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RRARNTDSPTEQESAILKAAAEEVALVGVGRLSMDVVARQAGVSRSTLYRRFPSRDALITELGRQTFEFA MARLQTVAIDDGPQQAAVAAFREGVRLLTGEPVMRRFLQLDGEFTATTEMVAEARLFLVSAATAMAKALR AAGATMPDSELLAVAEVHIRLAASLVQVNTDVLDVTDDEAVARYARTYLAPLVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5272 | - | - | 100% (195) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0059 | - | 7e-09 | 29.23% (195) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0142 | - | 1e-08 | 27.53% (178) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2274c | - | 2e-08 | 25.60% (168) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv2250c | - | 6e-08 | 26.19% (168) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00064 | - | 9e-06 | 33.33% (78) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4647 | - | 4e-26 | 37.50% (192) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0287 | - | 2e-26 | 34.57% (188) | transcriptional regulatory protein |
| M. avium 104 | MAV_5227 | - | 8e-22 | 32.97% (185) | TetR-family protein transcriptional regulator, putative |
| M. smegmatis MC2 155 | MSMEG_5340 | - | 6e-09 | 46.27% (67) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_1508 | - | 1e-09 | 30.00% (180) | Possible transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_4837 | - | 2e-26 | 34.57% (188) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0969 | - | 3e-92 | 91.24% (194) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2274c|M.bovis_AF2122/97 --------------MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEI
Rv2250c|M.tuberculosis_H37Rv --------------MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEI
TH_1508|M.thermoresistible__bu ------------------------VEDRILDAAAASVLAVGVNRVTLTDI
Mflv_5272|M.gilvum_PYR-GCK ------------MRRARNTDSPTEQESAILKAAAEEVALVGVGRLSMDVV
Mvan_0969|M.vanbaalenii_PYR-1 ------------MRRTRTRNTPTEQESAILKAAAEEVALVGVGRLSMDVV
MMAR_0287|M.marinum_M -----MQSRMGTETSTDGVESITDLDRTILDTARAVFETYGVRRANIEDV
MUL_4837|M.ulcerans_Agy99 ---------MGTETSTDGVESITDLDRTILDTAHAVFETYGVRRANIEDV
MAV_5227|M.avium_104 ---------MQSHRADAAAGERTDLDRLILDTARGVFETYGVRRANIDDV
MAB_4647|M.abscessus_ATCC_1997 ---------MTTLLRVTTSAPPTD---AVLDAARTEFERHGMRRANMDAI
MSMEG_5340|M.smegmatis_MC2_155 -----MAEKSAPRRTSGGPVLLDDVTTAIEKAFFEELAAVGYGRLSVDAV
MLBr_00064|M.leprae_Br4923 MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYL
: : . . .: :
Mb2274c|M.bovis_AF2122/97 ARRAGVSRPTVYRRWPDTRSIMASMLTSHIAAVLREVPLDGDD---REAL
Rv2250c|M.tuberculosis_H37Rv ARRAGVSRPTVYRRWPDTRSIMASMLTSHIADVLREVPLDGDD---REAL
TH_1508|M.thermoresistible__bu ARRARVSRPTIYRRWPDTNALLASLLTTRITAVLDEVPTRGND---RESL
Mflv_5272|M.gilvum_PYR-GCK ARQAGVSRSTLYRRFPSRDALITELGRQTFEFAMARLQTVAIDDGPQQAA
Mvan_0969|M.vanbaalenii_PYR-1 ARQAGVSRSTLYRRFPTRDALITELGRQTFDFAMARLQTVAIDSGPQQAA
MMAR_0287|M.marinum_M ATRAGVSRSTIYRRFPTKDELFERVVRREAELFFAALNQATNGHNPREAV
MUL_4837|M.ulcerans_Agy99 ATRAGVSRSTIYRRFPTKDELFERVVRREAELFFAALNQATNGHNPREAV
MAV_5227|M.avium_104 AARAGVSRSTIYRRFPTKKNLFGQVVRREAELFFSTLDQATAGCDPQQAV
MAB_4647|M.abscessus_ATCC_1997 ARRAGVSRRTLYRRFPTKEALFEHLIEAESITVFGQLAVAANGQDAPGAI
MSMEG_5340|M.smegmatis_MC2_155 ARRAGVGKAAIYRRWRSKQALAADLVAKVAVTAIDVPDTGSLRGDIREYL
MLBr_00064|M.leprae_Br4923 AKSAGISRPTFYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGN
* * :.: :.* : : :
Mb2274c|M.bovis_AF2122/97 VKQIVAVADRLRGDDLIMSVMH--SELARVYITERLGTSQQVLIEGLAAR
Rv2250c|M.tuberculosis_H37Rv VKQIVAVADRLRGDDLIMSVMH--SELARVYITERLGTSQQVLIEGLAAR
TH_1508|M.thermoresistible__bu VERIVGFAERLRADEVVMSVLYGAPEFTMVYITDRLGSSQRIMIEALARE
Mflv_5272|M.gilvum_PYR-GCK VAAFREGVRLLTGEPVMRRFLQLDGEFT---ATTEMVAEARLFLVSAATA
Mvan_0969|M.vanbaalenii_PYR-1 VAAFTEGVRLLTGEPVMRRFLQLDREFT---ATTEMVEEARLFLVSAATA
MMAR_0287|M.marinum_M IEAFTLGVRLIQDSPLYSRIAESEPE-----LFGMFSRSHVFPIGQFADG
MUL_4837|M.ulcerans_Agy99 IEAFTLGVRLIRDSPLYSRIAESEPE-----LFGMFSRSHVFPIGQFADG
MAV_5227|M.avium_104 IEAFALGVRLVKNSALYSRIAESEPE-----LFGLFSRSQVFPIRQFADG
MAB_4647|M.abscessus_ATCC_1997 VECFTLAMRLITESRLAGTIIENEPEL----VIGLNTPSGDKAIVRASAL
MSMEG_5340|M.smegmatis_MC2_155 RNGREALTHRLARKIIPDLIAEAVRD-------PEYGALLTDLIREPRRG
MLBr_00064|M.leprae_Br4923 KWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAV
:
Mb2274c|M.bovis_AF2122/97 LTVAQRSG--SVRSGDARRLATMVLLIAQSTIQSADIVDSILDSAALATE
Rv2250c|M.tuberculosis_H37Rv LTVAQRSG--SVRSGDARRLATMVLLIAQSTIQSADIVDSILDSAALATE
TH_1508|M.thermoresistible__bu IAEAQETG--TVRAGDPHQLAAMCGLIAQSAVQSARIVEPFLDSEALAAE
Mflv_5272|M.gilvum_PYR-GCK MAKALRAAGATMPDSELLAVAEVHIRLAASLVQVNTDVLDVTDDEAVARY
Mvan_0969|M.vanbaalenii_PYR-1 MAKALRAAGAGMPDDELLAVAEIHIRLAASLVQVSSDVLDVGDDEAVARY
MMAR_0287|M.marinum_M IAHTLRRCGADAPDADLANIADILLRVAVGIIMFPTERLDTSDDAAVREY
MUL_4837|M.ulcerans_Agy99 IAHTLRRCGADAPDADLANIADILLRVAVGIIMFPTERLDTSDDAAVREY
MAV_5227|M.avium_104 IAHTLRRCGAEQAEPDLDNIADILLRVALGIIVFPTDRLDTADPAAVRDY
MAB_4647|M.abscessus_ATCC_1997 VASSLRHSGATMPDDAVLAVSEILVRLVGSLLTNRAGVLDITDTAAVRHY
MSMEG_5340|M.smegmatis_MC2_155 RGSHIFERAIERGEIAPDADIDVALDVLAGALYWRQSILQTTADDDYLDR
MLBr_00064|M.leprae_Br4923 IDAERKRGVAPDTLPATELATALNLMNERALFASFTAEQPHVPESRVLDT
: . .
Mb2274c|M.bovis_AF2122/97 LTHALNGYLC----
Rv2250c|M.tuberculosis_H37Rv LTHALNGYLC----
TH_1508|M.thermoresistible__bu LRRSLNGYLKP---
Mflv_5272|M.gilvum_PYR-GCK ARTYLAPLVR----
Mvan_0969|M.vanbaalenii_PYR-1 ARTYLAPLVH----
MMAR_0287|M.marinum_M AARYLIPIITL---
MUL_4837|M.ulcerans_Agy99 AARYLIPIITL---
MAV_5227|M.avium_104 AARYLVPIIGR---
MAB_4647|M.abscessus_ATCC_1997 AQTYLARLVW----
MSMEG_5340|M.smegmatis_MC2_155 LTEVVLMAVGMGK-
MLBr_00064|M.leprae_Br4923 LVHIWVSSIYNEIR
: