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DLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLTAGK GHWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARI EASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHEQIFHWTNVILGFGDPDLTT DFDDFLQVSMAIGGYATALADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTIS HGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTKMAAGDKVTLWYCSAN RDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFI HGIKRLPVAWSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | - | 100% (433) | cytochrome P450 124A1, Cyp124A1 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 9e-76 | 39.09% (394) | cytochrome P450 125A7 Cyp125A7 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 2e-59 | 34.34% (399) | cytochrome P450 108B4 Cyp108B4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 0.0 | 84.74% (426) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_3307 | - | 0.0 | 72.55% (419) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 0.0 | 84.74% (426) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-37 | 31.72% (331) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 5e-78 | 39.29% (392) | cytochrome P450 |
| M. marinum M | MMAR_3361 | cyp124A1 | 0.0 | 99.31% (433) | cytochrome P450 124A1, Cyp124A1 |
| M. avium 104 | MAV_2174 | - | 0.0 | 81.71% (432) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 0.0 | 73.52% (423) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_4175 | - | 1e-176 | 71.33% (415) | PUTATIVE linalool 8-monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 0.0 | 69.91% (432) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MMAR_3361|M.marinum_M MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
MAV_2174|M.avium_104 MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRDGAFATL
Mflv_3307|M.gilvum_PYR-GCK -MDGMSLDAHPVRR-NGIAPPEVPLADIDLGSWEFWGLDDDFRDGAFATL
Mvan_3029|M.vanbaalenii_PYR-1 MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATL
MSMEG_3551|M.smegmatis_MC2_155 ----MGIAP----RVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATL
TH_4175|M.thermoresistible__bu ----MGIAA----RVNGAAPPPVPLADINLGDWTFWALDDDIRDGAFATL
MAB_1211c|M.abscessus_ATCC_199 -----------MTAMKTAAELGLPEG-FDFTDPELYG--NRMPHEEFATL
MLBr_02088|M.leprae_Br4923 ----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGT
: : .
MUL_1282|M.ulcerans_Agy99 RREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSSPNIV
MMAR_3361|M.marinum_M RREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSSPNIV
Mb2289|M.bovis_AF2122/97 RREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSYPNIT
Rv2266|M.tuberculosis_H37Rv RREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSYPNIT
MAV_2174|M.avium_104 RREAPISFWPAIEMDGFV-AGNGYWALTKHEDVHFASRHPEIFSSVPNIT
Mflv_3307|M.gilvum_PYR-GCK RREAPVSFHRAYITDEDA-EVAGHWALTRHDDVFFASRHPEIFSSALGIT
Mvan_3029|M.vanbaalenii_PYR-1 RREAPISFHEAYVIDPDN-EVAGHWALTRHDDVFYASRHPEIFSSALGIT
MSMEG_3551|M.smegmatis_MC2_155 RREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIV
TH_4175|M.thermoresistible__bu RREAPISFHPEYVDGGGT----GHWALTRYDDVFHASRHPEVFSSASGIT
MAB_1211c|M.abscessus_ATCC_199 RREAPVWWNPQPRTVGGF-ADEGYWVISKHRDVREVSLHTDTFSSGRKGA
MLBr_02088|M.leprae_Br4923 RADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKAT
* :. : .:: . * . *. . .
MUL_1282|M.ulcerans_Agy99 IH----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
MMAR_3361|M.marinum_M IH----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
Mb2289|M.bovis_AF2122/97 IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAA
Rv2266|M.tuberculosis_H37Rv IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAA
MAV_2174|M.avium_104 IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
Mflv_3307|M.gilvum_PYR-GCK VG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDS
Mvan_3029|M.vanbaalenii_PYR-1 VG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDS
MSMEG_3551|M.smegmatis_MC2_155 IG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDS
TH_4175|M.thermoresistible__bu LG----EQNPD-LTEYFGSMIAMDDPRHGRLRGIVRSAFTPRVVARTEES
MAB_1211c|M.abscessus_ATCC_199 IPRLEDHISPEEFQATLSVLINKDAPEHTQLRGLVSRMFTPRSIAALRIT
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGD
: .: . :: * * * :** :* *:*: : .
MUL_1282|M.ulcerans_Agy99 VRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHEQI
MMAR_3361|M.marinum_M VRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHEQI
Mb2289|M.bovis_AF2122/97 VRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRI
Rv2266|M.tuberculosis_H37Rv VRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRI
MAV_2174|M.avium_104 VRERARRLVSSLVANHPNGEAELVSELAGPLPLQVICDMMGIPEEDHQRV
Mflv_3307|M.gilvum_PYR-GCK VRQRARRLVEDMVAAHPDGRGELVSELAGPLPLQIICDMMGIPPRDHQKI
Mvan_3029|M.vanbaalenii_PYR-1 VRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKI
MSMEG_3551|M.smegmatis_MC2_155 VRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQI
TH_4175|M.thermoresistible__bu VRRRARRLVAAMVAGHPAGAAELVSAFAGPLPLQVICDMMGIPETDHQQI
MAB_1211c|M.abscessus_ATCC_199 LEERAERIVRAALEG---GHGEFVREVASELPMQAIAELIGVPEEDRVKL
MLBr_02088|M.leprae_Br4923 IAALVDSLLD---KGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEF
: . :: :.: .* *.: *. ::*:* * ..
MUL_1282|M.ulcerans_Agy99 FHWTNVILGFGDPDLTTDFDDFLQVSMAIGG------YATALADDRRVNH
MMAR_3361|M.marinum_M FHWTNVILGFGDPDLTTDFDEFLQVSMAIGG------YATALADDRRVNH
Mb2289|M.bovis_AF2122/97 FHWTNVILGFGDPDLATDFDEFMQVSADIGA------YATALAEDRRVNH
Rv2266|M.tuberculosis_H37Rv FHWTNVILGFGDPDLATDFDEFMQVSADIGA------YATALAEDRRVNH
MAV_2174|M.avium_104 FHWTNVILGFGDPDLATDFEEFLQVSMDIGA------YATALAEDRRVNH
Mflv_3307|M.gilvum_PYR-GCK FHWTNVILGFGDPDIATDFDEFVSVAMGIGA------YASELADDRRAHP
Mvan_3029|M.vanbaalenii_PYR-1 FHWTNVILGFGDPDIATDFDEFVSVAMGIGA------YATQLADDRRDHP
MSMEG_3551|M.smegmatis_MC2_155 FHWTNVILGFGDPDLTTDFDEFVTVAMDIGA------YATALADQRRSAP
TH_4175|M.thermoresistible__bu FHWTNVILGFGDPDLTTDYDEFVQVAVDIGG------YATDLAEQRRKNP
MAB_1211c|M.abscessus_ATCC_199 FEWSNQMTGYDEADVEIDP---RVGAAQILG------YSYQLAEQRRDCP
MLBr_02088|M.leprae_Br4923 GRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTP
. : : :. : : . * *.. **
MUL_1282|M.ulcerans_Agy99 HGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLALS
MMAR_3361|M.marinum_M HGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALS
Mb2289|M.bovis_AF2122/97 HDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALS
Rv2266|M.tuberculosis_H37Rv HDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALS
MAV_2174|M.avium_104 HDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETTRNAISHGVLALS
Mflv_3307|M.gilvum_PYR-GCK GDDLTTALIEAELDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALS
Mvan_3029|M.vanbaalenii_PYR-1 GDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALS
MSMEG_3551|M.smegmatis_MC2_155 ADDLTTSLVQAEVDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALT
TH_4175|M.thermoresistible__bu GPDLTTSLVQAEVDGEQLTSADIASFFILLVVAGNETTRNAISHGMLALT
MAB_1211c|M.abscessus_ATCC_199 GNDVVSRLLTGTVDGEQLTPEQFGFFVVMLSVAGNETTRNATTMGMMAFL
MLBr_02088|M.leprae_Br4923 GEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
*: : *: .*::*: :. :* ***:*** * : .::*:
MUL_1282|M.ulcerans_Agy99 RYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTKMA
MMAR_3361|M.marinum_M RYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMA
Mb2289|M.bovis_AF2122/97 RYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
Rv2266|M.tuberculosis_H37Rv RYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
MAV_2174|M.avium_104 RYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRGTKMK
Mflv_3307|M.gilvum_PYR-GCK RYPEERDRWWSDYAGLAPTAVEEIVRWASPVAYMRRTATRDVEVGGQTIA
Mvan_3029|M.vanbaalenii_PYR-1 RYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIA
MSMEG_3551|M.smegmatis_MC2_155 RYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRDTELAGTALP
TH_4175|M.thermoresistible__bu RHPDQRQDWWDHFDEVTPTAVEEIVRWASPVTYMRRTVTRDTELRGVRMA
MAB_1211c|M.abscessus_ATCC_199 EHPGQWELFKS---ARPSTTVDEIVRYTSPLISQQRTALQDTVISDVRIR
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
