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MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAG YDVVSEPAGVRRSIMVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGT YSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRI ILIDHGIIIAEGTANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGI RMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2936 | drrA | - | 100% (331) | PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA |
| M. tuberculosis H37Rv | Rv1458c | - | 3e-40 | 34.19% (313) | unidentified antibiotic-transport ATP-binding protein ABC |
| M. tuberculosis H37Rv | Rv1218c | - | 3e-29 | 29.97% (297) | tetronasin-transport ATP-binding protein ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 0.0 | 99.70% (331) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_3389 | - | 1e-117 | 66.88% (317) | daunorubicin resistance ABC transporter ATPase subunit |
| M. leprae Br4923 | MLBr_02352 | - | 1e-160 | 85.20% (331) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_2752 | - | 6e-37 | 31.74% (293) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_1771 | drrA | 1e-152 | 83.08% (331) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. avium 104 | MAV_3250 | - | 2e-87 | 54.37% (309) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_6509 | - | 1e-45 | 42.55% (235) | ABC-type drug export system, ATP-binding protein |
| M. thermoresistible (build 8) | TH_2538 | - | 1e-27 | 30.40% (227) | PUTATIVE ABC transporter related |
| M. ulcerans Agy99 | MUL_2014 | drrA | 1e-152 | 83.08% (331) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. vanbaalenii PYR-1 | Mvan_3122 | - | 1e-119 | 67.51% (317) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3389|M.gilvum_PYR-GCK ---------MPSTDKAVVVEGIKKSFG----AVTALRDVSFDVGRGEVLG
Mvan_3122|M.vanbaalenii_PYR-1 ---------MTRSDKAVVVAGIKKSFG----SVQALRDVSFEVERGEVLG
Rv2936|M.tuberculosis_H37Rv ---------MRNDDMAVVVNGVRKTYGK--GKIVALDDVSFKVRRGEVIG
Mb2961|M.bovis_AF2122/97 ---------MRNDDMAVVVNGVRKTYGK--GKIVALDDVSFKVRRGEVIG
MLBr_02352|M.leprae_Br4923 ---------MRNNDKAVMVRGVRKTYGK--GKIIALDDVSFDVDRGEVIG
MMAR_1771|M.marinum_M ---------MRNNDLAVEVRGVRKAFG----DVVALNDISFEVGRGEVIG
MUL_2014|M.ulcerans_Agy99 ---------MRNNDLAVEVRGVRKAFG----DVVALNDISFEVGRGEVIG
MAV_3250|M.avium_104 -----------MSAPAIEVEGLTKKFG---GSTLALAGVDFSVPAGTVCG
MSMEG_6509|M.smegmatis_MC2_155 MTDHMPEPTLPDRTPAIDCDGLTHRYG----QFTAVEDLTLQVRAGETLG
MAB_2752|M.abscessus_ATCC_1997 -----------------------------------MDSLDLEVHAAQVFA
TH_2538|M.thermoresistible__bu ---------------MIELTDLTKVYGCGEHRTVVLDRINFRVETGEVLA
: : : * . . .
Mflv_3389|M.gilvum_PYR-GCK LLGPNGAGKTTTVNILSTLIKPDSGRAMIAGHDVVTDPAG----VRRALM
Mvan_3122|M.vanbaalenii_PYR-1 LLGPNGAGKTTTVNILSTLIKPDSGRALIAGHDVVTDPAG----VRRALM
Rv2936|M.tuberculosis_H37Rv LLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAG----VRRSIM
Mb2961|M.bovis_AF2122/97 LLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAG----VRRSIM
MLBr_02352|M.leprae_Br4923 LLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAG----VRRSIM
MMAR_1771|M.marinum_M LLGPNGAGKTTMVDILSTLTRPDAGSAHVAGSDVVAQPAG----VRRSIM
MUL_2014|M.ulcerans_Agy99 LLGPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAG----VRRSIM
MAV_3250|M.avium_104 LLGHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAE----VRASIG
MSMEG_6509|M.smegmatis_MC2_155 LLGPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMD----IRHNIG
MAB_2752|M.abscessus_ATCC_1997 LLGPNGAGKTTTVELCEGFLHPDEGTVEVLGMDPVAKNSA----VRSRIG
TH_2538|M.thermoresistible__bu VVGPSGAGKSTLAQCINLLTRPTSGSVVVNGEDLTTLSTHRLRVARRRIG
::* .****:* : * . : * * * :
Mflv_3389|M.gilvum_PYR-GCK LTGQHAALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVGAGD
Mvan_3122|M.vanbaalenii_PYR-1 LTGQHAALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVQAAD
Rv2936|M.tuberculosis_H37Rv VTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGK
Mb2961|M.bovis_AF2122/97 VTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGK
MLBr_02352|M.leprae_Br4923 VTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGK
MMAR_1771|M.marinum_M VTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGK
MUL_2014|M.ulcerans_Agy99 VTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGK
MAV_3250|M.avium_104 MAGQFTGMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAAD
MSMEG_6509|M.smegmatis_MC2_155 YVPQQLSIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVAD
MAB_2752|M.abscessus_ATCC_1997 VMLQGGGAYPTARASEMLGLVASYS-----ANPLDPQWLLDTLGLTDAAR
TH_2538|M.thermoresistible__bu TVFQSSGLLERRTAAENVALPLEYLGVTAAETRKRVAELLDRVGLAARAN
* . . : : : *: . * .
Mflv_3389|M.gilvum_PYR-GCK RAVGNYSGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTD
Mvan_3122|M.vanbaalenii_PYR-1 RPVGTYSGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTD
Rv2936|M.tuberculosis_H37Rv RRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVAS
Mb2961|M.bovis_AF2122/97 RRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVAS
MLBr_02352|M.leprae_Br4923 RRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVAS
MMAR_1771|M.marinum_M RLVRTYSGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTS
MUL_2014|M.ulcerans_Agy99 RLVRTYSGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTS
MAV_3250|M.avium_104 RRLSTYSGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSS
MSMEG_6509|M.smegmatis_MC2_155 TVAGTYSGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVRA
MAB_2752|M.abscessus_ATCC_1997 TPYRRLSGGQQQRLALACALVGRPELVFLDEPTAGMDAHARLVVWELIDC
TH_2538|M.thermoresistible__bu HYPFQLSGGQRQRVGIARALALRPSVLLSDEATAGLDPTTTASVVELLRE
*** :*: :* .*. * : : **.*.*:*. : : :
Mflv_3389|M.gilvum_PYR-GCK FK-EAGIATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADQLKERTGGT
Mvan_3122|M.vanbaalenii_PYR-1 FK-EAGIATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADELKERTGGT
Rv2936|M.tuberculosis_H37Rv FK-KLGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDT
Mb2961|M.bovis_AF2122/97 FK-KLGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDT
MLBr_02352|M.leprae_Br4923 FK-QIGIATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGET
MMAR_1771|M.marinum_M FK-KLGIATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDT
MUL_2014|M.ulcerans_Agy99 FK-KLGIATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDT
MAV_3250|M.avium_104 LR-VQGISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGTS
MSMEG_6509|M.smegmatis_MC2_155 MQAEFGMTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS-
MAB_2752|M.abscessus_ATCC_1997 LR-RDGVSVVLTTHHMKEAEELADQLMIIDHGSVVAAGTPSELMQSGAEN
TH_2538|M.thermoresistible__bu LRDDLNLSIVFITHEMDTVLKIADSVARLDHGRIVEAGRLVDLLTDPASA
:: .:: :: *: : . :.* : :.:* : * :* .
