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LSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLERERIFNRSWMLVAHVDQVAKTGDYVTV SVAGEPVMVVRDVDGQLHALSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFN RRECRLPQFAVATWNGLVWINLDADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGH ENYHVLGLHRQTLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFPNSALA IAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLEAVQVGAGSRFAE RGHLSSKEWPGMLAFYRNLAMALVGDHPGAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3161c | - | - | 100% (382) | POSSIBLE DIOXYGENASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 0.0 | 99.74% (382) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0685 | - | 8e-27 | 33.49% (209) | ring hydroxylating dioxygenase, alpha subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 1e-17 | 29.67% (209) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_4744 | - | 1e-27 | 34.12% (211) | dioxygenase |
| M. avium 104 | MAV_5278 | - | 5e-28 | 35.27% (207) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4840 | - | 1e-28 | 33.18% (217) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3820 | - | 2e-29 | 34.27% (213) | PUTATIVE Rieske [2Fe-2S] domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 3e-15 | 23.86% (352) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_4213 | - | 6e-29 | 34.12% (211) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3161c|M.tuberculosis_H37Rv -----MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTS---SELWQ
Mb3186c|M.bovis_AF2122/97 -----MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTS---SELWQ
MSMEG_4840|M.smegmatis_MC2_155 --------------MAHFPKPAVGSWTENWPELGTAPVDYTDSIDPEQWK
Mvan_4213|M.vanbaalenii_PYR-1 --------------MAHFPKPAAGSWTENWPELGTAPVDYTDSIDPEQWK
TH_3820|M.thermoresistible__bu --------------VAHFPKPAVGSWTENWPELGTAPVDYTDSIDPEQWK
MMAR_4744|M.marinum_M --------------MPHFTKPAAGSWTQNYPELGTAPVDYTDSIDPQYFA
MAV_5278|M.avium_104 -----------MAAAAGNPARTRDEDAIGTPPPGPTLVPAERYYSPAFAA
MUL_3820|M.ulcerans_Agy99 ---------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDR
Mflv_0685|M.gilvum_PYR-GCK ----------------------MQDHGEVLEAVRTGMIPAHVYNDKQIFS
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
Rv3161c|M.tuberculosis_H37Rv LERE-RIFNRSWMLVAHVDQVAKTGDYVTVSV----AGEPVMVVRDVDGQ
Mb3186c|M.bovis_AF2122/97 LERE-RIFNRSWMLVAHVDQLAKTGDYVTVSV----AGEPVMVVRDVDGQ
MSMEG_4840|M.smegmatis_MC2_155 LEQQ-AIFRRTWLHVGRVERLPKTGSYFTREMPSVGKGTSIIVVKDKDGA
Mvan_4213|M.vanbaalenii_PYR-1 LEQQ-AIFRKLWLHVGRVERLPKAGSYFTREMPSVGAGTSIIVNKDKDGQ
TH_3820|M.thermoresistible__bu LEQQ-AIFRRLWLHVGRVERLPKAGSYFTREMPSVGAGTSIIVNRDKDGT
