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MSAHVLGAQIDRKVRPVDSMAPDATTMRTLENARGSILKGRLPASLIANAALYALELKRVFGRTWQFLCH EDEIPNAGDYVVRYIADNSIIVARQQDMTIRAMSNSCRHRGTLLCRTESGNESAFQCPYHGWTYRNNGDL IAIPAQQAVYGAAFDKSRLGLRALPMLDSYAGLVFGCVSDEAPGLDEYLGDMRWYLDLMMKKSPAGLEAW GAPQRWVIDANWKTGADNFVGDGYHTVMTHRSMCELGLLPPDNVAVSPAHVSLSGGHGAGVLGAPPGIPA PPYMGYPEEVVSGLSEGYGDDVHGELLKRTMFIHGNVFPNLSFLNAFIAKDGESMPVPILTLRQWRPLDA ARMEVWSWFFVERNAPEEFKQQSFETYVRTFGVGGVFEQDDAEIFQAITKGTRGELAGGVELNLEMGLDN LAPDPTWLGPGRPLASGYAEQNQREYWKQYFDYLATPRRDENV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0525 | - | - | 100% (463) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0546 | - | e-165 | 63.72% (419) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0488 | - | e-139 | 53.30% (439) | ring hydroxylating dioxygenase, alpha subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-17 | 29.91% (214) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0640 | - | 0.0 | 99.78% (463) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 1e-17 | 29.91% (214) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 2e-65 | 35.20% (429) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_4422 | - | 2e-20 | 30.19% (212) | dioxygenase |
| M. avium 104 | MAV_3509 | - | 2e-81 | 39.43% (459) | phthalate dioxygenase large subunit |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 2e-38 | 26.18% (424) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2976 | - | 1e-37 | 30.02% (423) | PUTATIVE dioxygenase large subunit |
| M. ulcerans Agy99 | MUL_3820 | - | 2e-16 | 30.73% (179) | ring-hydroxylating dioxygenase, large terminal subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 ------------MLSTDNRAELGDILTDIGDYLDDNPPALSLPP--AAYT
Rv3161c|M.tuberculosis_H37Rv ------------MLSTDNRAELGDILTDIGDYLDDNPPALSLPP--AAYT
Mvan_0525|M.vanbaalenii_PYR-1 MSAHVLGAQIDRKVRPVDSMAPDATTMRTLENARGSILKGRLPA--SLIA
Mflv_0640|M.gilvum_PYR-GCK MSAHVLGAQIDRKVRPVDSMAPDATTMRTLENARGSILKGRLPA--SLIA
MAV_3509|M.avium_104 ------------------MAGPDGGLLGVLENVR----RGMIPA--HIYN
MAB_4370c|M.abscessus_ATCC_199 ----MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDR--VIFT
MSMEG_1908|M.smegmatis_MC2_155 ---------------MTTHLSPDHLENVLADAVIEDPAAGVYRANRRIFT
TH_2976|M.thermoresistible__bu ------------------LIRPDRVHG-------------------SLYT
MMAR_4422|M.marinum_M ---------------MTAVRQPSALLPTLGG---------------AYYT
MUL_3820|M.ulcerans_Agy99 -------------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYT
