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VSRIRQRWAQPDHYHWLSGYLGDRNLQGFTRRMMGLINLVLAIVPALMVLSPSGPDTGFGVAAGLVVSVL CALMAGVWFLHWPTRAESIAFSILSNISIAVVALSWPDPLTGLLGCITFAALAGYVAFFHSSHYLVMVLA TAAGVAIICTADITAGGDAYLAAVAFMMIAVAVLAVPFSAQVLVHLLGDDALHSHTDPLTGLRNRRGFYR SVRRLLRAAPDRDLNFLTVAMIDLDRFKQINDTRGHATGDRLLVSISGCLCHCARGEAVVGRVGGEEFLI AEATRDDDAEALAERLRLAIASTSWGITASVGVACRRLNGDADTRELLGDLIEAADSAMYEAKRSGGNQY RRARESAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3822 | - | - | 100% (358) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1914 | - | 4e-62 | 40.12% (344) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_4783 | - | 2e-61 | 39.04% (356) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-15 | 30.74% (231) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-15 | 30.74% (231) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 4e-16 | 33.90% (177) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 9e-51 | 35.89% (365) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 8e-63 | 38.75% (351) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 1e-33 | 28.49% (344) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 1e-60 | 37.32% (351) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2385 | - | 1e-62 | 40.52% (348) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 ------------------MCNDTATPQLEELVTT--VANQLMTVDAATSA
Rv1354c|M.tuberculosis_H37Rv ------------------MCNDTATPQLEELVTT--VANQLMTVDAATSA
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
Mflv_3822|M.gilvum_PYR-GCK -----------MSRIRQRWAQPDHYHWLSGYLGDRNLQGFTRRMMGLINL
Mvan_2385|M.vanbaalenii_PYR-1 ----------MLGWWRGWWQRPDQFDWFSAYLRDRGLQVRWRMATFVFTV
MSMEG_2774|M.smegmatis_MC2_155 ------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTIT
TH_3406|M.thermoresistible__bu ----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITL
MLBr_00397|M.leprae_Br4923 --------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATR
:
Mb1389c|M.bovis_AF2122/97 EVSQRVLAYLVEQLGV--------------DVSFLRHNDRDRRATRLVAE
Rv1354c|M.tuberculosis_H37Rv EVSQRVLAYLVEQLGV--------------DVSFLRHNDRDRRATRLVAE
MAB_3940c|M.abscessus_ATCC_199 IFAAICIAVQFSDTGP--------------RSMIGRVIVGLCAVGSLGWA
MAV_1995|M.avium_104 SLVLVPANVLWGATPF--------------FPGLTLTVSVLAGMVGLGMA
Mflv_3822|M.gilvum_PYR-GCK VLAIVPALMVLSPSGP--------------DTGFGVAAGLVVSVLCALMA
Mvan_2385|M.vanbaalenii_PYR-1 LLVAVPVVMVGSPAGP--------------GGPLQTWIVIGAAASALAAS
MSMEG_2774|M.smegmatis_MC2_155 ALAFVPVLMLASPAGP--------------AGAL-RYVPLGATACGVLMS
TH_3406|M.thermoresistible__bu ILGLMPMVMLAGPAGP--------------QSMPGRLIAVAVTVTALVIT
MLBr_00397|M.leprae_Br4923 ILGLRAHDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVG
.