MMAR_4744|M.marinum_M DEQR-AIFRRTWLNVGRIERLPRTGSYFTKELPSTGAGMSVIVVKGKDGV
MAV_5278|M.avium_104 LEVE-RMWPRVWQLACMVDHVATPGDYFEYRCG----PYGVLIVRDDDGA
MUL_3820|M.ulcerans_Agy99 HERDRAMVLDSPQLVGYSSELPGPDTYRTKTIMG----RSILLTRAADRA
Mflv_0685|M.gilvum_PYR-GCK LEKE-RLFSRAWLFVAHESEIPQPGDYVVRQVLQ----DSFIVARDSAGE
MAB_4370c|M.abscessus_ATCC_199 QELR-RVFAPSWLFLAHADQFHRPGDFFTTYMGE----DPVIVSMDKNRR
* : ... .. : .::
Rv3161c|M.tuberculosis_H37Rv LHALSPICRHR---LMLMVEPG---AGRIDTLTCQYHLWRYGLDGRLRGA
Mb3186c|M.bovis_AF2122/97 LHALSPICRHR---LMLMVEPG---AGRIDTLTCQYHLWRYGLDGRLRGA
MSMEG_4840|M.smegmatis_MC2_155 VRAFYNMCRHRGNKLVWNDYPGEEVSGTCRQFTCKYHAWRYALNGDLTFI
Mvan_4213|M.vanbaalenii_PYR-1 VRAFYNLCRHRGNKLVWNDYPGEEVSGSCRQFTCKYHAWRYALDGELTFI
TH_3820|M.thermoresistible__bu IRAFYNLCRHRGNKLVWNDYPGEEVSGTCRQFTCKYHGWRYALNGDLTFI
MMAR_4744|M.marinum_M IRAFHNICRHRGNKLVWNDFPHEETAGTCRQFTCKYHAWRYGLDGELTFI
MAV_5278|M.avium_104 LRAFQNVCRHRGNSLCSGSGSG------LRELKCGYHGWTWDLAGALKRV
MUL_3820|M.ulcerans_Agy99 VRAFDNVCLHRQSRVATG-------CGTALRFTCPYHGWTYDNGGRLVGL
Mflv_0685|M.gilvum_PYR-GCK VRVMFNMCLHRGMQVCRAEMGN------ASNFRCPYHGWSYRNDGRIIGL
MAB_4370c|M.abscessus_ATCC_199 IRAFLNSCRHRGARVCRADYG------VTRGFTCTYHGWAYDLEGKLISV
::.: * ** : : * ** * : * :
Rv3161c|M.tuberculosis_H37Rv PHMAANLDFNR-----RECRLPQFAVATWNGLVWINLDADAEP-IAAHLD
Mb3186c|M.bovis_AF2122/97 PHMAANLDFNR-----RECRLPQFAVATWNGLVWINLDADAEP-IAAHLD
MSMEG_4840|M.smegmatis_MC2_155 QQEDEFFDVDK-----ADYPLKPVRCEIWEGFIFVNFDDDAMP-LEEYLG
Mvan_4213|M.vanbaalenii_PYR-1 QQEDEFFDVDK-----ADYPLKPVRCEVWEGFIFVNFDDDAEP-LVDYLG
TH_3820|M.thermoresistible__bu QQEDEFFDVDK-----ADYGLKPIRCEVWEGFIFVNFDDDAEP-LEDYLG
MMAR_4744|M.marinum_M QQEDEFFDVDK-----SQYGLKSVRCEVWEGFIFINLDPAAAP-LSEYLG
MAV_5278|M.avium_104 PDRKGFGSLRL-----SDYPLIPARVDTWAGLVFVNLDPDAMP-LPEYLE
MUL_3820|M.ulcerans_Agy99 PGREGFPGIAV-----GSDGLTELPATEFAGFLWVSLHPAARLDVPAHLG
Mflv_0685|M.gilvum_PYR-GCK PFHQEAYGGDAGFNKAGQTLLPAPSVASYNGLIFLSMDPDAES-LEEYLG
MAB_4370c|M.abscessus_ATCC_199 PNEEGYPDSFS---TDDWGLVEVPHVDSYHGLIFGTWNPAPVG-LRESLG
. : : *::: . . . : *
Rv3161c|M.tuberculosis_H37Rv LTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLGLH
Mb3186c|M.bovis_AF2122/97 LTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLGLH
MSMEG_4840|M.smegmatis_MC2_155 EFGQGLKGYP----FHEMTEVYSYRAEINSNWKLFIDAFV-EFYHAPILH
Mvan_4213|M.vanbaalenii_PYR-1 DFAKGLEGYP----FHEMTEVYSYRAEINSNWKLFIDAFV-EFYHAPILH
TH_3820|M.thermoresistible__bu EFGQNLKGYP----FHEMTEVYSYRAEVNANWKLFIDAFT-EFYHAPVLH
MMAR_4744|M.marinum_M SMAKGLQGYP----FHEMTEVYSYRAEVGSNWKLFIDAFA-EFYHAPVLH
MAV_5278|M.avium_104 AIPEDIAWCR----LDEFRCYATLTVEVDANWKTIADGYS-ETYHIQTLH