Mb3186c|M.bovis_AF2122/97 SSELWQLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDG
Rv3161c|M.tuberculosis_H37Rv SSELWQLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDG
Mvan_0525|M.vanbaalenii_PYR-1 NAALYALELKRVFGRTWQFLCHEDEIPNAGDYVVRYIADNSIIVARQQDM
Mflv_0640|M.gilvum_PYR-GCK NAALYELELKRVFGRTWQFLCHEDEIPNAGDYVVRYIADNSIIVARQQDM
MAV_3509|M.avium_104 DPELFALEKRRLFARAWTFVGHESEIPHDGDYMVRRVLDDSFIITRGSDG
MAB_4370c|M.abscessus_ATCC_199 DGELYRQELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNR
MSMEG_1908|M.smegmatis_MC2_155 DDEIFELEMKHIFEGNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDG
TH_2976|M.thermoresistible__bu DPAIFAEELRKIWYRTWVFVGHESEVSQPNDYVRKKLGLQDVIMTRDRDG
MMAR_4422|M.marinum_M SAAVFAAEQQHVFESMWFCVVRAADLNEPGQFKAVQVGRESVLLVRGRDR
MUL_3820|M.ulcerans_Agy99 SLDRHERDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRAADR
. : : : :. . : : .:: :
Mb3186c|M.bovis_AF2122/97 QLHALSPICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMA
Rv3161c|M.tuberculosis_H37Rv QLHALSPICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMA
Mvan_0525|M.vanbaalenii_PYR-1 TIRAMSNSCRHRGTLLCRTESGNES-AFQCPYHGWTYRNNGDLIAIPAQQ
Mflv_0640|M.gilvum_PYR-GCK TIRAMSNSCRHRGTLLCRTESGNES-AFQCPYHGWTYRNNGDLIAIPAQQ
MAV_3509|M.avium_104 RVRALFNMCLHRGMQVCRAELGNAS-NFRCPYHGWTYRNDGRLTGLPFHR
MAB_4370c|M.abscessus_ATCC_199 RIRAFLNSCRHRGARVCRADYGVTR-GFTCTYHGWAYDLEGKLISVPNEE
MSMEG_1908|M.smegmatis_MC2_155 DLHCLINACAHRGAMICRRKTDNRT-TLTCPFHGWTFRNDGTLLKVKDPD
TH_2976|M.thermoresistible__bu EIHLLLNRCSHRGNQVCADAKGNSS-TFRCPYHGWTFRNTGELVGFPFFK
MMAR_4422|M.marinum_M RLRAFLNICRHRGALLCTEPEGQVRRNLRCPYHSWTYGLDGTLIAAPNIA
MUL_3820|M.ulcerans_Agy99 AVRAFDNVCLHRQSRVATGCGTALR--FTCPYHGWTYDNGGRLVGLPGRE
:: : * ** : : * :* * : * *
Mb3186c|M.bovis_AF2122/97 ANLD-----FNRRECRLPQFAVATWNGLVWINLDADA-EPIAAHLD--LT
Rv3161c|M.tuberculosis_H37Rv ANLD-----FNRRECRLPQFAVATWNGLVWINLDADA-EPIAAHLD--LT
Mvan_0525|M.vanbaalenii_PYR-1 AVYG--AAFDKSRLGLRALPMLDSYAGLVFGCVSDEA-PGLDEYLG--DM
Mflv_0640|M.gilvum_PYR-GCK AVYG--AAFDKSRLGLRALPMLDSYAGLVFGCVSDEA-PGLDEYLG--DM
MAV_3509|M.avium_104 EAYGGDDGFVKDQT-LLPAPNFAGYNGLLFISLDPAA-PPLQDFLG--DF
MAB_4370c|M.abscessus_ATCC_199 GYPD---SFSTDDWGLVEVPHVDSYHGLIFGTWNPAP-VGLRESLG--DM
MSMEG_1908|M.smegmatis_MC2_155 GAGYPDTFNSNGSHNMTNVARFEGYRGFLFGSLNPDV-LPLTEHLG--DT
TH_2976|M.thermoresistible__bu GYGT-----RKLDLPLGRVPRVDSYGGFVFGSFATEG-PTLREHLG--AA
MMAR_4422|M.marinum_M ELTDTDGASIDRHRYGLVAVALREWLGYAWVCLAEDP-PSFEDDVVGSVT
