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ALAGSTSTWAPLGSPIFRALWIAQFVSNLGTWMQTVGAQWMLVDDPRAAVLVPLVQTATTLPVMLLALPS GVLADLIDRRRLLIATQGAMAAGVGLLAVLTGAGLTTPTVLLMLLFVIGCGQALTAPAWQAIQPDLVPAH QIPAAAALGSMSMNGARAIGPAIAGALVSLTGPTLVFALNAVSFIGIVLVLISWRRPAVQRDFPPERALA ALSAGGRYIRSSPIVRRILLRTVLFIAPASALWGLLPVIAANQLGLGSAGYGLLLGALGAGAVLGAFVLS GLRTRFGQNVLLTAGAAGFAVATAVLALVPDFAAVLAALVVGGGAWLLSLSTLNASMQLSLPAWVRARGL SVYQLIFMGGQAIGSLLWGLLAGATNSVTSLLVSAGLLVVCALSSLWWPLHAGTGNLDLTPSSHWPEPTL VFEPEPLDGPVLVLTSYCVPAHNEGAFLAAMAVLGRSRQRTGASQWRLFRSVEQESTFVETFIVRSWGEH MHQHYTRLTGQDQLIEQNVEQYTDGTPVSQHYLAVRDV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1167 | - | - | 100% (529) | protein of unknown function DUF894, DitE |
| M. vanbaalenii PYR-1 | Mvan_5800 | - | 1e-33 | 27.95% (390) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_4580 | - | 3e-17 | 25.79% (380) | H+ antiporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-16 | 22.62% (420) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_5163 | - | 0.0 | 87.00% (523) | protein of unknown function DUF894, DitE |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-16 | 22.62% (420) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_02143 | - | 6e-07 | 21.71% (387) | hypothetical protein MLBr_02143 |
| M. abscessus ATCC 19977 | MAB_0880 | - | 7e-47 | 33.89% (422) | hypothetical protein MAB_0880 |
| M. marinum M | MMAR_0333 | - | 2e-14 | 28.15% (373) | hypothetical protein MMAR_0333 |
| M. avium 104 | MAV_1406 | - | 3e-17 | 24.87% (398) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 0.0 | 78.01% (523) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_1317 | - | 0.0 | 69.17% (506) | transmembrane transport protein |
| M. ulcerans Agy99 | MUL_1084 | - | 7e-06 | 23.54% (378) | integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1167|M.vanbaalenii_PYR-1 --MALA----GSTSTWAPLGSPIFRALWIAQFVSNLGTWMQTVGAQWMLV
Mflv_5163|M.gilvum_PYR-GCK --MTSP----VSTSTWAPLQSPVFRALWIAQFVSNLGTWMQTVGAQWMLV
MSMEG_0357|M.smegmatis_MC2_155 --MTTATPAMGATSTWAPLASPIYRALWIAQFVSNLGTWMQTVGAQWMLV
TH_1317|M.thermoresistible__bu --------------------------LWIAQFVSNLGTWMQTVGAQWMLV
Mb1288c|M.bovis_AF2122/97 ---------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVL
Rv1258c|M.tuberculosis_H37Rv ---------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVL
MAV_1406|M.avium_104 -------------------------MILFATLLATAGTGISIVAFPWLAL
MAB_0880|M.abscessus_ATCC_1997 --------MADRGGIFVSLRTRNYRLWISGQMVSLIGTWMQRVAQDWLVL
MMAR_0333|M.marinum_M --------------MALAATRKLVRDPQLRRLMAVCATFLTSNSAHGVLL
MUL_1084|M.ulcerans_Agy99 ---------MTSEARTATTAARPWTPRVAAQLSVLAAAAFIYVTAEILPV
MLBr_02143|M.leprae_Br4923 MSGRRRNHPGRLASIPGLRTRTGSRNQHPGIANYPADSSDFRPAQQRRAL
