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MVRRRPKDRKQQILDQAVRLFIDRGFHSVKLEDIAEASGVTARALYRHYDNKQALLAAAIRAGQEQYQSA RPPAGGEAESPHRALSAELPDLVTAAVASRSLTVLWQREARYLDAAERAEVRRRIHAIVTGIEQSLRVEV PDLSPRHAELRAWAVSSVITSLGRHSLTLAKDELHRLLFGACMAVARTPPVGPLEPDVAPPNDERALFSR HETLLAAGARLFRAQGYPAVSTSEIGKGVGIAGPGLYRSFSSKQAILDALITRLDEWWSLACIRVLRTDT EAAECLRALVAGRVQISLDDPDLVAMSVTELSFASEEVRDRYMRNQADREAVWIELIGKLVPQTAPAEAR LLVGAANSFIDDAVRTWHLTRYAGIADEITAITLSILTSRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | - | 100% (391) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 3e-40 | 31.84% (380) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3985 | - | 4e-33 | 30.67% (375) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 1e-155 | 72.89% (391) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 3e-42 | 30.75% (374) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 1e-155 | 72.89% (391) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00717 | - | 4e-07 | 30.26% (76) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 7e-15 | 29.27% (164) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 1e-157 | 73.98% (392) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0110 | - | 3e-28 | 28.95% (373) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 4e-33 | 30.05% (376) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 2e-26 | 27.15% (372) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 1e-155 | 73.21% (392) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2873|M.marinum_M --------------------------------------------------
MUL_2880|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3994|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
MMAR_2873|M.marinum_M -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
MUL_2880|M.ulcerans_Agy99 -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
Mvan_3994|M.vanbaalenii_PYR-1 -----------------------------MVRRRPKDRKQQILDQAVRLF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MMAR_2873|M.marinum_M IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MUL_2880|M.ulcerans_Agy99 IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mvan_3994|M.vanbaalenii_PYR-1 IDRGFHSVKLEDIAEASGVTARALYRHYDNKQALLAAAIRAGQEQYQSAR
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEAD------
Mb1998c|M.bovis_AF2122/97 RLTEGETEPTPR-----PLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEGETEPTPR-----PLNADLEDLIAAAVASRALTVLWQREARYLNED
MMAR_2873|M.marinum_M RLTEGEQEPTPR-----PLSVDLPDLIAAAVASRSLTVLWQREARYLNDA
MUL_2880|M.ulcerans_Agy99 RLTEGEQEPTPR-----PLSVDLPDLIAAAVASRSLTVLSQREARYLNDA
Mvan_3994|M.vanbaalenii_PYR-1 PPAGGEAESPHR-----ALSAELPDLVTAAVASRSLTVLWQREARYLDAA
Mflv_0186|M.gilvum_PYR-GCK AGID-GDDPE------VVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAV_0110|M.avium_104 AFADDLPADADP---GETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDPAEDP---HGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
MMAR_2873|M.marinum_M DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
MUL_2880|M.ulcerans_Agy99 DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
Mvan_3994|M.vanbaalenii_PYR-1 ERAEVRRRIHAIVTGIEQSLRVEVPDLSPRHAELRAWAVSSVITSLGRHS
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLL--YQACMAAARTPPVCELPPLPAGDAARDEADVLFSRY
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLL--YQACMAAARTPPVCELPPLPAGDAARDEADVLFSRY
MMAR_2873|M.marinum_M LTLPAEELKERL--YQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRY
MUL_2880|M.ulcerans_Agy99 LTLPAEELKERL--YQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRY
Mvan_3994|M.vanbaalenii_PYR-1 LTLAKDELHRLL--FGACMAVARTPPVGPLEPDVAPP---NDERALFSRH
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPP-ATPAPAAERIRSAAESSKY
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLPELPELGAAAAPATTPVVSAA---KY
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELPTQRGRGSEPARAPTLTSAAG---SY
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLPTPRRRRAPDPPPPRVTLAAG---IY
