For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SGPDPASEQILDAAVVEFERHGFRRVALEDVARRAGVSRTTIYRRFANKDQLVGAVIERENVALFSDIAT ELKQAGPQSNYYVEAFTLSILKFRGHRVLHRMITEEPGLVLELASLYYRAAIERMAEALRVIFPPGFAER IGADAVDELADTILRYATMVLLLPSAQPLETADDIRAFARHHFLPSLPEALRSVPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0059 | - | - | 100% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4624 | - | 9e-12 | 26.78% (183) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3024 | - | 2e-11 | 27.17% (184) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 6e-07 | 36.23% (69) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 7e-07 | 36.23% (69) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 1e-06 | 26.77% (127) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1024 | - | 2e-20 | 31.82% (198) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0287 | - | 2e-20 | 35.68% (185) | transcriptional regulatory protein |
| M. avium 104 | MAV_5227 | - | 9e-19 | 35.36% (181) | TetR-family protein transcriptional regulator, putative |
| M. smegmatis MC2 155 | MSMEG_0962 | - | 6e-81 | 77.16% (197) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2255 | - | 5e-81 | 76.96% (191) | TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_4837 | - | 5e-21 | 36.22% (185) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0855 | - | 9e-90 | 85.28% (197) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0059|M.gilvum_PYR-GCK --------------------------------MS-GPDPASEQILDAAVV
Mvan_0855|M.vanbaalenii_PYR-1 --------------------------------MR-GTD-ATEHILDAAVV
MSMEG_0962|M.smegmatis_MC2_155 --------------------------------MP-GPDAASRAILDAALV
TH_2255|M.thermoresistible__bu --------------------------------MPERPDPARQAILDAAVV
MMAR_0287|M.marinum_M --------------------MQSRMGTETSTDGVESITDLDRTILDTARA
MUL_4837|M.ulcerans_Agy99 ------------------------MGTETSTDGVESITDLDRTILDTAHA
MAV_5227|M.avium_104 ------------------------MQSHRADAAAGERTDLDRLILDTARG
Mb1561|M.bovis_AF2122/97 --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
Rv1534|M.tuberculosis_H37Rv --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
MAB_1024|M.abscessus_ATCC_1997 --------------------------------MSADPDPTGERILEAALQ
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
:* .*
Mflv_0059|M.gilvum_PYR-GCK EFERHGFRRVALEDVARRAGVSRTTIYRRFANKDQLVGAVIERENVALFS
Mvan_0855|M.vanbaalenii_PYR-1 EFERHGFRRVALDDVARRAGVSRTTIYRRFANKDELVGAVIERENIQLFA
MSMEG_0962|M.smegmatis_MC2_155 EFERYGFRRVALDDVARRAGVSRTTIYRRFANRDDLVGAVIERENVSLFA
TH_2255|M.thermoresistible__bu EFEQHGFRKVALEDVARRAGVSRTTIYRRFTNRDELVAAVVDRENAALFA
MMAR_0287|M.marinum_M VFETYGVRRANIEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFA
MUL_4837|M.ulcerans_Agy99 VFETYGVRRANIEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFA
MAV_5227|M.avium_104 VFETYGVRRANIDDVAARAGVSRSTIYRRFPTKKNLFGQVVRREAELFFS
Mb1561|M.bovis_AF2122/97 VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
Rv1534|M.tuberculosis_H37Rv VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
MAB_1024|M.abscessus_ATCC_1997 TMLSFGIRRATVDEIARRAGVSHMTVYRRWSNKTDLVLAVLMREAQAIFT
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
: * : . : ::* :**:: :* : .: :* :: . : :
Mflv_0059|M.gilvum_PYR-GCK DIATELKQA-----GPQSNYYVEAFTLSILKFRGHRVLHRMITEEPGLVL
Mvan_0855|M.vanbaalenii_PYR-1 DIAAELKTA-----GPQSNYYVEAFTLSILKFRRHRVLHQMIIDEPGLVL
MSMEG_0962|M.smegmatis_MC2_155 DIAAELKDA-----KPQSNIYVEAFTLSILRFRRHRVLNQMMKDEPALVL
TH_2255|M.thermoresistible__bu DIAAELKHS-----GPQGDYYVEAFTLAILKFRRHRVLHRMITDEPGFIL
MMAR_0287|M.marinum_M ALNQATNGH-----NPR-EAVIEAFTLGVRLIQDSPLYSRIAESEP-ELF
MUL_4837|M.ulcerans_Agy99 ALNQATNGH-----NPR-EAVIEAFTLGVRLIRDSPLYSRIAESEP-ELF
MAV_5227|M.avium_104 TLDQATAGC-----DPQ-QAVIEAFALGVRLVKNSALYSRIAESEP-ELF
Mb1561|M.bovis_AF2122/97 HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALG
Rv1534|M.tuberculosis_H37Rv HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALG
MAB_1024|M.abscessus_ATCC_1997 SVDAEIAAL-----DSPEEKLVAGFTGIYWHVHTHPLMRRAVETDPESVL
MLBr_00815|M.leprae_Br4923 SVQQALRTT-----TNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITE
: .. .. : :
Mflv_0059|M.gilvum_PYR-GCK ELASLYYRAAIERMAEALRVIFPPGFAERIGADAVDELADTILRYATMVL
Mvan_0855|M.vanbaalenii_PYR-1 ELAGRYHRAAIDRMAAALRVIFPPGFAERIGPAAVDELADCILRYAAMVL
MSMEG_0962|M.smegmatis_MC2_155 ELAHRHYGAAIERMAAALRVIFPEGFADRIGEAAVNDLADTILRYALMAL
TH_2255|M.thermoresistible__bu HLAQQHWGAAVERMAEALRVIFPAGFAERIGEAAVIEFADTILRYAAMAL
MMAR_0287|M.marinum_M GMFSRSHVFPIGQFADGIAHTLRRCGADAP-DADLANIADILLRVAVGII
MUL_4837|M.ulcerans_Agy99 GMFSRSHVFPIGQFADGIAHTLRRCGADAP-DADLANIADILLRVAVGII
MAV_5227|M.avium_104 GLFSRSQVFPIRQFADGIAHTLRRCGAEQA-EPDLDNIADILLRVALGII
Mb1561|M.bovis_AF2122/97 GRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQL
Rv1534|M.tuberculosis_H37Rv GRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQL
MAB_1024|M.abscessus_ATCC_1997 PVMTSGAGPALDMATTYLAGHVSQSAGDLV--DDPYGIAEVFVRLTHSLI
MLBr_00815|M.leprae_Br4923 PRVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDCARY
: . .. :
Mflv_0059|M.gilvum_PYR-GCK LLPSAQPLETAD--DIRAFARHHFLPSLPEALRSVPA--------
Mvan_0855|M.vanbaalenii_PYR-1 LLPSAQPLETAD--DVRAFARQHFLPSLPAALRTVPA--------
MSMEG_0962|M.smegmatis_MC2_155 LIPSVEPLETAD--DIRSFATRHFLPSLPVSLRVVPA--------
TH_2255|M.thermoresistible__bu LLPSVQPLDTAD--DIRAFATRHFLPSLPAALHTGSA--------
MMAR_0287|M.marinum_M MFPTER-LDTSDDAAVREYAARYLIPIITL---------------
MUL_4837|M.ulcerans_Agy99 MFPTER-LDTSDDAAVREYAARYLIPIITL---------------
MAV_5227|M.avium_104 VFPTDR-LDTADPAAVRDYAARYLVPIIGR---------------
Mb1561|M.bovis_AF2122/97 AHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Rv1534|M.tuberculosis_H37Rv AHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
MAB_1024|M.abscessus_ATCC_1997 LAPSPR-RELATREDAQQYARRYILPIAQALVPAASPAVR-----
MLBr_00815|M.leprae_Br4923 WLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL------------
. . :