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RRSQSAVEVIDLVKRRGSVTAVDGISFAVPQGGILGLLGPNGAGKTTTVRMVATLTRPTSGTAWVAGHDV CTAPESVRREIGLTCQEATLDGLLTARENINMIGSLRGIRRKELASLSDRLLDQFSIAEFADRRVDTYSG GMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLGTLVDDGPTLVLTTQYLEEADRLADNIVLI DKGRVIAEGSPFELKQKAGDASIVVTVSRTEDVANVAAFLRTGVKEVRVDICARRITVATHGLLDLSEVA RMLHHYAAPVEDIRLARPSLDDVFVLLTGHHSSSSEGDGRLGAWPALVAGSAEHARGVRSCARSGRGVLW RSSTLHQLCCGETGNRLARVRWGWRVGLSAGLRRRTRRGRRAPRNRAASTGLGGLTRVRRRW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3577 | - | - | 100% (413) | ATP-binding protein ABC transporter |
| M. ulcerans Agy99 | MUL_2014 | drrA | 1e-67 | 45.69% (313) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. ulcerans Agy99 | MUL_4925 | - | 3e-42 | 34.74% (308) | ATP-binding protein ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2961 | drrA | 3e-66 | 44.13% (315) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. gilvum PYR-GCK | Mflv_1936 | - | 1e-103 | 62.74% (314) | daunorubicin resistance ABC transporter ATPase subunit |
| M. tuberculosis H37Rv | Rv2936 | drrA | 2e-65 | 43.81% (315) | daunorubicin-DIM-transport ATP-binding protein ABC |
| M. leprae Br4923 | MLBr_02352 | - | 5e-67 | 43.93% (321) | putative antibiotic resistance efflux protein |
| M. abscessus ATCC 19977 | MAB_1689 | - | 1e-42 | 35.83% (307) | daunorubicin resistance ABC transporter ATP-binding subunit |
| M. marinum M | MMAR_3263 | - | 1e-169 | 95.30% (319) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_3250 | - | 4e-71 | 47.40% (308) | daunorubicin resistance ATP-binding protein DrrA |
| M. smegmatis MC2 155 | MSMEG_6766 | - | 9e-42 | 36.27% (306) | ABC transporter, ATP-binding protein, NodI family protein |
| M. thermoresistible (build 8) | TH_2424 | - | 1e-31 | 38.18% (220) | PUTATIVE sulfate ABC transporter, ATPase subunit |
| M. vanbaalenii PYR-1 | Mvan_4796 | - | 1e-103 | 63.01% (319) | daunorubicin resistance ABC transporter ATPase subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3577|M.ulcerans_Agy99 ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPQ
MMAR_3263|M.marinum_M ---------------MRRSQSAVEVIDLVKRRG---SVTAVDGISFAVPP
Mflv_1936|M.gilvum_PYR-GCK ----------------MPFPPAIEALDLVKRFG---DQTAVAGVSFVVPP
Mvan_4796|M.vanbaalenii_PYR-1 MADKSVGPMSVCAYTVDAMESAIEAIDLVKRFGDTLDNPAVDGVSFAVPP
Mb2961|M.bovis_AF2122/97 ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
Rv2936|M.tuberculosis_H37Rv ---------------MRNDDMAVVVNGVRKTYGK-GKIVALDDVSFKVRR
MLBr_02352|M.leprae_Br4923 ---------------MRNNDKAVMVRGVRKTYGK-GKIIALDDVSFDVDR
MAV_3250|M.avium_104 ---------------MSAP--AIEVEGLTKKFG--GSTLALAGVDFSVPA
MAB_1689|M.abscessus_ATCC_1997 -------------MTTDTQIPALRAAELVKAYPG-SDARAVDGLDLTIPQ
MSMEG_6766|M.smegmatis_MC2_155 ------------------MSAAVEVRGLSKSYGR---RPAVRDLDLDVGY
TH_2424|M.thermoresistible__bu ------------------MTDAITVRGANKRYG---DFAALDNVDFAVPA
*: . * *: .:.: :
MUL_3577|M.ulcerans_Agy99 GGILGLLGPNGAGKTTTVRMVATLTRPTSGTAWVAGHDVCTAPESVRREI
MMAR_3263|M.marinum_M GGVLGLLGPNGAGKTTTVRMLATLTRPTSGAAWVAGHDVCAAPESVRREI
Mflv_1936|M.gilvum_PYR-GCK GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGFDVRTHPDEVRRHM
Mvan_4796|M.vanbaalenii_PYR-1 GTVLGLLGPNGAGKTTTVRMMTTLTEPTSGTARVAGYDVRAQPDDVRRHM
Mb2961|M.bovis_AF2122/97 GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
Rv2936|M.tuberculosis_H37Rv GEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSI
MLBr_02352|M.leprae_Br4923 GEVIGLLGPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSI
MAV_3250|M.avium_104 GTVCGLLGHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASI
MAB_1689|M.abscessus_ATCC_1997 GIVYCLLGRNGAGKTTTIRMATTLLAPTRGELEVLGVPVDN-TKELRPLI
MSMEG_6766|M.smegmatis_MC2_155 GEIFAILGPNGAGKTTTVEILEGNRRRDSGEVLVLGEDPGRAGRQWRARI
TH_2424|M.thermoresistible__bu GSLTALLGPSGSGKSTLLRAIAGLDRPDTGTITINGRDVTDVPPQRR-GI
* : :** .*:**:* : * : * * :
MUL_3577|M.ulcerans_Agy99 GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLSDRLLDQFSIAEFA
MMAR_3263|M.marinum_M GLTCQEATLDGLLTARENINMIGSLRGIRRKELASLTDRLLDQFSIAEFA
Mflv_1936|M.gilvum_PYR-GCK GLTGQVATVDELLTGRENIRMIGGLYGIRRRDLKNLGDQLLHQFSLTDAA
Mvan_4796|M.vanbaalenii_PYR-1 GLTGQVATVDELLTGRENIRMIGGLYGIRRKDLDRLGDQLLHQFSLTDAA
Mb2961|M.bovis_AF2122/97 MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
Rv2936|M.tuberculosis_H37Rv MVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAG
MLBr_02352|M.leprae_Br4923 MVTGQQVAVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAG
MAV_3250|M.avium_104 GMAGQFTGMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAA
MAB_1689|M.abscessus_ATCC_1997 GVALQEVALDLWMSPVEQIRMSLAIAGWPKARRKAREDELVEQFGLSTYV
MSMEG_6766|M.smegmatis_MC2_155 GIVLQEVSDAGMLTVGETVQMFSACYGTAR-----APADVLELVGLRHAS
TH_2424|M.thermoresistible__bu GFVFQHYAAFKHLTVRDNVAFGLKIRRRPKREIAEKVDNLLEVVGLAGFQ
.. * :: : : : : ::. ..:
MUL_3577|M.ulcerans_Agy99 DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLG
MMAR_3263|M.marinum_M DRRVDTYSGGMRRRLDVAISLLARPQVLFLDEPTAGLDPHSRIQLWEVLR
Mflv_1936|M.gilvum_PYR-GCK DRPVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mvan_4796|M.vanbaalenii_PYR-1 DRVVRSYSGGMRRRLDLAVSLLASPPVLFLDEPTTGLDPRSRSELWDVLR
Mb2961|M.bovis_AF2122/97 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
Rv2936|M.tuberculosis_H37Rv KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MLBr_02352|M.leprae_Br4923 KRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVA
MAV_3250|M.avium_104 DRRLSTYSGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVS
MAB_1689|M.abscessus_ATCC_1997 NRKVGALSGGMRRRVDVALAVAHNPQMLFLDEPSSGLDIEGKQEVWNAIR
MSMEG_6766|M.smegmatis_MC2_155 RSRVRTLSGGQRRRLDVALGIIGGPELVFLDEPTTGFDPEARQQFWELIR
TH_2424|M.thermoresistible__bu NRYPNQLSGGQRQRMALARALAVDPEVLLLDEPFGALDAKVREDLRTWLR
*** :*: :* .: * : :**** .:* . : . :
MUL_3577|M.ulcerans_Agy99 TLVDDG-PTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
MMAR_3263|M.marinum_M TLVDDG-LTLVLTTQYLEEADRLADNIVLIDKGRVIAEGSPFELKQKAGD
Mflv_1936|M.gilvum_PYR-GCK GLVAQG-TTLLLTTQYLEEADQLADNIVVIDRGRIIAEGSPLHLKQQAGR
Mvan_4796|M.vanbaalenii_PYR-1 GLVAQG-TTLLLTTQYLEEADQLADNIVVIDRGHIIAEGSPLELKQQAGR
Mb2961|M.bovis_AF2122/97 SFKKLG-IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
Rv2936|M.tuberculosis_H37Rv SFKKLG-IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGD
MLBr_02352|M.leprae_Br4923 SFKQIG-IATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGE
MAV_3250|M.avium_104 SLRVQG-ISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGT
MAB_1689|M.abscessus_ATCC_1997 LLRSEG-RTVVLTTHDMDEAVSLADEVGIVKSGRLVASGSTQEFTRSHGY
MSMEG_6766|M.smegmatis_MC2_155 LLAADG-TTIVLTTHYLEEAAALADRVAVIADGNVVAVDSPTRLTRHVDT
TH_2424|M.thermoresistible__bu RLHEEVHVTTVLVTHDQSEALDVADRIAVLNNGRIEQVGSPAEVYDSPAN
: : :*.*: .** ::* : :: * : .:. ..
MUL_3577|M.ulcerans_Agy99 ASIVVTVSRTEDVANVAAFLR----TGVKE---VRVDICARRITVAT-HG
MMAR_3263|M.marinum_M ASIVVTVSRTEDVANVAAFLR----TGAKE---VRVDISARRITVAT-HG
Mflv_1936|M.gilvum_PYR-GCK ASLVVTVADAADLESARGLLA----RTGAE---VYVDAGARRLTATA-DG
Mvan_4796|M.vanbaalenii_PYR-1 ASLVVTVGDAADLEGARTLLG----QTGAE---VFVDAGARRLTASA-DG
Mb2961|M.bovis_AF2122/97 TFCEIVPRDLKDLDAIVAALG----SLLPEHHRAMLTPDSDRITMPAPDG
Rv2936|M.tuberculosis_H37Rv TFCEIVPRDLKDLDAIVAALG----SLLPEHHRAMLTPDSDRITMPAPDG
MLBr_02352|M.leprae_Br4923 TFCEIVPRDLKDLGTVVAALG----SLLPERSRAMLTPTSDRITMPAPDG
MAV_3250|M.avium_104 SYCQVTPANPAELPQVAAALT----GLEG----IEIDSDTGSVSVFAPDG
MAB_1689|M.abscessus_ATCC_1997 AVEVSADSVIPEEAAGRLAEA----GYALR----RTDSGTLSGTLDS-AS
MSMEG_6766|M.smegmatis_MC2_155 A------------ATVRWMEG----GHVHE------------------ER
TH_2424|M.thermoresistible__bu EFVMSFLGAVSSLNGTLVRPHDIWVGRHPELPTSDSTLQATGVVRARIDR
MUL_3577|M.ulcerans_Agy99 LLDLSEVARMLHHYAAPVEDIRLARPSLDDVFVLLTGHHSSSSEGDGRLG
MMAR_3263|M.marinum_M LLDLSDVARMLHQYAAPIEDIRLTRPSLDDVFVLLTGHHGSSSEGD----
Mflv_1936|M.gilvum_PYR-GCK LDDMVKVAGWLRDSGITVDDIGLSRPSLDDVFLMLTGHRTDDTEEVG---
Mvan_4796|M.vanbaalenii_PYR-1 LDDMIRVAEWLRDSGIAVDDIGLSRPSLDDVFLTLTGHRTEDSEEIG---
Mb2961|M.bovis_AF2122/97 IRMLVEAARRIDEARIELADIALRRPSLDDVFLAMTTDPTESLTHLVSGS
Rv2936|M.tuberculosis_H37Rv IRMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGS
MLBr_02352|M.leprae_Br4923 TQTLIEAARRIDEVSVELADIALRRPSLDDVFLSMTTDPSESLSHLAAGA
MAV_3250|M.avium_104 VATLVEVFRRVDALGLELADISLRKPSLDEAFLHLTERT-------VARS
MAB_1689|M.abscessus_ATCC_1997 AADLGALSAELDRVGLGAASIEVRSTSLRDAFLEVTQ-------------
MSMEG_6766|M.smegmatis_MC2_155 TEFPTELIRQRSRVGAELAQLTVTRPSLEDAYLHLIGRT-----------
TH_2424|M.thermoresistible__bu VVMLGFEVRLELTSATNNAPFTAQITRGDAEALGLRSGDTVYVRATRVPA
: . : :
MUL_3577|M.ulcerans_Agy99 AWPALVAGSAEHARGVRSCARSGRGVLWRSSTLHQLCCGETGNRLARVRW
MMAR_3263|M.marinum_M --------SA----------------------------------------
Mflv_1936|M.gilvum_PYR-GCK ---------A----------------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 ---------A----------------------------------------
Mb2961|M.bovis_AF2122/97 AR------------------------------------------------
Rv2936|M.tuberculosis_H37Rv AR------------------------------------------------
MLBr_02352|M.leprae_Br4923 MR------------------------------------------------
MAV_3250|M.avium_104 --------------------------------------------------
MAB_1689|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_6766|M.smegmatis_MC2_155 --------------------------------------------------
TH_2424|M.thermoresistible__bu LPTGDVDERVAAR-------------------------------------
MUL_3577|M.ulcerans_Agy99 GWRVGLSAGLRRRTRRGRRAPRNRAASTGLGGLTRVRRRW
MMAR_3263|M.marinum_M ----------------------------------------
Mflv_1936|M.gilvum_PYR-GCK ----------------------------------------
Mvan_4796|M.vanbaalenii_PYR-1 ----------------------------------------
Mb2961|M.bovis_AF2122/97 ----------------------------------------
Rv2936|M.tuberculosis_H37Rv ----------------------------------------
MLBr_02352|M.leprae_Br4923 ----------------------------------------
MAV_3250|M.avium_104 ----------------------------------------
MAB_1689|M.abscessus_ATCC_1997 ----------------------------------------
MSMEG_6766|M.smegmatis_MC2_155 ----------------------------------------
TH_2424|M.thermoresistible__bu ----------------------------------------