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TTHLSPDHLENVLADAVIEDPAAGVYRANRRIFTDDEIFELEMKHIFEGNWVYLAHESQVPNPGDYFTTY IGRQPVVITRDRDGDLHCLINACAHRGAMICRRKTDNRTTLTCPFHGWTFRNDGTLLKVKDPDGAGYPDT FNSNGSHNMTNVARFEGYRGFLFGSLNPDVLPLTEHLGDTTTVIDMLVDQSPDGLEVLRGASTYTYDGNW KVQAENGADGYHVTATHWNYAATTSRRTCGESKNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANPQD RPLWDRLDELKARFGDAKGEFMVKGSRNLCLYPNVYVMDQFSTQIRHFRPIAPDKTEVTIYCIAPKGESA AARAHRIRQYEDFFNASGMATPDDLEEFRSCQLTFRAQAAPWNDMSRGAQHWLSGPDPVAESLGMHGIVS SGLRNEDEGLYPVQHGYWLETLRRAVTSNPTEH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1908 | - | - | 100% (454) | benzoate 1,2-dioxygenase alpha subunit |
| M. smegmatis MC2 155 | MSMEG_0657 | - | 9e-16 | 26.13% (199) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4840 | - | 2e-15 | 24.17% (211) | Rieske (2Fe-2S) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 3e-21 | 30.35% (201) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1355 | - | 0.0 | 89.04% (438) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 1e-21 | 30.85% (201) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 6e-45 | 30.41% (365) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_4422 | - | 4e-21 | 28.12% (224) | dioxygenase |
| M. avium 104 | MAV_2612 | - | 2e-48 | 31.66% (379) | dioxygenase large subunit |
| M. thermoresistible (build 8) | TH_2976 | - | 5e-45 | 31.23% (381) | PUTATIVE dioxygenase large subunit |
| M. ulcerans Agy99 | MUL_3820 | - | 7e-15 | 30.37% (191) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_0546 | - | 9e-42 | 28.57% (420) | ring hydroxylating dioxygenase, alpha subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 -MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAA--------YTSSELW
Rv3161c|M.tuberculosis_H37Rv -MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAA--------YTSSELW
MSMEG_1908|M.smegmatis_MC2_155 -MTTHLSP---DHLENVLADAVIEDPAAGVYRANR------RIFTDDEIF
Mflv_1355|M.gilvum_PYR-GCK MTQTTASPQPRTHLAAVLADAVIDDPEAGVFRANR------RIFTDEEIF
MAV_2612|M.avium_104 ---------MTTLESAPAVDDFDVGSVIRHDRVHG------TVYTSTEIF
TH_2976|M.thermoresistible__bu --------------------------LIRPDRVHG------SLYTDPAIF
MAB_4370c|M.abscessus_ATCC_199 -MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELY
Mvan_0546|M.vanbaalenii_PYR-1 --MSIVGKNDIQQLVAAGQEGLAKGRLPAGLVAN------------AELH
MMAR_4422|M.marinum_M -------------------MTAVRQPSALLPTLGG------AYYTSAAVF
MUL_3820|M.ulcerans_Agy99 --MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAR------EYTSLDRH