:
Mvan_1167|M.vanbaalenii_PYR-1 DDPRA-AVLVPLVQTATTLPVMLLALPSGVLADLIDRRR-LLIATQGAMA
Mflv_5163|M.gilvum_PYR-GCK DDPAA-AVLVPLVQTATTLPVMLLALPSGVLADLVDRRR-LLIATQGAMA
MSMEG_0357|M.smegmatis_MC2_155 GDPRA-AVLVPLVQTATTLPVMLLALPSGVLADLVDRRR-LLIAAQGATA
TH_1317|M.thermoresistible__bu STPAA-EVLVPLVQTATTLPIMLLSLPSGVVADLVDRRR-LLLATQSMMA
Mb1288c|M.bovis_AF2122/97 QREGS-AGQASIVASATMLPLLFATLVAGTAVDYFGRRR-VSMVADALSG
Rv1258c|M.tuberculosis_H37Rv QREGS-AGQASIVASATMLPLLFATLVAGTAVDYFGRRR-VSMVADALSG
MAV_1406|M.avium_104 QHRHS-ATDASIVAAAMTLPLVLATLIAGTAVDFFGRRR-VSLVCDWLSG
MAB_0880|M.abscessus_ATCC_1997 DLSHGNAFLLGVVMALQFGPTLLLSVWGGMLADRYDKRR-MLMLTQALMA
MMAR_0333|M.marinum_M TVFAFSVGGAATVGVVTLVRMLPSALLAPLAATLATSPRPQVHLAIGVGA
MUL_1084|M.ulcerans_Agy99 GALSAIARNLHISVVLVGTLLSWYALVAALTTVPLVRWT----AHWPRRH
MLBr_02143|M.leprae_Br4923 EQREQQAGQLDPARRSPSMPSANRYLPPLGQQQSEPQHN-SAPPCGPYPG
:
Mvan_1167|M.vanbaalenii_PYR-1 AGVGLLAVLTGAGLTTPTVLLMLLFVIGCGQALTAPAWQAIQPDLVPAHQ
Mflv_5163|M.gilvum_PYR-GCK AGVGLLATLTGAGLTTPTVLLTLLFVIGCGQALTAPAWQAIQPDLVPSDQ
MSMEG_0357|M.smegmatis_MC2_155 AGVASLATLTGAGLATPTVLLTLLFLIGCGQALTAPAWQAIQPDLVPREQ
TH_1317|M.thermoresistible__bu AAVAILAALTAAQLTTPTVLLILLFLIGCGQAFTAPAWQAIQPELVPREQ
Mb1288c|M.bovis_AF2122/97 AAVAGVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA
Rv1258c|M.tuberculosis_H37Rv AAVAGVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAA
MAV_1406|M.avium_104 AAVTAVP-LTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAA
MAB_0880|M.abscessus_ATCC_1997 LFALTVGLLQVTGLVRIWHVMAVAFAMGCAAAIEAPTRQSFTIEMVGPEH
MMAR_0333|M.marinum_M RGMTTIATVIVVVSGAPLGVVLVVLGVDSLMSAAVRSLHAALVVRLATSV
MUL_1084|M.ulcerans_Agy99 ALMVSLVCLTISQLISALAPNFAVLAAGRALCAITHGLLWSVIAPIATRL
MLBr_02143|M.leprae_Br4923 ERIKVTRAAAQRSREMGYRMYWMVQRAATADGADKSGLTALTWPVVTNFA
:
Mvan_1167|M.vanbaalenii_PYR-1 IPAAAALGSMS------MNGARAIGPAIAGALVSLTGPTLVFALNAVSFI
Mflv_5163|M.gilvum_PYR-GCK IPAAAALGSMS------MNGARAIGPAIAGALVSLTGPTIVFALNAVSFV
MSMEG_0357|M.smegmatis_MC2_155 IPAAAALGSMS------MNGARAIGPAIAGALVSLSGPTLVFALNAVSFV
TH_1317|M.thermoresistible__bu IPAAAALTSMS------LNAARAVGPAVAGVLVAISGPTLVFTLNAVSFA
Mb1288c|M.bovis_AF2122/97 ARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFG
Rv1258c|M.tuberculosis_H37Rv ARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFG
MAV_1406|M.avium_104 ARAGWSLDRTNSSYEAMLNLAFIVGPGLGGLLIATLGGINTMWVTAGCFA
MAB_0880|M.abscessus_ATCC_1997 LPNAVGLNSMV------FNLAGIIGPATSGVLIGLIGTGWVFLLNFVSFI
MMAR_0333|M.marinum_M AEAATANAATG----VLLYASALAGPALAGVMLAFVGVGWALTLPAALFV
MUL_1084|M.ulcerans_Agy99 VPPSHAGRATTS-----IYIGTSLALVIGSPLTAALSLMWGWRLAAVCVT
MLBr_02143|M.leprae_Br4923 VDSAMAVALAN-----TLFFAAASGESKSKVALYLLITIAPFAVIAPLIG
. . : . . . : .
Mvan_1167|M.vanbaalenii_PYR-1 GIVLVLISWRRPAVQRDFPPERA----------LAALSAGGRYIRSSPIV
Mflv_5163|M.gilvum_PYR-GCK GIVLVLMWWRRPPVRSDYPPERA----------LAALSAGGRYIRSSPIV
MSMEG_0357|M.smegmatis_MC2_155 GIVAVLLLWRRPAAERMLPAERP----------LAALSAGGRYIRSAPIV
TH_1317|M.thermoresistible__bu GIVVVLLLWKRSSAEQTLAAERP----------LAALQAGHRYVRSSPVV
Mb1288c|M.bovis_AF2122/97 LSILAIAALQLEGAGKPHHTSRPQGL-------VSGIAEGLRFVWNLRVL
Rv1258c|M.tuberculosis_H37Rv LSILAIAALQLEGAGKPHHTSRPQGL-------VSGIAEGLRFVWNLRVL
MAV_1406|M.avium_104 LSFLAIGALRLEGAGKPPRATRPVGL-------VTGIAEGVRFVWNLRVL
MAB_0880|M.abscessus_ATCC_1997 AVGIALWRMRPGELHSSEPIPAAKG----------QLRQGFSYVWRRRDL
MMAR_0333|M.marinum_M VGALTALRITVAPIDDMPDTGGARPSGGVARVQLRAVGAGFRAIIESRPA
MUL_1084|M.ulcerans_Agy99 VAAAVVTVAARLLLPEMVLSADQ----------LQHVGPRSRHHRNRALI
MLBr_02143|M.leprae_Br4923 PALDRLQHGRRVALATSFVLRTGLAT------LLIMNYDGATGSYPSMVL
Mvan_1167|M.vanbaalenii_PYR-1 RRILLRTVLFIAPASALWGLLPV-IAANQLGLGSAGYGLLLGALGAGAVL
Mflv_5163|M.gilvum_PYR-GCK RRILLRTVLFIAPGSAVWGLLPV-IARDQLGLGSAGYGALLGALGVGAVL
MSMEG_0357|M.smegmatis_MC2_155 RRILLRTVLFIAPGSALWGLLAV-IAKDQLDLTSSGYGVLLGALGLGAVC
TH_1317|M.thermoresistible__bu RRILFRAALFILPASALWGLLPV-VASSGLGLSSSGYGLMLGALGAGAVL
Mb1288c|M.bovis_AF2122/97 RTLGMIDLTVTALYLPMESVLFP-KYFTDHQQP-VQLGWALMAIAGGGLV
Rv1258c|M.tuberculosis_H37Rv RTLGMIDLTVTALYLPMESVLFP-KYFTDHQQP-VQLGWALMAIAGGGLV
MAV_1406|M.avium_104 RTLGLIDLAVTALYLPMESVLFP-KYFADQHQP-AQLGWALMALALGGVA
MAB_0880|M.abscessus_ATCC_1997 FMIMLTVFLVSTFGLNFSLTLAV-LARETFGRGAESYGLLSTALAIGTLL
MMAR_0333|M.marinum_M AAAATLFLLTTTLLDGFWYVASAPLAADQFGLGPSGVTTIMTIYGVGGLL
MUL_1084|M.ulcerans_Agy99 IVSLITMVGVTGHFVSYTYIVVI--IRQVVGVRGPSLAWLLAAYGVAGVV
MLBr_02143|M.leprae_Br4923 YPCALAMMVLSKSFSVLRSAVTPRVMPPSIDLVRVNSRLTVFGLLGGTIA
. :
Mvan_1167|M.vanbaalenii_PYR-1 GAFVLSGLRTRFGQNVLLTAG--AAGFAVATAVLALVPDFAAVLAALVVG
Mflv_5163|M.gilvum_PYR-GCK GAFALSRLRARFGQNKLLIAG--AAGFGMATAVLALVHNVALVAAALVVG
MSMEG_0357|M.smegmatis_MC2_155 GAFVLGRLQKMFELNTLLVVA--AIGFGGATVVLALVHQVAVVVIALVLG
TH_1317|M.thermoresistible__bu GALTLSAWQSAFRQNTLLALA--AVGFAAATAVAVLVPDVVVVLIGLTVG
Mb1288c|M.bovis_AF2122/97 GALGYAVLAIRVPRRVTMSTA--VLTLGLASMVIAFLPPLPVIMVLCAVV