MUL_3820|M.ulcerans_Agy99 GFPG-----IAVGSDGLTELPATEFAGFLWVSLHPAARLDVPAHLG--PL
: * : . :
Mb3186c|M.bovis_AF2122/97 DDEFAGYRLGEMVQ-VESWS----HEWRANWKVAAENGHEN-YHVLGLHR
Rv3161c|M.tuberculosis_H37Rv DDEFAGYRLGEMVQ-VESWS----HEWRANWKVAAENGHEN-YHVLGLHR
Mvan_0525|M.vanbaalenii_PYR-1 RWYLDLMMKKSPAG-LEAWGAPQRWVIDANWKTGADNFVGDGYHTVMTHR
Mflv_0640|M.gilvum_PYR-GCK RWYLDLMMKKSPAG-LEAWGAPQRWVIDANWKTGADNFVGDGYHTVMTHR
MAV_3509|M.avium_104 RFYLDYYTRQSAGG-VELRG-PQRWRIRANWKIGAENFAGDMYHTPHTHA
MAB_4370c|M.abscessus_ATCC_199 AWYMDAMLDHDSEG-TVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHA
MSMEG_1908|M.smegmatis_MC2_155 TTVIDMLVDQSPDG-LEVLRGASTYTYDGNWKVQAEN-GADGYHVTATHW
TH_2976|M.thermoresistible__bu AGEIDRLLRLSPEGKVALDAGWLRHRTRANWKLLVEN-ETDGYHPQFVHG
MMAR_4422|M.marinum_M ARLGDVSAIDTYRIEALQVGRRVSYDVAANWKLIVEN-FMECYHCATIHP
MUL_3820|M.ulcerans_Agy99 AGELQSWGIGRWSP-----LGEKVLGSPIDWKLATDTFAEN-YHFATVHR
:** .: : ** *
Mb3186c|M.bovis_AF2122/97 QTLEP---------------------------FVPGGGDLDVRQYSRWAL
Rv3161c|M.tuberculosis_H37Rv QTLEP---------------------------FVPGGGDLDVRQYSRWAL
Mvan_0525|M.vanbaalenii_PYR-1 SMCELGLLPPDNVAVSPAHVSLSGGHGAG-VLGAPPG--IPAPPYMGYPE
Mflv_0640|M.gilvum_PYR-GCK SMCELGLLPPDNVAVSPAHVSLSGGHGAG-VLGAPPG--IPAPPYMGYPE
MAV_3509|M.avium_104 SIVDIGLFREPKAQKRKDGATYWAHRGGGTTYKLPPGGFEERMRYVGYPD
MAB_4370c|M.abscessus_ATCC_199 SALMVMAPQGKAPKDEIVHRTGRQYVDPN-----GHGAGFPVHPKNRFDA
MSMEG_1908|M.smegmatis_MC2_155 NYAATTSRRTCGESKNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANP
TH_2976|M.thermoresistible__bu GIFGVTGSTIGPLYSDSSTAVTRDLGGGHSENDLRPEFRKFAEPLRWFGT
MMAR_4422|M.marinum_M ELTRVIPEFARGQAAQRS----------------VGRGAEFGSAVAGFTV
MUL_3820|M.ulcerans_Agy99 RTFATIAR-------------------------------SNCTVFDSYGP
Mb3186c|M.bovis_AF2122/97 RLRVPFTVP--VEAKSLQLNEVQKSN-LVVLWTFPNSALAIAG-------
Rv3161c|M.tuberculosis_H37Rv RLRVPFTVP--VEAKSLQLNEVQKSN-LVVLWTFPNSALAIAG-------
Mvan_0525|M.vanbaalenii_PYR-1 EVVSGLSEG--YGDDVHGELLKRTMF-IHGN-VFPNLSFLNAF-IAKDG-
Mflv_0640|M.gilvum_PYR-GCK EVVSGLSEG--YGDDVHGELLKRTMF-IHGN-VFPNLSFLNAF-IAKDG-
MAV_3509|M.avium_104 EMIGRIKQV--WTPRQQRVVGEDGFM-VSAATCFPNLSFVHNWPKVRDGR
MAB_4370c|M.abscessus_ATCC_199 RVVHQWTDYGALRERLGEARVQGPLT-NGHATVFPNLSYLPVN-------
MSMEG_1908|M.smegmatis_MC2_155 QDRPLWDRLDELKARFGDAKGEFMVKGSRNLCLYPNVYVMDQF-------
TH_2976|M.thermoresistible__bu TESRVPDYVAAMRARYGAEADQILIEGSPHVMIFPNLFIAEIQ-------
MMAR_4422|M.marinum_M DGRAGFTALPGIRPEQDRRYFAITVKPTVFINLVPDHAIIHRM-------
