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DHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATRILGLRAHDVVDMKHGHPFCFYDTDNQRVD LEREVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEA THDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRLRSAVRP DDVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADIL RDADSAMYAAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGMTFV IMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCR GITLMISDSSAKPMPFHGILGAMGAMPWILIVCLFVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPT RGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIIS MLSNGMVFMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00397 | - | - | 100% (602) | putative transporter protein |
| M. leprae Br4923 | MLBr_01419 | - | 2e-57 | 42.57% (296) | putative regulatory protein |
| M. leprae Br4923 | MLBr_01750 | - | 2e-23 | 37.14% (175) | hypothetical protein MLBr_01750 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-23 | 34.18% (196) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_2606 | - | 2e-28 | 28.21% (319) | inner-membrane translocator |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-23 | 34.18% (196) | hypothetical protein Rv1354c |
| M. abscessus ATCC 19977 | MAB_1839 | - | 2e-19 | 35.75% (221) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1132 | - | 5e-23 | 35.38% (195) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4171 | - | 8e-53 | 39.13% (299) | ribose transport system permease protein RbsC |
| M. thermoresistible (build 8) | TH_0811 | - | 1e-27 | 37.21% (215) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4010 | - | 2e-28 | 28.53% (319) | inner-membrane translocator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2606|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
TH_0811|M.thermoresistible__bu -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
MAV_1132|M.avium_104 -----MPRSLDLVVTSVATALMEATASTARSVSETVLAQLVEQFDVDASF
MLBr_00397|M.leprae_Br4923 -----------------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDG--
MSMEG_4171|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2606|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4010|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
MAV_1132|M.avium_104 LHHHDAAGPVP--VAEWPRRTDAAG--PMAALRSEDVESVLAQCERQRRP
MLBr_00397|M.leprae_Br4923 ---------------------RIESINPAATRILGLRAHDVVDMKHGHPF
MSMEG_4171|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 -----------------------------------MVTTYPGRNGFGSES
Mflv_2606|M.gilvum_PYR-GCK --MSTKEALDVGGHKVVRDERVKERNRLQRLLIRPEMGAGIG--------
Mvan_4010|M.vanbaalenii_PYR-1 --MSTHADLDVAAHKVVRDERVKERNRLQRLLIRPEMGAGIG--------
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
MAV_1132|M.avium_104 VVSSPDQADGWLRRWLQRDKAAGAPSVAAAPLVSGDATTGVLGFVKFGAR
MLBr_00397|M.leprae_Br4923 CFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNVSLL
MSMEG_4171|M.smegmatis_MC2_155 --MTTTSAPLKPPESGPTNTSRPRGRVLGGPSLRQLAQLGPVVA------
MAB_1839|M.abscessus_ATCC_1997 NRCSTGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLAATG--
. . .
Mflv_2606|M.gilvum_PYR-GCK ---------AIGIFVFFLVVAPPFREASSLATVLYASSTIGIMACGVAVL
Mvan_4010|M.vanbaalenii_PYR-1 ---------AIGIFVFFLVVAAPFREASSLATVLYASSTIGIMACGVAVL
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLA
MAV_1132|M.avium_104 RWKPEEINTLEAVAALFAQLQARIAAEERLRYLAEHDDLTGVYNRRALVA
MLBr_00397|M.leprae_Br4923 AYKAP---PHSALVVSFSDISAHHLSIERLTYEATHDCLTGLANRRFAED
MSMEG_4171|M.smegmatis_MC2_155 ---------LVLLAAVFAVSAPNFTSSANLTNVLQQVSITAIAAVGATVV
MAB_1839|M.abscessus_ATCC_1997 ----------MSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYC
: . : .
Mflv_2606|M.gilvum_PYR-GCK MIGGEFDLS--AGVAVTFSSLAASMLAYNLHLNLWVGALLALVLALTVGF
Mvan_4010|M.vanbaalenii_PYR-1 MIGGEFDLS--AGVAVTFSSLAASMLAYNLHLNLWVGALLALILSLTVGF
Mb1389c|M.bovis_AF2122/97 HLDQRLAPGQ-PGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGD
Rv1354c|M.tuberculosis_H37Rv HLDQRLAPGQ-PGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGD
TH_0811|M.thermoresistible__bu HLDARLAAGQ-PGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLRE
MAV_1132|M.avium_104 HLTERLAAGN-PGPVAVFYLDLDRLKPINDYLGHTAGDWFIRVFAQRIEE
MLBr_00397|M.leprae_Br4923 QITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRLRS
MSMEG_4171|M.smegmatis_MC2_155 ILVAGIDLS--VGSVVALTGSIAALYLQHAILSTGASAAVAVLLSLVVGT
MAB_1839|M.abscessus_ATCC_1997 DVAILIGICV-VTTTGVAFVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTA
: : . . : :. . :
Mflv_2606|M.gilvum_PYR-GCK FNG----FLVMKTKIPSFLIT-----------------------------
Mvan_4010|M.vanbaalenii_PYR-1 FNG----FLVMRTKIPSFLIT-----------------------------
Mb1389c|M.bovis_AF2122/97 ALVGE--SLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG
Rv1354c|M.tuberculosis_H37Rv ALVGE--SLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG
TH_0811|M.thermoresistible__bu GAGPD--DLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDG
MAV_1132|M.avium_104 CAGEQ--SMIARLGGDEFVVIPHQPMASEAAEAFARRLSTLLCDRLTIGG
MLBr_00397|M.leprae_Br4923 AVRPD--DVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQ
MSMEG_4171|M.smegmatis_MC2_155 ACGFLNGVLITFCRVPAFIAT-----------------------------
MAB_1839|M.abscessus_ATCC_1997 GTVLA---VVGAVSRDEYSAA-----------------------------
:: :
Mflv_2606|M.gilvum_PYR-GCK --------------------LSTFFMLAGINLAVTKLVAGQVATQSVSDM
Mvan_4010|M.vanbaalenii_PYR-1 --------------------LSTFFMLAGINLAVTKLVAGQVATQSVSDM
Mb1389c|M.bovis_AF2122/97 EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Rv1354c|M.tuberculosis_H37Rv EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
TH_0811|M.thermoresistible__bu EMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDM
MAV_1132|M.avium_104 HVISRTVSIGLAVGTPGADNCTDLLRRADEAVLTAKRAGGNQTAVSTDDM
MLBr_00397|M.leprae_Br4923 LTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQCAVTPQQLV
MSMEG_4171|M.smegmatis_MC2_155 --------------------LATLTALRGIALLVTN--------------
MAB_1839|M.abscessus_ATCC_1997 -----------------------ALAAAVVTMLLANLFAG----------
:
Mflv_2606|M.gilvum_PYR-GCK QG-----------------WDSAQKVFASSFTLFG---VGIRITVVWWL-
Mvan_4010|M.vanbaalenii_PYR-1 QG-----------------WDSAQKVFASSFTLFG---VSIRITVVWWL-
Mb1389c|M.bovis_AF2122/97 SVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHP
Rv1354c|M.tuberculosis_H37Rv SVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHP
TH_0811|M.thermoresistible__bu SLEAEFRNDIELHLQSVIQDEALLLHFLPEVDMRTGEILATEALVRWHHP
MAV_1132|M.avium_104 SLKRAFRNDIELHLQGDIESEGLLLHYLPEVDLWTGAVVGAEALVRWRHP
MLBr_00397|M.leprae_Br4923 PFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGMTFVIMAG
MSMEG_4171|M.smegmatis_MC2_155 --------------------SYPISINNSAFTQIGIGKVGAVPIPVIIMA
MAB_1839|M.abscessus_ATCC_1997 ------------------------LVIYVGKAQFSEHADGRDRLARHDVL
.
Mflv_2606|M.gilvum_PYR-GCK --------VFTAVATWVLFKTKVGNWIFAVGG------DADSARAVGVPV
Mvan_4010|M.vanbaalenii_PYR-1 --------VFTAIATWVLFKTKIGNWIFAVGG------DADSARAVGVPV
Mb1389c|M.bovis_AF2122/97 TRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLR
Rv1354c|M.tuberculosis_H37Rv TRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLR
TH_0811|M.thermoresistible__bu TRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLR
MAV_1132|M.avium_104 IWGLLLPDSFIGVAESTNLGAELGGWVMRSACADFSRWRANGVGHGAMLR
MLBr_00397|M.leprae_Br4923 SVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVG--LAAGMVNGIVFA
MSMEG_4171|M.smegmatis_MC2_155 --------VTFAVGYVILHRLKIGRRIYAVGG------NREAARLSGIRV
MAB_1839|M.abscessus_ATCC_1997 TG------LLNRRGLQEAYEATVGVPGMHVTV--------VVVDLNLFKQ
. . .
Mflv_2606|M.gilvum_PYR-GCK TKVKIGLFMFVGFCAWFVGMHLLFA--------FNTVQSGQGIGN-----
Mvan_4010|M.vanbaalenii_PYR-1 TKVKIGLFMFVGFCAWFVGMHLLFA--------FNTVQSGQGIGN-----
Mb1389c|M.bovis_AF2122/97 INVSAGQLVTGGFVDFVADTIGQHG--------LDASSVCLEITENVVVQ
Rv1354c|M.tuberculosis_H37Rv INVSAGQLVTGGFVDFVADTIGQHG--------LDASSVCLEITENVVVQ
TH_0811|M.thermoresistible__bu INVSPVQLVTDGFVASVADIIDEFG--------LDGSSVCLEITESVVVQ
MAV_1132|M.avium_104 INVSPIQLISRGFVETVADTIGEFG--------IDAGSVCLEITERAVVH
MLBr_00397|M.leprae_Br4923 YGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGAMPWILIV
MSMEG_4171|M.smegmatis_MC2_155 SRVLLFAFTFAGLCAGVASVILTAK--------LSSGQPAGAVGF-----
MAB_1839|M.abscessus_ATCC_1997 INDTFGHHVGDQVLQRTAHRLRSVVG-------PDALLARLGGDE-----
.
Mflv_2606|M.gilvum_PYR-GCK -----------------------------EFFYIIAAVIGGCLLTGGYGT
Mvan_4010|M.vanbaalenii_PYR-1 -----------------------------EFFYIIAAVIGGCLLTGGYGT
Mb1389c|M.bovis_AF2122/97 DLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVR
Rv1354c|M.tuberculosis_H37Rv DLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVR
TH_0811|M.thermoresistible__bu DIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQ
MAV_1132|M.avium_104 DTETTRKTLSELKEVGVQIAIDDFGTGYAVLSHLKSLPVDMLKIDAGFVR
MLBr_00397|M.leprae_Br4923 CLFVTILAGILFQFTMFGRWVKAIG-GNERVATLAGVPTRGIKVAIFAIC
MSMEG_4171|M.smegmatis_MC2_155 -----------------------------ELDVIAAVVVGGTSLFGGRGR
MAB_1839|M.abscessus_ATCC_1997 ---------------------------------FGIVVVGDAPPHIDYQR
:
Mflv_2606|M.gilvum_PYR-GCK AIGAAIG-------------ALIFGMTNQGIVYAGWDPDWFKFFLG---A
Mvan_4010|M.vanbaalenii_PYR-1 AVGAAIG-------------AFIFGMTNQGIVYAGWDPDWFKFFLG---A
Mb1389c|M.bovis_AF2122/97 QLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG
Rv1354c|M.tuberculosis_H37Rv QLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG
TH_0811|M.thermoresistible__bu DLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQG
MAV_1132|M.avium_104 EVGTDAGDLAIVRAIIGLAEAFGLEVVAEGVETPAAALTLMQHGCHRAQG
MLBr_00397|M.leprae_Br4923 GLTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSG
MSMEG_4171|M.smegmatis_MC2_155 LAGTFLG-------------ALVIAVLGNGLTLMNVPFYWQQIVTG---A
MAB_1839|M.abscessus_ATCC_1997 AVEEALN------------SASEDVPVSASVGVAAAILPESDRTTIHTLG
. : .
Mflv_2606|M.gilvum_PYR-GCK MLLFAVIA------------NNAFRSYAARK-------------------
Mvan_4010|M.vanbaalenii_PYR-1 MLLFAVIA------------NNAFRSYAAKK-------------------
Mb1389c|M.bovis_AF2122/97 FLFSRPVP------------GEAMRHMLSARRLPPTCIPATDPALS----
Rv1354c|M.tuberculosis_H37Rv FLFSRPVP------------GEAMRHMLSARRLPPTCIPATDPALS----
TH_0811|M.thermoresistible__bu FLLSRPIP------------SNEMRELLARGRIP-MRFSATP--------
MAV_1132|M.avium_104 FLLSRPIP------------GEAMEALLSARWMPMPFLADREASSMGSI-
MLBr_00397|M.leprae_Br4923 TLIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK
MSMEG_4171|M.smegmatis_MC2_155 VVVVAVVL------------DRVTRGGESGE-------------------
MAB_1839|M.abscessus_ATCC_1997 PIVTHLLV-------------EADGAMYGAKKAG----------------
:. : .