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MAGPDGGLLGVLENVRRGMIPAHIYNDPELFALEKRRLFARAWTFVGHESEIPHDGDYMVRRVLDDSFII TRGSDGRVRALFNMCLHRGMQVCRAELGNASNFRCPYHGWTYRNDGRLTGLPFHREAYGGDDGFVKDQTL LPAPNFAGYNGLLFISLDPAAPPLQDFLGDFRFYLDYYTRQSAGGVELRGPQRWRIRANWKIGAENFAGD MYHTPHTHASIVDIGLFREPKAQKRKDGATYWAHRGGGTTYKLPPGGFEERMRYVGYPDEMIGRIKQVWT PRQQRVVGEDGFMVSAATCFPNLSFVHNWPKVRDGRDDETLPFISIRLWQPISENETEVCSWFAVDSAAP AHYKQDSYKAYLMCFGSTGMFEQDDVENWVSLTTTAGGSMARRLLLNSRMGLYDDGRPVVEALAPSAFHG PGRAQVGYNEHNQRALLAMWADYLQEGDACENR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3509 | - | - | 100% (453) | phthalate dioxygenase large subunit |
| M. avium 104 | MAV_5084 | - | 3e-39 | 41.07% (224) | dioxygenase large subunit |
| M. avium 104 | MAV_1901 | - | 2e-37 | 38.68% (212) | dioxygenase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-22 | 32.69% (208) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0685 | - | 0.0 | 75.63% (435) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 1e-22 | 32.69% (208) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 3e-53 | 31.75% (441) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_3964 | - | 2e-24 | 39.23% (181) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 1e-39 | 30.67% (388) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2976 | - | 1e-36 | 40.57% (212) | PUTATIVE dioxygenase large subunit |
| M. ulcerans Agy99 | MUL_3820 | - | 1e-21 | 36.46% (181) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_0463 | - | 0.0 | 75.17% (435) | ring hydroxylating dioxygenase, alpha subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0685|M.gilvum_PYR-GCK ----------MQDHG----EVLEAVR----------TGMIPAHVYNDKQI
Mvan_0463|M.vanbaalenii_PYR-1 ----------MQDHG----EVLAAVR----------TGMIPAHVYNDKQI
MAV_3509|M.avium_104 ----------MAGPDGGLLGVLENVR----------RGMIPAHIYNDPEL
Mb3186c|M.bovis_AF2122/97 --------MLSTDNRAELGDILTDIG--DYLDDNPPALSLPPAAYTSSEL
Rv3161c|M.tuberculosis_H37Rv --------MLSTDNRAELGDILTDIG--DYLDDNPPALSLPPAAYTSSEL
MMAR_3964|M.marinum_M ---------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDACEYTSLDR
MUL_3820|M.ulcerans_Agy99 ---------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDR
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDS--HGGLLDRVIFTDGEL
TH_2976|M.thermoresistible__bu --------------------LIRPDR-------------VHGSLYTDPAI
MSMEG_1908|M.smegmatis_MC2_155 -----------MTTHLSPDHLENVLADAVIEDPAAGVYRANRRIFTDDEI
:..
