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VKRRPKDRKVQIARAATDAFSELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT AFADDLPADADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGDDQRKLAEQIKVINRRLQRPLIKL RPKLTSRQRWILSAATLSVIGSITDHRSRLGNAEIRATLSDIAAAVLKAELPTQRGRGSEPARAPTLTSA AGSYELLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYRRAADQLSADLSSILA TSSDPEQALARLIEAYVTRSFANPELACVYYTERHNLPETDAVLLYNIQRSTVESWARLAVAARPELTLG RARYAVHAAFALAVDIGRLVYPNTGAPASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0110 | - | - | 100% (410) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_2588 | - | 2e-14 | 27.47% (324) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1669 | - | 5e-14 | 31.51% (146) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 1e-29 | 28.34% (374) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 1e-115 | 54.06% (394) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 1e-29 | 28.34% (374) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00717 | - | 4e-07 | 30.73% (179) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 9e-15 | 30.10% (206) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 1e-115 | 53.73% (415) | putative regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-119 | 56.31% (396) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-120 | 56.78% (391) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-114 | 53.49% (415) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 1e-115 | 54.71% (393) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ----------------MSAAGS---DAHRNGRHRPKNRKALIARASADAF
MMAR_5559|M.marinum_M -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MAST------ADDHGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAAT
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
MAV_0110|M.avium_104 AFADDLPA---DADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDP---AEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
Mflv_0186|M.gilvum_PYR-GCK AGID-------GDDPEVVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 NIPP----------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPV-CELPPLPAGDAARDEADVLFSRYE
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELP--TQRGRGSEPARAPTLTSAAGSYE
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLP--TPRRRRAPDPPPPRVTLAAGIYE
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIVCAELP--EPGDVAVRKASWRIFAEDASVYE
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPPATPAPAAERIRSAAESSKYE
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVLGAELS-ADPPRYP-PDVVPARPTAEPSKYE
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLP--ELPELGAAAAPATTPVVSAAKYE
MAB_4541|M.abscessus_ATCC_1997 ---------------------------MTNLIPESETPNKRERAKADRRD
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
Rv1963c|M.tuberculosis_H37Rv TLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIR
MAV_0110|M.avium_104 LLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYR
TH_2795|M.thermoresistible__bu CVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLR
MMAR_5559|M.marinum_M TLLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLR
MUL_3597|M.ulcerans_Agy99 TLLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLR
Mflv_0186|M.gilvum_PYR-GCK ALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIFR
Mvan_0719|M.vanbaalenii_PYR-1 ALLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFR
MSMEG_0815|M.smegmatis_MC2_155 ALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFR
MAB_4541|M.abscessus_ATCC_1997 QLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLT
MLBr_00717|M.leprae_Br4923 ---PAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGIDD
. :: . . * : . :*
Mb1998c|M.bovis_AF2122/97 RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv RLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELS
MAV_0110|M.avium_104 RAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTERH
TH_2795|M.thermoresistible__bu RAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTERR
MMAR_5559|M.marinum_M RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
MUL_3597|M.ulcerans_Agy99 RAADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERA
Mflv_0186|M.gilvum_PYR-GCK RASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSERL
Mvan_0719|M.vanbaalenii_PYR-1 RAADRVSAELASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERL
MSMEG_0815|M.smegmatis_MC2_155 RAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERL
MAB_4541|M.abscessus_ATCC_1997 DVSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDLD
MLBr_00717|M.leprae_Br4923 EAKNRQMEHIMSRIGD--------------------------VVSVVPES
:
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
MMAR_5559|M.marinum_M NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MUL_3597|M.ulcerans_Agy99 NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
Mflv_0186|M.gilvum_PYR-GCK NMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVID
Mvan_0719|M.vanbaalenii_PYR-1 NMSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAMALVVD
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
MAB_4541|M.abscessus_ATCC_1997 SLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNS
MLBr_00717|M.leprae_Br4923 KLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLDA
: * .* .:
Mb1998c|M.bovis_AF2122/97 VARTWHLT----RYAGVADEISGLALAILTSGAGNLLRA-----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLT----RYAGVADEISGLALAILTSGAGNLLRA-----------
MAV_0110|M.avium_104 IGRLVYPN----TGAPASTTVRRLMEVTVLG-RPAAASRDGLRGAGRQRR
TH_2795|M.thermoresistible__bu LGRLTDSH----ASPSAQAAVQHLMEVVLLG-G-----------------
MMAR_5559|M.marinum_M LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MUL_3597|M.ulcerans_Agy99 LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
Mflv_0186|M.gilvum_PYR-GCK VGRLVHYA----ASDEARDTVEGLVDAALRGSYRLRATLPSM--------
Mvan_0719|M.vanbaalenii_PYR-1 LGRLMRYE----NSEEARETVSGLVDMTLLGRYRLRATLPAK--------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYR----NSEQARAVVSTMVDLVLLGRYRLRTALPAR--------
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRS----APSQTRTVLRQMVVAALRS-------------------
MLBr_00717|M.leprae_Br4923 IARVPEIS-------------KELADAMAIARQPPQ--------------
: .
Mb1998c|M.bovis_AF2122/97 -----------
Rv1963c|M.tuberculosis_H37Rv -----------
MAV_0110|M.avium_104 -----------
TH_2795|M.thermoresistible__bu -----------
MMAR_5559|M.marinum_M GSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 GSSNPGHVARR
Mflv_0186|M.gilvum_PYR-GCK -----------
Mvan_0719|M.vanbaalenii_PYR-1 -----------
MSMEG_0815|M.smegmatis_MC2_155 -----------
MAB_4541|M.abscessus_ATCC_1997 -----------
MLBr_00717|M.leprae_Br4923 -----------