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AAVSSDPRPARSRARLLDAATALLRSGGPSAVTIDAVTRKANVARATLYRHFPSANDLVAAAFVGLIPPP PMPPSTGSLRERLLAIVVEWAESIAEAPTTLTAMAWLSLGPDIEQVPSAGGSQVGSLRERIAEQYSAPFD AVFDSPDAAAELRPVDRTMAFALLIGPLAFGRISTLTEFDYRAVAIAAVDGFLSTFSATNTGREGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5054 | - | - | 100% (207) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4579 | - | 3e-39 | 45.18% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3021 | - | 2e-12 | 36.80% (125) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1581 | - | 4e-11 | 35.64% (101) | regulatory protein |
| M. tuberculosis H37Rv | Rv1556 | - | 4e-11 | 35.64% (101) | regulatory protein |
| M. leprae Br4923 | MLBr_00316 | - | 4e-06 | 42.37% (59) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0989 | - | 3e-08 | 39.44% (71) | putative HTH-type transcriptional regulator TetR |
| M. marinum M | MMAR_4834 | - | 3e-38 | 46.28% (188) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4473 | - | 6e-55 | 63.53% (170) | hypothetical protein MAV_4473 |
| M. smegmatis MC2 155 | MSMEG_1430 | - | 2e-69 | 65.00% (200) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0409 | - | 2e-71 | 66.83% (199) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_1934 | - | 1e-09 | 42.47% (73) | regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0323 | - | 3e-40 | 45.69% (197) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1581|M.bovis_AF2122/97 MVGAVTQ---IADRPTDPSPWSPRE--TELLAVTLRLLQEHGYDRLTVDA
Rv1556|M.tuberculosis_H37Rv MVGAVTQ---IADRPTDPSPWSPRE--TELLAVTLRLLQEHGYDRLTVDA
MUL_1934|M.ulcerans_Agy99 -MGAMTQ---TADRSAQVSPWSPRE--AELLAVTLQLLQEHGYDRLTIDA
MAB_0989|M.abscessus_ATCC_1997 MASDVSTGLTKAARGRQVSQWTPRE--VELLKVTLRLLQEHGYDRLSVDE
MAV_4473|M.avium_104 ---------------------------------------------MTVDA
MSMEG_1430|M.smegmatis_MC2_155 ----------MTPGSNDPRPARSR---ARLLEAATVLLRSGGPSAVTVDA
TH_0409|M.thermoresistible__bu ----------MAAATSDPRPARSR---ARLLEAATTLLRTGGPSAVTIDA
Mflv_5054|M.gilvum_PYR-GCK ----------MAAVSSDPRPARSR---ARLLDAATALLRSGGPSAVTIDA
MMAR_4834|M.marinum_M MERDTLEFPVDDDDDVDPRRLRSR---TRLLDAATKLLSAGGIEAVTIDA
Mvan_0323|M.vanbaalenii_PYR-1 MS-DSQSVPVPDDD-VDPRRIRSR---TRLLDAAATLLSTGGVEAVTIDA
MLBr_00316|M.leprae_Br4923 MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEG-LSVPIDE
:.:*
Mb1581|M.bovis_AF2122/97 VAASARASKATVYRRWPSKAELVLAAFIEGIRQVA----VPPNTGNLRDD
Rv1556|M.tuberculosis_H37Rv VAASARASKATVYRRWPSKAELVLAAFIEGIRQVA----VPPNTGNLRDD
MUL_1934|M.ulcerans_Agy99 VANTARASKATVYRRWPSKAELVLAAFIEGVRQVA----VAPNTGSLRDD
MAB_0989|M.abscessus_ATCC_1997 VAAESKASKATIYRRWPSKAELVLAAFIEGMRAQL----VRPNTGSLRED
MAV_4473|M.avium_104 VTRTANVARATLYRHFPSGNDLLAAAFNSLIPASP----TPPAEGSLRDR
MSMEG_1430|M.smegmatis_MC2_155 VTRAANVARATLYRHFPSGNDLLAAAFRQLIPAAP----TPPQEGTLRDR
TH_0409|M.thermoresistible__bu VTKSANVARATLYRHFAGANDLLAAAFTSLLEPAP----MPPAEGSLRDR
