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REYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVDVAVGAARRAFGRWSQSSREDRLDLLQ AILAEYQKRADDLAAAVTEEIGAPPSLAAGPQVFLGIGHLTTAIEVLKNFAFTEQRGATLIAREPIGVCG LITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFAEILAAAGVPAGVFNLVNGDGPGVGAALA SHPDIDLVSFTGSTRAGVEVARNAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNA PSRMLVPASRMAEAISIAREVAEQVQVGDPDDATAIGPVASRAQFEKVQRLIQQGIDEGATVVAGGPGRP AGLDQGYYVKPTVFADVTNDMTIAREEIFGPVLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREV AGKIRAGWVTINHAFDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSILGYAPAQADR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5202 | - | - | 100% (478) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1643 | - | 2e-97 | 41.18% (476) | aldehyde dehydrogenase |
| M. avium 104 | MAV_4946 | - | 6e-96 | 43.91% (476) | aldehyde dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 3e-90 | 40.63% (475) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1797 | - | 0.0 | 77.85% (474) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 2e-96 | 41.61% (483) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-46 | 29.25% (465) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-105 | 45.49% (477) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 7e-96 | 42.86% (476) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0455 | - | 0.0 | 77.89% (475) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4605 | - | 0.0 | 78.90% (474) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 2e-94 | 42.44% (476) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4953 | - | 0.0 | 76.37% (474) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1797|M.gilvum_PYR-GCK -----MREYLKHYIDGQWVDPVRPNALDVDNPATEEVSGKIALGSSADVD
Mvan_4953|M.vanbaalenii_PYR-1 -----MREYLKHYIDGRWVDPVRPNALEVDNPTTEEISGRIALGSSADVD
MSMEG_0455|M.smegmatis_MC2_155 -----MREYLKFYIDGRWVDPVEPRTLDVDNPTTEQVAGRIAIGAAADVD
TH_4605|M.thermoresistible__bu VEDEGMREYLKFYIDGAWVDPVDLKTLDVDDPATEEVSGRIAIGSATDVD
MAV_5202|M.avium_104 -----MREYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVD
MMAR_0472|M.marinum_M --MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKVPLAAAADVD
MUL_1122|M.ulcerans_Agy99 --MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKVPLAAAADVD
Rv0223c|M.tuberculosis_H37Rv -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
MAB_4484|M.abscessus_ATCC_1997 -----MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPADVD
Mb0791|M.bovis_AF2122/97 -MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAEDMG
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
: . *:* : . ::
Mflv_1797|M.gilvum_PYR-GCK LAVTAARRAFG--TWSQTTREERLELLGAIMAEYQNRAADLADAVHEEMG
Mvan_4953|M.vanbaalenii_PYR-1 LAVTAARRAFA--TWSQTTREERLELLGAIMAEYQKRAGDLAEAVTEEMG
MSMEG_0455|M.smegmatis_MC2_155 AAVEAARKAFT--TWSQTSRDERLAVLGAILDEYQKRAIDLADAVGEEMG
TH_4605|M.thermoresistible__bu NAVRAARRAFP--AWSQSSREERLELLQGILAEYQKRSADLADAVHEEMG
MAV_5202|M.avium_104 VAVGAARRAFG--RWSQSSREDRLDLLQAILAEYQKRADDLAAAVTEEIG
MMAR_0472|M.marinum_M AAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLLADETG
MUL_1122|M.ulcerans_Agy99 AAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLFADETG
Rv0223c|M.tuberculosis_H37Rv AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
MAB_4484|M.abscessus_ATCC_1997 AAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADETG
Mb0791|M.bovis_AF2122/97 RAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTISEVG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
*: * * : . * . * *
Mflv_1797|M.gilvum_PYR-GCK APASLASGPQVNLGIGHLATAID-ALKNFQFEEQH----GSTLVVK----
Mvan_4953|M.vanbaalenii_PYR-1 APAGLASGPQVNLGIGHLATTVD-ALKNFAFEEQH----GSTLVVK----
MSMEG_0455|M.smegmatis_MC2_155 APASLAAGPQVRMGLGHLTTSIE-ALKKFQFEEQY----GSTLVVK----
TH_4605|M.thermoresistible__bu APPSLAKGPQVNMGLGHLTTAID-VLKNFSFEEQR----GATLVVK----