Mflv_0685|M.gilvum_PYR-GCK FSLEKERLFSRAWLFVAHESEIPQPGDYVVRQVLQDSFIVARDSAGEVRV
Mvan_0463|M.vanbaalenii_PYR-1 FSLEKERLFSRAWLFVAHESEIPQPGDYVVRQVLQDSFIIARDSAGEVRV
MAV_3509|M.avium_104 FALEKRRLFARAWTFVGHESEIPHDGDYMVRRVLDDSFIITRGSDGRVRA
Mb3186c|M.bovis_AF2122/97 WQLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHA
Rv3161c|M.tuberculosis_H37Rv WQLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHA
MMAR_3964|M.marinum_M HERDRAMVLD-SPQLVGYSSELPGPGTYCTKTVMGRSILLTRAADGAVRA
MUL_3820|M.ulcerans_Agy99 HERDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRAADRAVRA
MAB_4370c|M.abscessus_ATCC_199 YRQELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRRIRA
TH_2976|M.thermoresistible__bu FAEELRKIWYRTWVFVGHESEVSQPNDYVRKKLGLQDVIMTRDRDGEIHL
MSMEG_1908|M.smegmatis_MC2_155 FELEMKHIFEGNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGDLHC
: : :.: .:. . : : .:: ::
Mflv_0685|M.gilvum_PYR-GCK MFNMCLHRGMQVCRAEMGNASNFRCPYHGWSYRNDGRIIGLPFHQEAYGG
Mvan_0463|M.vanbaalenii_PYR-1 MFNMCLHRGMQVCRAEMGNASNFRCPYHGWSYRNDGRIIGLPFHQEAYGG
MAV_3509|M.avium_104 LFNMCLHRGMQVCRAELGNASNFRCPYHGWTYRNDGRLTGLPFHREAYGG
Mb3186c|M.bovis_AF2122/97 LSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLD-
Rv3161c|M.tuberculosis_H37Rv LSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLD-
MMAR_3964|M.marinum_M FDNVCLHRQSRVAT-GCGTALRFTCPYHGWTYDNGGRLVGLPGREGFPG-
MUL_3820|M.ulcerans_Agy99 FDNVCLHRQSRVAT-GCGTALRFTCPYHGWTYDNGGRLVGLPGREGFPG-
MAB_4370c|M.abscessus_ATCC_199 FLNSCRHRGARVCRADYGVTRGFTCTYHGWAYDLEGKLISVPNEEGYPDS
TH_2976|M.thermoresistible__bu LLNRCSHRGNQVCADAKGNSSTFRCPYHGWTFRNTGELVGFPFFKGYGTR
MSMEG_1908|M.smegmatis_MC2_155 LINACAHRGAMICRRKTDNRTTLTCPFHGWTFRNDGTLLKVKDPDGAGYP
: * ** : . : * :* * : * :
Mflv_0685|M.gilvum_PYR-GCK DAGFNKAGQTLLPAPSVASYNGLIFLSMDPDAES-LEEYLGDFRFYLDFY
Mvan_0463|M.vanbaalenii_PYR-1 DAGFNKTGQTLLPAPSVASYNGLIFLSMDPDAES-LEDYLGDFRFYLDFY
MAV_3509|M.avium_104 DDGFVKD-QTLLPAPNFAGYNGLLFISLDPAAPP-LQDFLGDFRFYLDYY
Mb3186c|M.bovis_AF2122/97 ----FNRRECRLPQFAVATWNGLVWINLDADAEP-IAAHLDLTDDEFAGY
Rv3161c|M.tuberculosis_H37Rv ----FNRRECRLPQFAVATWNGLVWINLDADAEP-IAAHLDLTDDEFAGY
MMAR_3964|M.marinum_M ----IAVGSDGLTELPATEFAGFLWVSLHPAARLDVPAHLGPLAGELQSW
MUL_3820|M.ulcerans_Agy99 ----IAVGSDGLTELPATEFAGFLWVSLHPAARLDVPAHLGPLAGELQSW
MAB_4370c|M.abscessus_ATCC_199 ---FSTDDWGLVEVPHVDSYHGLIFGTWNPAPVG-LRESLGDMAWYMDAM
TH_2976|M.thermoresistible__bu -----KLDLPLGRVPRVDSYGGFVFGSFATEGPT-LREHLGAAAGEIDRL
MSMEG_1908|M.smegmatis_MC2_155 DTFNSNGSHNMTNVARFEGYRGFLFGSLNPDVLP-LTEHLGDTTTVIDML
: *::: . . : *. :
Mflv_0685|M.gilvum_PYR-GCK TRQGPNGLEVRG--PQRWRVKANWKIAAENFAGDMYHTPQTHTSVVEIGL
