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ADKSVGPMSVCAYTVDAMESAIEAIDLVKRFGDTLDNPAVDGVSFAVPPGTVLGLLGPNGAGKTTTVRMM TTLTEPTSGTARVAGYDVRAQPDDVRRHMGLTGQVATVDELLTGRENIRMIGGLYGIRRKDLDRLGDQLL HQFSLTDAADRVVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLRGLVAQGTTLLL TTQYLEEADQLADNIVVIDRGHIIAEGSPLELKQQAGRASLVVTVGDAADLEGARTLLGQTGAEVFVDAG ARRLTASADGLDDMIRVAEWLRDSGIAVDDIGLSRPSLDDVFLTLTGHRTEDSEEIGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4796 | - | - | 100% (339) | daunorubicin resistance ABC transporter ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_3122 | - | 6e-73 | 47.52% (322) | daunorubicin resistance ABC transporter ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_2730 | - | 1e-37 | 32.80% (314) | ABC transporter-related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 4e-69 | 47.47% (297) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_1936 | - | 1e-158 | 89.62% (318) | daunorubicin resistance ABC transporter ATPase subunit |
| M. tuberculosis H37Rv | Rv2936 | drrA | 3e-68 | 47.14% (297) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 5e-68 | 46.05% (304) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1689 | - | 2e-43 | 36.91% (317) | daunorubicin resistance ABC transporter ATP-binding subunit |
| M. marinum M | MMAR_3263 | - | 1e-105 | 63.92% (316) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_3250 | - | 1e-76 | 50.81% (307) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 2e-45 | 43.56% (225) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2788 | - | 1e-37 | 34.08% (314) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_3577 | - | 1e-103 | 63.01% (319) | ATP-binding protein ABC transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1689|M.abscessus_ATCC_1997 -------------MTTDTQIPALRAAELVKAYPG-SDARAVDGLDLTIPQ
TH_2788|M.thermoresistible__bu -----------------MMAAMIELTALTKVFG---RTRAVDDLTCTVEP
Mvan_4796|M.vanbaalenii_PYR-1 MADKSVGPMSVCAYTVDAMESAIEAIDLVKRFGDTLDNPAVDGVSFAVPP
Mflv_1936|M.gilvum_PYR-GCK ----------------MPFPPAIEALDLVKRFG---DQTAVAGVSFVVPP
MMAR_3263|M.marinum_M ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPP
MUL_3577|M.ulcerans_Agy99 ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPQ
Mb2961|M.bovis_AF2122/97 ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
Rv2936|M.tuberculosis_H37Rv ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
MLBr_02352|M.leprae_Br4923 ---------------MRNNDKAVMVRGVRKTYGK-GKIIALDDVSFDVDR
MAV_3250|M.avium_104 ---------------MSAP--AIEVEGLTKKFG--GSTLALAGVDFSVPA
MSMEG_6509|M.smegmatis_MC2_155 ------MTDHMPEPTLPDRTPAIDCDGLTHRYG---QFTAVEDLTLQVRA
: : : *: .: :
MAB_1689|M.abscessus_ATCC_1997 GIVYCLLGRNGAGKTTTIRMATTLLAPTRGELEVLGVPVDN-TKELRPLI
TH_2788|M.thermoresistible__bu GVVTGFLGPNGAGKTTTMRLILGLDRPTSGTATIDGRRYRD-LRDPLRTV
Mvan_4796|M.vanbaalenii_PYR-1 GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGYDVRAQPDDVRRHM
Mflv_1936|M.gilvum_PYR-GCK GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGFDVRTHPDEVRRHM
MMAR_3263|M.marinum_M GGVLGLLGPNGAGKTTTVRMLATLTRPTSGAAWVAGHDVCAAPESVRREI
MUL_3577|M.ulcerans_Agy99 GGILGLLGPNGAGKTTTVRMVATLTRPTSGTAWVAGHDVCTAPESVRREI
Mb2961|M.bovis_AF2122/97 GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
Rv2936|M.tuberculosis_H37Rv GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
MLBr_02352|M.leprae_Br4923 GEVIGLLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSI
MAV_3250|M.avium_104 GTVCGLLGHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASI
MSMEG_6509|M.smegmatis_MC2_155 GETLGLLGPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNI
* :** ******* : : * * : * :
MAB_1689|M.abscessus_ATCC_1997 GVALQEVALDLWMSPVEQIRMSLAIAGWPKARRKAREDELVEQFGLSTYV
TH_2788|M.thermoresistible__bu GALLDARAVHPARSARNHLRWLAAANRIPQRR----VDEVLELVGLTAVA
Mvan_4796|M.vanbaalenii_PYR-1 GLTGQVATVDELLTGRENIRMIGGLYGIRRKDLDRLGDQLLHQFSLTDAA
Mflv_1936|M.gilvum_PYR-GCK GLTGQVATVDELLTGRENIRMIGGLYGIRRRDLKNLGDQLLHQFSLTDAA
MMAR_3263|M.marinum_M GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFA
MUL_3577|M.ulcerans_Agy99 GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLSDRLLDQFSIAEFA
Mb2961|M.bovis_AF2122/97 MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
Rv2936|M.tuberculosis_H37Rv MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
MLBr_02352|M.leprae_Br4923 MVTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAG
MAV_3250|M.avium_104 GMAGQFTGMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAA
MSMEG_6509|M.smegmatis_MC2_155 GYVPQQLSIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVA
: :. : ::: : :. . :
MAB_1689|M.abscessus_ATCC_1997 NRKVGALSGGMRRRVDVALAVAHNPQMLFLDEPSSGLDIEGKQEVWNAIR
TH_2788|M.thermoresistible__bu ARPAGTLSLGMSQRLGIAGALLGDPPVLLFDEPVNGLDPEGIRWVRTLMR
Mvan_4796|M.vanbaalenii_PYR-1 DRVVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mflv_1936|M.gilvum_PYR-GCK DRPVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
MMAR_3263|M.marinum_M DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLR
MUL_3577|M.ulcerans_Agy99 DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLG
Mb2961|M.bovis_AF2122/97 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
Rv2936|M.tuberculosis_H37Rv KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MLBr_02352|M.leprae_Br4923 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MAV_3250|M.avium_104 DRRLSTYSGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVS
MSMEG_6509|M.smegmatis_MC2_155 DTVAGTYSGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVR
: * ** :*: :* .: * : ::*** *** . : :
MAB_1689|M.abscessus_ATCC_1997 LLRSE-GRTVVLTTHDMDEAVSLADEVGIVKSGRLVASGSTQEFTRSHGY
TH_2788|M.thermoresistible__bu TMAAE-GRTVLVSSHLLAEMANTADRLLVIGRGRLIASTSVAEFVGST-A
Mvan_4796|M.vanbaalenii_PYR-1 GLVAQ-GTTLLLTTQYLEEADQLADNIVVIDRGHIIAEGSPLELKQQAGR
Mflv_1936|M.gilvum_PYR-GCK GLVAQ-GTTLLLTTQYLEEADQLADNIVVIDRGRIIAEGSPLHLKQQAGR
MMAR_3263|M.marinum_M TLVDD-GLTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
MUL_3577|M.ulcerans_Agy99 TLVDD-GPTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
Mb2961|M.bovis_AF2122/97 SFKKL-GIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
Rv2936|M.tuberculosis_H37Rv SFKKL-GIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
MLBr_02352|M.leprae_Br4923 SFKQI-GIATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGE
MAV_3250|M.avium_104 SLRVQ-GISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGT
MSMEG_6509|M.smegmatis_MC2_155 AMQAEFGMTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS
: * : ::::: : * .* : :: * : * : .:
MAB_1689|M.abscessus_ATCC_1997 AVEVSADSVIPEEAAGRLAEAGYALR-----RTDSGTLSGTLDSASAADL
TH_2788|M.thermoresistible__bu AERVRVRSPEMDTLRGLLADAGVEVR-----LEPDG-AALTVRGAAPEVV
Mvan_4796|M.vanbaalenii_PYR-1 ASLVVTVGDAADLEGARTLLGQTGAE---VFVDAGARRLTASA-DGLDDM
Mflv_1936|M.gilvum_PYR-GCK ASLVVTVADAADLESARGLLARTGAE---VYVDAGARRLTATA-DGLDDM
MMAR_3263|M.marinum_M ASIVVTVSRTEDVANVAAFLRTGAKE---VRVDISARRITVAT-HGLLDL
MUL_3577|M.ulcerans_Agy99 ASIVVTVSRTEDVANVAAFLRTGVKE---VRVDICARRITVAT-HGLLDL
Mb2961|M.bovis_AF2122/97 TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRML
Rv2936|M.tuberculosis_H37Rv TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRML
MLBr_02352|M.leprae_Br4923 TFCEIVPRDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTL
MAV_3250|M.avium_104 SYCQVTPANPAELPQVAAALTGLEG----IEIDSDTGSVSVFAPDGVATL
MSMEG_6509|M.smegmatis_MC2_155 ------------------------------QASDDAGETTLEDVFRHYAG
MAB_1689|M.abscessus_ATCC_1997 GALSAELDRVGLGAASIEVRSTSLRDAFLEVTQ-----------------
TH_2788|M.thermoresistible__bu GELAARN---GITLHELSVQRASLEDAYLELTDAAVEYRAVPR-------
Mvan_4796|M.vanbaalenii_PYR-1 IRVAEWLRDSGIAVDDIGLSRPSLDDVFLTLTGHRTEDSEEIGA------
Mflv_1936|M.gilvum_PYR-GCK VKVAGWLRDSGITVDDIGLSRPSLDDVFLMLTGHRTDDTEEVGA------
MMAR_3263|M.marinum_M SDVARMLHQYAAPIEDIRLTRPSLDDVFVLLTGHHGSSSEGD--------
MUL_3577|M.ulcerans_Agy99 SEVARMLHHYAAPVEDIRLARPSLDDVFVLLTGHHSSSSEGDGRLGAWPA
Mb2961|M.bovis_AF2122/97 VEAARRIDEARIELADIALRRPSLDDVFLAMTTDPTESLTHLVSGSAR--
Rv2936|M.tuberculosis_H37Rv VEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR--
MLBr_02352|M.leprae_Br4923 IEAARRIDEVSVELADIALRRPSLDDVFLSMTTDPSESLSHLAAGAMR--
MAV_3250|M.avium_104 VEVFRRVDALGLELADISLRKPSLDEAFLHLTERT-------VARS----
MSMEG_6509|M.smegmatis_MC2_155 SDLEGGADPRRSGLGEVRSTRRTARRVS----------------------
.: : .
MAB_1689|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2788|M.thermoresistible__bu --------------------------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1936|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3263|M.marinum_M ----SA--------------------------------------------
MUL_3577|M.ulcerans_Agy99 LVAGSAEHARGVRSCARSGRGVLWRSSTLHQLCCGETGNRLARVRWGWRV
Mb2961|M.bovis_AF2122/97 --------------------------------------------------
Rv2936|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02352|M.leprae_Br4923 --------------------------------------------------
MAV_3250|M.avium_104 --------------------------------------------------
MSMEG_6509|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1689|M.abscessus_ATCC_1997 ------------------------------------
TH_2788|M.thermoresistible__bu ------------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 ------------------------------------
Mflv_1936|M.gilvum_PYR-GCK ------------------------------------
MMAR_3263|M.marinum_M ------------------------------------
MUL_3577|M.ulcerans_Agy99 GLSAGLRRRTRRGRRAPRNRAASTGLGGLTRVRRRW
Mb2961|M.bovis_AF2122/97 ------------------------------------
Rv2936|M.tuberculosis_H37Rv ------------------------------------
MLBr_02352|M.leprae_Br4923 ------------------------------------
MAV_3250|M.avium_104 ------------------------------------
MSMEG_6509|M.smegmatis_MC2_155 ------------------------------------