Rv1258c|M.tuberculosis_H37Rv GALGYAVLAIRVPRRVTMSTA--VLTLGLASMVIAFLPPLPVIMVLCAVV
MAV_1406|M.avium_104 GALGYAVLSARLRRRTAVLTA--TLTFGATTAGIAVLPPLPVILGLCAVT
MAB_0880|M.abscessus_ATCC_1997 GATFAARRTKKVR-MTLFYGA--AMAFGLSEVVVSVMPTYLSVALALVPA
MMAR_0333|M.marinum_M GAVAMLSIAGRGGLARMFTLARLSEALLLAAIGAASLPALGLVLAAGVGG
MUL_1084|M.ulcerans_Agy99 AVALVARPLDRRPKGTIIFCVAGLTFAFVLLTALAFGGHLAPMTALVVGT
MLBr_02143|M.leprae_Br4923 GGAIAAGVEFVCAHLFKLPGALFVVAAITISGALLSMRIPRWVEVTAGEI
. . :
Mvan_1167|M.vanbaalenii_PYR-1 G--GAWLLSLSTLNASMQLSLPAWVRAR---GLSVYQLIFMGGQAIGSLL
Mflv_5163|M.gilvum_PYR-GCK G--AAWLLTLSTLNASMQLSLPSWVRAR---GLSVYQLIFMGGQAVGSLL
MSMEG_0357|M.smegmatis_MC2_155 G--TAWLLALSTLNASMQLSLPGWVRAR---GLSVYQLVFMGGQALGSLL
TH_1317|M.thermoresistible__bu G--MSWLLALATLNASMQLSLPAWVRAR---GLSVYLLIFMGGQALGSTM
Mb1288c|M.bovis_AF2122/97 G--LVYGPIQPIYNYVIQTRAAQHLRGR---VVGVMTSLAYAAGPLGLLL
Rv1258c|M.tuberculosis_H37Rv G--LVYGPIQPIYNYVIQTRAAQHLRGR---VVGVMTSLAYAAGPLGLLL
MAV_1406|M.avium_104 G--VVYGPIQPIYNFVMQTRAPHHLRGR---VVGVMAGLTYAAGPLGLLV
MAB_0880|M.abscessus_ATCC_1997 G--LLALTFTTSAMNIIQLSVDSQLRGR---VMGIYMVAFLGGTPLGSPL
MMAR_0333|M.marinum_M GSAASWAIAPTLVQRSVNRASMVTAAAS---LQSVSQLAIAAGAGIAAVL
MUL_1084|M.ulcerans_Agy99 GAIVLWGAAVTAVSPMLQSAAMRSGADDPDGASGLYVTAFQVGIMAGSLI
MLBr_02143|M.leprae_Br4923 PATLSYRLHRKPLRQSWPEEVKKVSGRLR-QPLGRNIITSLWGNCTIKVM
. . :
Mvan_1167|M.vanbaalenii_PYR-1 WG------------------------------LLAGATNSVTSLLVSAGL
Mflv_5163|M.gilvum_PYR-GCK WG------------------------------LLAGGTSSVISLLVSAGL
MSMEG_0357|M.smegmatis_MC2_155 WG------------------------------LIAGAAGSVTALLVSAGL
TH_1317|M.thermoresistible__bu WG------------------------------LVAGSTSTVVAMLISAGL
Mb1288c|M.bovis_AF2122/97 AG------------------------------PLTDAAGLHATFLALALP
Rv1258c|M.tuberculosis_H37Rv AG------------------------------PLTDAAGLHATFLALALP
MAV_1406|M.avium_104 AG------------------------------PLADAAGLKATFLTLAVP
MAB_0880|M.abscessus_ATCC_1997 VG------------------------------WLADLHGGRMPLLVGGLV
MMAR_0333|M.marinum_M VGSLGLTGALAIVSGAAALITVLAWPQVRRADKLSDDDSAKLAVIRATPV
MUL_1084|M.ulcerans_Agy99 GG--------------------------------LLYERSVAMMLTASAG
MLBr_02143|M.leprae_Br4923 VG-----------------------FLFLYPAFVAKEHQANGWVQLGMLG
* .
