGVPAGV
TH_4531|M.thermoresistible__bu GWGM--CVAPPLAAGCCVILKPSELAP----FTSSFIARICEEEGMPPGV
Mvan_1031|M.vanbaalenii_PYR-1 FSVAGGDTASALAAGCPVVVKGHDAHPGTSELVARAVTDAVTTSGLPAGT
MSMEG_6134|M.smegmatis_MC2_155 FSVAGGDTASALAAGCPVVVKAHDAHPGTSELVGRAIAQAVTATGMPAGT
..* :* ::* . * .. .* .
Mb0239c|M.bovis_AF2122/97 FQTLLVSSGAVEAILR-DPRVAAATLTGSEPAGQSVGAIAGNEIK--PTV
Rv0234c|M.tuberculosis_H37Rv FQTLLVSSGAVEAILR-DPRVAAATLTGSEPAGQSVGAIAGNEIK--PTV
MLBr_02573|M.leprae_Br4923 FQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVGAIAGNEIK--PTV
Mflv_4860|M.gilvum_PYR-GCK LNVVTGSGADVGAALAGHADVDMVTFTGSTPVGRRVMLAAAAHGH--RTQ
MAB_3328|M.abscessus_ATCC_1997 LNVVTGRGDDVGYALASHPDVDLVTFTGSTAVGRKVMAAAAVHGH--RTQ
MUL_2789|M.ulcerans_Agy99 LNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAAAATHGR--RTQ
MMAR_2610|M.marinum_M CNLVCG-DRDTGAALVAHPVPQLVSITGSTRAGMAVAASAANDLK--RAH
MAV_5202|M.avium_104 FNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVARNAAPTVK--RVT
TH_4531|M.thermoresistible__bu VTVLPG-GPDAGEALVRHPGVAKVSFTGGGPTGRKIAAACGEQLK--PVL
Mvan_1031|M.vanbaalenii_PYR-1 FSLLFGSGPGLGIALVTDPRIKAVGFTGSRSGGMALVSAAAARPEPIPVY
MSMEG_6134|M.smegmatis_MC2_155 FSLLYGYGPDLGSALVTDPRIKAVGFTGSRAGGMALVAAAAARPEPIPVY
: * .. . :**. * : .. . .
Mb0239c|M.bovis_AF2122/97 LELGGSDPFIVMP---SADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHAD
Rv0234c|M.tuberculosis_H37Rv LELGGSDPFIVMP---SADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHAD
MLBr_02573|M.leprae_Br4923 LELGGSDPFIVMP---SADLDAAVATAVTGRVQNNGQSCIAAKRFIAHAD
Mflv_4860|M.gilvum_PYR-GCK LELGGKAPFVVFD---DADLDAAIQGAVAGALINTGQDCTAATRAIVAEG
MAB_3328|M.abscessus_ATCC_1997 LELGGKAPFVVFD---DADMDAAIAGAVAGAIINSGQDCTAATRALVARD
MUL_2789|M.ulcerans_Agy99 LELGGKAPFVVFD---DADLDAAIQGAVAGAVINSGQDCTAATRAIVARE
MMAR_2610|M.marinum_M LELGGKAPVVIFN---DADIAAAVEGLTAAGYFNAGQDCTAATRLIIQDG
MAV_5202|M.avium_104 QELGGKSPNIVLD---DGGFADAVRAGVANMMPNSGQSCNAPSRMLVPAS
TH_4531|M.thermoresistible__bu LELGGKSANIVFP---DADLAKAAETAAS-VIFSAGQACTLPTRILVHES
