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RRSQSAVEVIDLVKRRGSVTAVDGISFAVPPGGVLGLLGPNGAGKTTTVRMLATLTRPTSGAAWVAGHDV CAAPESVRREIGLTCQEATLDGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFADRRVDTYSG GMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLRTLVDDGLTLVLTTQYLEEADRLADNIVLI DKGRVIAEGSPFELKQKAGDASIVVTVSRTEDVANVAAFLRTGAKEVRVDISARRITVATHGLLDLSDVA RMLHQYAAPIEDIRLTRPSLDDVFVLLTGHHGSSSEGDSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3263 | - | - | 100% (321) | ATP-binding protein ABC transporter |
| M. marinum M | MMAR_1771 | drrA | 8e-69 | 46.96% (313) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. marinum M | MMAR_0171 | - | 6e-43 | 36.04% (308) | ATP-binding protein ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 6e-67 | 44.44% (315) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_1936 | - | 1e-104 | 64.10% (312) | daunorubicin resistance ABC transporter ATPase subunit |
| M. tuberculosis H37Rv | Rv2936 | drrA | 4e-66 | 44.13% (315) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 7e-68 | 44.76% (315) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1689 | - | 1e-42 | 36.16% (307) | daunorubicin resistance ABC transporter ATP-binding subunit |
| M. avium 104 | MAV_3250 | - | 5e-72 | 47.73% (308) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 1e-43 | 42.34% (222) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2424 | - | 3e-32 | 38.18% (220) | PUTATIVE sulfate ABC transporter, ATPase subunit |
| M. ulcerans Agy99 | MUL_3577 | - | 1e-169 | 95.30% (319) | ATP-binding protein ABC transporter |
| M. vanbaalenii PYR-1 | Mvan_4796 | - | 1e-105 | 63.92% (316) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3263|M.marinum_M ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPP
MUL_3577|M.ulcerans_Agy99 ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPQ
Mflv_1936|M.gilvum_PYR-GCK ----------------MPFPPAIEALDLVKRFG---DQTAVAGVSFVVPP
Mvan_4796|M.vanbaalenii_PYR-1 MADKSVGPMSVCAYTVDAMESAIEAIDLVKRFGDTLDNPAVDGVSFAVPP
Mb2961|M.bovis_AF2122/97 ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
Rv2936|M.tuberculosis_H37Rv ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
MLBr_02352|M.leprae_Br4923 ---------------MRNNDKAVMVRGVRKTYGK-GKIIALDDVSFDVDR
MAV_3250|M.avium_104 ---------------MSAP--AIEVEGLTKKFG--GSTLALAGVDFSVPA
MAB_1689|M.abscessus_ATCC_1997 -------------MTTDTQIPALRAAELVKAYPG-SDARAVDGLDLTIPQ
MSMEG_6509|M.smegmatis_MC2_155 ------MTDHMPEPTLPDRTPAIDCDGLTHRYG---QFTAVEDLTLQVRA
TH_2424|M.thermoresistible__bu ------------------MTDAITVRGANKRYG---DFAALDNVDFAVPA
*: : . *: .: : :
MMAR_3263|M.marinum_M GGVLGLLGPNGAGKTTTVRMLATLTRPTSGAAWVAGHDVCAAPESVRREI
MUL_3577|M.ulcerans_Agy99 GGILGLLGPNGAGKTTTVRMVATLTRPTSGTAWVAGHDVCTAPESVRREI
Mflv_1936|M.gilvum_PYR-GCK GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGFDVRTHPDEVRRHM
Mvan_4796|M.vanbaalenii_PYR-1 GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGYDVRAQPDDVRRHM
Mb2961|M.bovis_AF2122/97 GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
Rv2936|M.tuberculosis_H37Rv GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
MLBr_02352|M.leprae_Br4923 GEVIGLLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSI
MAV_3250|M.avium_104 GTVCGLLGHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASI
MAB_1689|M.abscessus_ATCC_1997 GIVYCLLGRNGAGKTTTIRMATTLLAPTRGELEVLGVPVDN-TKELRPLI
MSMEG_6509|M.smegmatis_MC2_155 GETLGLLGPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNI
TH_2424|M.thermoresistible__bu GSLTALLGPSGSGKSTLLRAIAGLDRPDTGTITINGRDVTDVPPQRR-GI
* *** .*:**:* : : * * : * . . * :
MMAR_3263|M.marinum_M GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFA
MUL_3577|M.ulcerans_Agy99 GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLSDRLLDQFSIAEFA
Mflv_1936|M.gilvum_PYR-GCK GLTGQVATVDELLTGRENIRMIGGLYGIRRRDLKNLGDQLLHQFSLTDAA
Mvan_4796|M.vanbaalenii_PYR-1 GLTGQVATVDELLTGRENIRMIGGLYGIRRKDLDRLGDQLLHQFSLTDAA
Mb2961|M.bovis_AF2122/97 MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
Rv2936|M.tuberculosis_H37Rv MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
MLBr_02352|M.leprae_Br4923 MVTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAG
MAV_3250|M.avium_104 GMAGQFTGMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAA
MAB_1689|M.abscessus_ATCC_1997 GVALQEVALDLWMSPVEQIRMSLAIAGWPKARRKAREDELVEQFGLSTYV
MSMEG_6509|M.smegmatis_MC2_155 GYVPQQLSIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVA
TH_2424|M.thermoresistible__bu GFVFQHYAAFKHLTVRDNVAFGLKIRRRPKREIAEKVDNLLEVVGLAGFQ
. * :: ::: : : : :. . :
MMAR_3263|M.marinum_M DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLR
MUL_3577|M.ulcerans_Agy99 DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLG
Mflv_1936|M.gilvum_PYR-GCK DRPVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mvan_4796|M.vanbaalenii_PYR-1 DRVVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mb2961|M.bovis_AF2122/97 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
Rv2936|M.tuberculosis_H37Rv KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MLBr_02352|M.leprae_Br4923 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MAV_3250|M.avium_104 DRRLSTYSGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVS
MAB_1689|M.abscessus_ATCC_1997 NRKVGALSGGMRRRVDVALAVAHNPQMLFLDEPSSGLDIEGKQEVWNAIR
MSMEG_6509|M.smegmatis_MC2_155 DTVAGTYSGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVR
TH_2424|M.thermoresistible__bu NRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREDLRTWLR
. *** :*: :* .: * : :**** .** : : :
MMAR_3263|M.marinum_M TLVDD-GLTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
MUL_3577|M.ulcerans_Agy99 TLVDD-GPTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
Mflv_1936|M.gilvum_PYR-GCK GLVAQ-GTTLLLTTQYLEEADQLADNIVVIDRGRIIAEGSPLHLKQQAGR
Mvan_4796|M.vanbaalenii_PYR-1 GLVAQ-GTTLLLTTQYLEEADQLADNIVVIDRGHIIAEGSPLELKQQAGR
Mb2961|M.bovis_AF2122/97 SFKKL-GIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
Rv2936|M.tuberculosis_H37Rv SFKKL-GIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
MLBr_02352|M.leprae_Br4923 SFKQI-GIATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGE
MAV_3250|M.avium_104 SLRVQ-GISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGT
MAB_1689|M.abscessus_ATCC_1997 LLRSE-GRTVVLTTHDMDEAVSLADEVGIVKSGRLVASGSTQEFTRSHGY
MSMEG_6509|M.smegmatis_MC2_155 AMQAEFGMTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS
TH_2424|M.thermoresistible__bu RLHEEVHVTTVLVTHDQSEALDVADRIAVLNNGRIEQVGSPAEVYDSPAN
: : :*.*: ** :.* : ::. * : *:. .. .
