For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ISSSTSKRRRLRPAANRWWNQPDQFDWLSGYLHARGLAPATRRLMAVISSALVLMAFGVLGSRDEHPVLT YTVAAAAAIAGIGYGTLWLRRWPTRRQSLMMGMVGGSMIAVGSGMQTEPVVALMGCTGLVVTGGYLAFFH NTKAVLFNFAVAATVGTYCALRVFETYDDRASALAGLWLIIELNLAVPLAIQTVVRTMGADVVRSDHDAL TGLLNRRGFYERASSLLTSPAADSDLIVVMIDLDAFKRLNDTYGHLAGDQALAAVGWALRKASPGSAVIG RTGGEEFLLIDILPVAQAEALPDELCAAIAALPHPVTASVGAAVVRGLPQSDAPAVIEALTRTADATMYE AKRSGGNQALIRRVSPLFQN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1453 | - | - | 100% (371) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_4783 | - | 1e-67 | 41.33% (346) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1914 | - | 2e-62 | 41.04% (346) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-18 | 32.82% (195) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-18 | 32.82% (195) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01419 | - | 8e-16 | 35.85% (159) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-41 | 30.30% (363) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 3e-82 | 47.67% (344) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 1e-25 | 26.09% (345) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 2e-46 | 32.68% (355) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1665 | - | 8e-71 | 42.98% (349) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1995|M.avium_104 ------------------------------------------------MK
Mvan_1665|M.vanbaalenii_PYR-1 ------------------------------------------------MG
Mflv_1453|M.gilvum_PYR-GCK ------------------------------------MISSSTSKRRRLRP
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu -----------------------------------------------MLK
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 -------------------------------------MIVSYIRSTAWMG
MLBr_01419|M.leprae_Br4923 MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQRLVDHSPNMTCVHE
MAV_1995|M.avium_104 WLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMA---VVGASLVLVPANVL
Mvan_1665|M.vanbaalenii_PYR-1 AIGRWWRQPDQYDWLSSYMHARGFTRPAQIFMA---VIAASGVLVPANAL
Mflv_1453|M.gilvum_PYR-GCK AANRWWNQPDQFDWLSGYLHARGLAPATRRLMA---VISSALVLMAFGVL
MSMEG_2774|M.smegmatis_MC2_155 -----MSPFDHYYARTAMLSAQGQRSRMRRIIG---VTITALAFVPVLML
TH_3406|M.thermoresistible__bu ALRRTWRKPDHYYWFTSFLAARRARTSTCRFIA---SITLILGLMPMVML
Mb1389c|M.bovis_AF2122/97 ----------MCNDTATPQLEELVTTVANQLMT---VDAATSAEVSQRVL
Rv1354c|M.tuberculosis_H37Rv ----------MCNDTATPQLEELVTTVANQLMT---VDAATSAEVSQRVL
MAB_3940c|M.abscessus_ATCC_199 FLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIG---GYALIFAAICIAVQ
MLBr_01419|M.leprae_Br4923 SGRVTYLNPVGVKWMAAQSPEQIIGHPLIEFVHPDSMPAMMSRIAPLREV
. :
MAV_1995|M.avium_104 WGATPFFPGLTLTVSVLAG-MVGLGMAVLWLHG--WPTRRQSVVFALTGS
Mvan_1665|M.vanbaalenii_PYR-1 WGPAATSHALLLALGVVAG-LAGLAYLVLWLSR--WPTRNQSIGFALTIC
Mflv_1453|M.gilvum_PYR-GCK G-SRDEHPVLTYTVAAAAA-IAGIGYGTLWLRR--WPTRRQSLMMGMVGG
MSMEG_2774|M.smegmatis_MC2_155 ASPAGPAGAL-RYVPLGAT-ACGVLMSVWWWRRK-WPSRNQSWLVVGIGT
TH_3406|M.thermoresistible__bu AGPAGPQSMPGRLIAVAVT-VTALVITLIWLRDR-WPSRNQSRVVSLAAG
Mb1389c|M.bovis_AF2122/97 AYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADA
Rv1354c|M.tuberculosis_H37Rv AYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADA
MAB_3940c|M.abscessus_ATCC_199 FSDTGPRSMIGRVIVGLCA-VGSLGWALRWAVGP-WPSLREAVAFVAFAD
MLBr_01419|M.leprae_Br4923 GDASQPSEAVLLRLDGTTLEVEAVSVLTVWEGKPAYQVIFRDLTTQKAAE
: . *
MAV_1995|M.avium_104 VAIGAGCLWQTEPLVGLMACSALSVTGGY---------------------
Mvan_1665|M.vanbaalenii_PYR-1 VCIALGSFTAADPAIGLMASAALAVSGGY---------------------
Mflv_1453|M.gilvum_PYR-GCK SMIAVGSGMQTEPVVALMGCTGLVVTGGY---------------------
MSMEG_2774|M.smegmatis_MC2_155 VGIAVTLSSMSDPTVGLLSSSVFSLVTTY---------------------
TH_3406|M.thermoresistible__bu LAIAVFAFTLPDPSAGLVWTAAFAVLAGY---------------------
Mb1389c|M.bovis_AF2122/97 DPVFALCEHAKEP----LVFRPEPATEDY---------------------
Rv1354c|M.tuberculosis_H37Rv DPVFALCEHAKEP----LVFRPEPATEDY---------------------
MAB_3940c|M.abscessus_ATCC_199 IGIAVACWQDSDPLAGLVGTVLFTPVGAY---------------------
MLBr_01419|M.leprae_Br4923 ETLRFQAALVNHVSDAIIATTSTGMVTSWNPAAEAIYRRSASDVLGMPIG
: . : :
MAV_1995|M.avium_104 -------------------NAFFHTAKFMGLNFGLAGAIGALQAARLAAS
Mvan_1665|M.vanbaalenii_PYR-1 -------------------LAFFHSARLVTANLVVALAVAAVHVARLAAD
Mflv_1453|M.gilvum_PYR-GCK -------------------LAFFHNTKAVLFNFAVAATVGTYCALRVFET
MSMEG_2774|M.smegmatis_MC2_155 -------------------SAFLHSRRVLVLSWIASGLTVGFLAIRVAFT
TH_3406|M.thermoresistible__bu -------------------VALFHSARYATFTVLFAAITAGVLSFELAKT
Mb1389c|M.bovis_AF2122/97 -------------------QRLIEEARGVPVTSAAAVPLVSGEITTGLLG
Rv1354c|M.tuberculosis_H37Rv -------------------QRLIEEARGVPVTSAAAVPLVSGEITTGLLG
MAB_3940c|M.abscessus_ATCC_199 -------------------VSFFLANRLLVAHVAWCAPMIIALSSRLFAE
MLBr_01419|M.leprae_Br4923 EAVGAPLDPGAIITEGGVLSTTQYASDGMALAVRVSAAVMENGFVLVCSD
.
MAV_1995|M.avium_104 -GQAMLAFTGYFLVLELNVIVPLSIQ------------------------
Mvan_1665|M.vanbaalenii_PYR-1 -GQAVLAVSMLFLVVELNAGVPLAIQ------------------------
Mflv_1453|M.gilvum_PYR-GCK YDDRASALAGLWLIIELNLAVPLAIQ------------------------
MSMEG_2774|M.smegmatis_MC2_155 S-IPMALSG-ALVSGLVIATTSMLCR------------------------
TH_3406|M.thermoresistible__bu AGVAAAVCG-FVFITVVTFAVVCACN------------------------
Mb1389c|M.bovis_AF2122/97 FIKFGDRKWHEAELNALMTIATLFAQ------------------------
Rv1354c|M.tuberculosis_H37Rv FIKFGDRKWHEAELNALMTIATLFAQ------------------------
MAB_3940c|M.abscessus_ATCC_199 GTVGAAMTALVKVTSMLLVVVLIPAV------------------------
MLBr_01419|M.leprae_Br4923 YTALLRVERRFQTVVALLEEGVIVLDGDGYVESVNPAALRILGVSDRSAL
:
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 DDPVRRAATLPMYDAQGRLLDHGRGAVREFLRTGTPKTGFIVGIDRPSDG
MAV_1995|M.avium_104 ----------------------------IVVRALWLDLLRA--NRDPLTG
Mvan_1665|M.vanbaalenii_PYR-1 ----------------------------IMVHALGIDLIKS--DRDPLTG
Mflv_1453|M.gilvum_PYR-GCK ----------------------------TVVRTMGADVVRS--DHDALTG
MSMEG_2774|M.smegmatis_MC2_155 ----------------------------MAIRLLDAGNVQHPNEIDRLTG
TH_3406|M.thermoresistible__bu ----------------------------LLVGLLDVDVLDA--DIEPLTG
Mb1389c|M.bovis_AF2122/97 ----------------------------VQARVAAEARLRYLADHDDLTG
Rv1354c|M.tuberculosis_H37Rv ----------------------------VQARVAAEARLRYLADHDDLTG
MAB_3940c|M.abscessus_ATCC_199 ----------------------------IQFGIAVVRWDALAAQRDPLTG
MLBr_01419|M.leprae_Br4923 TRVWLSVNSRSLNPVDPEDATLLISFTDVTAERQASQYLAHQAAHDTLTG
: ***
MAV_1995|M.avium_104 LLNRRACNRAIIGRM-LTG-ASHMF----LAVAMVDLDRFKALNDTHGHA
Mvan_1665|M.vanbaalenii_PYR-1 LLNRRSFQRAVVAAV-LDGQRSGTH----LAFAMLDLDRFKVLNDTLGHS
Mflv_1453|M.gilvum_PYR-GCK LLNRRGFY-ERASSL-LTSPAADSD----LIVVMIDLDAFKRLNDTYGHL
MSMEG_2774|M.smegmatis_MC2_155 LLNREAFEIQAATMLGSHSRHDDQY----LVILAVGIDDMSLLSDMDGTH
TH_3406|M.thermoresistible__bu LLNRDAFYRSAGHLI-SRSRDDDRQ----LVIALINIDNLRLLRDTQGQA
Mb1389c|M.bovis_AF2122/97 LHNRRALLQHLDQRL---APGQPGP----VAALFLDLDRLKAINDYLGHA
Rv1354c|M.tuberculosis_H37Rv LHNRRALLQHLDQRL---APGQPGP----VAALFLDLDRLKAINDYLGHA