Mvan_1167|M.vanbaalenii_PYR-1 LVVCALSSLWWPLHAGTGNLDLTPSSHWPEP-------------------
Mflv_5163|M.gilvum_PYR-GCK LIFCGLSLWWWPLHAGTGNLDLTPSSHWPEP-------------------
MSMEG_0357|M.smegmatis_MC2_155 MGVCAVSAIWWPLHARTGNLDMTPSAHWPEP-------------------
TH_1317|M.thermoresistible__bu LVVSGLSAWWWPLHPQTGQLDVSPSAHWPEP-------------------
Mb1288c|M.bovis_AF2122/97 IVCTGLVAIRLPALR---ELDLAPQADIDRP-------------------
Rv1258c|M.tuberculosis_H37Rv IVCTGLVAIRLPALR---ELDLAPQADIDRP-------------------
MAV_1406|M.avium_104 ILAIGVVACGLPSLR---ELDRAPQFADDPG-------------------
MAB_0880|M.abscessus_ATCC_1997 SAAAGLVCATYLHRHP----CPVVAGEVPEA-------------------
MMAR_0333|M.marinum_M LAPLPALALEQLARTATRMAVPAGSDVIRQGDRGDRFYMIASGLADATVN
MUL_1084|M.ulcerans_Agy99 LMGVALVGMTSARRVFEAPVAVAGATSHNQ--------------------
MLBr_02143|M.leprae_Br4923 LIGTAAAIGNFAGNFTSARLQLGRPAVLVVR-------------------
Mvan_1167|M.vanbaalenii_PYR-1 ---------------TLVFEPEPLDGPVLVLTSYCVPAHNEGAFLAAMAV
Mflv_5163|M.gilvum_PYR-GCK ---------------TLLFEPEPLDGPVLVITAYRVLPENEEPFMSAMAR
MSMEG_0357|M.smegmatis_MC2_155 ---------------ALIFEPEPLDGPVVVLVSYRVEPAQETGFFEAMAA
TH_1317|M.thermoresistible__bu ---------------ALVFEPEPRDGPVLVLSTYRVAPEDEPAFLVAMQR
Mb1288c|M.bovis_AF2122/97 ---------------VGSAQ------------------------------
Rv1258c|M.tuberculosis_H37Rv ---------------VGSAQ------------------------------
MAV_1406|M.avium_104 ---------------A----------------------------------
MAB_0880|M.abscessus_ATCC_1997 ---------------DDMVPPAPAATPVCEPTPLARRS------------
MMAR_0333|M.marinum_M GRRVATLGPGGSFGEIALLHDVARSATVTARKDLDLVAVDRAEFLAALSS
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02143|M.leprae_Br4923 ----------CTIAVTVLALAASVAGNLLMTTIATLITSGSSAIAKASLD
Mvan_1167|M.vanbaalenii_PYR-1 LGRSRQRTGASQWRLFRSVEQESTFVET----------------------
Mflv_5163|M.gilvum_PYR-GCK LGRSRQRTGASMWQLFRSIEQESTFVET----------------------
MSMEG_0357|M.smegmatis_MC2_155 LGRSRQRTGASQWQLFRSGEHAGTFVEA----------------------
TH_1317|M.thermoresistible__bu QARSRQRTGAALWRLYRHLEREHTFVEA----------------------
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0333|M.marinum_M NTAAGLRLGGLARTRLGTVPVEERLIELGPDPALNSQSLSELLAAQPALA
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02143|M.leprae_Br4923 ASLQNDLPEESRASGFGRSESTLQLAWVLGG-------------------
Mvan_1167|M.vanbaalenii_PYR-1 ----------------------FIVRSWGEHMHQHYTRLTGQDQLIEQNV
Mflv_5163|M.gilvum_PYR-GCK ----------------------FIVRSWGEHMHQHYTRLTGQDQLIEQDV
MSMEG_0357|M.smegmatis_MC2_155 ----------------------FIVRSWEEHLRQHHTRLTGHDLLVEETV
TH_1317|M.thermoresistible__bu ----------------------FLVRSWDEHLRQHHVRLTLVDQRVEEEV
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0333|M.marinum_M GIGDGALRELADTAKVLAAPDGALITCEGDHGDTYYVILEGAAQVLDDGT
MUL_1084|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02143|M.leprae_Br4923 -----------------ALGVMVYTDLWVGFTAVSALLILGLAQTVVSFR
Mvan_1167|M.vanbaalenii_PYR-1 EQYTDGTPVSQHYLAVRDV----------------------------
Mflv_5163|M.gilvum_PYR-GCK ERYTEGEAVAEHYLAVRDAR---------------------------
MSMEG_0357|M.smegmatis_MC2_155 RRFTVGEPTSQHLIAAKTH----------------------------
TH_1317|M.thermoresistible__bu RRYAEGPPLVEHLIAVNFDEITRRGV---------------------
Mb1288c|M.bovis_AF2122/97 -----------------------------------------------
Rv1258c|M.tuberculosis_H37Rv -----------------------------------------------
MAV_1406|M.avium_104 -----------------------------------------------
MAB_0880|M.abscessus_ATCC_1997 -----------------------------------------------
MMAR_0333|M.marinum_M AVHHLGPGEGFGEQAILRDVPRTATVRAVGDTTLVAVDREAFQRARR
MUL_1084|M.ulcerans_Agy99 -----------------------------------------------
MLBr_02143|M.leprae_Br4923 GDSLIPGLGGNRPVMIEQESMRRAAAVSPQ-----------------