For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_3822 (-)

annotation: regulatory protein GntR, HTH
coordinates: 3891418 - 3892152
length: 244

TAAKPALVPVRQIPAHELVVDQMRRALELGQFRPGDRLPTERELSEMLDVSRTTVRTAVAVLEREGLIAV
RRGRGGGFTVQAPEYDPVEMRREMRRNKRAVRDAFDYRVVVETGATRLAAERRRAADLNDLHKLLNGMDE
ALKTALDDQSPKHTTDFQTLDSAFHLGIAQAAQNDRLLDAVADARRRMWLPVGAIFGRLEPNANDYHESI
LEAIENREPELAAARMEAHINDTRHTIESWLKR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_3822--100% (244)regulatory protein GntR, HTH
M. smegmatis MC2 155MSMEG_1117-1e-2334.19% (234) transcriptional regulator
M. smegmatis MC2 155MSMEG_2599-6e-2334.30% (242) GntR-family protein transcriptional regulator

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3086c-3e-1027.52% (218) GntR family transcriptional regulator
M. gilvum PYR-GCKMflv_4061-4e-2635.74% (235) regulatory protein GntR, HTH
M. tuberculosis H37RvRv3060c-3e-1027.52% (218) GntR family transcriptional regulator
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2272c-2e-1129.38% (177) putative transcriptional regulator, GntR
M. marinum MMMAR_0749-2e-1631.05% (219) GntR family transcriptional regulator
M. avium 104MAV_2542-3e-1336.69% (139) regulatory protein GntR, HTH
M. thermoresistible (build 8)TH_4115-2e-1329.20% (226) PUTATIVE -
M. ulcerans Agy99MUL_1381-2e-1631.05% (219) GntR family transcriptional regulator
M. vanbaalenii PYR-1Mvan_0606-1e-11886.53% (245) GntR domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_3822|M.smegmatis_MC2_155      MTAAKP---------ALVPVRQIPAHELVVDQMRRALELGQFRPGDRLPT
Mvan_0606|M.vanbaalenii_PYR-1       MTAERPS--------ALSPVRQIPAHELVVDQMRRALELGQFRPGDRLPT
Mflv_4061|M.gilvum_PYR-GCK          MAAPDPADSSDASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPP
MMAR_0749|M.marinum_M               ----------------MQTVRRRTLIAQVSDQLRDEITSGRWKVGDRIPT
MUL_1381|M.ulcerans_Agy99           -------------------MRRRTLIAQVSDQLRDEITSGRWKVGDRIPT
MAB_2272c|M.abscessus_ATCC_199      ----------------MQPVRRQTLIGQVTEQLREEIVSGRWAIGARIPT
Mb3086c|M.bovis_AF2122/97           ------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGS
Rv3060c|M.tuberculosis_H37Rv        ------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGS
MAV_2542|M.avium_104                -MPKREPLAPMATSQNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFLPY
TH_4115|M.thermoresistible__bu      ---------------------VQSSYIQVADQLRDLILRGDLAVGQKLPS
                                                                    :   :       *  :  

MSMEG_3822|M.smegmatis_MC2_155      ERELSEMLDVSRTTVRTAVAVLEREGLIAVRRGRGGGFTVQAPEYDPVEM
Mvan_0606|M.vanbaalenii_PYR-1       ERELSEMLDVSRTTVRTAVAVLERDGLIAVRRGRGGGFTVQAPPVDPAEM
Mflv_4061|M.gilvum_PYR-GCK          ERELAARLGVSRDTVREAIKSLADAGYLVSRRGRYGGTFLADALPAPRAD
MMAR_0749|M.marinum_M               EPELCEMTGTARNTVREAVQALVHVGILERRQG--SGTYVIADVEQGSAL
MUL_1381|M.ulcerans_Agy99           EPELCEMTGTARNTVREAVQALVHVGILERRQG--SGTYVIADVEQGSAL
MAB_2272c|M.abscessus_ATCC_199      EPELCELTGTSRNTIREAVQALVHAGMLERRQG--SGTYVLS-LGGSSAI
Mb3086c|M.bovis_AF2122/97           ESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATR
Rv3060c|M.tuberculosis_H37Rv        ESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATR
MAV_2542|M.avium_104                EAELMDHFQVSRPSLREAVRVLESDRLVEVRRGSRTGARVRVPGPEIVAR
TH_4115|M.thermoresistible__bu      EAEMAPLLGVSRSTIREALRILTTEHLIETRRGIQGGAFVAVPDSER--L
                                    *  :     .:*  :* *:  :        *:*   *  :          

