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ASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYRQELRRVFAPSWLFLAHADQFH RPGDFFTTYMGEDPVIVSMDKNRRIRAFLNSCRHRGARVCRADYGVTRGFTCTYHGWAYDLEGKLISVPN EEGYPDSFSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRESLGDMAWYMDAMLDHDSEGTVVVGGVHKW VLDGNWKLAAEQFATDWYHVNMSHASALMVMAPQGKAPKDEIVHRTGRQYVDPNGHGAGFPVHPKNRFDA RVVHQWTDYGALRERLGEARVQGPLTNGHATVFPNLSYLPVNGSVRIWHPKGPDKMEVWAWTIVDRSMPE EVRDAQRLYNLRTFGPTGIFEQDDGENWSEVQSISRGFVTNSVALNYQMGLDSEREDGRHPGLTSELYSD AAGRSFYARWRDLMNTKAWHEEHV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4370c | - | - | 100% (445) | putative large terminal subunit of phenylpropionate dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 8e-18 | 29.67% (209) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0662 | - | 3e-74 | 36.47% (425) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 1e-17 | 29.67% (209) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0212 | - | 9e-21 | 29.49% (234) | oxidoreductase |
| M. avium 104 | MAV_3509 | - | 3e-53 | 31.75% (441) | phthalate dioxygenase large subunit |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 7e-45 | 30.41% (365) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2967 | - | 7e-35 | 29.58% (426) | PUTATIVE putative Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_4884 | - | 2e-15 | 24.43% (397) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4415 | - | 1e-102 | 43.93% (428) | ring hydroxylating dioxygenase, alpha subunit |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLV--DSHGGLLDR--VIFTDG
Mvan_4415|M.vanbaalenii_PYR-1 -----------------------MIDFTDLV--DPEHGWVSP--QIYTDP
Mflv_0662|M.gilvum_PYR-GCK ------MTTETTGTADATDPYLRRALRDVAD--GLKVGRLPA--RVVSDP
MAV_3509|M.avium_104 ------MAGPDGG------------LLGVLE--NVRRGMIPA--HIYNDP
Mb3186c|M.bovis_AF2122/97 --------MLSTDNRAELGDILTDIGDYLDD--NPPALSLPP--AAYTSS
Rv3161c|M.tuberculosis_H37Rv --------MLSTDNRAELGDILTDIGDYLDD--NPPALSLPP--AAYTSS
TH_2967|M.thermoresistible__bu --------------------------MPVFP--TSDGSRIPY--EVYSSQ
MSMEG_1908|M.smegmatis_MC2_155 -----------MTTHLSPDHLENVLADAVIE--DPAAGVYRANRRIFTDD
MUL_4884|M.ulcerans_Agy99 ------MSSPTKPLVAEDAEIVRRVLAHIDAGTTDEGEAWREPVENYASP
MMAR_0212|M.marinum_M -------------MSTAAGNPARTRDEDAIG--VPPASPTLVPAQRYHSP
.
MAB_4370c|M.abscessus_ATCC_199 ELYRQELRRVFA-PSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRR
Mvan_4415|M.vanbaalenii_PYR-1 EIYERELQHVFG-RSWLFLAHDSQLPKPGSFLQTYMGEDPVLVVRQRDGS
Mflv_0662|M.gilvum_PYR-GCK ALHTIEMERIFG-RAWVFLGHESELAKSGDFVVRHIGADSVIVCRDNSGR
MAV_3509|M.avium_104 ELFALEKRRLFA-RAWTFVGHESEIPHDGDYMVRRVLDDSFIITRGSDGR
Mb3186c|M.bovis_AF2122/97 ELWQLERERIFN-RSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQ
Rv3161c|M.tuberculosis_H37Rv ELWQLERERIFN-RSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQ
TH_2967|M.thermoresistible__bu AVYDREQERLFRGPIWNFLALEAELPNPFDFKSTFVGDTPVVVTRDGEGR
MSMEG_1908|M.smegmatis_MC2_155 EIFELEMKHIFE-GNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGD
MUL_4884|M.ulcerans_Agy99 ERFAAELRLLRG--MPSVFVPSAAIPNNGDHVERTAFGVPLFAVRGADGR
MMAR_0212|M.marinum_M AFAQLEIERMWP-KVWQLACMLDHVAAPGDYFEYRCGPYSVLIVHDCDGV
* . : . .. ... .
MAB_4370c|M.abscessus_ATCC_199 IRAFLNSCRHRGARVCRADYGVTRGFTCTYHGWAYDLEGKLISVPNEE-G
Mvan_4415|M.vanbaalenii_PYR-1 VRAFLNQCRHRGMRICRSEAGVSKAFTCTYHGWSYDLAGNLINVPLEERA
Mflv_0662|M.gilvum_PYR-GCK IQALSNSCRHRGALVCRAEMGNTAHFQCPYHGWVYSNTGELVGVPAMTEA
MAV_3509|M.avium_104 VRALFNMCLHRGMQVCRAELGNASNFRCPYHGWTYRNDGRLTGLPFHREA
Mb3186c|M.bovis_AF2122/97 LHALSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAAN
Rv3161c|M.tuberculosis_H37Rv LHALSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAAN
TH_2967|M.thermoresistible__bu LAAWVNRCAHRGATVCREQTGNTRSHVCVYHQWSYNAAGDLEGVPFRRGA
MSMEG_1908|M.smegmatis_MC2_155 LHCLINACAHRGAMICRRKTDNRTTLTCPFHGWTFRNDGTLLKVKDPDGA
MUL_4884|M.ulcerans_Agy99 ARVFRNARRHRGFALVEN-AGCSHALVCRYHGWIYRLDGSLSHVPHAEAF
MMAR_0212|M.marinum_M LRAFQNVCRHRGNSLCAGSGSGLRELKCGYHGWTWDLTGELRRVPNRKGF
** : . * :* * : * *
MAB_4370c|M.abscessus_ATCC_199 YPDS---FSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRESLGDMAWYM
Mvan_4415|M.vanbaalenii_PYR-1 YHSS---IDKKEWGAMKVPRVANYRGFYFGTWSEETPEFDAYLGDMAFYF
Mflv_0662|M.gilvum_PYR-GCK YPG---GFDKSQWGLRHIPHVDSYAGFIFGSVDPKAPSLTDYLGDTTFYL
MAV_3509|M.avium_104 YGGDD-GFVKDQT-LLPAPNFAGYNGLLFISLDPAAPPLQDFLGDFRFYL
Mb3186c|M.bovis_AF2122/97 LDFN------RRECRLPQFAVATWNGLVWINLDADAEPIAAHLD----LT
Rv3161c|M.tuberculosis_H37Rv LDFN------RRECRLPQFAVATWNGLVWINLDADAEPIAAHLD----LT
TH_2967|M.thermoresistible__bu NGTGMPKSFDPTQNGLQKLRVESYRGLVFGTFDEATPDLLAYLGNQTPGL
MSMEG_1908|M.smegmatis_MC2_155 GYPDT-FNSNGSHNMTNVARFEGYRGFLFGSLNPDVLPLTEHLGDTTTVI
MUL_4884|M.ulcerans_Agy99 PDLD-----MSARGLVEVESHEVDGLIVIGPLDPVDAGLIEDEGAIGWLT
MMAR_0212|M.marinum_M GSLH------MPDFPLLPVRVETWEGLVFVSLDVTAMPLMDYLDPIPEDI
: . : .
MAB_4370c|M.abscessus_ATCC_199 DAM-LDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHASALM
Mvan_4415|M.vanbaalenii_PYR-1 DAI-VDRFDSGLEFVKGTTKWVIDCNWKFASEQFASDMYHTQSAHASALL
Mflv_0662|M.gilvum_PYR-GCK DLI-AKKTAGGLEVIGAPHRWVMSANWKTAADNFVGDSYHTLFAHRSMVE
MAV_3509|M.avium_104 DYY-TRQSAGGVELRG-PQRWRIRANWKIGAENFAGDMYHTPHTHASIVD
Mb3186c|M.bovis_AF2122/97 DDE-FAGYRLGEMVQVESWSHEWRANWKVAAEN-GHENYHVLGLHRQTLE
Rv3161c|M.tuberculosis_H37Rv DDE-FAGYRLGEMVQVESWSHEWRANWKVAAEN-GHENYHVLGLHRQTLE
TH_2967|M.thermoresistible__bu DRI-FHKP---IEYLG-CTRQRIRGNWKLYLEN-VRDGYHASLLHAFHST
MSMEG_1908|M.smegmatis_MC2_155 DML-VDQSPDGLEVLRGASTYTYDGNWKVQAEN-GADGYHVTATHWNYAA
MUL_4884|M.ulcerans_Agy99 DGSPWRAKLVPAERLIVVESTLREINWKVLVEQ-FLEGYHIRSTHKDTFF
MMAR_0212|M.marinum_M AWCGLSDFR-----CYATLTVEVDANWKTIADG-YSETYHIQTLHPELLR
*** : : ** *
MAB_4370c|M.abscessus_ATCC_199 VMA---PQGKAPKDEIVHRTGR----------------------QYVDPN
Mvan_4415|M.vanbaalenii_PYR-1 ALTD-DPNPIGPLND-PNVPGR----------------------QFSG-N
Mflv_0662|M.gilvum_PYR-GCK LGMAPGDPNFASAPAEISLQNG----------------------HGVGVL
MAV_3509|M.avium_104 IGLFREPKAQKRKDGATYWAHR----------------------GGGTTY
Mb3186c|M.bovis_AF2122/97 PFVP----------------------------------------------
Rv3161c|M.tuberculosis_H37Rv PFVP----------------------------------------------
TH_2967|M.thermoresistible__bu FNLVRSGQRVKIVVG-------------------------------DTHE
MSMEG_1908|M.smegmatis_MC2_155 TTSRRTCGESKNDTKALDAGSW----------------------GKSGGG
MUL_4884|M.ulcerans_Agy99 PVQY----------------------------------------------
MMAR_0212|M.marinum_M CVDDIHAPQQIWRHAGKSDQPYGVPSPRFEGTLSDQEVWDAYVYTQGALM
MAB_4370c|M.abscessus_ATCC_199 GHGAG-----FPVHPKNRFDARVVHQWTDYG-ALRERLGEARVQGPLTNG
Mvan_4415|M.vanbaalenii_PYR-1 GHGSGGYFLPAPVVKTPEMTDTMFEWFKSREEEMVARIGADRLS-KVSIT
Mflv_0662|M.gilvum_PYR-GCK GFPP----TLADFPEYEGYPDEVVDQMATSYPSPVHKDLMRRSS--FIH-
MAV_3509|M.avium_104 KLPPG---GFEERMRYVGYPDEMIGRIKQVWT-PRQQRVVGEDG--FMVS
Mb3186c|M.bovis_AF2122/97 --GGG----DLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKS---NLV
Rv3161c|M.tuberculosis_H37Rv --GGG----DLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKS---NLV
TH_2967|M.thermoresistible__bu VHNCGDLFYTEDPTKGAAYANVTSFKEGLRLENPELVENWQEFDEIITNH
MSMEG_1908|M.smegmatis_MC2_155 YWSFPHGHLCLWTWAANPQDRPLWDRLDELKARFGDAKGEFMVK---GSR
MUL_4884|M.ulcerans_Agy99 --------DDLNVVEAFGPNTRITFPYRNIERLRDRPEHTWTTG-ARVTY
MMAR_0212|M.marinum_M GAAEGTPLPADERRPGQSVQDLIAARTRAFAATRGVDLEWADTDRITRLH
MAB_4370c|M.abscessus_ATCC_199 HATVFPNLSYLP--------------VNGSVRIWHPKGPDKMEVWAWTIV
Mvan_4415|M.vanbaalenii_PYR-1 HNTIFPNFSWLG--------------AHSTMRVWHPRGPGQIEVWAWTYV
Mflv_0662|M.gilvum_PYR-GCK -GTVFPNLSFIN--VTLAQDHMSPPTPFITFRVWHPLSHDRMEILSWFLV
MAV_3509|M.avium_104 AATCFPNLSFVHNWPKVRDGRDDETLPFISIRLWQPISENETEVCSWFAV
Mb3186c|M.bovis_AF2122/97 VLWTFPNSALAI---------------AGERVVWFGFIPQSIDRVQVLGG
Rv3161c|M.tuberculosis_H37Rv VLWTFPNSALAI---------------AGERVVWFGFIPQSIDRVQVLGG
TH_2967|M.thermoresistible__bu LQCIFPQLVVMQIQN------------VLAVRNVLPKGVDEFELIFNFFG
MSMEG_1908|M.smegmatis_MC2_155 NLCLYPNVYVMD-------------QFSTQIRHFRPIAPDKTEVTIYCIA
MUL_4884|M.ulcerans_Agy99 LYQLFPNVMLAT---------------FPDVIAMVVIDPVSVDRTAVTIY
MMAR_0212|M.marinum_M QYNVFPNMTFLAN-------ADHLTIMCSRPQPEHFADPDKGEMVMFLMT
:*: :
MAB_4370c|M.abscessus_ATCC_199 DRSMPEEVRDAQRLYNLRTFGPTGIFEQDDGENWSEVQSISRGFVTNSVA
Mvan_4415|M.vanbaalenii_PYR-1 PKDAPPKVKNEIRELTQRTFSPAGSFETDDGENWTEIQQVLRGSQARRNR
Mflv_0662|M.gilvum_PYR-GCK ERDAPEWLRDASQASYVNNFGPGGVFEQDDAEAWKAITESVQGPFAGEGL
MAV_3509|M.avium_104 DSAAPAHYKQDSYKAYLMCFGSTGMFEQDDVENWVSLTTTAGGSMARRLL
Mb3186c|M.bovis_AF2122/97 VLTTPELAADAAATAQTSQF-VMAMINDEDRLGLEAVQVGAGSRFAERGH
Rv3161c|M.tuberculosis_H37Rv VLTTPELAADAAATAQTSQF-VMAMINDEDRLGLEAVQVGAGSRFAERGH
TH_2967|M.thermoresistible__bu YADDTPEMRR-HRIAQFNLVGPAGLISMEDGEAIELVQRATAVGPAGEAI
MSMEG_1908|M.smegmatis_MC2_155 PKGESAAARAHRIRQYEDFFNASGMATPDDLEEFRSCQLTFRAQAAPWND
MUL_4884|M.ulcerans_Agy99 SMVTPDVAERDSLDASSNLAGAGSFIGQGLFEDNEMSEGVQRGLAAGANA
MMAR_0212|M.marinum_M RMPPDAPHNKPTDVRMAADQAEPGIVLTQDIRVLPGVQRGLHQPGFTHLV
.
MAB_4370c|M.abscessus_ATCC_199 LNYQMG---------LDSEREDGR-HPGLTS-ELYSDAAGRSFYARWRDL
Mvan_4415|M.vanbaalenii_PYR-1 LHTAMG---------VGYEERDAFGLPGLGN-DVYSETAARGFYRHWLDM
Mflv_0662|M.gilvum_PYR-GCK LNYEMG---------MDLTPLTDWPGPGEALPSGYAEQNQRRFWGRWLEY
MAV_3509|M.avium_104 LNSRMGLYDDG-RPVVEALAPSAFHGPGRAQ-VGYNEHNQRALLAMWADY
Mb3186c|M.bovis_AF2122/97 LSSKEWP-------------------------------GMLAFYRNLAMA
Rv3161c|M.tuberculosis_H37Rv LSSKEWP-------------------------------GMLAFYRNLAMA
TH_2967|M.thermoresistible__bu ALMALEA------------------DEEHRNQHPISEDAIRRFWVGYQKL
MSMEG_1908|M.smegmatis_MC2_155 MSRGAQHWLSGPDPVAESLGMHGIVSSGLRNEDEGLYPVQHGYWLETLRR
MUL_4884|M.ulcerans_Agy99 FVEFGRH-----------------------------ESAVGRFHAALGRR
MMAR_0212|M.marinum_M LSGEERR-----------------IINMHRNLERYLDLPEPERMSGGGLR
MAB_4370c|M.abscessus_ATCC_199 MNTKAWHEEHV-----------------
Mvan_4415|M.vanbaalenii_PYR-1 LTGKPWSEIQKWTPNGNHGELRDEGVTA
Mflv_0662|M.gilvum_PYR-GCK MGQPPAFGGRA-----------------
MAV_3509|M.avium_104 LQEGDACENR------------------
Mb3186c|M.bovis_AF2122/97 LVGDHPGAS-------------------
Rv3161c|M.tuberculosis_H37Rv LVGDHPGAS-------------------
TH_2967|M.thermoresistible__bu MGL-------------------------
MSMEG_1908|M.smegmatis_MC2_155 AVTSNPTEH-------------------
MUL_4884|M.ulcerans_Agy99 LARLTSAG--------------------
MMAR_0212|M.marinum_M PGPGAPRV--------------------