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SPFDHYYARTAMLSAQGQRSRMRRIIGVTITALAFVPVLMLASPAGPAGALRYVPLGATACGVLMSVWWW RRKWPSRNQSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSAFLHSRRVLVLSWIASGLTVGF LAIRVAFTSIPMALSGALVSGLVIATTSMLCRMAIRLLDAGNVQHPNEIDRLTGLLNREAFEIQAATMLG SHSRHDDQYLVILAVGIDDMSLLSDMDGTHSTLHARVAVAQALRETVRHRVPLAHVSDSEFLIADVFKTN DPSPLVERMRLAISTTPMRLTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMNESRAAGGNQTISVNY PTPTPNQE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2774 | - | - | 100% (359) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4894 | - | 3e-75 | 43.14% (350) | diguanylate cyclase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-19 | 26.18% (340) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 1e-27 | 29.11% (347) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 1e-64 | 40.51% (353) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4819 | - | 5e-33 | 29.33% (358) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
Mvan_4819|M.vanbaalenii_PYR-1 -----------MQWDQR---RVDHYEWFSGFLDARGAKPAVRLLIASIAL
MSMEG_2774|M.smegmatis_MC2_155 ---------MSP---------FDHYYARTAMLSAQGQRSRMRRIIGVTIT
Mflv_4894|M.gilvum_PYR-GCK --MFEGLRRLSANSLAPAVWRFDQYYWFTAILTARGFQTATGRLVAACIA
TH_3406|M.thermoresistible__bu --MLKALRRTWR--------KPDHYYWFTSFLAARRARTSTCRFIASITL
. * : :.
MAB_3940c|M.abscessus_ATCC_199 IFAAICIAVQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLREA
MAV_1995|M.avium_104 SLVLVPANVLWGATPFFPGLTLTVSVLAGMVGLGMAVLWLHG-WPTRRQS
Mvan_4819|M.vanbaalenii_PYR-1 LMAGSVLLLIFSAGGPEGQPQRAMMWLSVAGGVAGVMLWLWH-WPSRLQS
MSMEG_2774|M.smegmatis_MC2_155 ALAFVPVLMLASPAGPAGALRYVPLGATACG-VLMSVWWWRRKWPSRNQS
Mflv_4894|M.gilvum_PYR-GCK AFGLLPLGVIAGVFGPQSLVAQILAGIVVIASLAMAMLWLREHWPTRAQS
TH_3406|M.thermoresistible__bu ILGLMPMVMLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQS
: : . : : * **: ::
MAB_3940c|M.abscessus_ATCC_199 VAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANRLLVAH
MAV_1995|M.avium_104 VVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFFHTAKFMGLN
Mvan_4819|M.vanbaalenii_PYR-1 AAFATVTAFSVALAGLAYPDPLAALLGCIAFTTNGAYLAFFHTTRLLLGN
MSMEG_2774|M.smegmatis_MC2_155 WLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSAFLHSRRVLVLS
Mflv_4894|M.gilvum_PYR-GCK LACVAAGALGIGISSLLVADPFVGFLGTAAFVPLTIFIVCFHAARVLALS
TH_3406|M.thermoresistible__bu RVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALFHSARYATFT
..:. .:* ..:: : : : : :
MAB_3940c|M.abscessus_ATCC_199 VAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAVIQFGIA
MAV_1995|M.avium_104 FGLAGAIGALQAARLAAS---GQAMLAFTGYFLVLELNVIVPLSIQIVVR
Mvan_4819|M.vanbaalenii_PYR-1 IVIAIGVATVEAIQLAAQ---GRIALAAVDLFLVVQINIAVPLAIRILLH
MSMEG_2774|M.smegmatis_MC2_155 WIASGLTVGFLAIRVAFTS----IPMALSGALVSGLVIATTSMLCRMAIR
Mflv_4894|M.gilvum_PYR-GCK WTVGALVLAVLVVRMGSTD----LAVALTGLVIAVLINVFVAISCRTVIR
TH_3406|M.thermoresistible__bu VLFAAITAGVLSFELAKTAG---VAAAVCGFVFITVVTFAVVCACNLLVG
.: * : . :
MAB_3940c|M.abscessus_ATCC_199 VVRWD--ALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAA
MAV_1995|M.avium_104 ALWLD--LLRANRDPLTGLLNRR---ACNRAIIGRMLTG---ASHMFLAV
Mvan_4819|M.vanbaalenii_PYR-1 ALRGD--LHYADHDPLTGLLNRR---AFRRQILSLLARS--HGEGRYLVV
MSMEG_2774|M.smegmatis_MC2_155 LLDAGNVQHPNEIDRLTGLLNREAFEIQAATMLGSHSRHD----DQYLVI
Mflv_4894|M.gilvum_PYR-GCK LLKPD--AHHRDIEQLTGLLHRDAFYNSVATLLASRSRSD----DQYLVF
TH_3406|M.thermoresistible__bu LLDVD--VLDADIEPLTGLLNRDAFYRSAGHLIS-RSRDD----DRQLVI
: . : : *****:* : . .
