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CNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRL NIPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL LGFIKFGDRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQP GPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPL AERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSG ELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELD RWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDL HTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGF QLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1354c | - | - | 100% (623) | hypothetical protein Rv1354c |
| M. tuberculosis H37Rv | Rv1357c | - | 2e-33 | 32.81% (253) | hypothetical protein Rv1357c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 0.0 | 100.00% (623) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4377 | - | 0.0 | 65.28% (602) | diguanylate cyclase/phosphodiesterase with GAF sensor |
| M. leprae Br4923 | MLBr_01750 | - | 0.0 | 63.14% (605) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_3940c | - | 4e-17 | 33.01% (206) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 0.0 | 59.44% (604) | GGDEF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 0.0 | 62.96% (602) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 0.0 | 66.00% (603) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 0.0 | 65.47% (611) | diguanylate cyclase/phosphodiesterase with GAF sensor |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Mflv_4377|M.gilvum_PYR-GCK MSES-----LDLVVTSVATRLMGAGAATWAEASQQVLADLVEHFGVDVSF
Mvan_1967|M.vanbaalenii_PYR-1 MSDSDTLRSLDLVITSVATKLMAANAATSVEVSQRVLAELVDYLGVDVSF
MSMEG_2196|M.smegmatis_MC2_155 MSES-----LDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu VSTE-----LDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
MLBr_01750|M.leprae_Br4923 MTRS-----LDELVTRVASKLMAATAATAVTISEGVLAILVEHFGVDVSF
MAV_3132|M.avium_104 MSGT-----LDHLVTAAAAELMAATAADAAQISERVLADLVSHFGVNFGF
MAB_3940c|M.abscessus_ATCC_199 -------------------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGF
:: : .*
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Mflv_4377|M.gilvum_PYR-GCK LRRNDHTIRASVLVAEWPVRPGIPDPDPLAVVYFADADPVFALAEFQKEP
Mvan_1967|M.vanbaalenii_PYR-1 LRYNDHKIRASRLVAEWPVRPGVPDPDPLALVYFADADPVFAQSEHGKKP
MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
MLBr_01750|M.leprae_Br4923 LRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVFAMAEYLKEP
MAV_3132|M.avium_104 LRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADSVFARVETMKEP
MAB_3940c|M.abscessus_ATCC_199 LHARKLDRTVRNLIGGY-------------ALIFAAICIAVQFSDTGPRS
*: .. *: : : * .. : .
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Mflv_4377|M.gilvum_PYR-GCK LVFRPDANTDEYQKTIEEGRQVPQVSMAAVPLLSGDVTTGVLGFVKFGDR
Mvan_1967|M.vanbaalenii_PYR-1 MVFRPEPATDDYQKRIEETRAVPATSMAAAPLVSGELTTGVLGFIKFGDR
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
MLBr_01750|M.leprae_Br4923 AVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGVLGFVKYGDR
MAV_3132|M.avium_104 DVLRPEPANADYQRNIEDGTGIPEVSLAAVPLLSGDVTTGTLGFVKFGDR
MAB_3940c|M.abscessus_ATCC_199 MIGR---------------------------VIVGLCAVGSLGWALR---
: * :: * :.* **:
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Mflv_4377|M.gilvum_PYR-GCK DWTGVELNALKAIASLFAQVQARVEAETQLRYLAEHDDLTGLNNRRALLS
Mvan_1967|M.vanbaalenii_PYR-1 EWTAEELNGLEAIASLFAQVQARVQAEEQLRYLAEHDDLTGLYNRRALLA
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRALMA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLA
MLBr_01750|M.leprae_Br4923 EWHDDELRALQAIATLFAQLQARIVAEEQLRYLAEHDDLTGLLNRRALIA
MAV_3132|M.avium_104 EWLSEELNALQAIAALFAQLQARVVAEEQIHYLAEHDELTGLLNRRALIA
MAB_3940c|M.abscessus_ATCC_199 -WAVGPWPSLREAVAFVAFADIGIAVACWQ----DSDPLAGLVG------
* .* .::.* : : . : * *:** .
Rv1354c|M.tuberculosis_H37Rv HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Mb1389c|M.bovis_AF2122/97 HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Mflv_4377|M.gilvum_PYR-GCK HLDGRLAEGQPGPVSALFFDLDRLKAINDYLGHTAGDWFIRVLAERLREG
Mvan_1967|M.vanbaalenii_PYR-1 HLDERLAEGRPGPVSALFFDLDRLKAINDYLGHTAGDWFIRVLAERLRRG
MSMEG_2196|M.smegmatis_MC2_155 HLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRG
TH_0811|M.thermoresistible__bu HLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREG
MLBr_01750|M.leprae_Br4923 HLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREA
MAV_3132|M.avium_104 HLDKRLAPGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREA
MAB_3940c|M.abscessus_ATCC_199 --------------TVLFTPVG------AYVSFFLANRLLVAHVAWCAP-
. :: :. :. .: :: .
Rv1354c|M.tuberculosis_H37Rv LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Mb1389c|M.bovis_AF2122/97 LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Mflv_4377|M.gilvum_PYR-GCK ADPRALIARLGGDEFVVVPAGPMDGEAAESLAHQLQSTLKERVSIDGEML
Mvan_1967|M.vanbaalenii_PYR-1 ADCPNIIARLGGDEFVLVPTVPMDGAAAEALAHRLQSTLRERVSIDGEML
MSMEG_2196|M.smegmatis_MC2_155 DDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGEML
TH_0811|M.thermoresistible__bu AGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGEML
MLBr_01750|M.leprae_Br4923 AESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQVVIDGEIL
MAV_3132|M.avium_104 TEIPSVIARFGGDEFGVVPAAPMDVEAAESFAHSLHERLHHPIAIDDEML
MAB_3940c|M.abscessus_ATCC_199 -----MIIALSSRLFAEG-----TVGAAMTALVKVTSMLLVVVLIPAVIQ
:* :.. * * : * : : :
Rv1354c|M.tuberculosis_H37Rv TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Mb1389c|M.bovis_AF2122/97 TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Mflv_4377|M.gilvum_PYR-GCK TRTVSIGVAVGIPGQDTTSDLLRRADQAVLTAKNSGGNRVTVFTEEMSLK
Mvan_1967|M.vanbaalenii_PYR-1 TRTVSIGVAQGIPGRDTTSDLLRRADQAVLTAKGSGGNEVVVFTDDMSMR
MSMEG_2196|M.smegmatis_MC2_155 TRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAMAME
TH_0811|M.thermoresistible__bu TRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDMSLE
MLBr_01750|M.leprae_Br4923 TRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGISAQ
MAV_3132|M.avium_104 SRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEMSTI
MAB_3940c|M.abscessus_ATCC_199 FGIAVVRWDALAAQRDPLTGLLNRR---------------GIYAEWQRLY
. : . .. :.:*.
Rv1354c|M.tuberculosis_H37Rv GELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQHPT
Mb1389c|M.bovis_AF2122/97 GELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQHPT
Mflv_4377|M.gilvum_PYR-GCK QEFNNDIELHLQSVIEN--GALLLHYLPEIDMRTGDILAMEALVRWQHPT
Mvan_1967|M.vanbaalenii_PYR-1 HEFNNDIELHLQSVIEN--GALLLHYLPEVDMRTGEILACEALVRWQHPT
MSMEG_2196|M.smegmatis_MC2_155 IDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWEHPT
TH_0811|M.thermoresistible__bu AEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWHHPT
MLBr_01750|M.leprae_Br4923 HTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQHPT
MAV_3132|M.avium_104 DTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQHPT
MAB_3940c|M.abscessus_ATCC_199 GELRREQPLDGDQVTAA--AIVDIDRFKSINDRYGHGTGDRVLIDVAHAL
:. : * : : : ..: *. . ..* *.