Mvan_1031|M.vanbaalenii_PYR-1 AEMSSINPVFVLDGALKTRGAELGRAFVASLTMGSGQFCTNPGLVIAVDG
MSMEG_6134|M.smegmatis_MC2_155 AEMSAINPVFLLRGALSARAADLARAFVGSLTMGSGQFCTNPGLVIAVDG
*:.. . .:: . . . ** * . :
Mb0239c|M.bovis_AF2122/97 IYDDFVDKFVARMAALRVG-DPTDPDTDVGPLATEQGRNEVAKQVEDA-A
Rv0234c|M.tuberculosis_H37Rv IYDDFVDKFVARMAALRVG-DPTDPDTDVGPLATEQGRNEVAKQVEDA-A
MLBr_02573|M.leprae_Br4923 IYDEFVEKFVARMETLRVG-DPTDPDTDVGPLATESGRAQVEQQVDAA-A
Mflv_4860|M.gilvum_PYR-GCK LYDDFVAGVAEVMSKVVIG-DPADPDTDLGPLISAVHREKVAGMVERA-P
MAB_3328|M.abscessus_ATCC_1997 LYDDFVAGVGEVMSKVVVG-DPLDPDTDIGPLISAAHRAKVSSIVDRA-P
MUL_2789|M.ulcerans_Agy99 LCHDFVAGVADVMSTVVIG-DPMDPDTDIGPLISLAHRDRVADILAKA-P
MMAR_2610|M.marinum_M IYDEFLSAMAESVAGTRTGYDPADEDILFGPINNSNQMRHIDGLVSRA-P
MAV_5202|M.avium_104 RMAEAISIAREVAEQVQVG--DPDDATAIGPVASRAQFEKVQRLIQQG-I
TH_4531|M.thermoresistible__bu IYDEFTAMVAGALGQIPLG-DPLDPATMMGPVISEAAVERILRTVDEATR
Mvan_1031|M.vanbaalenii_PYR-1 PGLDTFAAAARDALAGSPATPMLTPTIARSYASGVEALSGAAQLVGRGAP
MSMEG_6134|M.smegmatis_MC2_155 PDLDAFVAAAAEAVAATAPTPMLTPGIAENFRTGVETLSGTAELIARGSD
: . : .
Mb0239c|M.bovis_AF2122/97 AAGAVIRCGGKRLDR---PGWFYPPTVITDISKDMALYTEEVFGPVASVF
Rv0234c|M.tuberculosis_H37Rv AAGAVIRCGGKRLDR---PGWFYPPTVITDISKDMALYTEEVFGPVASVF
MLBr_02573|M.leprae_Br4923 AAGAVIRCGGKRPDR---PGWFYPPTVITDITKDMALYTDEVFGPVASVY
Mflv_4860|M.gilvum_PYR-GCK GEGGRVVTGGVAPDG---PGSFYRPTLIADVAESSEVWRDEIFGPVLTVR
MAB_3328|M.abscessus_ATCC_1997 AQGGRIVTGATAPDL---PGSFYRPTLIADVAETSEVYRDEIFGPVLTVR
MUL_2789|M.ulcerans_Agy99 AQGARIVVGGRIPDL---AGAFYLPTLLADVGEQSQAYREEIFGPVLTVR
MMAR_2610|M.marinum_M AH-ARILAGGKQKDC---AGFFYEPTLIVDLQQDDELIQTEIFGPVVTAQ
MAV_5202|M.avium_104 DEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFGPVLCIL
TH_4531|M.thermoresistible__bu DNGAELLTGGSRAGGELASGYYIEPTLLGNVSPTSEVAQNEVFGPVTAAI
Mvan_1031|M.vanbaalenii_PYR-1 -GTSETACHAALFST------------DAQTFLASEALQAEVFGSSSLIV
MSMEG_6134|M.smegmatis_MC2_155 ENAPAVSCRAALFGS------------DVPTFLATEALQAEVFGASGVIV
. *:**.
Mb0239c|M.bovis_AF2122/97 RAANIDEAVEIANATTFGLGSNAWTRDETEQRR----FIDDIVAGQVFIN
Rv0234c|M.tuberculosis_H37Rv RAANIDEAVEIANATTFGLGSNAWTRDETEQRR----FIDDIVAGQVFIN
MLBr_02573|M.leprae_Br4923 CATNIDDAIEIANATPFGLGSNAWTQNESEQRH----FIDNIVAGQVFIN
Mflv_4860|M.gilvum_PYR-GCK SFTDDDDAIRQANDTKYGLAASAWTRDVYRAQR----ASREIHAGCVWIN
MAB_3328|M.abscessus_ATCC_1997 PFTDDDDALRQANDTAYGLAASAWTRDVYRAQR----ASREIRAGCVWIN
MUL_2789|M.ulcerans_Agy99 AHDGDDDALRQANDTDYGLAASAWTRDVYRAQR----ASREISAGCVWIN
MMAR_2610|M.marinum_M RFSDEQQALSFANGTEYGLASSVWTKDVDTAAR----MGARLDFGCVWIN
MAV_5202|M.avium_104 GYDDLDHAVRLANDTDYGLAGYVSGADLDTARE----VAGKIRAGWVTIN
TH_4531|M.thermoresistible__bu RFSDEEEAVAIANGTPYGLAGYVHTRDVSRVLR----LASALEAGTVAFN
Mvan_1031|M.vanbaalenii_PYR-1 RCADFEQMRAVAEGIEGQLTATVHADDSDLDDAGRLLPLLELKAGRILFG
MSMEG_6134|M.smegmatis_MC2_155 RCADDAEMLRVAAEVEGQLTATVHAEESDHAKAGELLEILELKAGRILFN
. . * * . . : : * : :.
Mb0239c|M.bovis_AF2122/97 ----GMTVSYPELPFGG---VKRSGYGRELSAHGIREFCN-------IKT
Rv0234c|M.tuberculosis_H37Rv ----GMTVSYPELPFGG---VKRSGYGRELSAHGIREFCN-------IKT
MLBr_02573|M.leprae_Br4923 ----GMTVSYPELPFGG---IKRSGYGRELSTHGIREFCN-------IKT
Mflv_4860|M.gilvum_PYR-GCK ----DHIPIISEMPHGG---FGASGFGKDMSQYSLEEYLS-------IKH
MAB_3328|M.abscessus_ATCC_1997 ----DHIPIISEMPHGG---FGASGFGKDMSDYSLEEYLT-------VKH
MUL_2789|M.ulcerans_Agy99 ----DHIPIVSEMPHGG---VAASGFGNDMSEYSFDEYLT-------IKH
MMAR_2610|M.marinum_M ----THIPLVAEMPHGG---FKHSGYGKDLSMYGFEDYTR-------IKH
MAV_5202|M.avium_104 ----HAFDLN--APFGG---YKRSGNGREWSDFGFHEYLE-------VKS
TH_4531|M.thermoresistible__bu ---GAGAPAGPGAPFGG---YKESGYGREGGKLGVLEFVQ-------HKT
Mvan_1031|M.vanbaalenii_PYR-1 GWP-TGVEVCHAMVHGGPFPATSDSRSTSVGSQAIERYLRPVCYQDVPAP
MSMEG_6134|M.smegmatis_MC2_155 GWP-TGVEVGHAMVHGGPFPSTSDSRTTSVGARAIERFLRPVCYQNAPKS
.** .. . . .. :
Mb0239c|M.bovis_AF2122/97 VWIA---------------------
Rv0234c|M.tuberculosis_H37Rv VWIA---------------------
MLBr_02573|M.leprae_Br4923 VWIA---------------------
Mflv_4860|M.gilvum_PYR-GCK VMSDITSAVDKDWHRTIFTKR----
MAB_3328|M.abscessus_ATCC_1997 VMSDITGTADKDWHRTIFAKR----
MUL_2789|M.ulcerans_Agy99 VMSDITGVAEKPWHRTIFSTRI---
MMAR_2610|M.marinum_M VM-----------HYHGFEG-----
MAV_5202|M.avium_104 ILGYAPAQADR--------------
TH_4531|M.thermoresistible__bu VSVALS-------------------
Mvan_1031|M.vanbaalenii_PYR-1 LLPSAIAEGNPEKLWRRVDGRLTQD
MSMEG_6134|M.smegmatis_MC2_155 LLPSAIADGNPDGMWRTVDGQLTKD
: