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MTTETTGTADATDPYLRRALREVADGLKVGRLPARVVSDPALHTIEMERIFGRAWVFLGHESELAKSGDF VVRHIGADSVIVCRDNSGRIQALSNSCRHRGALVCRAEMGNTAHFQCPYHGWVYSNTGELVGVPAMSEAY PGGFDKSQWGLRHIPHVDSYAGFIFGSVDPKAPSLTDYLGDTTFYLDLIAKKTAGGLEVIGAPHRWVMSA NWKTAADNFVGDSYHTLFAHRSMVELGMAPGDPNFASAPAEISLQNGHGVGVLGFPPTLADFPEYEGYPD EVVDQMATSYPSPVHKDLMRRSSFIHGTVFPNLSFINVTLAQDHMSPPTPFITFRVWHPLSHDRMEVLSW FLVERDAPEWLRDASQASYVNNFGPGGVFEQDDAEAWKAITESVQGPFAGEGLLNYEMGMDLTPLTDWPG PGEALPSGYAEQNQRRFWGRWLEYMGQPPAFGGRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0488 | - | - | 100% (455) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0546 | - | e-149 | 57.35% (422) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0525 | - | e-139 | 53.30% (439) | ring hydroxylating dioxygenase, alpha subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 3e-22 | 33.17% (205) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0662 | - | 0.0 | 99.34% (455) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 6e-22 | 32.68% (205) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 1e-74 | 36.71% (425) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_0212 | - | 1e-19 | 27.48% (262) | oxidoreductase |
| M. avium 104 | MAV_3509 | - | 2e-87 | 40.40% (448) | phthalate dioxygenase large subunit |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 4e-38 | 25.64% (433) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2976 | - | 5e-41 | 28.10% (427) | PUTATIVE dioxygenase large subunit |
| M. ulcerans Agy99 | MUL_3820 | - | 4e-16 | 32.78% (180) | ring-hydroxylating dioxygenase, large terminal subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPP--AAYTSSEL
Rv3161c|M.tuberculosis_H37Rv --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPP--AAYTSSEL
Mvan_0488|M.vanbaalenii_PYR-1 ------MTTETTGTADATDPYLRRALREVADGLKVGRLPA--RVVSDPAL
Mflv_0662|M.gilvum_PYR-GCK ------MTTETTGTADATDPYLRRALRDVADGLKVGRLPA--RVVSDPAL
MAV_3509|M.avium_104 ------MAGPDGG------------LLGVLENVRRGMIPA--HIYNDPEL
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDR--VIFTDGEL
MSMEG_1908|M.smegmatis_MC2_155 -----------MTTHLSPDHLENVLADAVIEDPAAGVYRANRRIFTDDEI
TH_2976|M.thermoresistible__bu -------------------------------LIRPDRVHG--SLYTDPAI
MMAR_0212|M.marinum_M -----------MSTAAGNPARTRDEDAIGVPPASPTLVPA--QRYHSPAF
MUL_3820|M.ulcerans_Agy99 ---------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDR
.
Mb3186c|M.bovis_AF2122/97 WQLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHA
Rv3161c|M.tuberculosis_H37Rv WQLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHA
Mvan_0488|M.vanbaalenii_PYR-1 HTIEMERIFGRAWVFLGHESELAKSGDFVVRHIGADSVIVCRDNSGRIQA
Mflv_0662|M.gilvum_PYR-GCK HTIEMERIFGRAWVFLGHESELAKSGDFVVRHIGADSVIVCRDNSGRIQA
MAV_3509|M.avium_104 FALEKRRLFARAWTFVGHESEIPHDGDYMVRRVLDDSFIITRGSDGRVRA
MAB_4370c|M.abscessus_ATCC_199 YRQELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRRIRA
MSMEG_1908|M.smegmatis_MC2_155 FELEMKHIFEGNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGDLHC
TH_2976|M.thermoresistible__bu FAEELRKIWYRTWVFVGHESEVSQPNDYVRKKLGLQDVIMTRDRDGEIHL
MMAR_0212|M.marinum_M AQLEIERMWPKVWQLACMLDHVAAPGDYFEYRCGPYSVLIVHDCDGVLRA
MUL_3820|M.ulcerans_Agy99 HERDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRAADRAVRA
: : ... . : .:: . ::
Mb3186c|M.bovis_AF2122/97 LSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDF
Rv3161c|M.tuberculosis_H37Rv LSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDF
Mvan_0488|M.vanbaalenii_PYR-1 LSNSCRHRGALVCRAEMGNTAHFQCPYHGWVYSNTGELVGVPAMSEAYPG
Mflv_0662|M.gilvum_PYR-GCK LSNSCRHRGALVCRAEMGNTAHFQCPYHGWVYSNTGELVGVPAMTEAYPG
MAV_3509|M.avium_104 LFNMCLHRGMQVCRAELGNASNFRCPYHGWTYRNDGRLTGLPFHREAYGG
MAB_4370c|M.abscessus_ATCC_199 FLNSCRHRGARVCRADYGVTRGFTCTYHGWAYDLEGKLISVPNE-EGYPD
MSMEG_1908|M.smegmatis_MC2_155 LINACAHRGAMICRRKTDNRTTLTCPFHGWTFRNDGTLLKVKDPDGAGYP
TH_2976|M.thermoresistible__bu LLNRCSHRGNQVCADAKGNSSTFRCPYHGWTFRNTGELVGFPFFKGYGTR
MMAR_0212|M.marinum_M FQNVCRHRGNSLCAGSGSGLRELKCGYHGWTWDLTGELRRVPNRKGFGSL
MUL_3820|M.ulcerans_Agy99 FDNVCLHRQSRVATG-CGTALRFTCPYHGWTYDNGGRLVGLPGREGFPGI
: * ** : . : * :* * : * *
Mb3186c|M.bovis_AF2122/97 N-----RRECRLPQFAVATWNGLVWINLDADA-EPIAAHLDLTDDEFAGY
Rv3161c|M.tuberculosis_H37Rv N-----RRECRLPQFAVATWNGLVWINLDADA-EPIAAHLDLTDDEFAGY
Mvan_0488|M.vanbaalenii_PYR-1 --GFDKSQWGLRHIPHVDSYAGFIFGSVDPKA-PSLTDYLGDTTFYLDLI
Mflv_0662|M.gilvum_PYR-GCK --GFDKSQWGLRHIPHVDSYAGFIFGSVDPKA-PSLTDYLGDTTFYLDLI
MAV_3509|M.avium_104 DDGFVKDQT-LLPAPNFAGYNGLLFISLDPAA-PPLQDFLGDFRFYLDYY
MAB_4370c|M.abscessus_ATCC_199 --SFSTDDWGLVEVPHVDSYHGLIFGTWNPAP-VGLRESLGDMAWYMDAM
MSMEG_1908|M.smegmatis_MC2_155 DTFNSNGSHNMTNVARFEGYRGFLFGSLNPDV-LPLTEHLGDTTTVIDML
TH_2976|M.thermoresistible__bu -----KLDLPLGRVPRVDSYGGFVFGSFATEG-PTLREHLGAAAGEIDRL
MMAR_0212|M.marinum_M H----MPDFPLLPVR-VETWEGLVFVSLDVTA-MPLMDYLDPIPEDIAWC
MUL_3820|M.ulcerans_Agy99 A-----VGSDGLTELPATEFAGFLWVSLHPAARLDVPAHLGPLAGELQSW
: *::: . : *. :
Mb3186c|M.bovis_AF2122/97 RLG--EMVQVESW-SHEWR--ANWKVAAEN-GHENYHVLGLHRQ------
Rv3161c|M.tuberculosis_H37Rv RLG--EMVQVESW-SHEWR--ANWKVAAEN-GHENYHVLGLHRQ------
Mvan_0488|M.vanbaalenii_PYR-1 AKKTAGGLEVIGA-PHRWVMSANWKTAADNFVGDSYHTLFAHRS----MV
Mflv_0662|M.gilvum_PYR-GCK AKKTAGGLEVIGA-PHRWVMSANWKTAADNFVGDSYHTLFAHRS----MV
MAV_3509|M.avium_104 TRQSAGGVELRG--PQRWRIRANWKIGAENFAGDMYHTPHTHAS----IV
MAB_4370c|M.abscessus_ATCC_199 LDHDSEGTVVVGG-VHKWVLDGNWKLAAEQFATDWYHVNMSHASALMVMA
MSMEG_1908|M.smegmatis_MC2_155 VDQSPDGLEVLRG-ASTYTYDGNWKVQAEN-GADGYHVTATHWN--YAAT
TH_2976|M.thermoresistible__bu LRLSPEGKVALDAGWLRHRTRANWKLLVEN-ETDGYHPQFVHGG--IFGV
MMAR_0212|M.marinum_M GLSDFRCYATLTV-----EVDANWKTIADG-YSETYHIQTLHPELLRCVD
MUL_3820|M.ulcerans_Agy99 GIGRWSPLGEKVL-----GSPIDWKLATDT-FAENYHFATVHRR------
:** .: : ** *
Mb3186c|M.bovis_AF2122/97 --------------TLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKS
Rv3161c|M.tuberculosis_H37Rv --------------TLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKS
Mvan_0488|M.vanbaalenii_PYR-1 ELGMAPGDPNFASAPAEISLQNGHGVGVLGFPP-TLADFPEYEGYPDEVV
Mflv_0662|M.gilvum_PYR-GCK ELGMAPGDPNFASAPAEISLQNGHGVGVLGFPP-TLADFPEYEGYPDEVV
MAV_3509|M.avium_104 DIGLFREPKAQKRKDGATYWAHRGGGTTYKLPPGGFEERMRYVGYPDEMI
MAB_4370c|M.abscessus_ATCC_199 PQGKAPKDEIVHRTGRQYVDPNGHGAGFPVHPKNRFDARVVHQWTDYGAL
MSMEG_1908|M.smegmatis_MC2_155 TSRRTCGESKNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANPQDRPL
TH_2976|M.thermoresistible__bu TGSTIGPLYSDSSTAVTRDLGGGHSENDLRPEFRKFAEPLRWFGTTESRV
MMAR_0212|M.marinum_M DIHAPQQIWRHAGKSDQPYGVPSPRFEGTLSDQEVWDAYVYTQGALMGAA
MUL_3820|M.ulcerans_Agy99 --------------TFATIARSNCTVFDSYGPHHRLIFPLNTILELENVP
Mb3186c|M.bovis_AF2122/97 ----------LQLNEVQKSNLVVLWTFPNSALAIAG--------------
Rv3161c|M.tuberculosis_H37Rv ----------LQLNEVQKSNLVVLWTFPNSALAIAG--------------
Mvan_0488|M.vanbaalenii_PYR-1 DQMATSYPSPVHKDLMRRSSFIH--GTVFPNLSFIN--VTLAQDHMSPPT
Mflv_0662|M.gilvum_PYR-GCK DQMATSYPSPVHKDLMRRSSFIH--GTVFPNLSFIN--VTLAQDHMSPPT
MAV_3509|M.avium_104 GRIKQVWT-PRQQRVVGEDGFMVSAATCFPNLSFVHNWPKVRDGRDDETL
MAB_4370c|M.abscessus_ATCC_199 R--------ERLGEARVQGPLTNGHATVFPNLSYLP-----VNG------
MSMEG_1908|M.smegmatis_MC2_155 WDRLDELKARFGDAKGEFMVKGSRNLCLYPNVYVMD-------------Q
TH_2976|M.thermoresistible__bu PDYVAAMRARYGAEADQILIEGSPHVMIFPNLFIAE--------------
