For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGASLVLVPANVLWGATPFFPGLTLTVSVLAGMV GLGMAVLWLHGWPTRRQSVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFFHTAKFMGLNFG LAGAIGALQAARLAASGQAMLAFTGYFLVLELNVIVPLSIQIVVRALWLDLLRANRDPLTGLLNRRACNR AIIGRMLTGASHMFLAVAMVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDTTVVGRVGGEEFLVAD IVTTEQLPGWGQQLCEAVAALDPPVTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMYEAKRCGGNQT RHRPAQVST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1995 | - | - | 100% (359) | diguanylate cyclase |
| M. avium 104 | MAV_1410 | - | 4e-17 | 33.63% (223) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. avium 104 | MAV_2738 | - | 9e-16 | 29.71% (313) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-12 | 29.84% (191) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_1453 | - | 3e-82 | 47.67% (344) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-12 | 29.84% (191) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 2e-14 | 34.81% (181) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_3940c | - | 1e-45 | 33.52% (364) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 1e-27 | 29.11% (347) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 2e-44 | 31.28% (358) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1665 | - | 6e-94 | 51.43% (350) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1995|M.avium_104 ------------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVG
Mvan_1665|M.vanbaalenii_PYR-1 ------------MGAIGRWWRQPDQYDWLSSYMHARGFTRPAQIFMAVIA
Mflv_1453|M.gilvum_PYR-GCK MISSSTSKRRRLRPAANRWWNQPDQFDWLSGYLHARGLAPATRRLMAVIS
MSMEG_2774|M.smegmatis_MC2_155 -------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTI
TH_3406|M.thermoresistible__bu -----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASIT
Mb1389c|M.bovis_AF2122/97 -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
Rv1354c|M.tuberculosis_H37Rv -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
MLBr_01750|M.leprae_Br4923 ----------------------------MTRSLDELVTRVASKLMAATAA
MAB_3940c|M.abscessus_ATCC_199 -MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYA
:
MAV_1995|M.avium_104 ASLVLVPANVLWGATPFFPGLTLTVSVLAGMVGLGMAVLWLHG--WPTRR
Mvan_1665|M.vanbaalenii_PYR-1 ASGVLVPANALWGPAATSHALLLALGVVAGLAGLAYLVLWLSR--WPTRN
Mflv_1453|M.gilvum_PYR-GCK SALVLMAFGVLG-SRDEHPVLTYTVAAAAAIAGIGYGTLWLRR--WPTRR
MSMEG_2774|M.smegmatis_MC2_155 TALAFVPVLMLASPAGPAGAL-RYVPLGATACGVLMSVWWWRRK-WPSRN
TH_3406|M.thermoresistible__bu LILGLMPMVMLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDR-WPSRN
Mb1389c|M.bovis_AF2122/97 TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
Rv1354c|M.tuberculosis_H37Rv TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
MLBr_01750|M.leprae_Br4923 TAVTISEGVLAILVEHFGVDVSFLRHNNHDIHETKLIVEWPPRDYVPDPD
MAB_3940c|M.abscessus_ATCC_199 LIFAAICIAVQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGP-WPSLR
* *
MAV_1995|M.avium_104 QSVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFFHTAKFMG
Mvan_1665|M.vanbaalenii_PYR-1 QSIGFALTICVCIALGSFTAADPAIGLMASAALAVSGGYLAFFHSARLVT
Mflv_1453|M.gilvum_PYR-GCK QSLMMGMVGGSMIAVGSGMQTEPVVALMGCTGLVVTGGYLAFFHNTKAVL
MSMEG_2774|M.smegmatis_MC2_155 QSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSAFLHSRRVLV
TH_3406|M.thermoresistible__bu QSRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALFHSARYAT
Mb1389c|M.bovis_AF2122/97 PLRLIYFADADPVFALCEHAKEP----LVFRPEPATEDYQRLIEEARGVP
Rv1354c|M.tuberculosis_H37Rv PLRLIYFADADPVFALCEHAKEP----LVFRPEPATEDYQRLIEEARGVP
MLBr_01750|M.leprae_Br4923 PIGVVYFADADPVFAMAEYLKEP----AVLRPEPANADYQRRIEEGASVP
MAB_3940c|M.abscessus_ATCC_199 EAVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANRLLV
. : :* * :
MAV_1995|M.avium_104 LNFGLAGAIGALQAARLAAS-GQAMLAFTGYFLVLELNVIVPLSIQIVVR
Mvan_1665|M.vanbaalenii_PYR-1 ANLVVALAVAAVHVARLAAD-GQAVLAVSMLFLVVELNAGVPLAIQIMVH
Mflv_1453|M.gilvum_PYR-GCK FNFAVAATVGTYCALRVFETYDDRASALAGLWLIIELNLAVPLAIQTVVR
MSMEG_2774|M.smegmatis_MC2_155 LSWIASGLTVGFLAIRVAFTS-IPMALSG-ALVSGLVIATTSMLCRMAIR
TH_3406|M.thermoresistible__bu FTVLFAAITAGVLSFELAKTAGVAAAVCG-FVFITVVTFAVVCACNLLVG
Mb1389c|M.bovis_AF2122/97 VTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQAR
Rv1354c|M.tuberculosis_H37Rv VTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQAR
MLBr_01750|M.leprae_Br4923 AVSLACVPLLSGEITTGVLGFVKYGDREWHDDELRALQAIATLFAQLQAR
MAB_3940c|M.abscessus_ATCC_199 AHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAVIQFG
. : .
MAV_1995|M.avium_104 ALWLDLLRA--NRDPLTGLLNRRACNRAIIGRM-LTG-ASHMF----LAV
Mvan_1665|M.vanbaalenii_PYR-1 ALGIDLIKS--DRDPLTGLLNRRSFQRAVVAAV-LDGQRSGTH----LAF
Mflv_1453|M.gilvum_PYR-GCK TMGADVVRS--DHDALTGLLNRRGFY-ERASSL-LTSPAADSD----LIV
MSMEG_2774|M.smegmatis_MC2_155 LLDAGNVQHPNEIDRLTGLLNREAFEIQAATMLGSHSRHDDQY----LVI
TH_3406|M.thermoresistible__bu LLDVDVLDA--DIEPLTGLLNRDAFYRSAGHLI-SRSRDDDRQ----LVI
Mb1389c|M.bovis_AF2122/97 VAAEARLRYLADHDDLTGLHNRRALLQHLDQRL---APGQPGP----VAA
Rv1354c|M.tuberculosis_H37Rv VAAEARLRYLADHDDLTGLHNRRALLQHLDQRL---APGQPGP----VAA
MLBr_01750|M.leprae_Br4923 IVAEEQLRYLAEHDDLTGLLNRRALIAHLDERL---ADGQRGP----VTL
MAB_3940c|M.abscessus_ATCC_199 IAVVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAA
: : **** ** .
MAV_1995|M.avium_104 AMVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDTTVVGRVGGEEFL
Mvan_1665|M.vanbaalenii_PYR-1 AMLDLDRFKVLNDTLGHSAGDDALVSVAQALTANLPDTAIIGRVGGEEFL
Mflv_1453|M.gilvum_PYR-GCK VMIDLDAFKRLNDTYGHLAGDQALAAVGWALRKASPGSAVIGRTGGEEFL
MSMEG_2774|M.smegmatis_MC2_155 LAVGIDDMSLLSDMDGTHSTLHARVAVAQALRETVRHRVPLAHVSDSEFL
TH_3406|M.thermoresistible__bu ALINIDNLRLLRDTQGQAAADRARVAIGQTLRENTRHNAFVAHLGQDEFL
Mb1389c|M.bovis_AF2122/97 LFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFV
Rv1354c|M.tuberculosis_H37Rv LFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFV
MLBr_01750|M.leprae_Br4923 LFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESLTVIARFGGDEFV
MAB_3940c|M.abscessus_ATCC_199 AIVDIDRFKSINDRYGHGTGDRVLIDVAHALTCGTTGTSVVGRSGGEEFL
:.:* : : * * : .. : :.: . .**:
MAV_1995|M.avium_104 VA--DIVTTEQLPGWGQQLCEAVAALD---PPVTASVGTATLPLRDLVSE
Mvan_1665|M.vanbaalenii_PYR-1 IA--DVIAAAVPEDLGERAREAVTFTP---YGLTTSVGTASFAVDALNAG
Mflv_1453|M.gilvum_PYR-GCK LI--DILPVAQAEALPDELCAAIAALP---HPVTASVGAA--VVRGLPQS
MSMEG_2774|M.smegmatis_MC2_155 IA--DVFKTNDPSPLVERMRLAISTTP---MRLTASIGTVCSPLAPLASL
