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MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHW ALTKYDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAA VRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFD EFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGV LALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDE SKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGI KTLPVTWS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | - | 100% (428) | Probable cytochrome P450 124 CYP124 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 5e-82 | 42.03% (395) | cytochrome P450 125 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 1e-60 | 37.89% (417) | cytochrome P450 126 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 0.0 | 100.00% (428) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_3307 | - | 0.0 | 73.27% (419) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-41 | 30.91% (427) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 6e-78 | 41.77% (395) | cytochrome P450 |
| M. marinum M | MMAR_3361 | cyp124A1 | 0.0 | 85.21% (426) | cytochrome P450 124A1, Cyp124A1 |
| M. avium 104 | MAV_2174 | - | 0.0 | 83.89% (422) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 0.0 | 74.88% (422) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_4175 | - | 1e-179 | 72.46% (414) | PUTATIVE linalool 8-monooxygenase |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 0.0 | 84.74% (426) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 0.0 | 72.90% (428) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2266|M.tuberculosis_H37Rv --------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGA
Mb2289|M.bovis_AF2122/97 --------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGA
MMAR_3361|M.marinum_M ----MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGA
MUL_1282|M.ulcerans_Agy99 ----MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGA
MAV_2174|M.avium_104 ----MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRDGA
Mflv_3307|M.gilvum_PYR-GCK -----MDGMSLDAHPVRR-NGIAPPEVPLADIDLGSWEFWGLDDDFRDGA
Mvan_3029|M.vanbaalenii_PYR-1 ----MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGA
MSMEG_3551|M.smegmatis_MC2_155 --------MGIAP----RVNGAAPPDVPLSEINLGSWDFWALDDDIRDGA
TH_4175|M.thermoresistible__bu --------MGIAA----RVNGAAPPPVPLADINLGDWTFWALDDDIRDGA
MAB_0101|M.abscessus_ATCC_1997 -----------------MTTCPFTPGFDFTDPDL-------IQHRIPAEE
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . :
Rv2266|M.tuberculosis_H37Rv FATLRREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSY
Mb2289|M.bovis_AF2122/97 FATLRREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSY
MMAR_3361|M.marinum_M FATLRREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSS
MUL_1282|M.ulcerans_Agy99 FATLRREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSS
MAV_2174|M.avium_104 FATLRREAPISFWPAIEMDGFV-AGNGYWALTKHEDVHFASRHPEIFSSV
Mflv_3307|M.gilvum_PYR-GCK FATLRREAPVSFHRAYITDEDA-EVAGHWALTRHDDVFFASRHPEIFSSA
Mvan_3029|M.vanbaalenii_PYR-1 FATLRREAPISFHEAYVIDPDN-EVAGHWALTRHDDVFYASRHPEIFSSA
MSMEG_3551|M.smegmatis_MC2_155 FATLRREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSA
TH_4175|M.thermoresistible__bu FATLRREAPISFHPEYVDGGGT----GHWALTRYDDVFHASRHPEVFSSA
MAB_0101|M.abscessus_ATCC_1997 FAYLRKTEPIWWNAQPRGVAGF-DDDGYWVVTKHADVKEVSRLNEVFSNS
MLBr_02088|M.leprae_Br4923 FPVYR--ALIDYGP-MQLPGMP-----LTVFSSFSDCDEALRHPLSASDR
*. * : : ..: . * . * .