Mflv_3389|M.gilvum_PYR-GCK YCEIVPRQLSQLREVARILGPLLPAA--HRDALSDTSDRISMPAPDGPNT
Mvan_3122|M.vanbaalenii_PYR-1 YCEIVPRNLADIPEVARVLGPLLPDA--NRAALTDTSDRISMPAPDGPNT
Rv2936|M.tuberculosis_H37Rv FCEIVPRDLKDLDAIVAALGSLLPEH--HRAMLTPDSDRITMPAPDGIRM
Mb2961|M.bovis_AF2122/97 FCEIVPRDLKDLDAIVAALGSLLPEH--HRAMLTPDSDRITMPAPDGIRM
MLBr_02352|M.leprae_Br4923 FCEIVPRDLKDLGTVVAALGSLLPER--SRAMLTPTSDRITMPAPDGTQT
MMAR_1771|M.marinum_M FCEIVPRHLKDLDATVAALGSLLPEH--NRAMVTSESDRITMPAPDGTRT
MUL_2014|M.ulcerans_Agy99 FCEIVPRHLKDLDATVAALGSLLPEH--NRAMVTSESDRITMPAPDGTRT
MAV_3250|M.avium_104 YCQVTPANPAELPQVAAALTGLEG------IEIDSDTGSVSVFAPDGVAT
MSMEG_6509|M.smegmatis_MC2_155 ----------------------------------------QASDDAGETT
MAB_2752|M.abscessus_ATCC_1997 QLRFAAPPRLDLTLLTSALPEG-------YKATEVTPGEYRVEGVVDPQV
TH_2538|M.thermoresistible__bu LGADLRPQGAAAPPAPPXXXRLRGVAGPDHPHRTGAVRAAGRTGPAAARR
Mflv_3389|M.gilvum_PYR-GCK LMQALHLLSEADIELSDIALRRPSLDEVFLALTGDHPKARDESEDPLVAA
Mvan_3122|M.vanbaalenii_PYR-1 LMQALHLLSEANIELMDIALRRPSLDEVFLALTGDHPRTRDGEADAVVAA
Rv2936|M.tuberculosis_H37Rv LVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTES----LTHLVSG
Mb2961|M.bovis_AF2122/97 LVEAARRIDEARIELADIALRRPSLDDVFLAMTTDPTES----LTHLVSG
MLBr_02352|M.leprae_Br4923 LIEAARRIDEVSVELADIALRRPSLDDVFLSMTTDPSES----LSHLAAG
MMAR_1771|M.marinum_M LIEAARRIDEANIELADIALRRPSLDDVFLSMTTDPSEAH--ALSHVASG
MUL_2014|M.ulcerans_Agy99 LIEAARKIDEANIELADIALRRPSLDDVFLSMTTDPSEAH--VLSHVASG
MAV_3250|M.avium_104 LVEVFRRVDALGLELADISLRKPSLDEAFLHLT-----------ERTVAR
MSMEG_6509|M.smegmatis_MC2_155 LEDVFRHYAGSDLEGG-ADPRRSGLGEVRSTRRTARRVS-----------
MAB_2752|M.abscessus_ATCC_1997 LATVTAWCARMDVLTTDLRVEKRSLEDVFLDLTGRELR------------
TH_2538|M.thermoresistible__bu CGGGTAVDAGSDRRVADRAGRRPGRRDDAVAAPRRRPIRP----------
.: . .
Mflv_3389|M.gilvum_PYR-GCK DAYA
Mvan_3122|M.vanbaalenii_PYR-1 DAYA
Rv2936|M.tuberculosis_H37Rv SAR-
Mb2961|M.bovis_AF2122/97 SAR-
MLBr_02352|M.leprae_Br4923 AMR-
MMAR_1771|M.marinum_M AML-
MUL_2014|M.ulcerans_Agy99 AML-
MAV_3250|M.avium_104 S---
MSMEG_6509|M.smegmatis_MC2_155 ----
MAB_2752|M.abscessus_ATCC_1997 ----
TH_2538|M.thermoresistible__bu ----