. * : . .. .*:* :*: ..: *. :* : :
MUL_1282|M.ulcerans_Agy99 AGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGANL
MMAR_3361|M.marinum_M AGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGANL
Mb2289|M.bovis_AF2122/97 AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANL
Rv2266|M.tuberculosis_H37Rv AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANL
MAV_2174|M.avium_104 AGDKVALWYNSANRDESTFDNPWLFDVARTPNPHLGFGGGGAHFCLGANL
Mflv_3307|M.gilvum_PYR-GCK AGDKVTLWYGSANRDETKFDNPWLFDVGRHPNPHVGFGGGGAHFCLGANL
Mvan_3029|M.vanbaalenii_PYR-1 AGDKVSLWYGSANRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANL
MSMEG_3551|M.smegmatis_MC2_155 AGSKVTLWYGSANRDETKFDNPWMFDVQRHPNPHVGFGGGGAHFCLGANL
TH_4175|M.thermoresistible__bu AGDKVTLWYGSANRDESRFSDPWLFDVRRHPNPHVGFGGGGVHFCLGANL
MAB_1211c|M.abscessus_ATCC_199 AGERVVMLYPSANFDEEVFENPHTFDITRDPNPHLGFGGTGAHYCLGANL
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGAAL
*. : : :** * : * ** * .. ::.*. *:**** *
MUL_1282|M.ulcerans_Agy99 ARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR------------
MMAR_3361|M.marinum_M ARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR------------
Mb2289|M.bovis_AF2122/97 ARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT------------
Rv2266|M.tuberculosis_H37Rv ARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT------------
MAV_2174|M.avium_104 ARREIRVVFDELRHEIPDIVATEEPARLLSQFIHGIKR------------
Mflv_3307|M.gilvum_PYR-GCK ARREITVAFEELHRLVPDIHATEEPGRLHSAFIHGIKT------------
Mvan_3029|M.vanbaalenii_PYR-1 ARREITVAFEELHRLVPGIRAVEEPDRLHSAFIHGIKR------------
MSMEG_3551|M.smegmatis_MC2_155 ARREITVLFSELHRHLPDIVATEEPDRLQSAFIHGIKR------------
TH_4175|M.thermoresistible__bu ARREIAVAFDELRRQVPDIEVTEEPDRLHSAFIHGIXXXAEPESLPEPPP
MAB_1211c|M.abscessus_ATCC_199 AKAELEIIFNKIADRMPDISRIGDAPRFHSGWINGIKK------------
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSA------------
*: * : :. : .* : : . :.*:
MUL_1282|M.ulcerans_Agy99 --------------------------------LPVAWSR-----------
MMAR_3361|M.marinum_M --------------------------------LPVAWSR-----------
Mb2289|M.bovis_AF2122/97 --------------------------------LPVTWS------------
Rv2266|M.tuberculosis_H37Rv --------------------------------LPVTWS------------
MAV_2174|M.avium_104 --------------------------------LPVAWTPPR---------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------LPVAWTPPTR--------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------LPVSWSA-----------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------LPVAWR------------
TH_4175|M.thermoresistible__bu VASPSEALVNPRFLVAPPEPPAVGPSAFVPPMLGVSSSAPTSTERSSSSE
MAB_1211c|M.abscessus_ATCC_199 --------------------------------FDTAYCPVTH--------
MLBr_02088|M.leprae_Br4923 --------------------------------LPVQV-------------
: .
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu PASVSTTSTPPFSEVASVRAALLAFLAGLSTKPATSTVSASDPWPVLSPT
MAB_1211c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu ASPPLASPSPSSKPTATNSPLPVLGSPTPPAADGADFSAALNNPPKGFVG
MAB_1211c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 -----------------------------------
MMAR_3361|M.marinum_M -----------------------------------
Mb2289|M.bovis_AF2122/97 -----------------------------------
Rv2266|M.tuberculosis_H37Rv -----------------------------------
MAV_2174|M.avium_104 -----------------------------------
Mflv_3307|M.gilvum_PYR-GCK -----------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 -----------------------------------
MSMEG_3551|M.smegmatis_MC2_155 -----------------------------------
TH_4175|M.thermoresistible__bu TPPEAPSASAIARGRVTVSTSTSPGIPSAPTRSPG
MAB_1211c|M.abscessus_ATCC_199 -----------------------------------
MLBr_02088|M.leprae_Br4923 -----------------------------------