MAV_5202|M.avium_104 APPSLAAGPQVFLGIGHLTTAIE-VLKNFAFTEQR----GATLIAR----
MMAR_0472|M.marinum_M QPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQTIVHR----
MUL_1122|M.ulcerans_Agy99 QPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQTIVHR----
Rv0223c|M.tuberculosis_H37Rv QPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYGQSIVSR----
MAB_4484|M.abscessus_ATCC_1997 APPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYGQTLVTR----
Mb0791|M.bovis_AF2122/97 APRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPLGIATRRTLA
MLBr_02573|M.leprae_Br4923 KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALAR----
. * :
Mflv_1797|M.gilvum_PYR-GCK -EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFT
Mvan_4953|M.vanbaalenii_PYR-1 -EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFT
MSMEG_0455|M.smegmatis_MC2_155 -EPIGVCGLITPWNWPINQIACKVFPALATGCTMVLKPSEVAPFSAQIFT
TH_4605|M.thermoresistible__bu -EPIGVCGLITPWNWPLNQIACKVFPALATGCTMVLKPSEVAPYSGQIFT
MAV_5202|M.avium_104 -EPIGVCGLITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFA
MMAR_0472|M.marinum_M -EPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPLTANALA
MUL_1122|M.ulcerans_Agy99 -EPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAETPLTANALA
Rv0223c|M.tuberculosis_H37Rv -EPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALA
MAB_4484|M.abscessus_ATCC_1997 -EPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFILA
Mb0791|M.bovis_AF2122/97 REAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALG
MLBr_02573|M.leprae_Br4923 YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLA
:. ** : .** * ** :* . :** : .* . :
Mflv_1797|M.gilvum_PYR-GCK EILDAAG-VPAGVYNLVYGDGPGVGAAISSHPEIDMVSFTGSTRAGIEVA
Mvan_4953|M.vanbaalenii_PYR-1 EIIDAAG-VPAGVYNLVYGDGPGVGASISSHPDIDMVSFTGSTRAGIEIA
MSMEG_0455|M.smegmatis_MC2_155 EIIEAAG-VPAGVYNLVYGDGPGVGSALSSHPDIDMVSFTGSTRAGIDVA
TH_4605|M.thermoresistible__bu EILDTAG-VPAGVYNMVFGDGPGVGVALSSHPDVDLVSFTGSTRAGVDVA
MAV_5202|M.avium_104 EILAAAG-VPAGVFNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVA
MMAR_0472|M.marinum_M EVFAEAG-LPEGVLSVVPG-GVETGQALTSNPGVDLFTFTGSSAVGKEIG
MUL_1122|M.ulcerans_Agy99 EVFAEAG-LPEGVLSVVPG-GVETGQALTSNPGVDLFTFTGSSAVGKEIG
Rv0223c|M.tuberculosis_H37Rv EVFAEVG-LPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGREVG
MAB_4484|M.abscessus_ATCC_1997 EVFAEAG-VPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVGKEIA
Mb0791|M.bovis_AF2122/97 EIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVM
MLBr_02573|M.leprae_Br4923 DVIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVG
::: .* . . : . : .* : ::*** .* :
Mflv_1797|M.gilvum_PYR-GCK RNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAP
Mvan_4953|M.vanbaalenii_PYR-1 RNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAP
MSMEG_0455|M.smegmatis_MC2_155 RNAAPTVKRVTQELGGKSPNIVLDDADFAKSVAAGVSAMMTNSGQSCNAP
TH_4605|M.thermoresistible__bu RNAAPTVKRVTQELGGKSANIVLDDADFAKSVTAGVTTMMLNSGQSCNAP
MAV_5202|M.avium_104 RNAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNAP
MMAR_0472|M.marinum_M RRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQACVGQ
MUL_1122|M.ulcerans_Agy99 RRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQACVGQ
Rv0223c|M.tuberculosis_H37Rv RRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQ
MAB_4484|M.abscessus_ATCC_1997 EIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVNQ
Mb0791|M.bovis_AF2122/97 ADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAIT
MLBr_02573|M.leprae_Br4923 AIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAA
*. :* ****... ::: . .: : . : **.*
Mflv_1797|M.gilvum_PYR-GCK SRMLVPNSRMDEAIAVARETAGAVKVGDPGD-QSAIGPVASRAQFEKIQG
Mvan_4953|M.vanbaalenii_PYR-1 SRMLVPNSRMDEAIAVARETAAAVKVGDPSD-KTAIGPVASKAQFDKIQG
MSMEG_0455|M.smegmatis_MC2_155 SRMLVPNSRMGEAITIARGTAAAVKVGDPSD-KKAIGPVASKAQFDKIQG
TH_4605|M.thermoresistible__bu SRMLVPNSRMDEAIEIARETAAQVAVGDPDN-KTAIGPVVSRVQFDKIQR
MAV_5202|M.avium_104 SRMLVPASRMAEAISIAREVAEQVQVGDPDD-ATAIGPVASRAQFEKVQR
MMAR_0472|M.marinum_M TRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQRARVEG
MUL_1122|M.ulcerans_Agy99 TRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLISEKQRARVEG
Rv0223c|M.tuberculosis_H37Rv TRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEG
MAB_4484|M.abscessus_ATCC_1997 TRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVEG
Mb0791|M.bovis_AF2122/97 TRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQG
MLBr_02573|M.leprae_Br4923 KRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQ
.*.:. * : : * * : *.: : :::
Mflv_1797|M.gilvum_PYR-GCK LIQKGIDEGATLVVGGTGRPDGVDKGYYVKPTVFANVTNDMTIAREEIFG
Mvan_4953|M.vanbaalenii_PYR-1 LIQKGIDEGATLVIGGTGRPDGIDKGYYVKPTVFANVTNDMTIAREEIFG
MSMEG_0455|M.smegmatis_MC2_155 LIQKGIDEGATLVAGGTGRPDGLDTGYYVKPTVFADVTNDMTIAREEIFG
TH_4605|M.thermoresistible__bu LIQQGIDEGATVVVGGPGRPDGLEVGYYVKPTVFANVKNDMTIAREEIFG
MAV_5202|M.avium_104 LIQQGIDEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFG
MMAR_0472|M.marinum_M YIAKGIEEGARLVSGG-GRPEGLDNGFFVQPTVFADVDNKMTIAQEEIFG
MUL_1122|M.ulcerans_Agy99 YIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKMTIAQEEIFG
Rv0223c|M.tuberculosis_H37Rv YIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFG
MAB_4484|M.abscessus_ATCC_1997 YIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEEIFG
Mb0791|M.bovis_AF2122/97 YLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARVAREEIFG
MLBr_02573|M.leprae_Br4923 QVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDEVFG
: . *. . ** ** *:: **:::.: :. : :*:**
Mflv_1797|M.gilvum_PYR-GCK PVLCILGYDDLDQAVAIGNDTEYGLAGYVSGSDLEQARAVARRIRAGSVA
Mvan_4953|M.vanbaalenii_PYR-1 PVLCILGYDDLDQAVEIGNDTEYGLAGYVSGADLDKARAVARRIRAGSVA
MSMEG_0455|M.smegmatis_MC2_155 PVLCILGYDDLDQAVEIANDTEYGLAGYVSGADLETARAVARRIRAGSVA
TH_4605|M.thermoresistible__bu PVLCILGYDDLDDAIEIANDTDYGLAGYVSGSDLEQARALARRIRAGSIA
MAV_5202|M.avium_104 PVLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREVAGKIRAGWVT
MMAR_0472|M.marinum_M PVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTGTYA
MUL_1122|M.ulcerans_Agy99 PVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTGTYA
Rv0223c|M.tuberculosis_H37Rv PVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYG
MAB_4484|M.abscessus_ATCC_1997 PVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGTYG
Mb0791|M.bovis_AF2122/97 PVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVN
MLBr_02573|M.leprae_Br4923 PVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVF
** : :.*: :.* : :**.. . : . .: .*
Mflv_1797|M.gilvum_PYR-GCK IN--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA--
Mvan_4953|M.vanbaalenii_PYR-1 IN--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA--
MSMEG_0455|M.smegmatis_MC2_155 IN--HGFDLSAPFGGYKRSGNGREWGHFGFDEYLETKAAM---GYAPPQ-
TH_4605|M.thermoresistible__bu IN--HGFDLNAPFGGYKRSGNGREWSDYGFHEYLETKAIL---GYSPS--
MAV_5202|M.avium_104 IN--HAFDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSIL---GYAPAQA
MMAR_0472|M.marinum_M INW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTLES-
MUL_1122|M.ulcerans_Agy99 INW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTLES-
Rv0223c|M.tuberculosis_H37Rv INW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA--
MAB_4484|M.abscessus_ATCC_1997 INW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLESI
Mb0791|M.bovis_AF2122/97 VNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIA-----TAAN-
MLBr_02573|M.leprae_Br4923 INGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA--------
:* **** *.** *** . .. .: : *
Mflv_1797|M.gilvum_PYR-GCK --
Mvan_4953|M.vanbaalenii_PYR-1 --
MSMEG_0455|M.smegmatis_MC2_155 --
TH_4605|M.thermoresistible__bu --
MAV_5202|M.avium_104 DR
MMAR_0472|M.marinum_M --
MUL_1122|M.ulcerans_Agy99 --
Rv0223c|M.tuberculosis_H37Rv --
MAB_4484|M.abscessus_ATCC_1997 --
Mb0791|M.bovis_AF2122/97 --
MLBr_02573|M.leprae_Br4923 --