MUL_3820|M.ulcerans_Agy99 HHRLIFPLNTILELENVPEGQWDPFHHMVVIYALFPNVVLSVT-------
Mb3186c|M.bovis_AF2122/97 -----ERVVWFGFIPQSIDRVQVLGGVLTTP----ELAADAAATAQTSQF
Rv3161c|M.tuberculosis_H37Rv -----ERVVWFGFIPQSIDRVQVLGGVLTTP----ELAADAAATAQTSQF
Mvan_0525|M.vanbaalenii_PYR-1 ESMPVPILTLRQWRPLDAARMEVWSWFFVERNAPEEFKQQSFETYVRTFG
Mflv_0640|M.gilvum_PYR-GCK ESMPVPILTLRQWRPLDAARMEVWSWFFVERNAPEEFKQQSFETYVRTFG
MAV_3509|M.avium_104 DDETLPFISIRLWQPISENETEVCSWFAVDSAAPAHYKQDSYKAYLMCFG
MAB_4370c|M.abscessus_ATCC_199 -------GSVRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFG
MSMEG_1908|M.smegmatis_MC2_155 ------STQIRHFRPIAPDKTEVTIYCIAPKGESAAARAHRIRQYEDFFN
TH_2976|M.thermoresistible__bu ---------VFNIQPVAVNECVQYSTAVQLVGAP-ELNRRMVSQCIGSVG
MMAR_4422|M.marinum_M -------------FPIAADRTIVECDWLYAP---------EVAAAGDIAH
MUL_3820|M.ulcerans_Agy99 -------IANGELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVF
Mb3186c|M.bovis_AF2122/97 VMAMINDEDRLGLEAVQVGAGSRFAERGHLSSKE----------------
Rv3161c|M.tuberculosis_H37Rv VMAMINDEDRLGLEAVQVGAGSRFAERGHLSSKE----------------
Mvan_0525|M.vanbaalenii_PYR-1 VGGVFEQDDAEIFQAITKGTRGELAGGVELNLEMGLDN--------LAPD
Mflv_0640|M.gilvum_PYR-GCK VGGVFEQDDAEIFQAITKGTRGELAGGVELNLEMGLDN--------LAPD
MAV_3509|M.avium_104 STGMFEQDDVENWVSLTTTAGGSMARRLLLNSRMGLYDDGRPVVEALAPS
MAB_4370c|M.abscessus_ATCC_199 PTGIFEQDDGENWSEVQSISRGFVTNSVALNYQMGLDS-----------E
MSMEG_1908|M.smegmatis_MC2_155 ASGMATPDDLEEFRSCQLTFRAQAAPWNDMSRGAQHWLSG------PDPV
TH_2976|M.thermoresistible__bu PAGMLLADDTEMYERNQQGLEALTPEWLDIRRGLNREH------------
MMAR_4422|M.marinum_M SVELFHRVNEQDFDACQRTQPAMSSRAYRTGGVLVP--------------
MUL_3820|M.ulcerans_Agy99 DYAHATVRDEDYRLAETLQTNLESGARQRLVFGR----------------
:
Mb3186c|M.bovis_AF2122/97 ----------WPGMLAFYRNLAMALVGDHPGAS-----------
Rv3161c|M.tuberculosis_H37Rv ----------WPGMLAFYRNLAMALVGDHPGAS-----------
Mvan_0525|M.vanbaalenii_PYR-1 PTWLGPGRPLASGYAEQNQREYWKQYFDYLATPRRDENV-----
Mflv_0640|M.gilvum_PYR-GCK PTWLGPGRPLASGYAEQNQREYWKQYFDYLATPRRDENV-----
MAV_3509|M.avium_104 -AFHGPGR-AQVGYNEHNQRALLAMWADYLQEGDACENR-----
MAB_4370c|M.abscessus_ATCC_199 REDGRHPGLTSELYSDAAGRSFYARWRDLMNTKAWHEEHV----
MSMEG_1908|M.smegmatis_MC2_155 AESLGMHGIVSSGLRNEDEGLYPVQHGYWLETLRRAVTSNPTEH
TH_2976|M.thermoresistible__bu --VDDHGFTVGGPTDETGMRAFWSEYRRLMEAE-----------
MMAR_4422|M.marinum_M ----------AEHHIAEFHQWVIARIGTPAVTG-----------
MUL_3820|M.ulcerans_Agy99 --------------NEPGLQHRHITWAQALETPG----------