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TPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQRTGSALDASIVAMAGTLPLLAATLIAGAAVD FLGRRRVSMISDALSALSVAAVPVIALVFGADAVNVAVLAALAALGAFFDPAGMTARETMLPEAAHRAGW TLDRANSFFEAVFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFVLSIAAIAVLRLEGTARPDPSTMSDG VWAGILEGLRFVWNNKVLRTLAFVDLAATGLYMPMESVLFPKYFTDRDEPAQLGWVLMALSIGGLLGALG FAVLSKYLKRRTVMLTAVLTLGVAMTVIAFLPPLPIILVLCALVGFVYGPIAPIYNYVMQTRAPQHLRGR VVGVMGSLAYAAGPLGLILAGPLADSAGLHVTFLALSLPMLALGIVSVFLPALRELDTPHP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2234 | - | - | 100% (412) | H+ antiporter protein |
| M. gilvum PYR-GCK | Mflv_5163 | - | 9e-14 | 21.71% (410) | protein of unknown function DUF894, DitE |
| M. gilvum PYR-GCK | Mflv_1730 | - | 2e-11 | 21.52% (474) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-157 | 69.25% (400) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-157 | 69.25% (400) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1409c | - | 1e-142 | 58.88% (411) | putative drug antiporter protein precursor |
| M. marinum M | MMAR_4182 | - | 1e-157 | 69.75% (400) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 1e-151 | 68.02% (394) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5187 | - | 1e-18 | 23.90% (410) | tetracycline-resistance determinant TetV |
| M. thermoresistible (build 8) | TH_2406 | - | 1e-176 | 77.36% (402) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. ulcerans Agy99 | MUL_4170 | - | 1e-05 | 26.18% (191) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_4461 | - | 0.0 | 88.78% (410) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2234|M.gilvum_PYR-GCK --------MTPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQRT
Mvan_4461|M.vanbaalenii_PYR-1 --------MTPNEAPSRRGPLLLILFAALMAGAGNGISLVAFPWLVLQRT
TH_2406|M.thermoresistible__bu ------------MSTSTRGPVLLIYSAALTAGAGNGISIIAFPWLVLQRN
Mb1288c|M.bovis_AF2122/97 ------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQRE
Rv1258c|M.tuberculosis_H37Rv ------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQRE
MMAR_4182|M.marinum_M ------------MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLERE
MAV_1406|M.avium_104 ----------------------MILFATLLATAGTGISIVAFPWLALQHR
MAB_1409c|M.abscessus_ATCC_199 --MSTPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQRN
MSMEG_5187|M.smegmatis_MC2_155 MRSPRPVAGWRVLAPFRIREYRLLIAAVTLSIFAEGMWSVVMALQVIAID
MUL_4170|M.ulcerans_Agy99 ---------MNRGNVRPKLVLGVIVLGSFIASIDLTIVNVALPTLSRALQ