Rv1354c|M.tuberculosis_H37Rv RGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRI
Mb1389c|M.bovis_AF2122/97 RGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRI
Mflv_4377|M.gilvum_PYR-GCK RGLLSPESFIGVAESINLAGELGRWVMRSACTDFARWRALGIGKDAIMRI
Mvan_1967|M.vanbaalenii_PYR-1 RGLLSPESFIGVAESINLAGELGRWVMRSACADFAGWRARGIGTGTVMRI
MSMEG_2196|M.smegmatis_MC2_155 RGLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRI
TH_0811|M.thermoresistible__bu RGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLRI
MLBr_01750|M.leprae_Br4923 RGLLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRI
MAV_3132|M.avium_104 LGLLMPDSFIQVAESINLGAKLGRLVMRSACAQFGQWRSRGVGQGTVLRI
MAB_3940c|M.abscessus_ATCC_199 TCGTTGTSVVGRSGGEEFL--VVTVCPASAVAEFATRLRQAVTASMPAGI
.: : . :: : * :*. .: . *
Rv1354c|M.tuberculosis_H37Rv NVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATL
Mb1389c|M.bovis_AF2122/97 NVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATL
Mflv_4377|M.gilvum_PYR-GCK NVSPVQLVTDGFVESVAGIVDEFGLEHGSVCLEITESVVVQDIETTRVTL
Mvan_1967|M.vanbaalenii_PYR-1 NVSPVQLVTDGFVESVAGIVDEFDLDEGSVCLEITESVVVQDIETTRVTL
MSMEG_2196|M.smegmatis_MC2_155 NVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTL
TH_0811|M.thermoresistible__bu NVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITL
MLBr_01750|M.leprae_Br4923 NVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTL
MAV_3132|M.avium_104 NVSPVQLVTAGIVDTVAATLDEFGLDPSTVCLEITESVVVQDIDATRQTL
MAB_3940c|M.abscessus_ATCC_199 AVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMYEAKHDGGDQSRIL
*:. *: * *. : : .* : : . :: *
Rv1354c|M.tuberculosis_H37Rv ARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDL
Mb1389c|M.bovis_AF2122/97 ARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDL
Mflv_4377|M.gilvum_PYR-GCK NGLKKAGVLVAIDDFGTGYSALSHLKSLPVDTLKIDKSFVRELGSDPGDL
Mvan_1967|M.vanbaalenii_PYR-1 KGLKEAGVRIAIDDFGTGYSALSHLKSLPVDTLKIDKSFVRELGSDPGDL
MSMEG_2196|M.smegmatis_MC2_155 TGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDL
TH_0811|M.thermoresistible__bu EGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDLGNSPGDL
MLBr_01750|M.leprae_Br4923 AGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDL
MAV_3132|M.avium_104 FGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDSLKIDKGFVQSLDTNPGDL
MAB_3940c|M.abscessus_ATCC_199 HADDDS-----------------------------EGRYLWRSGA-----
.. : :: .
Rv1354c|M.tuberculosis_H37Rv VIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPG
Mb1389c|M.bovis_AF2122/97 VIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPG
Mflv_4377|M.gilvum_PYR-GCK AIVRAIIALAEAFGLELVAEGVETDVGALTLLRHGCHRAQGFLLSRPIPT
Mvan_1967|M.vanbaalenii_PYR-1 AIVRAVIALAEAFGLELVAEGVETEAAAMTLLRHGCHRAQGFLLSRPIDG
MSMEG_2196|M.smegmatis_MC2_155 PIVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILG
TH_0811|M.thermoresistible__bu AIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPS
MLBr_01750|M.leprae_Br4923 AIVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDG
MAV_3132|M.avium_104 AIVRSTLALADAFGLDVVAEGVETVAAAETLLSLGCHRAQGFLLSRPLDS
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv EAMRHMLSARRLPPTCIPATDPALS-------
Mb1389c|M.bovis_AF2122/97 EAMRHMLSARRLPPTCIPATDPALS-------
Mflv_4377|M.gilvum_PYR-GCK DAMETLLAQGRIPVSFSKG-------------
Mvan_1967|M.vanbaalenii_PYR-1 AAMKALLARGRVPVSFAKS-------------
MSMEG_2196|M.smegmatis_MC2_155 SEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu NEMRELLARGRIPMRFSATP------------
MLBr_01750|M.leprae_Br4923 AAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MAV_3132|M.avium_104 AGMEALLIKGAIPMRFSDGGAPE-NQHVV---
MAB_3940c|M.abscessus_ATCC_199 --------------------------------