Rv2266|M.tuberculosis_H37Rv PNITIN----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPKVVA
Mb2289|M.bovis_AF2122/97 PNITIN----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPKVVA
MMAR_3361|M.marinum_M PNIVIH----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPKVVA
MUL_1282|M.ulcerans_Agy99 PNIVIH----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPKVVA
MAV_2174|M.avium_104 PNITIN----DQTPELAEYFGS--MIVLDDPRHQRLRSIVSRAFTPKVVA
Mflv_3307|M.gilvum_PYR-GCK LGITVG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPRVLA
Mvan_3029|M.vanbaalenii_PYR-1 LGITVG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPRVLA
MSMEG_3551|M.smegmatis_MC2_155 SGIVIG----DQTPELAEYFGS--MIAMDDPRHTRLRNIVRSAFTPRVLA
TH_4175|M.thermoresistible__bu SGITLG----EQNPDLTEYFGS--MIAMDDPRHGRLRGIVRSAFTPRVVA
MAB_0101|M.abscessus_ATCC_1997 VNTTVVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLFTPKAVN
MLBr_02088|M.leprae_Br4923 LKATLAQQAIAAGAEPRPFYASS-FMFLDPPDHTRLRKLVSKAFAPKVVQ
.: .: . :: :* * * ** :* *:*:.:
Rv2266|M.tuberculosis_H37Rv RIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKA
Mb2289|M.bovis_AF2122/97 RIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKA
MMAR_3361|M.marinum_M RIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEE
MUL_1282|M.ulcerans_Agy99 RIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEE
MAV_2174|M.avium_104 RIEASVRERARRLVSSLVANHPNGEAELVSELAGPLPLQVICDMMGIPEE
Mflv_3307|M.gilvum_PYR-GCK LIEDSVRQRARRLVEDMVAAHPDGRGELVSELAGPLPLQIICDMMGIPPR
Mvan_3029|M.vanbaalenii_PYR-1 LIEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEE
MSMEG_3551|M.smegmatis_MC2_155 VIEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIPES
TH_4175|M.thermoresistible__bu RTEESVRRRARRLVAAMVAGHPAGAAELVSAFAGPLPLQVICDMMGIPET
MAB_0101|M.abscessus_ATCC_1997 GLHARLVERAHGIVEEAAEKS---SGNFVSDIASVLPMHAIADLVGIPES
MLBr_02088|M.leprae_Br4923 ALEGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPYE
. : . :: :.:: :* *.: *. ::*:*
Rv2266|M.tuberculosis_H37Rv DHQRIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATALAED
Mb2289|M.bovis_AF2122/97 DHQRIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATALAED
MMAR_3361|M.marinum_M DHEQIFHWTNVILGFGDPDLTTD------FDEFLQVSMAIGGYATALADD
MUL_1282|M.ulcerans_Agy99 DHEQIFHWTNVILGFGDPDLTTD------FDDFLQVSMAIGGYATALADD
MAV_2174|M.avium_104 DHQRVFHWTNVILGFGDPDLATD------FEEFLQVSMDIGAYATALAED
Mflv_3307|M.gilvum_PYR-GCK DHQKIFHWTNVILGFGDPDIATD------FDEFVSVAMGIGAYASELADD
Mvan_3029|M.vanbaalenii_PYR-1 DHQKIFHWTNVILGFGDPDIATD------FDEFVSVAMGIGAYATQLADD
MSMEG_3551|M.smegmatis_MC2_155 DHQQIFHWTNVILGFGDPDLTTD------FDEFVTVAMDIGAYATALADQ
TH_4175|M.thermoresistible__bu DHQQIFHWTNVILGFGDPDLTTD------YDEFVQVAVDIGGYATDLAEQ
MAB_0101|M.abscessus_ATCC_1997 DRQQVLDWTNQMFAYDDPAIGRD------TATTATVSMLG--YAYAMAEE
MLBr_02088|M.leprae_Br4923 DAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKC
* .. : :. ** : .. * :..
Rv2266|M.tuberculosis_H37Rv RRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHG
Mb2289|M.bovis_AF2122/97 RRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHG
MMAR_3361|M.marinum_M RRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHG
MUL_1282|M.ulcerans_Agy99 RRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHG
MAV_2174|M.avium_104 RRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETTRNAISHG
Mflv_3307|M.gilvum_PYR-GCK RRAHPGDDLTTALIEAELDGERLTSAEVASFFILLVVAGNETTRNAISHG
Mvan_3029|M.vanbaalenii_PYR-1 RRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAISHG
MSMEG_3551|M.smegmatis_MC2_155 RRSAPADDLTTSLVQAEVDGERLTSAEVASFFILLVVAGNETTRNAISHG
TH_4175|M.thermoresistible__bu RRKNPGPDLTTSLVQAEVDGEQLTSADIASFFILLVVAGNETTRNAISHG
MAB_0101|M.abscessus_ATCC_1997 RQLNPQDDILTGLVRGAYDDRPLTPLEFAYFVIQLMVAGNETSRNAITHG
MLBr_02088|M.leprae_Br4923 RRGTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANA
*: *: : *: .. *: :. *:***:**: * *::.