:: . : : :.:.
Mflv_2234|M.gilvum_PYR-GCK GSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVAA
Mvan_4461|M.vanbaalenii_PYR-1 GSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVAA
TH_2406|M.thermoresistible__bu GSALEASVVAMAATXPLLVATLFAGVAVDYLGRRRVSMISDLLSALSVAA
Mb1288c|M.bovis_AF2122/97 GSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAG
Rv1258c|M.tuberculosis_H37Rv GSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAG
MMAR_4182|M.marinum_M GSAGQASIVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVAI
MAV_1406|M.avium_104 HSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSGAAVTA
MAB_1409c|M.abscessus_ATCC_199 GSAADAAIVAAAGTLPLVFSTLISGTAVDYFGRRVMSIFSDVLSLVSVSA
MSMEG_5187|M.smegmatis_MC2_155 NDPASLSLVATCLGVGLVAFVLVGGITADRINQRTIIIAVEVVNFVTVAV
MUL_4170|M.ulcerans_Agy99 ASNAELQWIVDSYAIAAAGLLLAAGNLGDRYGRRGWLTIG----LVIVGA
. . :. . * .* * .:* *
Mflv_2234|M.gilvum_PYR-GCK VPVIALVFGADAVNVAVLA-ALAALGAFFDPAGMTARETMLPEAAHRAGW
Mvan_4461|M.vanbaalenii_PYR-1 VPVLALAFGTDVINVAVLA-GLAALGAIFDPAGMTARETMLPEAANRAGW
TH_2406|M.thermoresistible__bu VPVIALTFGVQAVNVAVLA-ALAALGAFFDPAGMTARETMLPEAAARAGW
Mb1288c|M.bovis_AF2122/97 VPLVAWGYGGDAVNVLVLA-VLAALAAAFGPAGMTARDSMLPEAAARAGW
Rv1258c|M.tuberculosis_H37Rv VPLVAWGYGGDAVNVLVLA-VLAALAAAFGPAGMTARDSMLPEAAARAGW
MMAR_4182|M.marinum_M VPLIAWAFGDDAVSVAVLA-ALGACSATFDPAGITARQSMLPEAAARAGW
MAV_1406|M.avium_104 VPLTAWIFGAAAIDVAELA-VLAFCAAAFDPAGMTARQSMLPEAAARAGW
MAB_1409c|M.abscessus_ATCC_199 IPILAMTTG---LNVPLLA-ALAALGAIFDPAGITARESMLPAAAKSAGW
MSMEG_5187|M.smegmatis_MC2_155 ISALALLGVLKIWHMAVAAGILGIAAAFFFPAYSAILPRILPPEQLLA--
MUL_4170|M.ulcerans_Agy99 SSAVAASAGSAQAVIGARA-VMGVGAAIIFPTSLALVTNVFVDSTHRA--
. * : * :. .* : *: : :: *
Mflv_2234|M.gilvum_PYR-GCK TLDRANSFFEAVFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFVLSIAA
Mvan_4461|M.vanbaalenii_PYR-1 TLDHANSVFEAIFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFGLSIFA
TH_2406|M.thermoresistible__bu TLDKTNSGYEAIFNLAYIVGPGIGGLLIATLGGVNTMWVTAALFVVSIVT
Mb1288c|M.bovis_AF2122/97 SLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILA
Rv1258c|M.tuberculosis_H37Rv SLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILA
MMAR_4182|M.marinum_M SLDRINSSYEAILNLAFVVGPGIGGLMIATVGGITTMWITAGAFGLSLLA
MAV_1406|M.avium_104 SLDRTNSSYEAMLNLAFIVGPGLGGLLIATLGGINTMWVTAGCFALSFLA
MAB_1409c|M.abscessus_ATCC_199 SLDKMNSMYEATFNVAYIVGPGLGGLLIASVGGVNTMWVTAASFVVSIIA
MSMEG_5187|M.smegmatis_MC2_155 -ANGVEGVVRPVFQRS--VGPAVAGMVIGATMPSIGAVVVAVLFALGLAL
MUL_4170|M.ulcerans_Agy99 ---RAIGVWSAVTGIAVVIGPILGGWLIEHFSVGSVFWVNVPIAVVAIVS
. . : :** :.* :* : . :.:
Mflv_2234|M.gilvum_PYR-GCK IAVLRLEGTARPDPSTMSDGVWAG----------ILEGLRFVWNNKVLRT
Mvan_4461|M.vanbaalenii_PYR-1 IAALKLEGAGRPDPTAMSDGVWAG----------IIEGLRFVWRNKVLRT
TH_2406|M.thermoresistible__bu IAALRLEGAGLPDRALLTDSVLAG----------IVEGLRFVWRTPVLRA
Mb1288c|M.bovis_AF2122/97 IAALQLEGAGKPHHTSRPQGLVSG----------IAEGLRFVWNLRVLRT
Rv1258c|M.tuberculosis_H37Rv IAALQLEGAGKPHHTSRPQGLVSG----------IAEGLRFVWNLRVLRT
MMAR_4182|M.marinum_M IGALRLEGAGRPHHETRPDGLVSG----------VTQGLRFVWNLRVLRA
MAV_1406|M.avium_104 IGALRLEGAGKPPRATRPVGLVTG----------IAEGVRFVWNLRVLRT
MAB_1409c|M.abscessus_ATCC_199 IALLKVDGAGKPAHETRPTGVFSG----------VLEGLRFFWNIKILRT
MSMEG_5187|M.smegmatis_MC2_155 LVATRPPAQPASEHHERP-HVLRD----------LREGFAFVLKTPWLLW
MUL_4170|M.ulcerans_Agy99 VNMFVPTSRNPDRPPLDLPGLLVSTVGVTVLTYTLIETPNIGWASARTAA
: . : . : : :
Mflv_2234|M.gilvum_PYR-GCK LAFVDLAATGLYMPMES-----VLFPKYFTD-----------RDEPAQLG
Mvan_4461|M.vanbaalenii_PYR-1 LALVDLVATGLYVPMES-----VLFPKYFTD-----------RNEPAQLG
TH_2406|M.thermoresistible__bu LLIVDLVVTGLYMPMES-----VLFPKYFTD-----------RDEPAHLG
Mb1288c|M.bovis_AF2122/97 LGMIDLTVTALYLPMES-----VLFPKYFTD-----------HQQPVQLG
Rv1258c|M.tuberculosis_H37Rv LGMIDLTVTALYLPMES-----VLFPKYFTD-----------HQQPVQLG
MMAR_4182|M.marinum_M LALIDLTVTALYLPMES-----VLFPTYFSD-----------RQQPAQLG
MAV_1406|M.avium_104 LGLIDLAVTALYLPMES-----VLFPKYFAD-----------QHQPAQLG
MAB_1409c|M.abscessus_ATCC_199 IALVDMAITALYLPIES-----VLLPKHFSD-----------IGAPQQLG
MSMEG_5187|M.smegmatis_MC2_155 TVLFASMFVLVVLGPIE-----VLLPFIAQDR---------FADGARAYG
MUL_4170|M.ulcerans_Agy99 GFALAVVLLAVFLWLERRTWHPILDLSIFANRRFSGGTAAVTTAYLVMCG
. : : :* : *
Mflv_2234|M.gilvum_PYR-GCK WVLMALSIGGLLG--------------ALGFAVLSKYLKRRTVMLTAVLT
Mvan_4461|M.vanbaalenii_PYR-1 WVLMALSIGGLIG--------------ALGYAVMSRYMKRRTVMLTAVLT
TH_2406|M.thermoresistible__bu WVLMALSIGGLTG--------------ALAYAWVSRFVSRRATLITAVLT
Mb1288c|M.bovis_AF2122/97 WALMAIAGGGLVG--------------ALGYAVLAIRVPRRVTMSTAVLT
Rv1258c|M.tuberculosis_H37Rv WALMAIAGGGLVG--------------ALGYAVLAIRVPRRVTMSTAVLT
MMAR_4182|M.marinum_M SVLVALSLGSLVG--------------ALGYGMLSNYVSRRTIMLTAVLT
MAV_1406|M.avium_104 WALMALALGGVAG--------------ALGYAVLSARLRRRTAVLTATLT
MAB_1409c|M.abscessus_ATCC_199 WMLMAISVGGLLG--------------ALGYATMVRHFQRRTIMLCATFT
MSMEG_5187|M.smegmatis_MC2_155 FILAFFGIGSAMG--------------ALTVSSRRMPRRYLTTMMLMWGL
MUL_4170|M.ulcerans_Agy99 FIFVATQYLQFVAAYRAFDTGVRLVPLAFSYAGLSVIAPRIVERVGTTAV
: . *: . .
