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MIELRALTKTYRSVRAVDGLTATIEPGVVTGFLGPNGAGKTTTMRIILGLDHPTSGTATIDGKTYRQLRN PLRTVGALLDARQIHPNRTARNHLRWIAATNGIGATRPDEVLEMVGLTAVAGSRAGTLSLGMSQRLGIAA ALLGDPPVLLFDEPVNGLDPEGIHWVRTLMRTLAGEGRTVLVSSHLLSEMANTADRLVVIGRGRLIASTT VTEFIGRSGGAVVRVRSPRLRDLRTVLAAAGLAVREDGASLTVHDTTTEAVGELAAAHSIALHELSSQQV SLEQAYLASTDDATEYRGTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0712 | - | - | 100% (301) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_2047 | - | 3e-45 | 48.53% (204) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_4796 | - | 4e-34 | 34.47% (293) | daunorubicin resistance ABC transporter ATPase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 1e-26 | 29.43% (316) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_0193 | - | 1e-136 | 81.70% (306) | ABC transporter related |
| M. tuberculosis H37Rv | Rv2936 | drrA | 1e-26 | 29.43% (316) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_00590 | - | 3e-30 | 33.11% (296) | putative ABC transporter ATP-binding protein |
| M. abscessus ATCC 19977 | MAB_4215c | - | 1e-109 | 67.22% (302) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_3263 | - | 3e-34 | 33.96% (268) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_3250 | - | 2e-31 | 33.99% (306) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_0795 | - | 1e-123 | 75.25% (299) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_2788 | - | 1e-121 | 74.26% (303) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_3577 | - | 2e-33 | 33.58% (268) | ATP-binding protein ABC transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0712|M.vanbaalenii_PYR-1 -------MIELRALTKTYRSVR--------AVDGLTATIEPGVVTGFLGP
Mflv_0193|M.gilvum_PYR-GCK -------MIELDALTKVFGSGRDGR---APAVDGLTCTIEPGVVTGFLGP
MSMEG_0795|M.smegmatis_MC2_155 -------MIELAGLTKLYGTHR--------AVDDLSFTVEPGVVTGFLGP
TH_2788|M.thermoresistible__bu ---MMAAMIELTALTKVFGRTR--------AVDDLTCTVEPGVVTGFLGP
MAB_4215c|M.abscessus_ATCC_199 -------MIELRSLTKVYGQTP--------AVDDLSVTIESGVVTGFLGP
Mb2961|M.bovis_AF2122/97 -------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGP
Rv2936|M.tuberculosis_H37Rv -------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGP
MAV_3250|M.avium_104 -------MSAP--AIEVEGLTKKFG-GSTLALAGVDFSVPAGTVCGLLGH
MMAR_3263|M.marinum_M -------MRRSQSAVEVIDLVKRRG--SVTAVDGISFAVPPGGVLGLLGP
MUL_3577|M.ulcerans_Agy99 -------MRRSQSAVEVIDLVKRRG--SVTAVDGISFAVPQGGILGLLGP
MLBr_00590|M.leprae_Br4923 MSSACTVPETPEVVIRLRGVCKHYG--SILAVSNLDLDIHSAEVLALLGP
*: .: : . : .:**
Mvan_0712|M.vanbaalenii_PYR-1 NGAGKTTTMRIILGLDHPTSGTATIDGKTYRQLRNPLR-TVGALLDARQI
Mflv_0193|M.gilvum_PYR-GCK NGAGKTTTMRMILGLDRPTSGTATIDGRTYRQLAEPLR-TVGALLDAKQV
MSMEG_0795|M.smegmatis_MC2_155 NGAGKTTTMRLILGLDHPTSGTATIDGKRYRELKNPLR-TVGALLDARQA
TH_2788|M.thermoresistible__bu NGAGKTTTMRLILGLDRPTSGTATIDGRRYRDLRDPLR-TVGALLDARAV
MAB_4215c|M.abscessus_ATCC_199 NGAGKSTTLRMIVGLARPTSGTATIGGKQYHEIDHPLR-EVGALLDPKQF
Mb2961|M.bovis_AF2122/97 NGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAV
Rv2936|M.tuberculosis_H37Rv NGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAV
MAV_3250|M.avium_104 NGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASIGMAGQFTGM
MMAR_3263|M.marinum_M NGAGKTTTVRMLATLTRPTSGAAWVAGHDVCAAPESVRREIGLTCQEATL
MUL_3577|M.ulcerans_Agy99 NGAGKTTTVRMVATLTRPTSGTAWVAGHDVCTAPESVRREIGLTCQEATL
MLBr_00590|M.leprae_Br4923 NGAGKTTTVEMCEGFVRPDAGTIEVLGLDPITDNARLRARIGVMLQGGGG
*****:* : : : :* :* : * :* : :
Mvan_0712|M.vanbaalenii_PYR-1 HPNRTARNHLRWIAATNGIG----ATRPDEVLEMVGLTAVAGSRAGTLSL
Mflv_0193|M.gilvum_PYR-GCK HPNRTVRNHLRWIAATHRIA----SRRVDDVVDMVGLSAVAGSRAGTLSL
MSMEG_0795|M.smegmatis_MC2_155 HPNRSARSHLRWIAAANRIP----ASRVDEVLEMVGLASAADRNAGALSL
TH_2788|M.thermoresistible__bu HPARSARNHLRWLAAANRIP----QRRVDEVLELVGLTAVAARPAGTLSL
MAB_4215c|M.abscessus_ATCC_199 HPNRSARNHLRWIAAANDIS----AQRVDEVLEMVGLTEVANRHAGTFSL
Mb2961|M.bovis_AF2122/97 DDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSG
Rv2936|M.tuberculosis_H37Rv DDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSG
MAV_3250|M.avium_104 DPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAADRRLSTYSG
MMAR_3263|M.marinum_M DGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFADRRVDTYSG
MUL_3577|M.ulcerans_Agy99 DGLLTARENINMIGSLRGIRRKELASLSDRLLDQFSIAEFADRRVDTYSG
MLBr_00590|M.leprae_Br4923 YPAARAGEMLNLVASYAADP-----LDPEWLLETLGLTDVARTTYRRLSG
. : .. ::: ..: . *
Mvan_0712|M.vanbaalenii_PYR-1 GMSQRLGIAAALLGDPPVLLFDEPVNGLDPEGIHWVRTLMRTLAGEGRTV
Mflv_0193|M.gilvum_PYR-GCK GMSQRLGIAAALIGDPPVLLFDEPVNGLDPEGIHWVRTLMRTLAAEGRTV
MSMEG_0795|M.smegmatis_MC2_155 GMSQRLGIAAALLGDPPVLLFDEPVNGLDPEGIHWVRTLMRELAGEGRTV
TH_2788|M.thermoresistible__bu GMSQRLGIAGALLGDPPVLLFDEPVNGLDPEGIRWVRTLMRTMAAEGRTV
MAB_4215c|M.abscessus_ATCC_199 GMSQRLGIAVALLGDPKVLLFDEPVNGLDPEGIHWIRTLMQSLAAQGRTV
Mb2961|M.bovis_AF2122/97 GMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIAT
Rv2936|M.tuberculosis_H37Rv GMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIAT
MAV_3250|M.avium_104 GMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSSLRVQGISV
MMAR_3263|M.marinum_M GMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLRTLVDDGLTL
MUL_3577|M.ulcerans_Agy99 GMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLGTLVDDGPTL
MLBr_00590|M.leprae_Br4923 GQQQRLALACTLVGRPELVFLDEPTAGMDTHARLLVWELIDTLRRDGVTV
* :*: :* *: * : ::***. *:*... : :: : * :
Mvan_0712|M.vanbaalenii_PYR-1 LVSSHLLSEMANTADRLVVIGRGRLIASTTVTEFIGRSGGAVVRVRSPRL
Mflv_0193|M.gilvum_PYR-GCK LVSSHLLAEMAETADRLVVIGRGRLIASTTVAEFIGGADGAAVRVRSPRL
MSMEG_0795|M.smegmatis_MC2_155 FVSSHLLAEMANTADRLVVIGQGKLIASTTVTEFVNGSDADTVRVRSPQL
TH_2788|M.thermoresistible__bu LVSSHLLAEMANTADRLLVIGRGRLIASTSVAEFVGSTAAERVRVRSPEM
MAB_4215c|M.abscessus_ATCC_199 LVSSHLLSEMANTADQLVVIGRGRLIAATSMHEFVSRAGADVVRVRSPQI
Mb2961|M.bovis_AF2122/97 LLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVPRDL
Rv2936|M.tuberculosis_H37Rv LLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVPRDL
MAV_3250|M.avium_104 LLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGTSYCQVTPANP
MMAR_3263|M.marinum_M VLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGDASIVVTVSRT
MUL_3577|M.ulcerans_Agy99 VLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGDASIVVTVSRT
MLBr_00590|M.leprae_Br4923 VLTTHQLKEAEELADRLVIIDHGRMIAAGTPTELMHTGAKDQLRFSAPPR
.:::: * * :* :::*.:* :** : *: .
Mvan_0712|M.vanbaalenii_PYR-1 RDLRTVLAAAGLAVRE------------DGASLTVHDTTTEAVGELAAAH
Mflv_0193|M.gilvum_PYR-GCK DDLAAALAAAGMAVVR------------DGAALTVRHTTTDAVGELAATH
MSMEG_0795|M.smegmatis_MC2_155 ETLRDVLSDAGLDVVTE-------P---DGGALNVHGVAIEVIGDLAARN
TH_2788|M.thermoresistible__bu DTLRGLLADAGVEVRLE-------P---DGAALTVRGAAPEVVGELAARN
MAB_4215c|M.abscessus_ATCC_199 DILRSAAEESGFSVVGG-------ERTGEPGVLEISGALIEQVGELAARR
Mb2961|M.bovis_AF2122/97 KDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRIDEA
Rv2936|M.tuberculosis_H37Rv KDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRIDEA
MAV_3250|M.avium_104 AELPQVAAALTGLEG----IEIDSDTGSVSVFAPDGVATLVEVFRRVDAL
MMAR_3263|M.marinum_M EDVANVAAFLRTGAK---EVRVDISARRITV-ATHGLLDLSDVARMLHQY
MUL_3577|M.ulcerans_Agy99 EDVANVAAFLRTGVK---EVRVDICARRITV-ATHGLLDLSEVARMLHHY
MLBr_00590|M.leprae_Br4923 LDLSLLAFALPEDYK-----TTELTPGEYLVAGPIDPQVLATVTAWCAQI
:
Mvan_0712|M.vanbaalenii_PYR-1 SIALHELSSQQVSLEQAYLASTDDATEYRGTPR-----------------
Mflv_0193|M.gilvum_PYR-GCK SIPLHELTGQQVSLEQAYLAVTDDATEYRGRTR-----------------
MSMEG_0795|M.smegmatis_MC2_155 AITLHELSRRQASLEEAYLKLTDDAVDYRAVQP-----------------
TH_2788|M.thermoresistible__bu GITLHELSVQRASLEDAYLELTDAAVEYRAVPR-----------------
MAB_4215c|M.abscessus_ATCC_199 GVTLYELSPQRVSLEDAYLSLTDDAVQYRSQVNDPLAARATGAVADAEGT
Mb2961|M.bovis_AF2122/97 RIELADIALRRPSLDDVFLAMTTDPTES---------LTHLVSGSAR---
Rv2936|M.tuberculosis_H37Rv RIELADIALRRPSLDHVFLAMTTDPTES---------LTHLVSGSAR---
MAV_3250|M.avium_104 GLELADISLRKPSLDEAFLHLTER----------------TVARS-----
MMAR_3263|M.marinum_M AAPIEDIRLTRPSLDDVFVLLTGHHGSSSEGD------------SA----
MUL_3577|M.ulcerans_Agy99 AAPVEDIRLARPSLDDVFVLLTGHHSSSSEGDGRLGAWPALVAGSAEHAR
MLBr_00590|M.leprae_Br4923 NVLTTNMRVEQHSLEDVFLDLTGRKLR-----------------------
:: : **:..:: *
Mvan_0712|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0193|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0795|M.smegmatis_MC2_155 --------------------------------------------------
TH_2788|M.thermoresistible__bu --------------------------------------------------
MAB_4215c|M.abscessus_ATCC_199 H-------------------------------------------------
Mb2961|M.bovis_AF2122/97 --------------------------------------------------
Rv2936|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3250|M.avium_104 --------------------------------------------------
MMAR_3263|M.marinum_M --------------------------------------------------
MUL_3577|M.ulcerans_Agy99 GVRSCARSGRGVLWRSSTLHQLCCGETGNRLARVRWGWRVGLSAGLRRRT
MLBr_00590|M.leprae_Br4923 --------------------------------------------------
Mvan_0712|M.vanbaalenii_PYR-1 --------------------------
Mflv_0193|M.gilvum_PYR-GCK --------------------------
MSMEG_0795|M.smegmatis_MC2_155 --------------------------
TH_2788|M.thermoresistible__bu --------------------------
MAB_4215c|M.abscessus_ATCC_199 --------------------------
Mb2961|M.bovis_AF2122/97 --------------------------
Rv2936|M.tuberculosis_H37Rv --------------------------
MAV_3250|M.avium_104 --------------------------
MMAR_3263|M.marinum_M --------------------------
MUL_3577|M.ulcerans_Agy99 RRGRRAPRNRAASTGLGGLTRVRRRW
MLBr_00590|M.leprae_Br4923 --------------------------