TH_3406|M.thermoresistible__bu IA--DTFSSTDSFPLVERVRGAIATTP---PRLTASIGVVSTPMRGLAVC
Mb1389c|M.bovis_AF2122/97 LIPASPMSADAAQPLAERLRDQLKDH----VAIGGEVLTRTVSIGVASGT
Rv1354c|M.tuberculosis_H37Rv LIPASPMSADAAQPLAERLRDQLKDH----VAIGGEVLTRTVSIGVASGT
MLBr_01750|M.leprae_Br4923 VVPAESVSVDVAESFAHRLQTRLQKQ----VVIDGEILTRTVSIGVATGL
MAB_3940c|M.abscessus_ATCC_199 VV--TVCPASAVAEFATRLRQAVTASMPAGIAVTASVGVAAQAVSRVVSA
: . : : .: . :
MAV_1995|M.avium_104 YAEHAFHQLVAQADSAMYEAKRCGGNQTRHR-PAQVST------------
Mvan_1665|M.vanbaalenii_PYR-1 NIVDSMHWLTAQADVAMYSAKRAGGNGVRHHTPARRDEDSPREDAPQRP-
Mflv_1453|M.gilvum_PYR-GCK DAPAVIEALTRTADATMYEAKRSGGNQALIRRVSPLFQN-----------
MSMEG_2774|M.smegmatis_MC2_155 PAEQVLQELIDVAMRAMNESRAAGGNQTISVNYPTPTPNQE---------
TH_3406|M.thermoresistible__bu PPETLLDELIAVASATMYEARRAGGNQARYRKYPNPTAVTEAHYPEQAAD
Mb1389c|M.bovis_AF2122/97 PGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELHLR
Rv1354c|M.tuberculosis_H37Rv PGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELHLR
MLBr_01750|M.leprae_Br4923 PGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGISAQHTLRTEVELHLA
MAB_3940c|M.abscessus_ATCC_199 TSQEAIEVLTACADRAMYEAKHDGGDQSRILHADDDSEGRYLWRSGA---
* * : :: * .
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu DF------------------------------------------------
Mb1389c|M.bovis_AF2122/97 RGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAE
Rv1354c|M.tuberculosis_H37Rv RGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAE
MLBr_01750|M.leprae_Br4923 GMIDTD-LVLHYLPEVDMSTGKVLGTEALVRWQHPTRGLLFPDSFIPVAE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 SINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVD
Rv1354c|M.tuberculosis_H37Rv SINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVD
MLBr_01750|M.leprae_Br4923 SINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRINVSPVQLVAEGFVD
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 FVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDD
Rv1354c|M.tuberculosis_H37Rv FVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDD
MLBr_01750|M.leprae_Br4923 NVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTLAGLKEVGVHLAIDD
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 FGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQ
Rv1354c|M.tuberculosis_H37Rv FGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQ
MLBr_01750|M.leprae_Br4923 FGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDLAIVRAIMALAKEFE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPP
Rv1354c|M.tuberculosis_H37Rv LDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPP
MLBr_01750|M.leprae_Br4923 LEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDGAAMESLLAKGVIPM
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 ------------------
Mvan_1665|M.vanbaalenii_PYR-1 ------------------
Mflv_1453|M.gilvum_PYR-GCK ------------------
MSMEG_2774|M.smegmatis_MC2_155 ------------------
TH_3406|M.thermoresistible__bu ------------------
Mb1389c|M.bovis_AF2122/97 TCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv TCIPATDPALS-------
MLBr_01750|M.leprae_Br4923 ALGTCQSPEPSEHQIHRS
MAB_3940c|M.abscessus_ATCC_199 ------------------