MUL_3820|M.ulcerans_Agy99 PLAGELQSWG----IGRWSPLGEKVLGSPIDWKLATDTFA-ENYHFATVH
Mflv_0685|M.gilvum_PYR-GCK DFRFYLDFYTRQ-GPNGLEVRGPQRWRVKANWKIAAENFAGDMYHTPQTH
MAB_4370c|M.abscessus_ATCC_199 DMAWYMDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSH
: :** : : ** *
Rv3161c|M.tuberculosis_H37Rv R----------------------------------------QTLEPFVPG
Mb3186c|M.bovis_AF2122/97 R----------------------------------------QTLEPFVPG
MSMEG_4840|M.smegmatis_MC2_155 MKQA-TPEEAAKLAKIGFEALHYDIKGDHSMISSWGGMSPPKDLNMVKPI
Mvan_4213|M.vanbaalenii_PYR-1 MKQA-TAEEAAKLAKVGFEALHYDIKDQHSMISSWGGMSPPKDLNMVKPI
TH_3820|M.thermoresistible__bu NKQA-VKEEAEKLAKYGYEALHYDIKGPHSMISSWGGMAPPKDPSMVKPI
MMAR_4744|M.marinum_M QGQY-TKEEAAKIMKYGFEALHYELAGPHAMISVWGGQSPPADLKMVKPM
MAV_5278|M.avium_104 PELLRCVDDIHAPQQIWRHTGKSDQPYGVPSPRFEGALSDEEVWDAYVST
MUL_3820|M.ulcerans_Agy99 RRTF-----------------------------------------ATIAR
Mflv_0685|M.gilvum_PYR-GCK TSVVEIGLFREPKANKRKDGATYWAGRGGGTTYKLPEGSFEDRMSYVGYP
MAB_4370c|M.abscessus_ATCC_199 ASAL---MVMAPQGKAPKDEIVHRTGRQYVDPNGHGAGFPVHPKNRFDAR
Rv3161c|M.tuberculosis_H37Rv GGDLDVRQYSR--WALRLRVPFTVPVEAKSLQLNEVQKSNLVV-------
Mb3186c|M.bovis_AF2122/97 GGDLDVRQYSR--WALRLRVPFTVPVEAKSLQLNEVQKSNLVV-------
MSMEG_4840|M.smegmatis_MC2_155 ERILHSGLFGP--WDRPDIKGILPDELPPAVNPARQPTWGQDS-------
Mvan_4213|M.vanbaalenii_PYR-1 ERILHSGLFGP--WDRPDIKGILPDELPPAVNPARQPTWGQDS-------
TH_3820|M.thermoresistible__bu ERILNSGLFGP--WDRPDIKGIAPDELPPAINPSRQPFWGQDS-------
MMAR_4744|M.marinum_M DRVLRSGLFGP--WDRP-APITDLEELPPGINPTKAKQWGIDS-------
MAV_5278|M.avium_104 QGALMGAAEGTPFPAADRRPGQTVADLIADRTRAFAATRGVDLGWADTDR
MUL_3820|M.ulcerans_Agy99 SNCTVFDSYGP--HHRLIFPLNTILELENVPEGQWDPFHHMVV-------
Mflv_0685|M.gilvum_PYR-GCK AEMISRAKATWTEQQQQVVGTDGFMISAATCFPNISFVHNWPKVEDGEHV
MAB_4370c|M.abscessus_ATCC_199 VVHQWTDYGALRERLGEARVQGPLTNGHATVFPNLSYLPVNGS-------
Rv3161c|M.tuberculosis_H37Rv ------LWTFPNSALAIAG-ERVVWFG-------FIPQSIDRVQVLGG-V
Mb3186c|M.bovis_AF2122/97 ------LWTFPNSALAIAG-ERVVWFG-------FIPQSIDRVQVLGG-V
MSMEG_4840|M.smegmatis_MC2_155 ------FEFFPNFTLLLWVPGWYLTYN-------YWPTDVDKHIFECN-L
Mvan_4213|M.vanbaalenii_PYR-1 ------FEFFPNFTLLLWAPGWYLTYN-------YWPTAVDKHIFECN-L
TH_3820|M.thermoresistible__bu ------FEFFPNFTLLIWAPGWYLTYN-------YWPTDVTKHIFEAS-L
MMAR_4744|M.marinum_M ------FLFFPNFMLLIWEPGWYLTYH-------YWPTTVDKHIFETT-L
MAV_5278|M.avium_104 ITRLHQYNVFPNMTFLTNADHLTVMCSRPAPDPAAAPDKGELVMFLTTRM
MUL_3820|M.ulcerans_Agy99 -----IYALFPNVVLSVTIANGELFRIYP------GDRPGSSITVHQNST
Mflv_0685|M.gilvum_PYR-GCK LPFISIRVWQPISENETEVLSWFAVDSDAPEAFKADSYKAYLMCFGSTGM
MAB_4370c|M.abscessus_ATCC_199 -----VRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGI
* .
Rv3161c|M.tuberculosis_H37Rv LTTPELAADAAATAQTSQFVMAMINDEDRLGLEAVQVGAGSRFAERGHLS
Mb3186c|M.bovis_AF2122/97 LTTPELAADAAATAQTSQFVMAMINDEDRLGLEAVQVGAGSRFAERGHLS
MSMEG_4840|M.smegmatis_MC2_155 YFVPPKNTRQRLAQELAAVTFKEYALQDANTLEATQTQINTRAVTEFPLC
Mvan_4213|M.vanbaalenii_PYR-1 YFVPPKNTRQRLSQELAAVTFKEYALQDANTLEATQTQIGTRAVTEFPLC
TH_3820|M.thermoresistible__bu YFVPPKTTRQRLAQELAAVTFKEYALQDANTLEATQTQIGTRAVTEFPLC
MMAR_4744|M.marinum_M YFVPPRNARERLAQELAAVTFKEYALQDSNTLEATQTMIGTGVVKDFPLC
MAV_5278|M.avium_104 PPGAPRTKPTDVRMSAGEAEPGLVLTQDIAVLAGLQRGMHQPGFTHLVLS
MUL_3820|M.ulcerans_Agy99 PLDLSDESVATGAQAVFDYAHATVRDEDYRLAETLQTNLESGARQRLVFG
Mflv_0685|M.gilvum_PYR-GCK FEQDDVENWVSLTNTAGGSMARRLRLNSRMGLLADDARVVDTLSSAQFHG
MAB_4370c|M.abscessus_ATCC_199 FEQDDGENWSEVQSISRGFVTNSVALNYQMGLDSEREDGRHPGLTSELYS
:
Rv3161c|M.tuberculosis_H37Rv SKEWPG-----MLAFYRNLAMALVGDHP-------------GAS------
Mb3186c|M.bovis_AF2122/97 SKEWPG-----MLAFYRNLAMALVGDHP-------------GAS------
MSMEG_4840|M.smegmatis_MC2_155 DQEV-------LLRHLHHTAHKYVDAYKAELAEKTQKAESNGSAVTSEKD
Mvan_4213|M.vanbaalenii_PYR-1 DQEI-------LLRHLHHTAHKYVDKYKLEQAAK---AATNGSASKTEKE
TH_3820|M.thermoresistible__bu DQEV-------LLRHLHHTAHQYVDKYKEELAQK--AQQTNGSKKEGARS
MMAR_4744|M.marinum_M DQEI-------LLRHLHKMTGDYVKEYR-----------NNGHAK-----
MAV_5278|M.avium_104 SEER-------RVINMHRNLERYLDLPAAQRMSG-------GAGT-----
MUL_3820|M.ulcerans_Agy99 RNEP-------GLQHRHITWAQALETPG----------------------
Mflv_0685|M.gilvum_PYR-GCK PGYAQLGYNENNQRELLRLWADYLDMPPLRVDPATVLTDNPQGIEPMVQT
MAB_4370c|M.abscessus_ATCC_199 DAAG---------RSFYARWRDLMNTKAWHEEHV----------------
:
Rv3161c|M.tuberculosis_H37Rv -------------------
Mb3186c|M.bovis_AF2122/97 -------------------
MSMEG_4840|M.smegmatis_MC2_155 AAHV---------------
Mvan_4213|M.vanbaalenii_PYR-1 GANV---------------
TH_3820|M.thermoresistible__bu TAHV---------------
MMAR_4744|M.marinum_M -------------------
MAV_5278|M.avium_104 -------------------
MUL_3820|M.ulcerans_Agy99 -------------------
Mflv_0685|M.gilvum_PYR-GCK NGGAVAGIDSESATTSVTL
MAB_4370c|M.abscessus_ATCC_199 -------------------