Mb1389c|M.bovis_AF2122/97 WPPRLN---IPDPDPLRLIYFADADPVFALCEHAKEP----LVFRPEPAT
Rv1354c|M.tuberculosis_H37Rv WPPRLN---IPDPDPLRLIYFADADPVFALCEHAKEP----LVFRPEPAT
MAB_3940c|M.abscessus_ATCC_199 LRWAVGP--WPSLREAVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPV
MAV_1995|M.avium_104 VLWLHG---WPTRRQSVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVT
Mflv_3822|M.gilvum_PYR-GCK GVWFLH---WPTRAESIAFSILSNISIAVVALSWPDPLTGLLGCITFAAL
Mvan_2385|M.vanbaalenii_PYR-1 LLWLFR---WPSRAQSLAYSTVCSVSIAAGCLAIQDPYAGLMGCTMFAAI
MSMEG_2774|M.smegmatis_MC2_155 VWWWRRK--WPSRNQSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLV
TH_3406|M.thermoresistible__bu LIWLRDR--WPSRNQSRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVL
MLBr_00397|M.leprae_Br4923 IDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEAT
. .. :
Mb1389c|M.bovis_AF2122/97 EDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLG--FIKFGDRKWHEAEL
Rv1354c|M.tuberculosis_H37Rv EDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLG--FIKFGDRKWHEAEL
MAB_3940c|M.abscessus_ATCC_199 GAYVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSM
MAV_1995|M.avium_104 GGYNAFFHTAKFMGLNFGLAGAIGALQAARLAAS---GQAMLAFTGYFLV
Mflv_3822|M.gilvum_PYR-GCK AGYVAFFHSSHYLVMVLATAAGVAIICTADITAG---GDAYLAAVAFMMI
Mvan_2385|M.vanbaalenii_PYR-1 GGFVAYFHALAHVVANLVVALSCATINAVRILVET--DDIRIVAGSAALV
MSMEG_2774|M.smegmatis_MC2_155 TTYSAFLHSRRVLVLSWIASGLTVGFLAIRVAFTS----IPMALSGALVS
TH_3406|M.thermoresistible__bu AGYVALFHSARYATFTVLFAAITAGVLSFELAKTAG---VAAAVCGFVFI
MLBr_00397|M.leprae_Br4923 HDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHD
: .
Mb1389c|M.bovis_AF2122/97 NALMTIATLFAQVQARVAAEARLRYLADHDDLTGLH------NRR-----
Rv1354c|M.tuberculosis_H37Rv NALMTIATLFAQVQARVAAEARLRYLADHDDLTGLH------NRR-----
MAB_3940c|M.abscessus_ATCC_199 LLVVVLIPAVIQFGIAVVRWDALAA--QRDPLTGLL------NRRGIYAE
MAV_1995|M.avium_104 LELNVIVPLSIQIVVRALWLDLLRA--NRDPLTGLL------NRR---AC
Mflv_3822|M.gilvum_PYR-GCK AVAVLAVPFSAQVLVHLLGDDALHS--HTDPLTGLR------NRR----G
Mvan_2385|M.vanbaalenii_PYR-1 LGLNLGVPFGIHTLVHSLHIDLRDS--DRDPLTGLL------NRR----S
MSMEG_2774|M.smegmatis_MC2_155 GLVIATTSMLCRMAIRLLDAGNVQHPNEIDRLTGLL------NRE----A
TH_3406|M.thermoresistible__bu TVVTFAVVCACNLLVGLLDVDVLDA--DIEPLTGLL------NRD----A
MLBr_00397|M.leprae_Br4923 VGDAVLQTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDVAKR
. : :. * *
Mb1389c|M.bovis_AF2122/97 --ALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFA
Rv1354c|M.tuberculosis_H37Rv --ALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFA
MAB_3940c|M.abscessus_ATCC_199 WQRLYGELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVA
MAV_1995|M.avium_104 NRAIIGRMLTG---ASHMFLAVAMVDLDRFKALNDTHGHAAGDEALIAVA
Mflv_3822|M.gilvum_PYR-GCK FYRSVRRLLRAAPDRDLNFLTVAMIDLDRFKQINDTRGHATGDRLLVSIS
Mvan_2385|M.vanbaalenii_PYR-1 FYNMVRDLIAARR-QVNTPVNVTMVDLDDFKLLNDTHGHAVGDAALVSVA
MSMEG_2774|M.smegmatis_MC2_155 FEIQAATMLGSHSRHDDQYLVILAVGIDDMSLLSDMDGTHSTLHARVAVA
TH_3406|M.thermoresistible__bu FYRSAGHLI-SRSRDDDRQLVIALINIDNLRLLRDTQGQAAADRARVAIG
MLBr_00397|M.leprae_Br4923 LHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAK
: :
Mb1389c|M.bovis_AF2122/97 QRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------LAERLRDQ
Rv1354c|M.tuberculosis_H37Rv QRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------LAERLRDQ
MAB_3940c|M.abscessus_ATCC_199 HALTCGTTGTSVVGRSGGEEFLVVTVCPA--SAVAE------FATRLRQA
MAV_1995|M.avium_104 GALTAACGDTTVVGRVGGEEFLVADIVTT--EQLPG------WGQQLCEA
Mflv_3822|M.gilvum_PYR-GCK GCLCHCARGEAVVGRVGGEEFLIAEATRD--DDAEA------LAERLRLA