MAB_4541|M.abscessus_ATCC_1997 --------------MTNLIPESETPNKRERAKAD--------------RR
MLBr_00717|M.leprae_Br4923 ----------------RLYAATNIPP------------------------
: *
Mb1998c|M.bovis_AF2122/97 ETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALI
Rv1963c|M.tuberculosis_H37Rv ETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALI
MMAR_2873|M.marinum_M ETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALI
MUL_2880|M.ulcerans_Agy99 ETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALI
Mvan_3994|M.vanbaalenii_PYR-1 ETLLAAGARLFRAQGYPAVSTSEIGKGVGIAGPGLYRSFSSKQAILDALI
Mflv_0186|M.gilvum_PYR-GCK EALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIF
MSMEG_0815|M.smegmatis_MC2_155 EALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGF
MAV_0110|M.avium_104 ELLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYY
TH_2795|M.thermoresistible__bu ECVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASL
MAB_4541|M.abscessus_ATCC_1997 DQLLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLL
MLBr_00717|M.leprae_Br4923 ----PAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGID
. :: . . * : . :*
Mb1998c|M.bovis_AF2122/97 RRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTEL
Rv1963c|M.tuberculosis_H37Rv RRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTEL
MMAR_2873|M.marinum_M RRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCVTEL
MUL_2880|M.ulcerans_Agy99 RRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCATEL
Mvan_3994|M.vanbaalenii_PYR-1 TRLDEWWSLACIRVLRTDTEAAECLRALVAGRVQISLDDPDLVAMSVTEL
Mflv_0186|M.gilvum_PYR-GCK RRASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSER
MSMEG_0815|M.smegmatis_MC2_155 RRAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTER
MAV_0110|M.avium_104 RRAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTER
TH_2795|M.thermoresistible__bu RRAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTER
MAB_4541|M.abscessus_ATCC_1997 TDVSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDL
MLBr_00717|M.leprae_Br4923 DEAKNRQMEHIMSRIGD--------------------------VVSVVPE
:
Mb1998c|M.bovis_AF2122/97 SHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIE
Rv1963c|M.tuberculosis_H37Rv SHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIE
MMAR_2873|M.marinum_M NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
MUL_2880|M.ulcerans_Agy99 NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
Mvan_3994|M.vanbaalenii_PYR-1 SFASEEVRDRYMRNQADREAVWIELIGKLVPQTAPAEARLLVGAANSFID
Mflv_0186|M.gilvum_PYR-GCK LNMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVI
MSMEG_0815|M.smegmatis_MC2_155 LNMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVI
MAV_0110|M.avium_104 HNLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAV
TH_2795|M.thermoresistible__bu RNLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVT
MAB_4541|M.abscessus_ATCC_1997 DSLPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMN
MLBr_00717|M.leprae_Br4923 SKLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLD
: * .* .:
Mb1998c|M.bovis_AF2122/97 DVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
Rv1963c|M.tuberculosis_H37Rv DVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
MMAR_2873|M.marinum_M DVARTWHLTRYAAVADEITAIALSILTSRS----------------
MUL_2880|M.ulcerans_Agy99 DVARTWHLTRYAAVADEITEIALSILTSRS----------------
Mvan_3994|M.vanbaalenii_PYR-1 DAVRTWHLTRYAGIADEITAITLSILTSRQ----------------
Mflv_0186|M.gilvum_PYR-GCK DVGRLVHYAASDEARDTVEGLVDAALRGSYRLRATLPSM-------
MSMEG_0815|M.smegmatis_MC2_155 DLGRLMGYRNSEQARAVVSTMVDLVLLGRYRLRTALPAR-------
MAV_0110|M.avium_104 DIGRLVYPNTGAPASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR
TH_2795|M.thermoresistible__bu DLGRLTDSHASPSAQAAVQHLMEVVLLGG-----------------
MAB_4541|M.abscessus_ATCC_1997 STPYSAGRSAPSQTRTVLRQMVVAALRS------------------
MLBr_00717|M.leprae_Br4923 AIARVPEISKELADAMAIARQPPQ----------------------
: