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LSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIADVLR EVPLDGDDREALVKQIVAVADRLRGDDLIMSVMHSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSV RSGDARRLATMVLLIAQSTIQSADIVDSILDSAALATELTHALNGYLC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2250c | - | - | 100% (189) | Possible transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1776c | - | 2e-05 | 29.90% (97) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv2912c | - | 3e-05 | 21.08% (185) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2274c | - | 1e-99 | 99.47% (189) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2773 | - | 3e-52 | 59.32% (177) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 4e-05 | 31.15% (61) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3883c | - | 2e-36 | 45.76% (177) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3343 | - | 7e-76 | 75.00% (188) | transcriptional regulatory protein |
| M. avium 104 | MAV_2187 | - | 2e-73 | 73.96% (192) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4333 | - | 3e-61 | 65.10% (192) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1508 | - | 8e-52 | 58.19% (177) | Possible transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_1299 | - | 1e-75 | 75.00% (188) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3760 | - | 2e-51 | 54.21% (190) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2250c|M.tuberculosis_H37Rv MLSMSNDR--------------ADTGGR---------------ILRAAAS
Mb2274c|M.bovis_AF2122/97 MLSMSNDR--------------ADTGGR---------------ILRAAAS
MMAR_3343|M.marinum_M MLSMSNAP--------------EDIGDR---------------ILQAAAS
MUL_1299|M.ulcerans_Agy99 MLSMSNAP--------------EDIGDR---------------ILQAAAS
MAV_2187|M.avium_104 MLSIRNDRP----------DAALDTGER---------------ILAAAAS
MSMEG_4333|M.smegmatis_MC2_155 MVSISNDDA----------G--ESLGER---------------ILEAAAS
Mflv_2773|M.gilvum_PYR-GCK MMSIRNSE---------------PVEQR---------------ILDAAAE
Mvan_3760|M.vanbaalenii_PYR-1 MVSIRNPER--------------SVEQR---------------ILDAAAA
TH_1508|M.thermoresistible__bu ------------------------VEDR---------------ILDAAAA
MAB_3883c|M.abscessus_ATCC_199 MAPLVDAGGGVTVQAMDAQASADPVTER---------------ILDAALS
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
:* .*
Rv2250c|M.tuberculosis_H37Rv CVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIA----
Mb2274c|M.bovis_AF2122/97 CVVDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIMASMLTSHIA----
MMAR_3343|M.marinum_M CVRDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIISALLTSHVT----
MUL_1299|M.ulcerans_Agy99 CVRDYGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIISALLTSHVT----
MAV_2187|M.avium_104 CVVDFGVDRVTLAEIARRAGVSRPTVYRRWPDTRSIVAALLTRHVT----
MSMEG_4333|M.smegmatis_MC2_155 CVMAFGVDRVTLAEIARRAGVSRPTVYRRFPDTRSILAALLTARIV----
Mflv_2773|M.gilvum_PYR-GCK CIRAYGVERTTVTEIARRAGVSRPTIYRRWPDIRWVIAEVLTVRIS----
Mvan_3760|M.vanbaalenii_PYR-1 CILAYGVERTTMTEIARRARVSRPTIYRRWPDIRWVIAELLTVRIT----
TH_1508|M.thermoresistible__bu SVLAVGVNRVTLTDIARRARVSRPTIYRRWPDTNALLASLLTTRIT----
MAB_3883c|M.abscessus_ATCC_199 CVTEFGVRRTTLVEVAKRAGVSRPSVYRRWPDVRTLVAELLTREMG----
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
. * . : ::* ** **:* :*:::.. : :* .:
Rv2250c|M.tuberculosis_H37Rv DVLREVPLDGDDREALVKQIVAVADRLRGDDLIMSVMHS--ELARVYITE
Mb2274c|M.bovis_AF2122/97 AVLREVPLDGDDREALVKQIVAVADRLRGDDLIMSVMHS--ELARVYITE
MMAR_3343|M.marinum_M DVVRAVSLDGHDRQTVVRQVVAVADRLRGDELVKALMHS--DLARVYITE
MUL_1299|M.ulcerans_Agy99 DVVRAVFLDGHDRQTVVRQVVAVADRLRGDELVKALMHS--DLARVYITE
MAV_2187|M.avium_104 DVMRAAPLLGDDRESLVRQIVTVADLLRQDRLVMSVLHS--ELAPIYITE
MSMEG_4333|M.smegmatis_MC2_155 RVLDEVESDARGREALVRRIVAVAERLRHDEVIMAVLHTAPDVAMVYIAE
Mflv_2773|M.gilvum_PYR-GCK DVLAAVPAAGPGREELVDRVVRIAEHLRRDDIVMSVIFNAPTLAMVYITE
Mvan_3760|M.vanbaalenii_PYR-1 GVLEAVPDRGAGRESVVGRVVAVADHLRADEIVQSVIRNAPGLAMTYITD
TH_1508|M.thermoresistible__bu AVLDEVPTRGNDRESLVERIVGFAERLRADEVVMSVLYGAPEFTMVYITD
MAB_3883c|M.abscessus_ATCC_199 SILPATG-RGCARERLVRSVTGLVTQVREHSIFAAILRSDPELLLTYIVQ
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPRVAA
: *: : : . :. . :: . :.
Rv2250c|M.tuberculosis_H37Rv RLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQSTIQSAD
Mb2274c|M.bovis_AF2122/97 RLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQSTIQSAD
MMAR_3343|M.marinum_M RLGASQHFLLEGLAARLQVAQGTGSVRAGDPRKLAAMVLLITQSTIQSVD
MUL_1299|M.ulcerans_Agy99 RLGASQHFLLEGLAARLQVAQGTGSVRAGDPRKLAAMVLLITQSTIQSVD
MAV_2187|M.avium_104 RLGTSQHMLIDALAARLRVAQRNGSVRPGDPVQMATMVLLIAQSTIQSAQ
MSMEG_4333|M.smegmatis_MC2_155 RLGTSQQILIDAVAGEIKIAQEGGSVRAGDARQLATMCLLITQSAIQSAQ
Mflv_2773|M.gilvum_PYR-GCK RLGTSQQLLIDTLAAAIVQGQAHGSVRAGDPHQMGAMCLLIAQSTIQSAQ
Mvan_3760|M.vanbaalenii_PYR-1 RLGTSQQILIDALAEAIKAGQDEGSIRAGDPRGMAAMCLLITQSTIQSAQ
TH_1508|M.thermoresistible__bu RLGSSQRIMIEALAREIAEAQETGTVRAGDPHQLAAMCGLIAQSAVQSAR
MAB_3883c|M.abscessus_ATCC_199 RLGTSQRALIGWTAMLIVEGQADGSIRAGIPEQMAAMVLLIGQSVLQSAR
MLBr_00815|M.leprae_Br4923 QVRVATESCIDAVFALISADSRLDPHRAR--MVAVGLVGISVDCARYWLD
:: : . : : . .. *. : : :..
Rv2250c|M.tuberculosis_H37Rv IVDSILDSAALATELTHALNGYLC------
Mb2274c|M.bovis_AF2122/97 IVDSILDSAALATELTHALNGYLC------
MMAR_3343|M.marinum_M IIDPILDSEALAAELTYSLNGYLA------
MUL_1299|M.ulcerans_Agy99 IIDPILDSEALAAELTYSLNGYLA------
MAV_2187|M.avium_104 IVEPLLDAEALATELAYSLNGYLS------
MSMEG_4333|M.smegmatis_MC2_155 MVAPILDADALARELAYSLNGYLKP-----
Mflv_2773|M.gilvum_PYR-GCK MVEKFLDRDALNAELAHSLNGYLKP-----
Mvan_3760|M.vanbaalenii_PYR-1 MVAELLDNEALNEELAHSLNGYLKP-----
TH_1508|M.thermoresistible__bu IVEPFLDSEALAAELRRSLNGYLKP-----
MAB_3883c|M.abscessus_ATCC_199 IVADILSPDELVDELATAIDGYLKA-----
MLBr_00815|M.leprae_Br4923 TNRPISKSDAVEGTVQFAWGGLSHVPLTRL
: . : : : .*