Rv2266|M.tuberculosis_H37Rv VLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELR
Mb2289|M.bovis_AF2122/97 VLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELR
MMAR_3361|M.marinum_M MLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLR
MUL_1282|M.ulcerans_Agy99 MLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLR
MAV_2174|M.avium_104 VLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLR
Mflv_3307|M.gilvum_PYR-GCK VLALSRYPEERDRWWSDYAGLAPTAVEEIVRWASPVAYMRRTATRDVEVG
Mvan_3029|M.vanbaalenii_PYR-1 VLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMS
MSMEG_3551|M.smegmatis_MC2_155 VLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRDTELA
TH_4175|M.thermoresistible__bu MLALTRHPDQRQDWWDHFDEVTPTAVEEIVRWASPVTYMRRTVTRDTELR
MAB_0101|M.abscessus_ATCC_1997 VLAFADNP---AQWRLYRERRPSTAADEIIRWASPIIAFQRTALQDVELG
MLBr_02088|M.leprae_Br4923 VLAMLRNPSQWKALSSNPQR-APLVVEETLRYDPAIHLIGRVAAKDMTIG
:**: * .. ..:* :*: ..: : *. :* :
Rv2266|M.tuberculosis_H37Rv GTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFC
Mb2289|M.bovis_AF2122/97 GTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFC
MMAR_3361|M.marinum_M GTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFC
MUL_1282|M.ulcerans_Agy99 GTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFC
MAV_2174|M.avium_104 GTKMKAGDKVALWYNSANRDESTFDNPWLFDVARTPNPHLGFGGGGAHFC
Mflv_3307|M.gilvum_PYR-GCK GQTIAAGDKVTLWYGSANRDETKFDNPWLFDVGRHPNPHVGFGGGGAHFC
Mvan_3029|M.vanbaalenii_PYR-1 GVRIAAGDKVSLWYGSANRDESKFENPWLFDVGRHPNPHVGFGGGGAHFC
MSMEG_3551|M.smegmatis_MC2_155 GTALPAGSKVTLWYGSANRDETKFDNPWMFDVQRHPNPHVGFGGGGAHFC
TH_4175|M.thermoresistible__bu GVRMAAGDKVTLWYGSANRDESRFSDPWLFDVRRHPNPHVGFGGGGVHFC
MAB_0101|M.abscessus_ATCC_1997 GVQIRKDQRVGMFYASANFDEDVFDDPFAFNIERDPNPHLAFGGHGIHYC
MLBr_02088|M.leprae_Br4923 QTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFC
: .. : : :** * : * *: * .. ::.*. *:*
Rv2266|M.tuberculosis_H37Rv LGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT-------
Mb2289|M.bovis_AF2122/97 LGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT-------
MMAR_3361|M.marinum_M LGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR-------
MUL_1282|M.ulcerans_Agy99 LGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR-------
MAV_2174|M.avium_104 LGANLARREIRVVFDELRHEIPDIVATEEPARLLSQFIHGIKR-------
Mflv_3307|M.gilvum_PYR-GCK LGANLARREITVAFEELHRLVPDIHATEEPGRLHSAFIHGIKT-------
Mvan_3029|M.vanbaalenii_PYR-1 LGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAFIHGIKR-------
MSMEG_3551|M.smegmatis_MC2_155 LGANLARREITVLFSELHRHLPDIVATEEPDRLQSAFIHGIKR-------
TH_4175|M.thermoresistible__bu LGANLARREIAVAFDELRRQVPDIEVTEEPDRLHSAFIHGIXXXAEPESL
MAB_0101|M.abscessus_ATCC_1997 LGANLARLEIGIMFDALADRLPDLMPTGAPTRFRSGWINGVVA-------
MLBr_02088|M.leprae_Br4923 LGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSA-------
*** *** * : :. : .* : . . :.*:
Rv2266|M.tuberculosis_H37Rv -------------------------------------LPVTWS-------
Mb2289|M.bovis_AF2122/97 -------------------------------------LPVTWS-------
MMAR_3361|M.marinum_M -------------------------------------LPVAWSR------
MUL_1282|M.ulcerans_Agy99 -------------------------------------LPVAWSR------
MAV_2174|M.avium_104 -------------------------------------LPVAWTPPR----
Mflv_3307|M.gilvum_PYR-GCK -------------------------------------LPVAWTPPTR---
Mvan_3029|M.vanbaalenii_PYR-1 -------------------------------------LPVSWSA------
MSMEG_3551|M.smegmatis_MC2_155 -------------------------------------LPVAWR-------
TH_4175|M.thermoresistible__bu PEPPPVASPSEALVNPRFLVAPPEPPAVGPSAFVPPMLGVSSSAPTSTER
MAB_0101|M.abscessus_ATCC_1997 -------------------------------------LPANYHGSGPRG-
MLBr_02088|M.leprae_Br4923 -------------------------------------LPVQV--------
* .
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu SSSSEPASVSTTSTPPFSEVASVRAALLAFLAGLSTKPATSTVSASDPWP
MAB_0101|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu VLSPTASPPLASPSPSSKPTATNSPLPVLGSPTPPAADGADFSAALNNPP
MAB_0101|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv ----------------------------------------
Mb2289|M.bovis_AF2122/97 ----------------------------------------
MMAR_3361|M.marinum_M ----------------------------------------
MUL_1282|M.ulcerans_Agy99 ----------------------------------------
MAV_2174|M.avium_104 ----------------------------------------
Mflv_3307|M.gilvum_PYR-GCK ----------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 ----------------------------------------
TH_4175|M.thermoresistible__bu KGFVGTPPEAPSASAIARGRVTVSTSTSPGIPSAPTRSPG
MAB_0101|M.abscessus_ATCC_1997 ----------------------------------------
MLBr_02088|M.leprae_Br4923 ----------------------------------------