Mflv_2234|M.gilvum_PYR-GCK LGVAMTVIAFLPPLP----------IILVLCALVGFVYGPIAPIYNYVMQ
Mvan_4461|M.vanbaalenii_PYR-1 LGVAMTVIAFLPPLP----------IILVLCAIVGFVYGPIAPIYNYVMQ
TH_2406|M.thermoresistible__bu LGATMTVIAFLPPLP----------LILAMAAVGGFAYGPIQPIYNYVMQ
Mb1288c|M.bovis_AF2122/97 LGLASMVIAFLPPLP----------VIMVLCAVVGLVYGPIQPIYNYVIQ
Rv1258c|M.tuberculosis_H37Rv LGLASMVIAFLPPLP----------VIMVLCAVVGLVYGPIQPIYNYVIQ
MMAR_4182|M.marinum_M LGAATTGIALLPPLP----------VILVLCALIGVVYGPIQPIYNYVMQ
MAV_1406|M.avium_104 FGATTAGIAVLPPLP----------VILGLCAVTGVVYGPIQPIYNFVMQ
MAB_1409c|M.abscessus_ATCC_199 AGITTLGMSLLPPIA----------VLLVLAACLGFIYGPVAPIANFVMQ
MSMEG_5187|M.smegmatis_MC2_155 GSIPLVIVGYTSSFP----------LMAAATFVIGVTDGAGMVIWGTLLQ
MUL_4170|M.ulcerans_Agy99 VTSGLVMVAVSVACAGGFDAGTPYWLIAAVMAALGSGLGLTMAPASEAIM
:. . . :: * * . :
Mflv_2234|M.gilvum_PYR-GCK TRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADSAGLHVTFLALSLP-
Mvan_4461|M.vanbaalenii_PYR-1 TRAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADATGLRTTFLALSLP-
TH_2406|M.thermoresistible__bu TRAPQHLRGRVVGVMGSLAYAAGPLGLVIAGPLADSAGLRVTFLALSLP-
Mb1288c|M.bovis_AF2122/97 TRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALP-
Rv1258c|M.tuberculosis_H37Rv TRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALP-
MMAR_4182|M.marinum_M TRAPHYLRGRVVGVMTSLAYAAGPLGLLLAGPVADAAGLKVAFFALALP-
MAV_1406|M.avium_104 TRAPHHLRGRVVGVMAGLTYAAGPLGLLVAGPLADAAGLKATFLTLAVP-
MAB_1409c|M.abscessus_ATCC_199 TRSPEHLRGRVVGVMTSTAYCAGPLGFMLAGPIADKFGVATTLVILGAP-
MSMEG_5187|M.smegmatis_MC2_155 RRVPTEMLGRVSSLDFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLV-
MUL_4170|M.ulcerans_Agy99 GSLSPTAAGVGSAVTGVARQLGACLGVAIVGSVFASVYLRSMSSNAALHG
. * .: *.. :.*.: : .
Mflv_2234|M.gilvum_PYR-GCK ------MLALGIVSVFLPALRELDTPHP----------------------
Mvan_4461|M.vanbaalenii_PYR-1 ------MLALGIVAVFLPALRDLDRPAAGP--------------------
TH_2406|M.thermoresistible__bu ------MVALGLIAIGLPVLTTLNQPAADQIDLQFDD-------------
Mb1288c|M.bovis_AF2122/97 ------IVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ-----------
Rv1258c|M.tuberculosis_H37Rv ------IVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ-----------
MMAR_4182|M.marinum_M ------IAITGLMCIRLPSLRELDHAPTQDISETSLL-------------
MAV_1406|M.avium_104 ------ILAIGVVACGLPSLRELDRAPQFADDPGA---------------
MAB_1409c|M.abscessus_ATCC_199 ------MLLIAIASTRMRVLRELDQDEPQPDKEPTR--------------
MSMEG_5187|M.smegmatis_MC2_155 ------PVAIAAVAFTAARMHRDEVANPLL--------------------
MUL_4170|M.ulcerans_Agy99 LDPAARAAMRQSMAAAKQVLDQLPVGEAPAIRHAVESAFLESFGVGCLAC
. :
Mflv_2234|M.gilvum_PYR-GCK -----------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 -----------------------------------------
TH_2406|M.thermoresistible__bu -----------------------------------------
Mb1288c|M.bovis_AF2122/97 -----------------------------------------
Rv1258c|M.tuberculosis_H37Rv -----------------------------------------
MMAR_4182|M.marinum_M -----------------------------------------
MAV_1406|M.avium_104 -----------------------------------------
MAB_1409c|M.abscessus_ATCC_199 -----------------------------------------
MSMEG_5187|M.smegmatis_MC2_155 -----------------------------------------
MUL_4170|M.ulcerans_Agy99 AVFAAVGAVVVAFLLPARGEVRDDVAVSVAASAIGPAEGGK