MAB_3940c|M.abscessus_ATCC_199 LLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHG
MLBr_01419|M.leprae_Br4923 LPNRTSILARIDEQRYCGAPDQLLT-----AVLFIDLDNFKGINDSLGHD
* ** . :.:* : : * *
MAV_1995|M.avium_104 AGDEALIAVAGALTAACGDTTVVGRVGGEEFLVA--DIVTTEQLPGWGQQ
Mvan_1665|M.vanbaalenii_PYR-1 AGDDALVSVAQALTANLPDTAIIGRVGGEEFLIA--DVIAAAVPEDLGER
Mflv_1453|M.gilvum_PYR-GCK AGDQALAAVGWALRKASPGSAVIGRTGGEEFLLI--DILPVAQAEALPDE
MSMEG_2774|M.smegmatis_MC2_155 STLHARVAVAQALRETVRHRVPLAHVSDSEFLIA--DVFKTNDPSPLVER
TH_3406|M.thermoresistible__bu AADRARVAIGQTLRENTRHNAFVAHLGQDEFLIA--DTFSSTDSFPLVER
Mb1389c|M.bovis_AF2122/97 AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAER
Rv1354c|M.tuberculosis_H37Rv AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAER
MAB_3940c|M.abscessus_ATCC_199 TGDRVLIDVAHALTCGTTGTSVVGRSGGEEFLVV--TVCPASAVAEFATR
MLBr_01419|M.leprae_Br4923 VGDVVLQTAAQRLRAGLRSRDVVGRFGGDEFVALILGKITHTELSKVVDR
. : :.: . .**: .
MAV_1995|M.avium_104 LCEAVAALD---PPVTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMY
Mvan_1665|M.vanbaalenii_PYR-1 AREAVTFTP---YGLTTSVGTASFAVDALNAGNIVDSMHWLTAQADVAMY
Mflv_1453|M.gilvum_PYR-GCK LCAAIAALP---HPVTASVGAA--VVRGLPQSDAPAVIEALTRTADATMY
MSMEG_2774|M.smegmatis_MC2_155 MRLAISTTP---MRLTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMN
TH_3406|M.thermoresistible__bu VRGAIATTP---PRLTASIGVVSTPMRGLAVCPPETLLDELIAVASATMY
Mb1389c|M.bovis_AF2122/97 LRDQLKDH----VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAAL
Rv1354c|M.tuberculosis_H37Rv LRDQLKDH----VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAAL
MAB_3940c|M.abscessus_ATCC_199 LRQAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMY
MLBr_01419|M.leprae_Br4923 MHAALSEPT---YVADAVLHLRASIGVVAIKGDDPRNIGQILRDADTAMY
: : : * :
MAV_1995|M.avium_104 EAKRCGGNQTRHR-PAQVST------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 SAKRAGGNGVRHHTPARRDEDSPREDAPQRP-------------------
Mflv_1453|M.gilvum_PYR-GCK EAKRSGGNQALIRRVSPLFQN-----------------------------
MSMEG_2774|M.smegmatis_MC2_155 ESRAAGGNQTISVNYPTPTPNQE---------------------------
TH_3406|M.thermoresistible__bu EARRAGGNQARYRKYPNPTAVTEAHYPEQAADDF----------------
Mb1389c|M.bovis_AF2122/97 AAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDL
Rv1354c|M.tuberculosis_H37Rv AAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDL
MAB_3940c|M.abscessus_ATCC_199 EAKHDGGDQSRILHADDDSEGRYLWRSGA---------------------
MLBr_01419|M.leprae_Br4923 RAKLSGEGTSYYTDTFNQQPS-----------------------------
:: * .
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
Rv1354c|M.tuberculosis_H37Rv RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
Rv1354c|M.tuberculosis_H37Rv EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
Rv1354c|M.tuberculosis_H37Rv EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
Rv1354c|M.tuberculosis_H37Rv LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
MAV_1995|M.avium_104 -------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 -------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK -------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 -------------------------------------------
TH_3406|M.thermoresistible__bu -------------------------------------------
Mb1389c|M.bovis_AF2122/97 DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
MAB_3940c|M.abscessus_ATCC_199 -------------------------------------------
MLBr_01419|M.leprae_Br4923 -------------------------------------------