MSMEG_3822|M.smegmatis_MC2_155      RREMRRNKR--AVRDAFDYRVVVETGATRLAAERRRAADLNDLHKLLNGM
Mvan_0606|M.vanbaalenii_PYR-1       RRELRRNKR--AIRDAFDYRIIVETGATRLAAERRRAIELADLRKLLVGM
Mflv_4061|M.gilvum_PYR-GCK          GTEMHRDD----IDDAVRLREILEVGAARMAAVR----------TLAAVE
MMAR_0749|M.marinum_M               AEYFAAAR----ERDLWELREAVEVTAAVLSARRRDAADIEDLRALLARR
MUL_1381|M.ulcerans_Agy99           AEYFAAAR----ERDLWELREAVEVTAAVLSARRRDAADIEDLRVLLARR
MAB_2272c|M.abscessus_ATCC_199      ADYFAAAN----NRDLIELRQTLEVTAAGLAAQRRDEDDIEQLRALLVRR
Mb3086c|M.bovis_AF2122/97           AVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPGIERLRAVLR-A
Rv3060c|M.tuberculosis_H37Rv        AVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPGIERLRAVLR-A
MAV_2542|M.avium_104                PAGFLLEMAGTTLADVMTARMGIEPYAARLLAEDGTAAAHRELRELIEEI
TH_4115|M.thermoresistible__bu      EGMFNTSFSMLALTNQVDARSFLQAMRALEGPAAALAAAARGGDQVEELK
                                       :          :    *  ::   :   .             :    

MSMEG_3822|M.smegmatis_MC2_155      DEALKTALDDQSPKHTTDFQTLDSAFHLGIAQAAQNDRLLDAVADARRRM
Mvan_0606|M.vanbaalenii_PYR-1       EAALDAALKDQSAQRTTEFQTLDTAFHMGIAQAAQNDRLLDAVADARRRM
Mflv_4061|M.gilvum_PYR-GCK          REALRSRLTDVRGADPADYRRLDSRLHLAIAEAAGVPSLVPLVAQNRMRL
MMAR_0749|M.marinum_M               NELWSREPAN--DKERTEMTSADTALHRAIVAASHNEIYLQFYDLLLPTI
MUL_1381|M.ulcerans_Agy99           NELWSREPAN--DKERTEMTSADTALHRAIVAASHNETYLQFYDLLLPTI
MAB_2272c|M.abscessus_ATCC_199      NELWAPHHVE--PHNVEEAISTDIAVHRAVVAASHNALYLELYDSLLGLM
Mb3086c|M.bovis_AF2122/97           EERWRPGLPP----PPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQKS
Rv3060c|M.tuberculosis_H37Rv        EERWRPGLPP----PPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQKS
MAV_2542|M.avium_104                PAAWETGKLG---AASTALHRRLVELSGNATLTVIVGMLHEIFERHMTAA
TH_4115|M.thermoresistible__bu      RTAAMVDPAD-----QEAAMQQSADFHSAILRASGNKLLEAMGRPVSAVA
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      WLPVG--AIFGRLEPNANDYHESILEAIENREPELAAARMEAHINDTRHT
Mvan_0606|M.vanbaalenii_PYR-1       WLPVG--AIFGRLEPNANDYHESILEAIENRDPELAGSRMEAHINDTRNT
Mflv_4061|M.gilvum_PYR-GCK          NELLDRIPLMTRNIAHSDEQHEAIVSAILAGDADTAAQTMAAHVWGSAAL
MMAR_0749|M.marinum_M               HRAVE--AGPVGTCTSYEREHTELVEAIIAGDPQRAEAAAQVFIARLRP-
MUL_1381|M.ulcerans_Agy99           HRAVE--AGPVGTCTSYEREHTELVEAIIAGDPQRAEAAAQVFIARLRR-
MAB_2272c|M.abscessus_ATCC_199      DHYMR--GNPIGAECSFEHEHTRLVESVIAGDIGGATSATEQLFAELRLS
Mb3086c|M.bovis_AF2122/97           GTQSA--GEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEAVAGW
Rv3060c|M.tuberculosis_H37Rv        GTQSA--GEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEAVAGW
MAV_2542|M.avium_104                FLSVQN-VVPKAQYNKLMRSYTRLADLVAARDGAEAEAHWRRHMENASAE
TH_4115|M.thermoresistible__bu      RSKFRRTVPGLEFWERNQRAHQELLKAILAGDENLAYELATRHIDEDLSP
                                                        :  :   :   :   *       .      

