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M. gilvum PYR-GCK Mflv_4783 (-)

annotation: diguanylate cyclase
coordinates: 5094441 - 5095607
length: 388

VPRQLSVVAGLRHWWRQADHYDWFADYLSARGLVGLARVITAVTAAGLALVGATVMFCPGGPTGTLDVTL
GWAAVALAFGCAIVRWSIWPSKRQSVVLILALNLAIALFCQVQTDQLIGVVGATAFATTGISIACLHSAK
YMLYNVVVAAYIGGLQAVRAMDETDGHLILAALGLVLIINISVPFSVQSLVHALGGDVVQSDRDPLTGLC
HRRALFRQLNALLLSHREHADFLAVTMIDLDKFKVLNDTYGHSAGDDALVAVGEALLTAANGRALVGRVG
GEEFMVAELCETARDTGLSERLRAAIAALPHHITGSVGTAVASINDVPTDDFQDLVVTLFRRSDRAMYEA
KRAGGNQIRHTVIDLPAIPVSGADNLPAGNRPARRTSD
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4783--100% (388)diguanylate cyclase
M. gilvum PYR-GCKMflv_1453-1e-6741.33% (346) diguanylate cyclase
M. gilvum PYR-GCKMflv_3822-2e-6139.04% (356) diguanylate cyclase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1389c-1e-1633.73% (169) hypothetical protein Mb1389c
M. tuberculosis H37RvRv1354c-1e-1633.73% (169) hypothetical protein Rv1354c
M. leprae Br4923MLBr_00397-2e-1432.69% (156) putative transporter protein
M. abscessus ATCC 19977MAB_3940c-1e-4231.68% (363) hypothetical protein MAB_3940c
M. marinum M-----
M. avium 104MAV_1995-9e-7042.54% (355) diguanylate cyclase
M. smegmatis MC2 155MSMEG_2774-6e-3029.19% (346) diguanylate cyclase
M. thermoresistible (build 8)TH_3406-3e-4632.03% (359) PUTATIVE diguanylate cyclase
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_1665-2e-7040.23% (353) diguanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1389c|M.bovis_AF2122/97           -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
Rv1354c|M.tuberculosis_H37Rv        -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
MAV_1995|M.avium_104                -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
Mvan_1665|M.vanbaalenii_PYR-1       -----------MGAIGRWWRQPDQYDWLSSYMHARGFTRPAQIFMAVIAA
Mflv_4783|M.gilvum_PYR-GCK          ----MPRQLSVVAGLRHWWRQADHYDWFADYLSARGLVGLARVITAVTAA
MSMEG_2774|M.smegmatis_MC2_155      ------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTIT
TH_3406|M.thermoresistible__bu      ----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITL
MAB_3940c|M.abscessus_ATCC_199      MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
MLBr_00397|M.leprae_Br4923          -----------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPA
                                                                                      

Mb1389c|M.bovis_AF2122/97           TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
Rv1354c|M.tuberculosis_H37Rv        TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
MAV_1995|M.avium_104                SLVLVPANVLWGATPFFPGLTLTVSVLAGMVGLGMAVLWLH-GWPTRRQS
Mvan_1665|M.vanbaalenii_PYR-1       SGVLVPANALWGPAATSHALLLALGVVAGLAGLAYLVLWLS-RWPTRNQS
Mflv_4783|M.gilvum_PYR-GCK          GLALVGATVMFCPGGPTGTLDVTLGWAAVALAFGCAIVRWS-IWPSKRQS
MSMEG_2774|M.smegmatis_MC2_155      ALAFVPVLMLASPAGPAGAL-RYVPLGATACGVLMSVWWWRRKWPSRNQS
TH_3406|M.thermoresistible__bu      ILGLMPMVMLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQS
MAB_3940c|M.abscessus_ATCC_199      IFAAICIAVQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLREA
MLBr_00397|M.leprae_Br4923          ATRILGLRAHDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSK
                                        :                               :             

Mb1389c|M.bovis_AF2122/97           PL---------RLIYFADADPVFALCEHAKEP-LVFRPEPATEDYQRLIE
Rv1354c|M.tuberculosis_H37Rv        PL---------RLIYFADADPVFALCEHAKEP-LVFRPEPATEDYQRLIE
MAV_1995|M.avium_104                VV---------FALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFF
Mvan_1665|M.vanbaalenii_PYR-1       IG---------FALTICVCIALGSFTAADPAIGLMASAALAVSGGYLAFF
Mflv_4783|M.gilvum_PYR-GCK          VV---------LILALNLAIALFCQVQTDQLIGVVGATAFATTGISIACL
MSMEG_2774|M.smegmatis_MC2_155      WL---------VVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSAFL
TH_3406|M.thermoresistible__bu      RV---------VSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALF
MAB_3940c|M.abscessus_ATCC_199      VA---------FVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFF
MLBr_00397|M.leprae_Br4923          VVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTY
                                                                      .               

Mb1389c|M.bovis_AF2122/97           EARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELN---ALMTIA
Rv1354c|M.tuberculosis_H37Rv        EARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELN---ALMTIA
MAV_1995|M.avium_104                HTAKFMGLNFGLAGAIGALQAARLAASGQAMLAFTGYFLVL---ELNVIV
Mvan_1665|M.vanbaalenii_PYR-1       HSARLVTANLVVALAVAAVHVARLAADGQAVLAVSMLFLVV---ELNAGV
Mflv_4783|M.gilvum_PYR-GCK          HSAKYMLYNVVVAAYIGGLQAVRAMDETDGHLILAALGLVL---IINISV
MSMEG_2774|M.smegmatis_MC2_155      HSRRVLVLSWIASGLTVGFLAIRVAFTS-IPMALSGALVSG---LVIATT
TH_3406|M.thermoresistible__bu      HSARYATFTVLFAAITAGVLSFELAKTAGVAAAVCGFVFIT---VVTFAV
MAB_3940c|M.abscessus_ATCC_199      LANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLI
MLBr_00397|M.leprae_Br4923          EATHDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSL
                                     :                                           :    

Mb1389c|M.bovis_AF2122/97           TLFAQVQARVAAEARLRYLADHDDLTGLHNRR----ALLQHLDQRLAPG-
Rv1354c|M.tuberculosis_H37Rv        TLFAQVQARVAAEARLRYLADHDDLTGLHNRR----ALLQHLDQRLAPG-
MAV_1995|M.avium_104                PLSIQIVVRALWLDLLRA--NRDPLTGLLNRR----ACNRAIIGRMLTG-
Mvan_1665|M.vanbaalenii_PYR-1       PLAIQIMVHALGIDLIKS--DRDPLTGLLNRR----SFQRAVVAAVLDGQ
Mflv_4783|M.gilvum_PYR-GCK          PFSVQSLVHALGGDVVQS--DRDPLTGLCHRR----ALFRQLNALLLSHR
MSMEG_2774|M.smegmatis_MC2_155      SMLCRMAIRLLDAGNVQHPNEIDRLTGLLNRE----AFEIQAATMLGSHS
TH_3406|M.thermoresistible__bu      VCACNLLVGLLDVDVLDA--DIEPLTGLLNRD----AFYRSAGHLI-SRS
MAB_3940c|M.abscessus_ATCC_199      PAVIQFGIAVVRWDALAA--QRDPLTGLLNRRGIYAEWQRLYGELRREQP
MLBr_00397|M.leprae_Br4923          GHDVGDAVLQTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDV
                                                   :      : :..                       

Mb1389c|M.bovis_AF2122/97           --QPGPVAALFLDLDRLKAINDYLG----------------HAAGDQFIH
Rv1354c|M.tuberculosis_H37Rv        --QPGPVAALFLDLDRLKAINDYLG----------------HAAGDQFIH
MAV_1995|M.avium_104                ASHMF-LAVAMVDLDRFKALNDTHG----------------HAAGDEALI
Mvan_1665|M.vanbaalenii_PYR-1       RSGTH-LAFAMLDLDRFKVLNDTLG----------------HSAGDDALV
Mflv_4783|M.gilvum_PYR-GCK          EHADF-LAVTMIDLDKFKVLNDTYG----------------HSAGDDALV
MSMEG_2774|M.smegmatis_MC2_155      RHDDQYLVILAVGIDDMSLLSDMDG----------------THSTLHARV
TH_3406|M.thermoresistible__bu      RDDDRQLVIALINIDNLRLLRDTQG----------------QAAADRARV
MAB_3940c|M.abscessus_ATCC_199      LDGDQVTAAAIVDIDRFKSINDRYG----------------HGTGDRVLI
MLBr_00397|M.leprae_Br4923          AKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMY
                                               : :* :    .                            

Mb1389c|M.bovis_AF2122/97           VFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------LAERL
Rv1354c|M.tuberculosis_H37Rv        VFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------LAERL
MAV_1995|M.avium_104                AVAGALTAACGDTTVVGRVGGEEFLVA--DIVTTEQLPG------WGQQL
Mvan_1665|M.vanbaalenii_PYR-1       SVAQALTANLPDTAIIGRVGGEEFLIA--DVIAAAVPED------LGERA
Mflv_4783|M.gilvum_PYR-GCK          AVGEALLTAANGRALVGRVGGEEFMVA--ELCETARDTG------LSERL
MSMEG_2774|M.smegmatis_MC2_155      AVAQALRETVRHRVPLAHVSDSEFLIA--DVFKTNDPSP------LVERM
TH_3406|M.thermoresistible__bu      AIGQTLRENTRHNAFVAHLGQDEFLIA--DTFSSTDSFP------LVERV
MAB_3940c|M.abscessus_ATCC_199      DVAHALTCGTTGTSVVGRSGGEEFLVV--TVCPASAVAE------FATRL
MLBr_00397|M.leprae_Br4923          AAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTV
                                                   :   .   :.:       :                

Mb1389c|M.bovis_AF2122/97           RDQLKDH----VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALA
Rv1354c|M.tuberculosis_H37Rv        RDQLKDH----VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALA
MAV_1995|M.avium_104                CEAVAALD---PPVTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMYE
Mvan_1665|M.vanbaalenii_PYR-1       REAVTFTP---YGLTTSVGTASFAVDALNAGNIVDSMHWLTAQADVAMYS
Mflv_4783|M.gilvum_PYR-GCK          RAAIAALP---HHITGSVGTAVASINDVPTDDFQDLVVTLFRRSDRAMYE
MSMEG_2774|M.smegmatis_MC2_155      RLAISTTP---MRLTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMNE
TH_3406|M.thermoresistible__bu      RGAIATTP---PRLTASIGVVSTPMRGLAVCPPETLLDELIAVASATMYE
MAB_3940c|M.abscessus_ATCC_199      RQAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMYE
MLBr_00397|M.leprae_Br4923          VLAIVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALL
                                       :         :  .:     .:                  :  :   

Mb1389c|M.bovis_AF2122/97           AKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLR
Rv1354c|M.tuberculosis_H37Rv        AKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLR
MAV_1995|M.avium_104                AKRCGGNQTRHR-------PAQVST-------------------------
Mvan_1665|M.vanbaalenii_PYR-1       AKRAGGNGVRHHT------PARRDEDSPREDAPQRP--------------
Mflv_4783|M.gilvum_PYR-GCK          AKRAGGNQIRHTVIDLPAIPVSGADNLPAGNRPARRTSD-----------
MSMEG_2774|M.smegmatis_MC2_155      SRAAGGNQTISVNYP---TPTPNQE-------------------------
TH_3406|M.thermoresistible__bu      ARRAGGNQARYRKYP---NPTAVTEAHYPEQAADDF--------------
MAB_3940c|M.abscessus_ATCC_199      AKHDGGDQSRILHAD------DDSEGRYLWRSGA----------------
MLBr_00397|M.leprae_Br4923          VGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHG
                                        .*                                            

Mb1389c|M.bovis_AF2122/97           TGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNE
Rv1354c|M.tuberculosis_H37Rv        TGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNE
MAV_1995|M.avium_104                --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4783|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155      --------------------------------------------------
TH_3406|M.thermoresistible__bu      --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_00397|M.leprae_Br4923          ILGAMGAMPWILIVCLFVTILAG--------ILFQFTMFGRWVKAIGGNE
                                                                                      

Mb1389c|M.bovis_AF2122/97           FSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLE
Rv1354c|M.tuberculosis_H37Rv        FSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLE
MAV_1995|M.avium_104                --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4783|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155      --------------------------------------------------
TH_3406|M.thermoresistible__bu      --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_00397|M.leprae_Br4923          RVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGFEID
                                                                                      

Mb1389c|M.bovis_AF2122/97           ITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTL
Rv1354c|M.tuberculosis_H37Rv        ITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTL
MAV_1995|M.avium_104                --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4783|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155      --------------------------------------------------
TH_3406|M.thermoresistible__bu      --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_00397|M.leprae_Br4923          VIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIK
                                                                                      

Mb1389c|M.bovis_AF2122/97           KIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLD
Rv1354c|M.tuberculosis_H37Rv        KIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLD
MAV_1995|M.avium_104                --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_4783|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155      --------------------------------------------------
TH_3406|M.thermoresistible__bu      --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199      --------------------------------------------------
MLBr_00397|M.leprae_Br4923          GIMLAAAVFVFLQRRKIGIIK-----------------------------
                                                                                      

Mb1389c|M.bovis_AF2122/97           QRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv        QRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
MAV_1995|M.avium_104                ------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1       ------------------------------------------
Mflv_4783|M.gilvum_PYR-GCK          ------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155      ------------------------------------------
TH_3406|M.thermoresistible__bu      ------------------------------------------
MAB_3940c|M.abscessus_ATCC_199      ------------------------------------------
MLBr_00397|M.leprae_Br4923          ------------------------------------------