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VSAPAIEVEGLTKKFGGSTLALAGVDFSVPAGTVCGLLGHNGAGKTTTINILSTLIRPTSGRARVAGYDV VRQPAEVRASIGMAGQFTGMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAADRRLSTYSG GMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSSLRVQGISVLLTTQYLEEADVLSDSIVVI DHGRVIASGTSEELKRAVGTSYCQVTPANPAELPQVAAALTGLEGIEIDSDTGSVSVFAPDGVATLVEVF RRVDALGLELADISLRKPSLDEAFLHLTERTVARS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3250 | - | - | 100% (315) | daunorubicin resistance ATP-binding protein DrrA |
| M. avium 104 | MAV_5181 | - | 5e-45 | 43.11% (225) | daunorubicin resistance ABC transporter ATPase subunit |
| M. avium 104 | MAV_3321 | - | 8e-40 | 35.58% (312) | ABC transporter, ATP-binding subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 8e-88 | 54.37% (309) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_3389 | - | 6e-89 | 55.84% (308) | daunorubicin resistance ABC transporter ATPase subunit |
| M. tuberculosis H37Rv | Rv2936 | drrA | 1e-87 | 54.37% (309) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 4e-88 | 54.37% (309) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1689 | - | 6e-48 | 37.54% (309) | daunorubicin resistance ABC transporter ATP-binding subunit |
| M. marinum M | MMAR_1771 | drrA | 6e-88 | 54.55% (308) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 3e-48 | 45.18% (228) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2788 | - | 6e-33 | 33.96% (318) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_2014 | drrA | 8e-89 | 54.55% (308) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_3122 | - | 2e-91 | 55.95% (311) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1771|M.marinum_M ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
MUL_2014|M.ulcerans_Agy99 ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
Mb2961|M.bovis_AF2122/97 ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
Rv2936|M.tuberculosis_H37Rv ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
MLBr_02352|M.leprae_Br4923 ---------MRNNDKAVMVRGVRKTYGKGKIIALDDVSFDVDRGEVIGLL
Mflv_3389|M.gilvum_PYR-GCK ---------MPSTDKAVVVEGIKKSFG--AVTALRDVSFDVGRGEVLGLL
Mvan_3122|M.vanbaalenii_PYR-1 ---------MTRSDKAVVVAGIKKSFG--SVQALRDVSFEVERGEVLGLL
MAV_3250|M.avium_104 -----------MSAPAIEVEGLTKKFG-GSTLALAGVDFSVPAGTVCGLL
MSMEG_6509|M.smegmatis_MC2_155 MTDHMPEPTLPDRTPAIDCDGLTHRYG--QFTAVEDLTLQVRAGETLGLL
MAB_1689|M.abscessus_ATCC_1997 -------MTTDTQIPALRAAELVKAYPGSDARAVDGLDLTIPQGIVYCLL
TH_2788|M.thermoresistible__bu -----------MMAAMIELTALTKVFG--RTRAVDDLTCTVEPGVVTGFL
: : : : *: .: : * . :*
MMAR_1771|M.marinum_M GPNGAGKTTMVDILSTLTRPDAGSAHVAGSDVVAQPAGVRRSIMVTGQQV
MUL_2014|M.ulcerans_Agy99 GPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSIMVTGQQV
Mb2961|M.bovis_AF2122/97 GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
Rv2936|M.tuberculosis_H37Rv GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
MLBr_02352|M.leprae_Br4923 GPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSIMVTGQQV
Mflv_3389|M.gilvum_PYR-GCK GPNGAGKTTTVNILSTLIKPDSGRAMIAGHDVVTDPAGVRRALMLTGQHA
Mvan_3122|M.vanbaalenii_PYR-1 GPNGAGKTTTVNILSTLIKPDSGRALIAGHDVVTDPAGVRRALMLTGQHA
MAV_3250|M.avium_104 GHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASIGMAGQFT
MSMEG_6509|M.smegmatis_MC2_155 GPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNIGYVPQQL
MAB_1689|M.abscessus_ATCC_1997 GRNGAGKTTTIRMATTLLAPTRGELEVLGV-PVDNTKELRPLIGVALQEV
TH_2788|M.thermoresistible__bu GPNGAGKTTTMRLILGLDRPTSGTATIDGR-RYRDLRDPLRTVGALLDAR
* ******* : : * * : * . : :
MMAR_1771|M.marinum_M AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
MUL_2014|M.ulcerans_Agy99 AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
Mb2961|M.bovis_AF2122/97 AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
Rv2936|M.tuberculosis_H37Rv AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
MLBr_02352|M.leprae_Br4923 AVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGKRRVGTY
Mflv_3389|M.gilvum_PYR-GCK ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVGAGDRAVGNY
Mvan_3122|M.vanbaalenii_PYR-1 ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVQAADRPVGTY
MAV_3250|M.avium_104 GMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAADRRLSTY
MSMEG_6509|M.smegmatis_MC2_155 SIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVADTVAGTY
MAB_1689|M.abscessus_ATCC_1997 ALDLWMSPVEQIRMSLAIAGWPKARRKAREDELVEQFGLSTYVNRKVGAL
TH_2788|M.thermoresistible__bu AVHPARSARNHLRWLAAANRIPQRR----VDEVLELVGLTAVAARPAGTL
.:. : ::: : :: . *
MMAR_1771|M.marinum_M SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
MUL_2014|M.ulcerans_Agy99 SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
Mb2961|M.bovis_AF2122/97 SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
Rv2936|M.tuberculosis_H37Rv SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
MLBr_02352|M.leprae_Br4923 SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-QIG
Mflv_3389|M.gilvum_PYR-GCK SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
Mvan_3122|M.vanbaalenii_PYR-1 SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
MAV_3250|M.avium_104 SGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSSLR-VQG
MSMEG_6509|M.smegmatis_MC2_155 SGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVRAMQAEFG
MAB_1689|M.abscessus_ATCC_1997 SGGMRRRVDVALAVAHNPQMLFLDEPSSGLDIEGKQEVWNAIRLLR-SEG
TH_2788|M.thermoresistible__bu SLGMSQRLGIAGALLGDPPVLLFDEPVNGLDPEGIRWVRTLMRTMA-AEG
* ** :*: :* .: * : ::*** *** . : : : *
MMAR_1771|M.marinum_M IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
MUL_2014|M.ulcerans_Agy99 IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
Mb2961|M.bovis_AF2122/97 IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
Rv2936|M.tuberculosis_H37Rv IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
MLBr_02352|M.leprae_Br4923 IATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGETFCEIVP
Mflv_3389|M.gilvum_PYR-GCK IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADQLKERTGGTYCEIVP
Mvan_3122|M.vanbaalenii_PYR-1 IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADELKERTGGTYCEIVP
MAV_3250|M.avium_104 ISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGTSYCQVTP
MSMEG_6509|M.smegmatis_MC2_155 MTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS-------
MAB_1689|M.abscessus_ATCC_1997 RTVVLTTHDMDEAVSLADEVGIVKSGRLVASGSTQEFTRSHGYAVEVSAD
TH_2788|M.thermoresistible__bu RTVLVSSHLLAEMANTADRLLVIGRGRLIASTSVAEFVGST-AAERVRVR
:.::::: : * .* : :: * : * : ::
MMAR_1771|M.marinum_M RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARRI
MUL_2014|M.ulcerans_Agy99 RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARKI
Mb2961|M.bovis_AF2122/97 RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
Rv2936|M.tuberculosis_H37Rv RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
MLBr_02352|M.leprae_Br4923 RDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTLIEAARRI
Mflv_3389|M.gilvum_PYR-GCK RQLSQLREVARILGPLLPAAHRDALSDTSDRISMPAPDGPNTLMQALHLL
Mvan_3122|M.vanbaalenii_PYR-1 RNLADIPEVARVLGPLLPDANRAALTDTSDRISMPAPDGPNTLMQALHLL
MAV_3250|M.avium_104 ANPAELPQVAAALTGLEG----IEIDSDTGSVSVFAPDGVATLVEVFRRV
MSMEG_6509|M.smegmatis_MC2_155 --------------------------------QASDDAGETTLEDVFRHY
MAB_1689|M.abscessus_ATCC_1997 S-----VIPEEAAGRLAEAGYALRRTDSGTLSGTLDSASAADLGALSAEL
TH_2788|M.thermoresistible__bu S-----PEMDTLRGLLADAGVEVRLEPDG-AALTVRGAAPEVVGELAARN
. :
MMAR_1771|M.marinum_M DEANIELADIALRRPSLDDVFLSMTTDPSEAH--ALSHVASGAML-
MUL_2014|M.ulcerans_Agy99 DEANIELADIALRRPSLDDVFLSMTTDPSEAH--VLSHVASGAML-
Mb2961|M.bovis_AF2122/97 DEARIELADIALRRPSLDDVFLAMTTDPTES----LTHLVSGSAR-
Rv2936|M.tuberculosis_H37Rv DEARIELADIALRRPSLDHVFLAMTTDPTES----LTHLVSGSAR-
MLBr_02352|M.leprae_Br4923 DEVSVELADIALRRPSLDDVFLSMTTDPSES----LSHLAAGAMR-
Mflv_3389|M.gilvum_PYR-GCK SEADIELSDIALRRPSLDEVFLALTGDHPKARDESEDPLVAADAYA
Mvan_3122|M.vanbaalenii_PYR-1 SEANIELMDIALRRPSLDEVFLALTGDHPRTRDGEADAVVAADAYA
MAV_3250|M.avium_104 DALGLELADISLRKPSLDEAFLHLT-----------ERTVARS---
MSMEG_6509|M.smegmatis_MC2_155 AGSDLEGG-ADPRRSGLGEVRSTRRTARRVS---------------
MAB_1689|M.abscessus_ATCC_1997 DRVGLGAASIEVRSTSLRDAFLEVTQ--------------------
TH_2788|M.thermoresistible__bu ---GITLHELSVQRASLEDAYLELTDAAVEYRAVPR----------
: : ..* ..