Mflv_5054|M.gilvum_PYR-GCK VTRKANVARATLYRHFPSANDLVAAAFVGLIPPPP----MPPSTGSLRER
MMAR_4834|M.marinum_M VTKASKVARTTLYRHFSSSTQLLAATFERLLPQVH----PPPATGSMRDQ
Mvan_0323|M.vanbaalenii_PYR-1 VTKASKVARTTLYRHFHSSSHLLAATFERLLPQVTT---PAPTSGPLREQ
MLBr_00316|M.leprae_Br4923 IARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKSAGPGEA
:: : .. *:**:: * *.: : . :
Mb1581|M.bovis_AF2122/97 LLRLGELICREVGQHASTIRAVLVEVSR------------NPALNDVLQH
Rv1556|M.tuberculosis_H37Rv LLRLGELICREVGQHASTIRAVLVEVSR------------NPALNDVLQH
MUL_1934|M.ulcerans_Agy99 LVKIGEGICGQAHQQASTIRAVLVEVSR------------HPALSDALQR
MAB_0989|M.abscessus_ATCC_1997 LLRIGTNALADVRRNTPVMRGLLIEIER------------NPALTKAFRT
MAV_4473|M.avium_104 LVAVVLAQAEAVAQAPTMMTAMTWLALGRDLEAWPQPRADDSVAITTLRE
MSMEG_1430|M.smegmatis_MC2_155 LIALVSAQAELIAEAPVTVTAMSWLALGADMEHLPLS---ASPEVLSLRE
TH_0409|M.thermoresistible__bu LLAVVLGWAETIAEAPTMLTAMTWMASGPDVGPYPDARETDSDAVGTLRS
Mflv_5054|M.gilvum_PYR-GCK LLAIVVEWAESIAEAPTTLTAMAWLSLGPDIEQVPSA---GGSQVGSLRE
MMAR_4834|M.marinum_M LIELLSRQATLFQEAPLHVTTLAWVALGPTPDGTQETQ--DRH---ALRA
Mvan_0323|M.vanbaalenii_PYR-1 LIELLSRQAALFNDAPLHVTTLAWLSLGPTGS-NNEAD--DRHTSGALRA
MLBr_00316|M.leprae_Br4923 LFTYLRSLVLHWGATDRGLVDALAGAGG-------------IDILGVAPD
*. :
Mb1581|M.bovis_AF2122/97 QFVDHRKALIQYILQQAVDRGEISSAAISDELWDLLPGYLIFRSIIPNRP
Rv1556|M.tuberculosis_H37Rv QFVDHRKALIQYILQQAVDRGEISSAAISDELWDLLPGYLIFRSIIPNRP
MUL_1934|M.ulcerans_Agy99 QFVDQRKALIQQVLQQAVDRGEITQAAITDELWDLLPGYLIFRSIIPNRP
MAB_0989|M.abscessus_ATCC_1997 KFVDERKALIDDVLFAAVQRGEIDADAVNEELWDLLPGYLVFRSLLPVRS
MAV_4473|M.avium_104 RIAQQYSEPFDVIFDSPEA-AELGEVDRSRAIALLIGPLVLGRLSTLPDF
MSMEG_1430|M.smegmatis_MC2_155 RVAEQYAAPFEAIFTSPEAREELGDVDRAQAAALLLGPIVLGKLSTLPEF
TH_0409|M.thermoresistible__bu RIVQLYSVPFDAILDSPQAAEELDEVDRIQTIALLIGPLILGKLSTVADF
Mflv_5054|M.gilvum_PYR-GCK RIAEQYSAPFDAVFDSPDAAAELRPVDRTMAFALLIGPLAFGRISTLTEF
MMAR_4834|M.marinum_M RIIDQYRQPFVALLQSPEARADLDDFDMELILCQLIGPVAFARLTGLRAI
Mvan_0323|M.vanbaalenii_PYR-1 RVVDQYRQPFDAILTSPKAQAELDDFDRELALCQLVGPLAFARMTGIRTI
MLBr_00316|M.leprae_Br4923 AEDAFLTILSDLLYAAQYAGTARTDVGVREVKSILVG---CQAMEAYNSA
: *:
Mb1581|M.bovis_AF2122/97 PTQDTVQALVDDVILPSLTRSTG-------------------
Rv1556|M.tuberculosis_H37Rv PTQDTVQALVDDVILPSLTRSTG-------------------
MUL_1934|M.ulcerans_Agy99 PTPHTVQLLVDDFIMPGLTQATG-------------------
MAB_0989|M.abscessus_ATCC_1997 PTADTVRTLVDDVIMPSLTRER--------------------
MAV_4473|M.avium_104 DYRECALAAVDGFLHVQS--ARARAARVESAGA---------
MSMEG_1430|M.smegmatis_MC2_155 DYATCVRSAVDGFLATHR--RTVSESSNESAGA---------
TH_0409|M.thermoresistible__bu DYRRCAEAAVDGFLATHAKKREITSASTESGGA---------
Mflv_5054|M.gilvum_PYR-GCK DYRAVAIAAVDGFLSTFS------ATNTGREGA---------
MMAR_4834|M.marinum_M DRQDCER-IVDDFLVAHRRQADKPAQRAVSRKPVSRRSGSD-
Mvan_0323|M.vanbaalenii_PYR-1 THNDCAN-IVDDFLTAHR-KTDSDAK--ESKIATSRRAAPRV
MLBr_00316|M.leprae_Br4923 LAERVTDVVVDGLRAAR-------------------------
**..