MSMEG_3822|M.smegmatis_MC2_155      IESWLKR-------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1       LESWLKR-------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK          LHGFLD--------------------------------------------
MMAR_0749|M.marinum_M               --------------------------------------------------
MUL_1381|M.ulcerans_Agy99           --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199      RDQPGRNFPHHPHD------------------------------------
Mb3086c|M.bovis_AF2122/97           LQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGDDIAA
Rv3060c|M.tuberculosis_H37Rv        LQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGDDIAA
MAV_2542|M.avium_104                LLKGHEKTKVRDIMH-----------------------------------
TH_4115|M.thermoresistible__bu      YYLPPEEADRDGAGA-----------------------------------
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK          --------------------------------------------------
MMAR_0749|M.marinum_M               --------------------------------------------------
MUL_1381|M.ulcerans_Agy99           --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199      --------------------------------------------------
Mb3086c|M.bovis_AF2122/97           SGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLV
Rv3060c|M.tuberculosis_H37Rv        SGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLV
MAV_2542|M.avium_104                --------------------------------------------------
TH_4115|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK          --------------------------------------------------
MMAR_0749|M.marinum_M               --------------------------------------------------
MUL_1381|M.ulcerans_Agy99           --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199      --------------------------------------------------
Mb3086c|M.bovis_AF2122/97           VTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPE
Rv3060c|M.tuberculosis_H37Rv        VTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPE
MAV_2542|M.avium_104                --------------------------------------------------
TH_4115|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK          --------------------------------------------------
MMAR_0749|M.marinum_M               --------------------------------------------------
MUL_1381|M.ulcerans_Agy99           --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199      --------------------------------------------------
Mb3086c|M.bovis_AF2122/97           VASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLIL
Rv3060c|M.tuberculosis_H37Rv        VASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLIL
MAV_2542|M.avium_104                --------------------------------------------------
TH_4115|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK          --------------------------------------------------
MMAR_0749|M.marinum_M               --------------------------------------------------
MUL_1381|M.ulcerans_Agy99           --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199      --------------------------------------------------
Mb3086c|M.bovis_AF2122/97           VELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCRTRRH
Rv3060c|M.tuberculosis_H37Rv        VELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCRTRRH
MAV_2542|M.avium_104                --------------------------------------------------
TH_4115|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MSMEG_3822|M.smegmatis_MC2_155      ---------
Mvan_0606|M.vanbaalenii_PYR-1       ---------
Mflv_4061|M.gilvum_PYR-GCK          ---------
MMAR_0749|M.marinum_M               ---------
MUL_1381|M.ulcerans_Agy99           ---------
MAB_2272c|M.abscessus_ATCC_199      ---------
Mb3086c|M.bovis_AF2122/97           LDAAASWWL
Rv3060c|M.tuberculosis_H37Rv        LDAAASWWL
MAV_2542|M.avium_104                ---------
TH_4115|M.thermoresistible__bu      ---------