Mb3186c|M.bovis_AF2122/97 QLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHAL
Rv3161c|M.tuberculosis_H37Rv QLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHAL
MSMEG_1908|M.smegmatis_MC2_155 ELEMKHIFEGNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGDLHCL
Mflv_1355|M.gilvum_PYR-GCK ELEMKHIFEGNWIYLAHESQVANPGDYFTTYIGRQPVVITRSKDGSLNCL
MAV_2612|M.avium_104 RREMDTIFKTGWVYVAHESEVSEPGDYLTRMIGHDPVVVARGKDGVVRVM
TH_2976|M.thermoresistible__bu AEELRKIWYRTWVFVGHESEVSQPNDYVRKKLGLQDVIMTRDRDGEIHLL
MAB_4370c|M.abscessus_ATCC_199 RQELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRRIRAF
Mvan_0546|M.vanbaalenii_PYR-1 KLEAQRVFGRCWQFLAHETEIPQAGDYVVRYLGGGSIIVVRGEDGEVRAM
MMAR_4422|M.marinum_M AAEQQHVFESMWFCVVRAADLNEPGQFKAVQVGRESVLLVRGRDRRLRAF
MUL_3820|M.ulcerans_Agy99 ERDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRAADRAVRAF
: : : :. .. : : ::: : :. :
Mb3186c|M.bovis_AF2122/97 SPICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMAANLDF
Rv3161c|M.tuberculosis_H37Rv SPICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMAANLDF
MSMEG_1908|M.smegmatis_MC2_155 INACAHRGAMICRRKTDNRT-TLTCPFHGWTFRNDGTLLKVKDP-DGAGY
Mflv_1355|M.gilvum_PYR-GCK INACAHRGAMICRRKTDNRM-TLTCPFHGWTFRNDGALLKVKDP-DGAGY
MAV_2612|M.avium_104 LNRCTHRANKLCNAEKGNAN-SFRCPYHGWTFGNTGALQGVPMR-EGYGE
TH_2976|M.thermoresistible__bu LNRCSHRGNQVCADAKGNSS-TFRCPYHGWTFRNTGELVGFPFF-KGYGT
MAB_4370c|M.abscessus_ATCC_199 LNSCRHRGARVCRADYGVTR-GFTCTYHGWAYDLEGKLISVPNE-EGYPD
Mvan_0546|M.vanbaalenii_PYR-1 ANSCRHRGTMLCRTEMGNTS-HFRCPYHGWTYRNTGTLAGVPAQKEVYGV
MMAR_4422|M.marinum_M LNICRHRGALLCTEPEGQVRRNLRCPYHSWTYGLDGTLIAAPNIAELTDT
MUL_3820|M.ulcerans_Agy99 DNVCLHRQSRVATGCGTALR--FTCPYHGWTYDNGGRLVGLPGREGFPGI
* ** : : * :* * : * *
Mb3186c|M.bovis_AF2122/97 N-----RRECRLPQFA-VATWNGLVWINLDADA-EPIAAHLD-LTDDEFA
Rv3161c|M.tuberculosis_H37Rv N-----RRECRLPQFA-VATWNGLVWINLDADA-EPIAAHLD-LTDDEFA
MSMEG_1908|M.smegmatis_MC2_155 PDTFNSNGSHNMTNVARFEGYRGFLFGSLNPDV-LPLTEHLG-DTTTVID
Mflv_1355|M.gilvum_PYR-GCK PEAFNVNGSHNMTTVARFESYRGFLFGSLNPDV-LPLTEHLG-DATKIID
MAV_2612|M.avium_104 EFNK-VRSELGLAQAPRVDSYGGFVFASLAPDG-ISLTEHLG-KATRAID
TH_2976|M.thermoresistible__bu R-----KLDLPLGRVPRVDSYGGFVFGSFATEG-PTLREHLG-AAAGEID
MAB_4370c|M.abscessus_ATCC_199 SFS---TDDWGLVEVPHVDSYHGLIFGTWNPAP-VGLRESLG-DMAWYMD
Mvan_0546|M.vanbaalenii_PYR-1 EMD---KNEWSLTQVPRLENYRGMIFGCLDEKA-EPLVDYLG-DMAWYLD
MMAR_4422|M.marinum_M DGASIDRHRYGLVAVA-LREWLGYAWVCLAEDP-PSFEDDVVGSVTARLG
MUL_3820|M.ulcerans_Agy99 AVG-----SDGLTELP-ATEFAGFLWVSLHPAARLDVPAHLG-PLAGELQ
: . : * : . : :
Mb3186c|M.bovis_AF2122/97 GYRLG-----EMVQVES-WSHEWRANWKVAAEN-GHENYHVLGLHRQTLE
Rv3161c|M.tuberculosis_H37Rv GYRLG-----EMVQVES-WSHEWRANWKVAAEN-GHENYHVLGLHRQTLE
MSMEG_1908|M.smegmatis_MC2_155 MLVDQSPDG-LEVLRGA-STYTYDGNWKVQAEN-GADGYHVTATHWN-YA
Mflv_1355|M.gilvum_PYR-GCK MLVDQSPDG-LEVLRGS-STYTYDGNWKVQAEN-GADGYHVTATHWN-YA
MAV_2612|M.avium_104 RLLNLSPTREIDLRANW-MKHLHHANWKMVVEN-NVDGYHALFTHASVYD
TH_2976|M.thermoresistible__bu RLLRLSPEGKVALDAGW-LRHRTRANWKLLVEN-ETDGYHPQFVHGGIFG
MAB_4370c|M.abscessus_ATCC_199 AMLDHDSEG-TVVVGGV-HKWVLDGNWKLAAEQFATDWYHVNMSHASALM
Mvan_0546|M.vanbaalenii_PYR-1 LITQKSKGG-LEVRGEP-QRWIIDSNWKLGADNFVGDAYHTLMTHRSAVE
MMAR_4422|M.marinum_M DVSAIDTYRIEALQVGRRVSYDVAANWKLIVEN-FMECYHCATIHPELTR
MUL_3820|M.ulcerans_Agy99 SWGIGRWSPLGEKVLGS------PIDWKLATDT-FAENYHFATVHRRTFA
:**: .: : ** *
Mb3186c|M.bovis_AF2122/97 PFVPGGGDLDVRQYSRWALR---------------------------LRV
Rv3161c|M.tuberculosis_H37Rv PFVPGGGDLDVRQYSRWALR---------------------------LRV
MSMEG_1908|M.smegmatis_MC2_155 ATTSRRTCGESKNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANPQDR
Mflv_1355|M.gilvum_PYR-GCK ATTSRRGTGESKNETKALDAGGWGKSGGGYWSFPHGHLCLWTWAANPQDR
MAV_2612|M.avium_104 AIKPAKVSHVPTKVDVLVRDLGNGHSEIDYSDEYRKLDEEFVWYGRIPRA
TH_2976|M.thermoresistible__bu VTGSTIGPLYSDSSTAVTRDLGGGHSENDLRPEFRKFAEPLRWFG-TTES
MAB_4370c|M.abscessus_ATCC_199 VMAPQGK---APKDEIVHRTGRQYVDPNGHG---AGFPVHPKNRFDARVV
Mvan_0546|M.vanbaalenii_PYR-1 LGLAPPDPKFASEPAHISLSNGHGLGVLGVP---PGQPMPPFMNYPPEVV
MMAR_4422|M.marinum_M VIPEFARGQAAQRSVGRGAEFGSAVAG--------------------FTV
MUL_3820|M.ulcerans_Agy99 TIARSNCTVFDSYG--------------------------------PHHR
Mb3186c|M.bovis_AF2122/97 PFTVPVEAKSLQLNEVQKSNLVVLWT-----FPNSALAIAGER-------
Rv3161c|M.tuberculosis_H37Rv PFTVPVEAKSLQLNEVQKSNLVVLWT-----FPNSALAIAGER-------
MSMEG_1908|M.smegmatis_MC2_155 PLWDRLDELKARFG-DAKGEFMVKGSRNLCLYPNVYVMDQFST-------
Mflv_1355|M.gilvum_PYR-GCK PLWDKLDELKATHG-DAKGEFMVKGSRNLCVYPNVYVMDQFST-------
MAV_2612|M.avium_104 KLADYVGALEGAYGPEQAHDALVVGPPHTLIWPNLFLAEMN---------
TH_2976|M.thermoresistible__bu RVPDYVAAMRARYG-AEADQILIEGSPHVMIFPNLFIAEIQ---------
MAB_4370c|M.abscessus_ATCC_199 HQWTDYGALRERLGEARVQGPLTNG--HATVFPNLSYLPVNG--------
Mvan_0546|M.vanbaalenii_PYR-1 DGLAAAYGDQDRADMLQRSAFIHG-----TVFPNLSFLNVLIGRDKKSMP
MMAR_4422|M.marinum_M DGRAGFTALPGIRPEQDRRYFAITVK------PTVFINLVPDH-------
MUL_3820|M.ulcerans_Agy99 LIFPLNTILELENVPEGQWDPFHHMVVIYALFPNVVLSVTIAN-------
*.