MMAR_0212|M.marinum_M EG--TPLPADERRPGQSVQDLIAARTRAFAATRGVDLEWADTDRITRLHQ
MUL_3820|M.ulcerans_Agy99 EG--------QWDPFHHMVVIYALFPNVVLSVTIAN--------------
Mb3186c|M.bovis_AF2122/97 ---ERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQF-VMAMI
Rv3161c|M.tuberculosis_H37Rv ---ERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQF-VMAMI
Mvan_0488|M.vanbaalenii_PYR-1 PFITFRVWHPLSHDRMEVLSWFLVERDAPEWLRDASQASYVNNFGPGGVF
Mflv_0662|M.gilvum_PYR-GCK PFITFRVWHPLSHDRMEILSWFLVERDAPEWLRDASQASYVNNFGPGGVF
MAV_3509|M.avium_104 PFISIRLWQPISENETEVCSWFAVDSAAPAHYKQDSYKAYLMCFGSTGMF
MAB_4370c|M.abscessus_ATCC_199 ---SVRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIF
MSMEG_1908|M.smegmatis_MC2_155 FSTQIRHFRPIAPDKTEVTIYCIAPKGESAAARAHRIRQYEDFFNASGMA
TH_2976|M.thermoresistible__bu --IQVFNIQPVAVNECVQYSTAVQLVGAPELNRR-MVSQCIGSVGPAGML
MMAR_0212|M.marinum_M YNVFPNMTFLANADHLTIMCSRPQPEHFADPDKGEMVMFLMTRMPPDAPH
MUL_3820|M.ulcerans_Agy99 -----GELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHA
. . .
Mb3186c|M.bovis_AF2122/97 NDEDRLGLEAVQVGAGSRFAERGHLS-----------------SKEWPG-
Rv3161c|M.tuberculosis_H37Rv NDEDRLGLEAVQVGAGSRFAERGHLS-----------------SKEWPG-
Mvan_0488|M.vanbaalenii_PYR-1 EQDDAEAWKAITESVQGPFAGEGLLNYEMG--------MDLTPLTDWPGP
Mflv_0662|M.gilvum_PYR-GCK EQDDAEAWKAITESVQGPFAGEGLLNYEMG--------MDLTPLTDWPGP
MAV_3509|M.avium_104 EQDDVENWVSLTTTAGGSMARRLLLNSRMGLYDDGRPVVEALAPSAFHGP
MAB_4370c|M.abscessus_ATCC_199 EQDDGENWSEVQSISRGFVTNSVALNYQMG----------LDSEREDGRH
MSMEG_1908|M.smegmatis_MC2_155 TPDDLEEFRSCQLTFRAQAAPWNDMSRGAQHWLSGP--DPVAESLGMHGI
TH_2976|M.thermoresistible__bu LADDTEMYERNQQGLEALTPEWLDIRRGLN-------------REHVDDH
MMAR_0212|M.marinum_M NKPTDVRMAADQAEPGIVLTQDIRVLPGVQRGLHQPGFTHLVLSGEERRI
MUL_3820|M.ulcerans_Agy99 TVRDEDYRLAETLQTNLESGARQRLVFGRN--------------------
:
Mb3186c|M.bovis_AF2122/97 ------------MLAFYRNLAMALVGDHPGAS---
Rv3161c|M.tuberculosis_H37Rv ------------MLAFYRNLAMALVGDHPGAS---
Mvan_0488|M.vanbaalenii_PYR-1 GEALPSGYAEQNQRRFWGRWLEYMGQPPAFGGRA-
Mflv_0662|M.gilvum_PYR-GCK GEALPSGYAEQNQRRFWGRWLEYMGQPPAFGGRA-
MAV_3509|M.avium_104 GRAQ-VGYNEHNQRALLAMWADYLQEGDACENR--
MAB_4370c|M.abscessus_ATCC_199 PGLTSELYSDAAGRSFYARWRDLMNTKAWHEEHV-
MSMEG_1908|M.smegmatis_MC2_155 VSSGLRNEDEGLYPVQHGYWLETLRRAVTSNPTEH
TH_2976|M.thermoresistible__bu GFTVGGPTDETGMRAFWSEYRRLMEAE--------
MMAR_0212|M.marinum_M INMHRNLERYLDLPEPERMSGGGLRPGPGAPRV--
MUL_3820|M.ulcerans_Agy99 ---------EPGLQHRHITWAQALETPG-------
: