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ATRIRGDRAIGCRVSRSHGAAEEGAEGVTSVARPERGTRPSNRRELIGAAATELFCTRGYEHVGMGDIAE AVAVGPSALYRHFAGKQELLDFVVAGCLGSATALVDSVDLEDFDLSLLRAAEVSVSNRYTGILLGREARH LAAGAQARLRVAVRHLIGRIAALLAVLRPDLDKDAADLMAWSVVGIVLSPAFSQSDLSDREQARLLAQLI GGILTAEAPVGYTIERRRRERTGLLPRSRREALLQEAIRLFAERRYASVGIEDVAASLGMAGPSVYNHFD TKMDLLVTALNRGAAYLYMQASDGLAASDSAQDALSGLVASYVEFALTHPALVDLLVTEVRNLPEPHRDA ALTAQRDYVEEWVHLLRQCHPDRARSAARLQVQAVLSLVNLVARVPHLQATRATAGAVAEMGRHLLAVPP ASSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3985 | - | - | 100% (425) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 4e-33 | 30.67% (375) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 2e-32 | 27.88% (391) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 2e-33 | 29.80% (406) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_1640 | - | 1e-40 | 31.62% (389) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 2e-33 | 29.80% (406) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_02568 | - | 3e-06 | 21.59% (176) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 1e-20 | 33.90% (177) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 2e-35 | 30.57% (386) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 2e-36 | 30.81% (370) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 8e-38 | 28.81% (420) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 6e-37 | 30.03% (393) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 3e-35 | 30.31% (386) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1640|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3985|M.vanbaalenii_PYR-1 --------------------------------------------MATRIR
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK ------------------------MPQPVRQQARTSVRKQQLSQAAARLF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5559|M.marinum_M -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu -------------------MSAAGSDAHRNGRHRPKNRKALIARASADAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Mvan_3985|M.vanbaalenii_PYR-1 GDRAIGCRVSRSHGAAEEGAEGVTSVARPERGTRPSNRRELIGAAATELF
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK TDRGYHNVSMDDIASAVGLTGPALYRHFRKKHDILMQVISEQLGAVEAVA
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mvan_3985|M.vanbaalenii_PYR-1 CTRGYEHVGMGDIAEAVAVGPSALYRHFAGKQELLDFVVAGCLGSATALV
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK ARAVD-------AGPTDERAEVFLAALADLLLEREQVLLWKRERRQLAEE
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAV_0110|M.avium_104 AFADDLPA---DADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDP---AEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Mvan_3985|M.vanbaalenii_PYR-1 DS-----------VDLEDFDLSLLRAAEVSVSNRYTGILLGREARHLAAG
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK AQRQCRLKLSDVLRLSSQALGLTSGEKPSGQAELRTWAVLGIYSSVAPIR
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Mvan_3985|M.vanbaalenii_PYR-1 AQARLRVAVRHLIGRIAALLAVLRPDLDKDAADLMAWSVVGIVLSPAFSQ
MLBr_02568|M.leprae_Br4923 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK NRVENATAKRLLR---AAALNILGCELDTGLPRSATPVTHRRQPPGRRER
MAB_4541|M.abscessus_ATCC_1997 --------------------------MTNLIPESETPNKRERAKADRRDQ
MMAR_5559|M.marinum_M ARLAADEIRALLG-EAASAIVCAELPEPGDVAVRKASWRIFAEDASVYET
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLG-EAASAIVCAELPEPGDVAVRKASWRIFAEDASVYET
MAV_0110|M.avium_104 SRLGNAEIRATLS-DIAAAVLKAELPTQRGRGSEPARAPTLTSAAGSYEL
TH_2795|M.thermoresistible__bu APLSVPGIRSFLA-SVVEDLLAADLPTPRRRRAPDPPPPRVTLAAGIYEC
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLG-EIVESVLAADLPELPELGAAAAPATTPVVSAAKYEA
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
Mvan_3985|M.vanbaalenii_PYR-1 SDLSDREQARLLA-QLIGGILTAEAPVGYTIERRRRERTG-LLPRSRREA
MLBr_02568|M.leprae_Br4923 ----------------------------------MAGGAKRIPRAVREQQ
:
Mflv_1640|M.gilvum_PYR-GCK ILSTAGRLFHAQSYHAVGIEEIAAESDTAIATFYQYFNGKGELLHALLNR
MAB_4541|M.abscessus_ATCC_1997 LLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLTD
MMAR_5559|M.marinum_M LLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLRR
MUL_3597|M.ulcerans_Agy99 LLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLRR
MAV_0110|M.avium_104 LLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYRR
TH_2795|M.thermoresistible__bu VLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLRR
MSMEG_0815|M.smegmatis_MC2_155 LLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFRR
Mb1998c|M.bovis_AF2122/97 LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
Rv1963c|M.tuberculosis_H37Rv LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
Mvan_3985|M.vanbaalenii_PYR-1 LLQEAIRLFAERRYASVGIEDVAASLGMAGPSVYNHFDTKMDLLVTALNR
MLBr_02568|M.leprae_Br4923 MLDAAVQMFSVNGYHKTSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNR
:* . :: . : . :. . . .* : * ::
Mflv_1640|M.gilvum_PYR-GCK GAEGLHYVTNHRLASAATAQDALDTVASTLIELALGPHQPILAILAADLV
MAB_4541|M.abscessus_ATCC_1997 VSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESD-LIRVQDRDLD
MMAR_5559|M.marinum_M AADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPE-LAAVYYTERA
MUL_3597|M.ulcerans_Agy99 AADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPE-LAAVYYTERA
MAV_0110|M.avium_104 AADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPE-LACVYYTERH
TH_2795|M.thermoresistible__bu AVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPA-LAYVQHTERR
MSMEG_0815|M.smegmatis_MC2_155 AADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPE-LEHVYYTERL
Mb1998c|M.bovis_AF2122/97 LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPD-LVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPD-LVAVSVTELS
Mvan_3985|M.vanbaalenii_PYR-1 GAAYLYMQASDGLAASDSAQDALSGLVASYVEFALTHPA-LVDLLVTEVR
MLBr_02568|M.leprae_Br4923 EMSRFIAMVRADIDFTQSPKDLLRNTIVSFLRYIDANRA---SWIVMYIQ
. * :
Mflv_1640|M.gilvum_PYR-GCK YLPDAARELIRMSEREYTDEWVAALVGVCPELTPPHARLLARAAIGLITD
MAB_4541|M.abscessus_ATCC_1997 SLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNS
MMAR_5559|M.marinum_M NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MUL_3597|M.ulcerans_Agy99 NLTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVD
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Mvan_3985|M.vanbaalenii_PYR-1 NLPEPHRDAALTAQRDYVEEWVHLLRQCHPDRARSAARLQVQAVLSLVNL
MLBr_02568|M.leprae_Br4923 AMSLPAFAQTVREARDQITELVAGLMRVGTRSSRPDHEYEIMAGALVGAG
. . . .
Mflv_1640|M.gilvum_PYR-GCK ITQIQKMRMRPG----IATELHQLVNAVLAA-------------------
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRSAPSQ----TRTVLRQMVVAALRS-------------------
MMAR_5559|M.marinum_M LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MUL_3597|M.ulcerans_Agy99 LGRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRR
MAV_0110|M.avium_104 IGRLVYPNTGA----PASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR-
TH_2795|M.thermoresistible__bu LGRLTDSHASP----SAQAAVQHLMEVVLLGG------------------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYRNSE----QARAVVSTMVDLVLLGR------YRLRTALPAR--
Mb1998c|M.bovis_AF2122/97 VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA-----------
Mvan_3985|M.vanbaalenii_PYR-1 VARVPHLQATRATAGAVAEMGRHLLAVPPASSA-----------------
MLBr_02568|M.leprae_Br4923 EAMATRLTTGDIAVDEAAELMINLFWHGLKGAPADRDFGPSIVAG-----
: .
Mflv_1640|M.gilvum_PYR-GCK -----------
MAB_4541|M.abscessus_ATCC_1997 -----------
MMAR_5559|M.marinum_M GSSNPGHVARR
MUL_3597|M.ulcerans_Agy99 GSSNPGHVARR
MAV_0110|M.avium_104 -----------
TH_2795|M.thermoresistible__bu -----------
MSMEG_0815|M.smegmatis_MC2_155 -----------
Mb1998c|M.bovis_AF2122/97 -----------
Rv1963c|M.tuberculosis_H37Rv -----------
Mvan_3985|M.vanbaalenii_PYR-1 -----------
MLBr_02568|M.leprae_Br4923 -----------