MMAR_3263|M.marinum_M ASIVVTVSRTEDVANVAAFLRTGAKE---VRVDISA---------RRITV
MUL_3577|M.ulcerans_Agy99 ASIVVTVSRTEDVANVAAFLRTGVKE---VRVDICA---------RRITV
Mflv_1936|M.gilvum_PYR-GCK ASLVVTVADAADLESARGLLARTGAE---VYVDAGA---------RRLTA
Mvan_4796|M.vanbaalenii_PYR-1 ASLVVTVGDAADLEGARTLLGQTGAE---VFVDAGA---------RRLTA
Mb2961|M.bovis_AF2122/97 TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDS---------DRITM
Rv2936|M.tuberculosis_H37Rv TFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDS---------DRITM
MLBr_02352|M.leprae_Br4923 TFCEIVPRDLKDLGTVVAALGSLLPERSRAMLTPTS---------DRITM
MAV_3250|M.avium_104 SYCQVTPANPAELPQVAAALTGLEG----IEIDSDT---------GSVSV
MAB_1689|M.abscessus_ATCC_1997 AVEVSADSVIPEEAAGRLAEAGYALR----RTDSGT---------LSGTL
MSMEG_6509|M.smegmatis_MC2_155 ------------------------------QASDDA---------GETTL
TH_2424|M.thermoresistible__bu EFVMSFLGAVSSLNGTLVRPHDIWVGRHPELPTSDSTLQATGVVRARIDR
:
MMAR_3263|M.marinum_M AT-HGLLDLSDVARMLHQYAAPIEDIR-----LTRPSLDDVFVLLTGHHG
MUL_3577|M.ulcerans_Agy99 AT-HGLLDLSEVARMLHHYAAPVEDIR-----LARPSLDDVFVLLTGHHS
Mflv_1936|M.gilvum_PYR-GCK TA-DGLDDMVKVAGWLRDSGITVDDIG-----LSRPSLDDVFLMLTGHRT
Mvan_4796|M.vanbaalenii_PYR-1 SA-DGLDDMIRVAEWLRDSGIAVDDIG-----LSRPSLDDVFLTLTGHRT
Mb2961|M.bovis_AF2122/97 PAPDGIRMLVEAARRIDEARIELADIA-----LRRPSLDDVFLAMTTDPT
Rv2936|M.tuberculosis_H37Rv PAPDGIRMLVEAARRIDEARIELADIA-----LRRPSLDHVFLAMTTDPT
MLBr_02352|M.leprae_Br4923 PAPDGTQTLIEAARRIDEVSVELADIA-----LRRPSLDDVFLSMTTDPS
MAV_3250|M.avium_104 FAPDGVATLVEVFRRVDALGLELADIS-----LRKPSLDEAFLHLTERT-
MAB_1689|M.abscessus_ATCC_1997 DS-ASAADLGALSAELDRVGLGAASIE-----VRSTSLRDAFLEVTQ---
MSMEG_6509|M.smegmatis_MC2_155 EDVFRHYAGSDLEGGADPRRSGLGEVR-----STRRTARRVS--------
TH_2424|M.thermoresistible__bu VVMLGFEVRLELTSATNNAPFTAQITRGDAEALGLRSGDTVYVRATRVPA
: .
MMAR_3263|M.marinum_M SSSEGD------------SA------------------------------
MUL_3577|M.ulcerans_Agy99 SSSEGDGRLGAWPALVAGSAEHARGVRSCARSGRGVLWRSSTLHQLCCGE
Mflv_1936|M.gilvum_PYR-GCK DDTEEVG------------A------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 EDSEEIG------------A------------------------------
Mb2961|M.bovis_AF2122/97 ESLTHLVSGSAR--------------------------------------
Rv2936|M.tuberculosis_H37Rv ESLTHLVSGSAR--------------------------------------
MLBr_02352|M.leprae_Br4923 ESLSHLAAGAMR--------------------------------------
MAV_3250|M.avium_104 ------VARS----------------------------------------
MAB_1689|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6509|M.smegmatis_MC2_155 --------------------------------------------------
TH_2424|M.thermoresistible__bu LPTGDVDERVAAR-------------------------------------
MMAR_3263|M.marinum_M --------------------------------------------------
MUL_3577|M.ulcerans_Agy99 TGNRLARVRWGWRVGLSAGLRRRTRRGRRAPRNRAASTGLGGLTRVRRRW
Mflv_1936|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2961|M.bovis_AF2122/97 --------------------------------------------------
Rv2936|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02352|M.leprae_Br4923 --------------------------------------------------
MAV_3250|M.avium_104 --------------------------------------------------
MAB_1689|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6509|M.smegmatis_MC2_155 --------------------------------------------------
TH_2424|M.thermoresistible__bu --------------------------------------------------