Mb3186c|M.bovis_AF2122/97 ---VVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTS----QFVMAM
Rv3161c|M.tuberculosis_H37Rv ---VVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTS----QFVMAM
MSMEG_1908|M.smegmatis_MC2_155 ----QIRHFRPIAPDKTEVTIYCIAPKGESAAARAHRIRQYEDFFNASGM
Mflv_1355|M.gilvum_PYR-GCK ----QIRHFRPIAPDKTEVTIYCIAPKSESAQARANRIRQYEDFFNASGM
MAV_2612|M.avium_104 -----VMFVEPQAPDRTIAYTTAVLIPGQDALN-ERTLRRSEGAMGPAGF
TH_2976|M.thermoresistible__bu -----VFNIQPVAVNECVQYSTAVQLVGAPELN-RRMVSQCIGSVGPAGM
MAB_4370c|M.abscessus_ATCC_199 ----SVRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGI
Mvan_0546|M.vanbaalenii_PYR-1 VPMLTFRLWRPLSHDTMEVWSWFLVEKDADEEFKQQSYETYVRTFGISGV
MMAR_4422|M.marinum_M ---AIIHRMFPIAADRTIVECDWLYAPEVAAAG------DIAHSVELFHR
MUL_3820|M.ulcerans_Agy99 ---GELFRIYPGDRPGSSITVHQNSTP-LDLSDESVATGAQAVFDYAHAT
*
Mb3186c|M.bovis_AF2122/97 INDEDRLGLEAVQVGAGSRFAERGHLSSK---------------------
Rv3161c|M.tuberculosis_H37Rv INDEDRLGLEAVQVGAGSRFAERGHLSSK---------------------
MSMEG_1908|M.smegmatis_MC2_155 ATPDDLEEFRSCQLTFRAQAAPWNDMSRGAQHWLSGPDPVAESLGMHGIV
Mflv_1355|M.gilvum_PYR-GCK ATPDDLEEFRSCQLTFRAEAAPWNDMSRGAQHWLDGPDDVARSLGLDAVI
MAV_2612|M.avium_104 LIADDGEIGMRNQAGLAAELPEWLMLARG--------------IESDVDD
TH_2976|M.thermoresistible__bu LLADDTEMYERNQQGLEALTPEWLDIRRG--------------LNREHVD
MAB_4370c|M.abscessus_ATCC_199 FEQDDGENWSEVQSISRGFVTNSVALNYQMG--------LDSEREDGRHP
Mvan_0546|M.vanbaalenii_PYR-1 FEQDDAETWRSITAGTQGILAGSQTLNFEMG--------MGVLTSDDTWK
MMAR_4422|M.marinum_M VNEQDFDACQRTQPAMSSRAYRTGGVLVP---------------------
MUL_3820|M.ulcerans_Agy99 VRDEDYRLAETLQTNLESGARQRLVFGRN---------------------
:* . .
Mb3186c|M.bovis_AF2122/97 ----------EWPGMLAFYRNLAMALVGDHPGAS----------------
Rv3161c|M.tuberculosis_H37Rv ----------EWPGMLAFYRNLAMALVGDHPGAS----------------
MSMEG_1908|M.smegmatis_MC2_155 SSGLRNEDEGLYPVQHGYWLETLRRAVTSNPTEH----------------
Mflv_1355|M.gilvum_PYR-GCK SAGVKNEDEGLYPVQHGYWLETMRAAAQKEAR------------------
MAV_2612|M.avium_104 MTGIINRDKSAETPQRGFYSHWASVVGGRSGA------------------
TH_2976|M.thermoresistible__bu DHGFTVGGPTDETGMRAFWSEYRRLMEAE---------------------
MAB_4370c|M.abscessus_ATCC_199 G---LTSELYSDAAGRSFYARWRDLMNTKAWHEEHV--------------
Mvan_0546|M.vanbaalenii_PYR-1 GPGRPLSSGYAERNQREFWGRLLELLTDSGDDASETEPKPQLLAQSRTNT
MMAR_4422|M.marinum_M ----------AEHHIAEFHQWVIARIGTPAVTG-----------------
MUL_3820|M.ulcerans_Agy99 -----------EPGLQHRHITWAQALETPG--------------------
Mb3186c|M.bovis_AF2122/97 ----
Rv3161c|M.tuberculosis_H37Rv ----
MSMEG_1908|M.smegmatis_MC2_155 ----
Mflv_1355|M.gilvum_PYR-GCK ----
MAV_2612|M.avium_104 ----
TH_2976|M.thermoresistible__bu ----
MAB_4370c|M.abscessus_ATCC_199 ----
Mvan_0546|M.vanbaalenii_PYR-1 DEVA
MMAR_4422|M.marinum_M ----
MUL_3820|M.ulcerans_Agy99 ----