Mvan_2385|M.vanbaalenii_PYR-1 AVLQEHTEPGTVLGRLGGEEFVIADVDAA--ARHAI------TAERIRRG
MSMEG_2774|M.smegmatis_MC2_155 QALRETVRHRVPLAHVSDSEFLIADVFKT--NDPSP------LVERMRLA
TH_3406|M.thermoresistible__bu QTLRENTRHNAFVAHLGQDEFLIADTFSS--TDSFP------LVERVRGA
MLBr_00397|M.leprae_Br4923 NKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLA
: . :.: :
Mb1389c|M.bovis_AF2122/97 LKDHVAIG----GEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKH
Rv1354c|M.tuberculosis_H37Rv LKDHVAIG----GEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKH
MAB_3940c|M.abscessus_ATCC_199 VTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMYEAKH
MAV_1995|M.avium_104 VAALDPP---VTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMYEAKR
Mflv_3822|M.gilvum_PYR-GCK IASTSWG---ITASVGVACRRLN--GDADTRELLGDLIEAADSAMYEAKR
Mvan_2385|M.vanbaalenii_PYR-1 IAATPFQ---ITASFGICSTTVAAGAEIDHPGFLDRLIRAADAAMYQSKR
MSMEG_2774|M.smegmatis_MC2_155 ISTTPMR---LTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMNESRA
TH_3406|M.thermoresistible__bu IATTPPR---LTASIGVVSTPMRGLAVCPPETLLDELIAVASATMYEARR
MLBr_00397|M.leprae_Br4923 IVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGL
: ... : * :
Mb1389c|M.bovis_AF2122/97 AGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGD
Rv1354c|M.tuberculosis_H37Rv AGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGD
MAB_3940c|M.abscessus_ATCC_199 DGGDQSRILHADDDSEGRYLWRSGA-------------------------
MAV_1995|M.avium_104 CGGNQTRHRPAQVST-----------------------------------
Mflv_3822|M.gilvum_PYR-GCK SGGNQYRRARESAA------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 AGGNRVVHDRLDIPG-----------------------------------
MSMEG_2774|M.smegmatis_MC2_155 AGGNQTISVNYPTPTPNQE-------------------------------
TH_3406|M.thermoresistible__bu AGGNQARYRKYPNPTAVTEAHYPEQAADDF--------------------
MLBr_00397|M.leprae_Br4923 AAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILG
.*
Mb1389c|M.bovis_AF2122/97 IVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSE
Rv1354c|M.tuberculosis_H37Rv IVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 AMGAMPWILIVCLFVTILAG--------ILFQFTMFGRWVKAIGGNERVA
Mb1389c|M.bovis_AF2122/97 WQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITE
Rv1354c|M.tuberculosis_H37Rv WQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 TLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGFEIDVIA
Mb1389c|M.bovis_AF2122/97 NVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKID
Rv1354c|M.tuberculosis_H37Rv NVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKID
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 AVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIM
Mb1389c|M.bovis_AF2122/97 KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRC
Rv1354c|M.tuberculosis_H37Rv KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRC
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 LAAAVFVFLQRRKIGIIK--------------------------------
Mb1389c|M.bovis_AF2122/97 YRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv YRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
MAB_3940c|M.abscessus_ATCC_199 ---------------------------------------
MAV_1995|M.avium_104 ---------------------------------------
Mflv_3822|M.gilvum_PYR-GCK ---------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 ---------------------------------------
TH_3406|M.thermoresistible__bu ---------------------------------------
MLBr_00397|M.leprae_Br4923 ---------------------------------------