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MVEKKVFHNIIGGEIQATPDGNTMDIVNPSTGEVYASAPNSSGKDVDDAFTAAAKAFESWRWSTPSERQR ALLRLADLIEDNAEELVALECENTGKPISLTMSEEIPPMVDQIRFFAGAARVLEGRSQGEYMRGHTSSIR REPVGPVAQVAPWNYPMMMAVWKFAPALAAGCTVVLKPSDTTPASSYWMVEKMQEIFPPGVCNLVCGDRD TGAALVAHPVPQLVSITGSTRAGMAVAASAANDLKRAHLELGGKAPVVIFNDADIAAAVEGLTAAGYFNA GQDCTAATRLIIQDGIYDEFLSAMAESVAGTRTGYDPADEDILFGPINNSNQMRHIDGLVSRAPAHARIL AGGKQKDCAGFFYEPTLIVDLQQDDELIQTEIFGPVVTAQRFSDEQQALSFANGTEYGLASSVWTKDVDT AARMGARLDFGCVWINTHIPLVAEMPHGGFKHSGYGKDLSMYGFEDYTRIKHVMHYHGFEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2610 | - | - | 100% (481) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | e-120 | 48.39% (467) | aldehyde dehydrogenase NAD dependent |
| M. marinum M | MMAR_4912 | - | 1e-75 | 35.26% (485) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 2e-75 | 34.72% (481) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3819 | - | 1e-170 | 61.44% (472) | gamma-aminobutyraldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 2e-75 | 34.72% (481) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 9e-60 | 31.93% (451) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4203 | - | 1e-147 | 54.32% (475) | putative aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 3e-83 | 37.29% (472) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1665 | - | 1e-121 | 48.11% (476) | gamma-aminobutyraldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2957 | - | 5e-78 | 37.79% (471) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 1e-117 | 47.32% (467) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2580 | - | 1e-170 | 61.65% (472) | gamma-aminobutyraldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3819|M.gilvum_PYR-GCK ----------------MTTVKNFIGGELVDST---GGATMPLIDPSTGEQ
Mvan_2580|M.vanbaalenii_PYR-1 ----------------MTTVQNFIDGQLVDST---SGATMPLVDPSTGEQ
MMAR_2610|M.marinum_M -------------MVEKKVFHNIIGGEIQATP---DGNTMDIVNPSTGEV
MAB_4203|M.abscessus_ATCC_1997 --------------MPDSVLQNYIDGQFVDALSLKSSEPIDLINPVDESV
MSMEG_1665|M.smegmatis_MC2_155 --------------MAVKVASSWINGASVETS----GETHQIIDPATGKS
MUL_2789|M.ulcerans_Agy99 ------------MTTTVSVAGSWINGAAHSTG----GRQHAVINPATQET
MAV_1897|M.avium_104 ---MTDTTISNGVTEQLVHFDLVIGGESVAAE---SGRTYDSIDPYTALP
TH_2957|M.thermoresistible__bu ---MTSTLERPEVT-------LRIGGEKRRTA---SGGTFDHINPCTGAP
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAGALMSYESRYQNFIGGQWVAPV---HGRYFENPTPVTGQP
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAGALMSYESRYQNFIGGQWVAPV---HGRYFENPTPVTGQP
MLBr_02573|M.leprae_Br4923 -------------------------------------MSIATINPATGET
*
Mflv_3819|M.gilvum_PYR-GCK YGTAPVSNEQDIDNAYAAASGAFKE-WKKTTPSQRQKALLDFADEVERNA
