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MTAVRQPSALLPTLGGAYYTSAAVFAAEQQHVFESMWFCVVRAADLNEPGQFKAVQVGRESVLLVRGRDR RLRAFLNICRHRGALLCTEPEGQVRRNLRCPYHSWTYGLDGTLIAAPNIAELTDTDGASIDRHRYGLVAV ALREWLGYAWVCLAEDPPSFEDDVVGSVTARLGDVSAIDTYRIEALQVGRRVSYDVAANWKLIVENFMEC YHCATIHPELTRVIPEFARGQAAQRSVGRGAEFGSAVAGFTVDGRAGFTALPGIRPEQDRRYFAITVKPT VFINLVPDHAIIHRMFPIAADRTIVECDWLYAPEVAAAGDIAHSVELFHRVNEQDFDACQRTQPAMSSRA YRTGGVLVPAEHHIAEFHQWVIARIGTPAVTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4422 | - | - | 100% (382) | dioxygenase |
| M. marinum M | MMAR_0212 | - | 1e-21 | 31.60% (231) | oxidoreductase |
| M. marinum M | MMAR_4744 | - | 3e-20 | 30.54% (203) | dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 2e-23 | 28.45% (355) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_3082 | - | 1e-165 | 73.12% (372) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 6e-23 | 28.17% (355) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 4e-19 | 29.39% (228) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. avium 104 | MAV_5278 | - | 2e-23 | 32.05% (234) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0657 | - | 5e-61 | 39.83% (354) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3877 | - | 3e-23 | 31.40% (207) | PUTATIVE Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 2e-14 | 30.29% (175) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_4319 | - | 3e-28 | 31.58% (266) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4422|M.marinum_M --------------------------M---TAVRQPSALLPTLGGAYYTS
Mflv_3082|M.gilvum_PYR-GCK -----------------------------------MTALMATLEGHYYTS
MSMEG_0657|M.smegmatis_MC2_155 MDHFPAADYPDCMFKQIGPAPVPADDL---AAALAPFGHSRMLPREAYVD
Mb3186c|M.bovis_AF2122/97 ----------MLSTDNRAELGDILTDI---GDYLDDNPPALSLPPAAYTS
Rv3161c|M.tuberculosis_H37Rv ----------MLSTDNRAELGDILTDI---GDYLDDNPPALSLPPAAYTS
TH_3877|M.thermoresistible__bu ----------------MKKWPKPAEGS---WTEHYPELGTGPVSFRDSTS
MAV_5278|M.avium_104 -------------MAAAAGNPARTRDE---DAIGTPPPGPTLVPAERYYS
Mvan_4319|M.vanbaalenii_PYR-1 -----------MPATRPGEWLDPASGLGLGLDDVQPGTFNMTISTDRYTC
MUL_3820|M.ulcerans_Agy99 -----------MDRDQLIDLTRRALKLAR-DKTTDLAPHQHAVDAREYTS
MAB_4370c|M.abscessus_ATCC_199 -----MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTD
:
MMAR_4422|M.marinum_M AAVFAAEQQHVFESMWFCVVRAADLNEPGQFKA--VQVGRESVLLVRGRD
Mflv_3082|M.gilvum_PYR-GCK AEVFAAEQQGIFENMWFCAVRTSDLEKPGKFTK--VQVGRESVLLVRGRD
MSMEG_0657|M.smegmatis_MC2_155 PAVFAWEQQAIFS-GWTCVGHAADLETPGAQRA--VGSGANGVLLVRGED
Mb3186c|M.bovis_AF2122/97 SELWQLERERIFNRSWMLVAHVDQLAKTGDYVT--VSVAGEPVMVVRDVD
Rv3161c|M.tuberculosis_H37Rv SELWQLERERIFNRSWMLVAHVDQVAKTGDYVT--VSVAGEPVMVVRDVD
TH_3877|M.thermoresistible__bu PEFYELEREAVFKRAWLHVGRVEELPRAGSYLTKNIDVAKTSVIVVRGRD
MAV_5278|M.avium_104 PAFAALEVERMWPRVWQLACMVDHVATPGDYFE--YRCGPYGVLIVRDDD
Mvan_4319|M.vanbaalenii_PYR-1 PDYAARERGSIWMRTWQIAGRVEDLPKPGDWKK--YEILDQSFIIVRGKD
MUL_3820|M.ulcerans_Agy99 LDRHERDR-AMVLDSPQLVGYSSELPGPDTYRT--KTIMGRSILLTRAAD
MAB_4370c|M.abscessus_ATCC_199 GELYRQELRRVFAPSWLFLAHADQFHRPGDFFT--TYMGEDPVIVSMDKN
: : .. .. .:: :
MMAR_4422|M.marinum_M RRLRAFLNICRHRGALLCT-----EPEGQVRRNLRCPYHSWTYGLDGTLI
Mflv_3082|M.gilvum_PYR-GCK GLLRAFLNVCRHRGAQLCS-----ESEGEVRRTLRCPYHSWTYALDGKLV
MSMEG_0657|M.smegmatis_MC2_155 NRVRAFANACRHRGHELLS-----CGASAKRRSIVCPYHAWSYRLDGSVR
Mb3186c|M.bovis_AF2122/97 GQLHALSPICRHR-LMLMV-----EPGAGRIDTLTCQYHLWRYGLDGRLR
Rv3161c|M.tuberculosis_H37Rv GQLHALSPICRHR-LMLMV-----EPGAGRIDTLTCQYHLWRYGLDGRLR
TH_3877|M.thermoresistible__bu EQIRAFYNICRHRGNKLVWNDYPHEEVKGACRQFTCKYHGWRYDLKGDLT
MAV_5278|M.avium_104 GALRAFQNVCRHRGNSLCS------GSGSGLRELKCGYHGWTWDLAGALK
Mvan_4319|M.vanbaalenii_PYR-1 DVLRGFVNACRHRGNALCT-----TDTGNAKRGFLCQYHLWSYDLEGKLK
MUL_3820|M.ulcerans_Agy99 RAVRAFDNVCLHRQSRVAT-------GCGTALRFTCPYHGWTYDNGGRLV
MAB_4370c|M.abscessus_ATCC_199 RRIRAFLNSCRHRGARVCR------ADYGVTRGFTCTYHGWAYDLEGKLI
::.: * ** : : * ** * : * :
MMAR_4422|M.marinum_M AAPNIAELTDTDGASIDRHRYGLVAVA-LREWLGYAWVCLAEDP---PSF
Mflv_3082|M.gilvum_PYR-GCK AAPNIGTLTDDAGSPIDRYRYGLIPVA-LTEWLGYAWVCLSDTP---PPF
MSMEG_0657|M.smegmatis_MC2_155 NAPGFKDVDG-----FDPGGFGLVELR-LVDWHGWLFVDPSGQD---ADF
Mb3186c|M.bovis_AF2122/97 GAPHMAANLD-----FNRRECRLPQFA-VATWNGLVWINLDADA---EPI
Rv3161c|M.tuberculosis_H37Rv GAPHMAANLD-----FNRRECRLPQFA-VATWNGLVWINLDADA---EPI
TH_3877|M.thermoresistible__bu FVQQESEFFD-----LDTARYGLKPVN-CDVWNGFIFINFDPEPKWSLR-
MAV_5278|M.avium_104 RVPDRKGFGS-----LRLSDYPLIPAR-VDTWAGLVFVNLDPDA---MPL
Mvan_4319|M.vanbaalenii_PYR-1 GLLRENLAGP-----IDKTENSLLQVS-VDTFAGFIFLNPDPDAAPLREY
MUL_3820|M.ulcerans_Agy99 GLPGREGFPG-----IAVGSDGLTELP-ATEFAGFLWVSLHPAARLDVPA
MAB_4370c|M.abscessus_ATCC_199 SVPNEEGYPDS----FSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRES
: * : * :
MMAR_4422|M.marinum_M EDDVVGSVTARLGDVSAIDTYRIEALQVGRRVSYDVAANWKLIVENFM-E
Mflv_3082|M.gilvum_PYR-GCK ED-VVAEATRTLGDADAINRYGIGGLDVGHRVVYEVAANWKLIVENFM-E
MSMEG_0657|M.smegmatis_MC2_155 AT-------HVAGLEEVVSPYRPEDLTIVARHSYELAANWKIIAENYQ-E
Mb3186c|M.bovis_AF2122/97 AA-------HLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGH-E
Rv3161c|M.tuberculosis_H37Rv AA-------HLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGH-E
TH_3877|M.thermoresistible__bu --------EFLGPMITALDDYPFGLMTERYEFEAHNNSNWKIFADAFQ-E
MAV_5278|M.avium_104 PE-------YLEAIPEDIAWCRLDEFRCYATLTVEVDANWKTIADGYS-E
Mvan_4319|M.vanbaalenii_PYR-1 LG---------EDVVSLLEPYNIEQFTTVMDVTEAIECNWKVVMDAFE-E
MUL_3820|M.ulcerans_Agy99 ---------HLGPLAGELQSWGIGRWSPLGEKVLGSPIDWKLATDTFA-E
MAB_4370c|M.abscessus_ATCC_199 LG------DMAWYMDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATD
. :** : :
MMAR_4422|M.marinum_M CYHCATIHPELTRVIPEFARGQAAQRSVGRG-------------------
Mflv_3082|M.gilvum_PYR-GCK CYHCSSIHPELVDVLPEFAKGQAAQANIGLG-------------------
MSMEG_0657|M.smegmatis_MC2_155 CYHCSSIHPELSRISPPTSGENLELPGAWMGG------------------
Mb3186c|M.bovis_AF2122/97 NYHVLGLH---RQTLEPFVPGGGDLDVRQYSR------------------
Rv3161c|M.tuberculosis_H37Rv NYHVLGLH---RQTLEPFVPGGGDLDVRQYSR------------------
TH_3877|M.thermoresistible__bu YYHVPSLHSQQVPSAVRQPNATFECGHFQIDG------------------
MAV_5278|M.avium_104 TYHIQTLHPELLRCVDDIHAPQQIWRHTGKSDQPYGVPSPRFEGALSDEE
Mvan_4319|M.vanbaalenii_PYR-1 GYHINGIHPQLLQVLHINPKTARYRFFENHSVAMAPFEVVGAGVQDQVAG
MUL_3820|M.ulcerans_Agy99 NYHFATVHRRTFATIARSNCTVFDSYGPHHR-------------------
MAB_4370c|M.abscessus_ATCC_199 WYHVNMSHASALMVMAPQGKAPKDEIVHRTGR------------------
** *
MMAR_4422|M.marinum_M --AEFGSAVAG----------FTVD---------------------GRAG
Mflv_3082|M.gilvum_PYR-GCK --AEFGSEVAG----------FTVD---------------------GGAG
MSMEG_0657|M.smegmatis_MC2_155 -WMSIIDGAET----------MSLD---------------------GRSG
Mb3186c|M.bovis_AF2122/97 -WALRLRVPFT----------VPVE---------------------AKS-
Rv3161c|M.tuberculosis_H37Rv -WALRLRVPFT----------VPVE---------------------AKS-
TH_3877|M.thermoresistible__bu -PHRLVSTAGTRRWLMPPEYMYPVERATRSGLVGPW--------RTPKTH
MAV_5278|M.avium_104 VWDAYVSTQGALMGAAEGTPFPAADRRPGQTVADLI--------ADRTRA
Mvan_4319|M.vanbaalenii_PYR-1 ILALPETFPGTVAVIPRFQELIAPYQDSDGNVAFPDGVTARALLQQATRE
MUL_3820|M.ulcerans_Agy99 ----LIFPLNT---------ILELEN------------------------
MAB_4370c|M.abscessus_ATCC_199 ---QYVDPNGHGAG-------FPVHPK-------------------NRFD
MMAR_4422|M.marinum_M FTALPGIRP-----EQDRRYFAITVKPTVFINLVPDHAIIHRMFPI----
Mflv_3082|M.gilvum_PYR-GCK FERLPGIAD-----DQDRRYYAITVKPTVFINLVPDHVIFHRMYPV----
MSMEG_0657|M.smegmatis_MC2_155 GVAIAGLSE-----HELRTVMYLVGYPNLLVSLHPDYVMTHLMTPL----
Mb3186c|M.bovis_AF2122/97 ----LQLNE-----VQKSNLVVLWTFPNSALAIAGERVVWFGFIPQ----
Rv3161c|M.tuberculosis_H37Rv ----LQLNE-----VQKSNLVVLWTFPNSALAIAGERVVWFGFIPQ----
TH_3877|M.thermoresistible__bu FSAGLNPGG-----IEPWGITNFQIFPNLEILIYHGWYLLYQYWPT----
MAV_5278|M.avium_104 FAATRGVDLGWADTDRITRLHQYNVFPNMTFLTNADHLTVMCSRPA----
Mvan_4319|M.vanbaalenii_PYR-1 VLTGMGLDVSRLTDDQMVDNQGWVLFPNYFMTVRAGECHVIMSVPH----
MUL_3820|M.ulcerans_Agy99 -VPEGQWDP------FHHMVVIYALFPNVVLSVTIANGELFRIYPG----
MAB_4370c|M.abscessus_ATCC_199 ARVVHQWTDYGALRERLGEARVQGPLTNGHATVFPNLSYLPVNGSVRIWH
.. .
MMAR_4422|M.marinum_M AADRTIVECDWLYAPEVA-AAG-DIAHSVELFHRVN---------EQDFD
Mflv_3082|M.gilvum_PYR-GCK AADRTVVECDWLYTREVL-GSGRDVSRSVELFHRVN---------MQDFD
MSMEG_0657|M.smegmatis_MC2_155 AVDRTHVECAWAFPREAAERPGFDPAYAVDFWDLTN---------RQDWA
Mb3186c|M.bovis_AF2122/97 SIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMIN---------DEDRL
Rv3161c|M.tuberculosis_H37Rv SIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMIN---------DEDRL
TH_3877|M.thermoresistible__bu SYNTHRFEAYTAFHPARTVRERIEHEVASVVLKEFA---------LQDAG
MAV_5278|M.avium_104 PDPAAAPDKGELVMFLTTRMPPGAPRTKPTDVRMSAGEAEPGLVLTQDIA
Mvan_4319|M.vanbaalenii_PYR-1 PDGDPNRCIWHVASYMYVPQDFRDAVRAEALVVDTPGSYKYFEALQQDYE
MUL_3820|M.ulcerans_Agy99 DRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVR------DEDYR
MAB_4370c|M.abscessus_ATCC_199 PKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQDDGENWS
::
MMAR_4422|M.marinum_M ACQRTQPAMSS--RAYRTGGVLVPAEHHIAEFHQWVIARIGTPAVTG---
Mflv_3082|M.gilvum_PYR-GCK ACERTQPAMSS--RAYRSGGVLVPAEHHLAEFHRWVVSRLATPV------
MSMEG_0657|M.smegmatis_MC2_155 ACESVQRGLSS--PHARPG-PLAPDEDGVYQFVTRVARAYQGA-------
Mb3186c|M.bovis_AF2122/97 GLEAVQVGAGS--RFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS--
Rv3161c|M.tuberculosis_H37Rv GLEAVQVGAGS--RFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS--
TH_3877|M.thermoresistible__bu MLGGTQAALEYGLDEPIVDEFPLSDQEILVRHLHKVVVDWVEEYQSERTA
MAV_5278|M.avium_104 VLAGLQRGMHQ---PGFTHLVLSSEERRVINMHRNLERYLDLPAAQRMSG
Mvan_4319|M.vanbaalenii_PYR-1 QMPRQQKGLRN---DRLDHMSLVKEEVVIAHYHSVVDRHLADSVTADTAR
MUL_3820|M.ulcerans_Agy99 LAETLQTNLES---GARQRLVFGRNEPGLQHRHITWAQALETPG------
MAB_4370c|M.abscessus_ATCC_199 EVQSISRGFVTN--SVALNYQMGLDSEREDGRHPGLTSELYSDAAGRSFY
.
MMAR_4422|M.marinum_M -----------------
Mflv_3082|M.gilvum_PYR-GCK -----------------
MSMEG_0657|M.smegmatis_MC2_155 -----------------
Mb3186c|M.bovis_AF2122/97 -----------------
Rv3161c|M.tuberculosis_H37Rv -----------------
TH_3877|M.thermoresistible__bu VGV--------------
MAV_5278|M.avium_104 GAGT-------------
Mvan_4319|M.vanbaalenii_PYR-1 STSSVKESRD-------
MUL_3820|M.ulcerans_Agy99 -----------------
MAB_4370c|M.abscessus_ATCC_199 ARWRDLMNTKAWHEEHV