MAB_3940c|M.abscessus_ATCC_199 AIVDIDRFKSINDRYGHGTGDRVLIDVAHALTCGTTGTSVVGRSGGEEFL
MAV_1995|M.avium_104 AMVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDTTVVGRVGGEEFL
Mvan_4819|M.vanbaalenii_PYR-1 ALMDLDHFKALNDARGHIAGDQALIAVADALRTTATSTAVVARSGGEEFL
MSMEG_2774|M.smegmatis_MC2_155 LAVGIDDMSLLSDMDGTHSTLHARVAVAQALRETVRHRVPLAHVSDSEFL
Mflv_4894|M.gilvum_PYR-GCK VAVNIDSFSLLLGLSGSGGGNRARVTVGQALRETVRHNAIVAHVSDDDFV
TH_3406|M.thermoresistible__bu ALINIDNLRLLRDTQGQAAADRARVAIGQTLRENTRHNAFVAHLGQDEFL
:.:* : : . * .. : :. :* :.: . .:*:
MAB_3940c|M.abscessus_ATCC_199 VVTVCPASAVAEFATRLRQAVTASMPAGIAVTASVGVAAQAVSRVVSATS
MAV_1995|M.avium_104 VADIVTTEQLPGWGQQLCEAVAALDPP---VTASVGTATLPLRDLVSEYA
Mvan_4819|M.vanbaalenii_PYR-1 IADVTGSPSAAAHYQQVCDAITALPVG---LTASIGTAVAALRDVPVEAF
MSMEG_2774|M.smegmatis_MC2_155 IADVFKTNDPSPLVERMRLAISTTPMR---LTASIGTVCSPLAPLASLPA
Mflv_4894|M.gilvum_PYR-GCK IADTFTTSDASPLVERIRGAIAATPQR---LTASIGVVVTPLPPLAAEPP
TH_3406|M.thermoresistible__bu IADTFSSTDSFPLVERVRGAIATTPPR---LTASIGVVSTPMRGLAVCPP
:. : :: *::: :***:*.. .: :
MAB_3940c|M.abscessus_ATCC_199 QEAIEVLTACADRAMYEAKHDGGDQSRILHADDDSEGRYLWRSGA-----
MAV_1995|M.avium_104 EHAFHQLVAQADSAMYEAKRCGGNQTRHRPAQVST---------------
Mvan_4819|M.vanbaalenii_PYR-1 ESTIDRLVSAADMAMYRAKRNGGNQCHHLDAWPPPGPA------------
MSMEG_2774|M.smegmatis_MC2_155 EQVLQELIDVAMRAMNESRAAGGNQTISVNYPTPTPNQE-----------
Mflv_4894|M.gilvum_PYR-GCK DEVLDKLIAISQQAIEQARMAGGNQVRYVLRPDLGEGDDNGDDWPEQNRP
TH_3406|M.thermoresistible__bu ETLLDELIAVASATMYEARRAGGNQARYRKYPNPTAVTEAHYPEQAADDF
: :. * : :: .:: **:*
MAB_3940c|M.abscessus_ATCC_199 -
MAV_1995|M.avium_104 -
Mvan_4819|M.vanbaalenii_PYR-1 -
MSMEG_2774|M.smegmatis_MC2_155 -
Mflv_4894|M.gilvum_PYR-GCK A
TH_3406|M.thermoresistible__bu -