Mvan_2580|M.vanbaalenii_PYR-1 YGTAPVSNEQDIDNAYAAAARAFKE-WKKTTPSQRQKALLDFADEVERNA
MMAR_2610|M.marinum_M YASAPNSSGKDVDDAFTAAAKAFES-WRWSTPSERQRALLRLADLIEDNA
MAB_4203|M.abscessus_ATCC_1997 VGRAPVSNLEDVNAAVAAAERAFES-WGRSTPSFRQQALLKLADAIEAHT
MSMEG_1665|M.smegmatis_MC2_155 VSEYNLATAADVDTAVAAARAAFPA-WAGATPAERSAVLAKLAKLADEHA
MUL_2789|M.ulcerans_Agy99 IAELALATPADVDHAVVAARRALPQ-WAGVTTAERSAVLAELADLLEQRA
MAV_1897|M.avium_104 WARVPDCGPADVDRAVAAARAALRGPWGQLTGTARGKLLWRLGELIAREA
TH_2957|M.thermoresistible__bu DAAIPLAGPAEIDDAVKAAHDAFHS-WRQTNPAERRRLLFRLAELIEQHT
Mb0467|M.bovis_AF2122/97 FCEVPRSDAADIDKALDAAHAAAPG-WGKTAPAERAAILNMIADRIDKNA
Rv0458|M.tuberculosis_H37Rv FCEVPRSDAADIDKALDAAHAAAPG-WGKTAPAERAAILNMIADRIDKNA
MLBr_02573|M.leprae_Br4923 VKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEAEA
::: * * : : * .. .:
Mflv_3819|M.gilvum_PYR-GCK DALVAAEGRNTGKPNHVTTVEEIPPMVDQIRFFAGAARVLEGKSAGEY-M
Mvan_2580|M.vanbaalenii_PYR-1 DALVAAEGRNTGKPDHVTAAEEIPPMVDQIRFFAGAARVLEGKSAGEY-M
MMAR_2610|M.marinum_M EELVALECENTGKPISLTMSEEIPPMVDQIRFFAGAARVLEGRSQGEY-M
MAB_4203|M.abscessus_ATCC_1997 DEIVDAQCRNTGQPKAVIAAEEVAVSADQIRFFAGAARLVEGKSAGEY-M
MSMEG_1665|M.smegmatis_MC2_155 EQFVAEEVSQTGKPVRLATEFDVPGSVDNIDFFAGAARHLEGKATAEY-S
MUL_2789|M.ulcerans_Agy99 PELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEY-S
MAV_1897|M.avium_104 ESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGEVVPVD-K
TH_2957|M.thermoresistible__bu DDFVRLGTFDNGTPVGLVAG-LVAMSAEWTRYYAGWADKITSEVSGTYGT
Mb0467|M.bovis_AF2122/97 AALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQID--
Rv0458|M.tuberculosis_H37Rv AALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQID--
MLBr_02573|M.leprae_Br4923 NQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAV
: * : : .
Mflv_3819|M.gilvum_PYR-GCK ADHTSWIRREPVGVIGQVAPWNYPMMMAIWKICPAVAAGNTVVIKPSDTT
Mvan_2580|M.vanbaalenii_PYR-1 ADHTSWIRREPIGVIGQVAPWNYPMMMAIWKICPAIAAGNTVVIKPSDTT
MMAR_2610|M.marinum_M RGHTSSIRREPVGPVAQVAPWNYPMMMAVWKFAPALAAGCTVVLKPSDTT
MAB_4203|M.abscessus_ATCC_1997 EGFTSYVRREPIGVVGQVTPWNYPFMMAIWKIGPALAAGNTVVLKPSDTT
MSMEG_1665|M.smegmatis_MC2_155 GDHTSSIRREAVGVVATITPWNYPLQMAVWKVIPALAAGCAVVIKPAEIT
MUL_2789|M.ulcerans_Agy99 ADHTSSIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELT
MAV_1897|M.avium_104 PNFFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHT
TH_2957|M.thermoresistible__bu TGEFSYTLSQPYGVIGVIITWNGPLISLAMKVPAALAAGNTVVVKPSELT
Mb0467|M.bovis_AF2122/97 EDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQT
Rv0458|M.tuberculosis_H37Rv EDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQT
MLBr_02573|M.leprae_Br4923 GASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNV
:. * : : .** *: ..: ** . ::* :. .
Mflv_3819|M.gilvum_PYR-GCK PVTTVMLAELAAKH-LPPGVLNVVTGD-RVTGANLVSHPTPEMVAITGSV
Mvan_2580|M.vanbaalenii_PYR-1 PVTTVMLAELAAKY-LPAGVLNVVTGD-RVTGASLVAHPTPEMVAITGSV
MMAR_2610|M.marinum_M PASSYWMVEKMQEI-FPPGVCNLVCGD-RDTGAALVAHPVPQLVSITGST
MAB_4203|M.abscessus_ATCC_1997 PESTLVLARLTKGI-LPDGVFNVVLGT-AATGSDLVSHPAIGLVSITGSV
MSMEG_1665|M.smegmatis_MC2_155 PLTTLTLARLASEAGLPDGVFNVVTGSGAEVGTALAGHRDVDVVTFTGST
MUL_2789|M.ulcerans_Agy99 PLTTLTLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGST
MAV_1897|M.avium_104 PASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGST
TH_2957|M.thermoresistible__bu PFSATLFADLAAEAGIPDGVINVVPGTG-DAGAALVAHPLVKKVTFTGGP
Mb0467|M.bovis_AF2122/97 PASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGET
Rv0458|M.tuberculosis_H37Rv PASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGET
MLBr_02573|M.leprae_Br4923 PQCALYLADVIARGGFPEDCFQTLLIS-ANGVEAILRDPRVAAATLTGSE
* : :* . : : : ::**
Mflv_3819|M.gilvum_PYR-GCK AAGKAVAVSAGGNLKRTHLELGGKAPVIVFDD--ADLAATAE-GIATAGY
Mvan_2580|M.vanbaalenii_PYR-1 AAGKAVAVSAGGNLKRTHLELGGKAPVIVFDD--ADLAAAAE-GIATAGY
MMAR_2610|M.marinum_M RAGMAVAASAANDLKRAHLELGGKAPVVIFND--ADIAAAVE-GLTAAGY
MAB_4203|M.abscessus_ATCC_1997 RAGIAVATSAAGQLKRSHLELGGKAPAVVFGD--VDIDKAAL-GIAQAAF
MSMEG_1665|M.smegmatis_MC2_155 AVGRKVMASAAVHGHRTQLELGGKAPFVVFSD--ADLDAAVQ-GAVAGAL
MUL_2789|M.ulcerans_Agy99 AVGRKVMAAAATHGRRTQLELGGKAPFVVFDD--ADLDAAIQ-GAVAGAV
MAV_1897|M.avium_104 ATGISVGKAAIDNMTRFTLELGGKSAQVVFDD--ADLDAAAN-GVIAGVF
TH_2957|M.thermoresistible__bu DTARKILQSCAEHIKPSVMELGGKSGNIIFED--ANLDTACSVGTLMSVG
Mb0467|M.bovis_AF2122/97 TTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTM
Rv0458|M.tuberculosis_H37Rv TTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTM
MLBr_02573|M.leprae_Br4923 PAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS--ADLDAAVA-TAVTGRV
.. : . . :****. :.: . .
Mflv_3819|M.gilvum_PYR-GCK FNAGQD--CTAATRVLASASIAADLTAALAEQAKGATTTFGRPADDEDAW
Mvan_2580|M.vanbaalenii_PYR-1 FNAGQD--CTAATRVLASASIAADLTAALAEQAKGATTTFGRAAGDEDAW
MMAR_2610|M.marinum_M FNAGQD--CTAATRLIIQDGIYDEFLSAMAESVAGTRT--GYDPADEDIL
MAB_4203|M.abscessus_ATCC_1997 FNAGQD--CTAATRVIVHESIHDDFVNALDTAAQTLRP---GLPDDPDSF
MSMEG_1665|M.smegmatis_MC2_155 INTGQD--CTAATRAIVARELYDDFVAGVAEVMGKIVVG---DPHDPDTD
MUL_2789|M.ulcerans_Agy99 INSGQD--CTAATRAIVARELCHDFVAGVADVMSTVVIG---DPMDPDTD
MAV_1897|M.avium_104 AATGQT--CLAGSRLLVHESVADALVERIVARASTIKLG---DPKDPATE
TH_2957|M.thermoresistible__bu MMSGQG--CAFPTRMIVARPLYDEVLTRVSALAPMVKVG---DPLEPDTV
Mb0467|M.bovis_AF2122/97 FALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETM
Rv0458|M.tuberculosis_H37Rv FALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETM
MLBr_02573|M.leprae_Br4923 QNNGQS--CIAAKRFIAHADIYDEFVEKFVARMETLRVG---DPTDPDTD
.* * .* : : . . :
Mflv_3819|M.gilvum_PYR-GCK VPPVNNVNQMERVLSFFSDIPSH-ATVAVGGNRQGDK-----GFYVEPTV
Mvan_2580|M.vanbaalenii_PYR-1 VPPVNNVNQMERVLSFFSDIPSH-ATVAVGGNRQGDK-----GFYVEPTV
MMAR_2610|M.marinum_M FGPINNSNQMRHIDGLVSRAPAH-ARILAGGKQKDCA-----GFFYEPTL
MAB_4203|M.abscessus_ATCC_1997 YGPMNNINHFTTVTEKLDNLPAH-ATVVTGGKRWGET-----GYFIEPTI
MSMEG_1665|M.smegmatis_MC2_155 LGPLISYAHRDKVAGMVARAPQQGGRVVTGGEAPDLP-----GAFYRPTL
MUL_2789|M.ulcerans_Agy99 IGPLISLAHRDRVADILAKAPAQGARIVVGGRIPDLA-----GAFYLPTL
MAV_1897|M.avium_104 MGPVSNQPQYEKVLSHFASAREQGATVAYGGE--PAG-ELG-GFFVKPTV
TH_2957|M.thermoresistible__bu AGPVVNEAALQRILGMIERAKQDGARLLTGGE--RLGGDLADEYFVAPTV
Mb0467|M.bovis_AF2122/97 LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTI
Rv0458|M.tuberculosis_H37Rv LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTI
MLBr_02573|M.leprae_Br4923 VGPLATESGRAQVEQQVDAAAAAGAVIRCGGKRPDRP-----GWFYPPTV
. . : . . : **. : **:
Mflv_3819|M.gilvum_PYR-GCK VGGLRQDDRLIQQEIFGPVITVQSFTDEDEAIGYANGVEYGLASSVWTKD
Mvan_2580|M.vanbaalenii_PYR-1 IGGLRQADRLIQQEIFGPVITVQSFSDEEEAIGWANGVEYGLASSVWTKD
MMAR_2610|M.marinum_M IVDLQQDDELIQTEIFGPVVTAQRFSDEQQALSFANGTEYGLASSVWTKD
MAB_4203|M.abscessus_ATCC_1997 VTGVRQDDAIVQEETFGPILTVQSFADAGEALRLANGVRYALASSVWTKD
MSMEG_1665|M.smegmatis_MC2_155 IADVDESSEVYRDEIFGPVLTVRSFTDDDDALRQANDTEYGLAASAWTRD
MUL_2789|M.ulcerans_Agy99 LADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRD
MAV_1897|M.avium_104 LTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKD
TH_2957|M.thermoresistible__bu FADVDPYSELAQKEVFGPVLSIIPFDTEEQAVEIANSTPYGLSGYVFTND
Mb0467|M.bovis_AF2122/97 FTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRD
Rv0458|M.tuberculosis_H37Rv FTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRD
MLBr_02573|M.leprae_Br4923 ITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQN
. . * ***: : :*: ** . :.*.. .::.:
Mflv_3819|M.gilvum_PYR-GCK VSRALRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDY
Mvan_2580|M.vanbaalenii_PYR-1 VSRALRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDY
MMAR_2610|M.marinum_M VDTAARMGARLDFGCVWINTHIPLVAEMPHGGFKHSGYGKDLSMYGFEDY
MAB_4203|M.abscessus_ATCC_1997 HATAETFTRELNFGCVWVNCHIPLVAEMPHGGFKYSGYGKDLSAYSVEDY
MSMEG_1665|M.smegmatis_MC2_155 VYRAQRASREINAGCVWINDHIPIISEMPHGGVGASGFGKDMSDYSFEEY
MUL_2789|M.ulcerans_Agy99 VYRAQRASREISAGCVWINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEY
MAV_1897|M.avium_104 VHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDF
TH_2957|M.thermoresistible__bu LKRAHRVAEQLETGEVLINGAAPLTVHRPFGGFGISGIGKEGGREGLAEF
Mb0467|M.bovis_AF2122/97 GNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHY
Rv0458|M.tuberculosis_H37Rv GNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHY
MLBr_02573|M.leprae_Br4923 ESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREF
: * * :* . ..** ** *.: . .:
Mflv_3819|M.gilvum_PYR-GCK TRIKHVMAYTG----------------
Mvan_2580|M.vanbaalenii_PYR-1 TRIKHVMAYTG----------------
MMAR_2610|M.marinum_M TRIKHVMHYHGFEG-------------
MAB_4203|M.abscessus_ATCC_1997 TRIKHIMSAHA----------------
MSMEG_1665|M.smegmatis_MC2_155 LTIKHVMSDITGVAEKEWHRTIFNKR-
MUL_2789|M.ulcerans_Agy99 LTIKHVMSDITGVAEKPWHRTIFSTRI
MAV_1897|M.avium_104 TETKAVWVELSGATRDPFTLG------
TH_2957|M.thermoresistible__bu LRTKSVSIA------------------
Mb0467|M.bovis_AF2122/97 QHTKNLLVSYSDKALGFF---------
Rv0458|M.tuberculosis_H37Rv QHTKNLLVSYSDKALGFF---------
MLBr_02573|M.leprae_Br4923 CNIKTVWIA------------------
* :