Mvan_0463|M.vanbaalenii_PYR-1 TRQGPNGLEVQG--PQRWRVKANWKIAAENFAGDMYHTPQTHTSVVEIGL
MAV_3509|M.avium_104 TRQSAGGVELRG--PQRWRIRANWKIGAENFAGDMYHTPHTHASIVDIGL
Mb3186c|M.bovis_AF2122/97 R---LGEMVQVE--SWSHEWRANWKVAAENGHENYHVL----------GL
Rv3161c|M.tuberculosis_H37Rv R---LGEMVQVE--SWSHEWRANWKVAAENGHENYHVL----------GL
MMAR_3964|M.marinum_M G---IGRWSPLG--EKVLDSPINWKLAADTFAENYHFA----------TV
MUL_3820|M.ulcerans_Agy99 G---IGRWSPLG--EKVLGSPIDWKLATDTFAENYHFA----------TV
MAB_4370c|M.abscessus_ATCC_199 LDHDSEGTVVVGG-VHKWVLDGNWKLAAEQFATDWYHVN---------MS
TH_2976|M.thermoresistible__bu LRLSPEGKVALDAGWLRHRTRANWKLLVENETDGYHPQFVHGG---IFGV
MSMEG_1908|M.smegmatis_MC2_155 VDQSPDGLEVLRG-ASTYTYDGNWKVQAENGADGYHVTATHWN---YAAT
:**: .: . :
Mflv_0685|M.gilvum_PYR-GCK FREPKANKRKDGATYWA-GRGGGTTYKLPEGSFEDRMSYVGYPAEMISRA
Mvan_0463|M.vanbaalenii_PYR-1 FREPKAHKRKDGATYWA-GRGGGTTYKLPEGSFEDRMSYVGYPAEMISRA
MAV_3509|M.avium_104 FREPKAQKRKDGATYWA-HRGGGTTYKLPPGGFEERMRYVGYPDEMIGRI
Mb3186c|M.bovis_AF2122/97 HRQTLEPFVPGGGDLDV-RQYSRWALRLR----------VPFTVPVEAKS
Rv3161c|M.tuberculosis_H37Rv HRQTLEPFVPGGGDLDV-RQYSRWALRLR----------VPFTVPVEAKS
MMAR_3964|M.marinum_M HRRTFATIARSNCTVFD-SYGPHHRLIFP----------LNTILELENVP
MUL_3820|M.ulcerans_Agy99 HRRTFATIARSNCTVFD-SYGPHHRLIFP----------LNTILELENVP
MAB_4370c|M.abscessus_ATCC_199 HASALMVMAPQGKAPKD-EIVHRTGRQYVDPNGHGAGFPVHPKNRFDARV
TH_2976|M.thermoresistible__bu TGSTIGPLYSDSSTAVTRDLGGGHSENDLRPEFRKFAEPLRWFGTTESRV
MSMEG_1908|M.smegmatis_MC2_155 TSRRTCGESKNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANPQDRPL
.
Mflv_0685|M.gilvum_PYR-GCK KATWTEQQQQVVGTDGFMISAATCFPNISFVHNWPKVEDG--EHVLPFIS
Mvan_0463|M.vanbaalenii_PYR-1 KATWTEQQRQVVGADGFMISAATCFPNISFVHNWPKVEDG--EHVLPFIS
MAV_3509|M.avium_104 KQVWTPRQQRVVGEDGFMVSAATCFPNLSFVHNWPKVRDGRDDETLPFIS
Mb3186c|M.bovis_AF2122/97 LQLNEVQKS--------NLVVLWTFPNSALAIAGERVVWFG---------
Rv3161c|M.tuberculosis_H37Rv LQLNEVQKS--------NLVVLWTFPNSALAIAGERVVWFG---------
MMAR_3964|M.marinum_M EGQWDPFHH--------MVVIYALFPNVVLSVTIANGELFR---------
MUL_3820|M.ulcerans_Agy99 EGQWDPFHH--------MVVIYALFPNVVLSVTIANGELFR---------
MAB_4370c|M.abscessus_ATCC_199 VHQWTDYGALRERLGEARVQGPLTNGHATVFPNLSYLPVNG--------S
TH_2976|M.thermoresistible__bu PDYVAAMRARYGAEADQILIEGSPHVMIFPNLFIAEIQVFN---------
MSMEG_1908|M.smegmatis_MC2_155 WDRLDELKARFGDAKGEFMVKGSRNLCLYPNVYVMDQFSTQ---------
:
Mflv_0685|M.gilvum_PYR-GCK IRVWQPISENETEVLSWFAVDSDAPEAFKADSYKAYLMCFGSTGMFEQDD
Mvan_0463|M.vanbaalenii_PYR-1 IRVWQPISENETEVLSWFAVDSDAPEAFKAASYKAYLMCFGSTGMFEQDD
MAV_3509|M.avium_104 IRLWQPISENETEVCSWFAVDSAAPAHYKQDSYKAYLMCFGSTGMFEQDD
Mb3186c|M.bovis_AF2122/97 ---FIPQSIDRVQVLGGVLTTP-ELAADAAAT--AQTSQFVMAMINDEDR
Rv3161c|M.tuberculosis_H37Rv ---FIPQSIDRVQVLGGVLTTP-ELAADAAAT--AQTSQFVMAMINDEDR
MMAR_3964|M.marinum_M ---IYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDY
MUL_3820|M.ulcerans_Agy99 ---IYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDEDY
MAB_4370c|M.abscessus_ATCC_199 VRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQDD
TH_2976|M.thermoresistible__bu ---IQPVAVN-ECVQYSTAVQLVGAPELNRRMVSQCIGSVGPAGMLLADD
MSMEG_1908|M.smegmatis_MC2_155 IRHFRPIAPDKTEVTIYCIAPKGESAAARAHRIRQYEDFFNASGMATPDD
* : : : *
Mflv_0685|M.gilvum_PYR-GCK VENWVSLTNTAGGSMARRLRLNSRMGLLADDARVVDTLSSAQFHGPGYAQ
Mvan_0463|M.vanbaalenii_PYR-1 VENWVSLTNTAGGSMARRLRLNSRMGLLADDARVVDTLSSAQFHGPGYAQ
MAV_3509|M.avium_104 VENWVSLTTTAGGSMARRLLLNSRMGLYDDGRPVVEALAPSAFHGPGRAQ
Mb3186c|M.bovis_AF2122/97 LGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS---
Rv3161c|M.tuberculosis_H37Rv LGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS---
MMAR_3964|M.marinum_M RLAETLQTNFESGARQR-LVFGRNEPGLQ--HRHITWAQALKTPG-----
MUL_3820|M.ulcerans_Agy99 RLAETLQTNLESGARQR-LVFGRNEPGLQ--HRHITWAQALETPG-----
MAB_4370c|M.abscessus_ATCC_199 GENWSEVQSISRGFVTNSVALNYQMGLDSEREDGRHPGLTSELYSDAAGR
TH_2976|M.thermoresistible__bu TEMYERNQQGLEALTPEWLDIRRGLNREHVDDHGFTVGGPTDETGMRAFW
MSMEG_1908|M.smegmatis_MC2_155 LEEFRSCQLTFRAQAAPWNDMSRGAQHWLSGPDPVAESLGMHGIVSSGLR
Mflv_0685|M.gilvum_PYR-GCK LGYNENNQRELLRLWADYLDMPPLRVDPATVLTDNPQGIEPMVQTNGGAV
Mvan_0463|M.vanbaalenii_PYR-1 LGYNENNQRQLLRLWADYLDMPPLRVDPATVLTDNPQGIEPMVQTNGGAV
MAV_3509|M.avium_104 VGYNEHNQRALLAMWADYLQE-------------------------GDAC
Mb3186c|M.bovis_AF2122/97 --------------------------------------------------
Rv3161c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3964|M.marinum_M --------------------------------------------------
MUL_3820|M.ulcerans_Agy99 --------------------------------------------------
MAB_4370c|M.abscessus_ATCC_199 SFYARWRDLMNTKAWHEEHV------------------------------
TH_2976|M.thermoresistible__bu SEYRRLMEAE----------------------------------------
MSMEG_1908|M.smegmatis_MC2_155 NEDEGLYPVQHGYWLETLRRAVTSNPTEH---------------------
Mflv_0685|M.gilvum_PYR-GCK AGIDSESATTSVTL
Mvan_0463|M.vanbaalenii_PYR-1 AGIDSESATTSVTL
MAV_3509|M.avium_104 ENR-----------
Mb3186c|M.bovis_AF2122/97 --------------
Rv3161c|M.tuberculosis_H37Rv --------------
MMAR_3964|M.marinum_M --------------
MUL_3820|M.ulcerans_Agy99 --------------
MAB_4370c|M.abscessus_ATCC_199 --------------
TH_2976|M.thermoresistible__bu --------------
MSMEG_1908|M.smegmatis_MC2_155 --------------