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IVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQFSDTGPRSMIG RVIVGLCAVGSLGWALRWAVGPWPSLREAVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFF LANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAVIQFGIAVVRWDALAAQR DPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTC GTTGTSVVGRSGGEEFLVVTVCPASAVAEFATRLRQAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEA IEVLTACADRAMYEAKHDGGDQSRILHADDDSEGRYLWRSGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3940c | - | - | 100% (393) | hypothetical protein MAB_3940c |
| M. abscessus ATCC 19977 | MAB_1867 | - | 2e-36 | 34.34% (332) | hypothetical protein MAB_1867 |
| M. abscessus ATCC 19977 | MAB_0124 | - | 9e-31 | 31.66% (259) | hypothetical protein MAB_0124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-17 | 33.01% (206) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_0112 | - | 7e-56 | 35.65% (359) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-17 | 33.01% (206) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01419 | - | 8e-14 | 35.29% (170) | putative regulatory protein |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 1e-45 | 33.52% (364) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 3e-19 | 25.58% (344) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 2e-35 | 28.81% (361) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0796 | - | 2e-52 | 36.21% (359) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01419|M.leprae_Br4923 MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQRLVDHSPNMTCVHE
Mflv_0112|M.gilvum_PYR-GCK --------------MVDGTVRTLLRQWWNQRDDYQWRIDFLR--------
Mvan_0796|M.vanbaalenii_PYR-1 --------------MGDGAVGDLLLQWWRQRDEYQWRIGFLR--------
MAB_3940c|M.abscessus_ATCC_199 ---------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLH--------
MAV_1995|M.avium_104 --------------------MKWLAAWWGQPDHFDWLTGYLQ--------
MSMEG_2774|M.smegmatis_MC2_155 ---------------------------MSPFDHYYARTAMLS--------
TH_3406|M.thermoresistible__bu -------------------MLKALRRTWRKPDHYYWFTSFLA--------
Mb1389c|M.bovis_AF2122/97 -------------------------------MCNDTATPQLE--------
Rv1354c|M.tuberculosis_H37Rv -------------------------------MCNDTATPQLE--------
MLBr_01419|M.leprae_Br4923 SGRVTYLNPVGVKWMAAQSPEQIIGHPLIEFVHPDSMPAMMSRIAPLREV
:
Mflv_0112|M.gilvum_PYR-GCK TRGLLPVLRYIIAGIGGSLGVLSVYNAFVPPG------------------
Mvan_0796|M.vanbaalenii_PYR-1 SRGLLPVLRWLIAGIGATMGVLSAVNVVLPPG------------------
MAB_3940c|M.abscessus_ATCC_199 ARKLDRTVRNLIGGYALIFAAICIAVQFSDTG------------------
MAV_1995|M.avium_104 DHGFGTATRRAMAVVGASLVLVPANVLWGATP------------------
MSMEG_2774|M.smegmatis_MC2_155 AQGQRSRMRRIIGVTITALAFVPVLMLASPAG------------------
TH_3406|M.thermoresistible__bu ARRARTSTCRFIASITLILGLMPMVMLAGPAG------------------
Mb1389c|M.bovis_AF2122/97 ELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ------------------
Rv1354c|M.tuberculosis_H37Rv ELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ------------------
MLBr_01419|M.leprae_Br4923 GDASQPSEAVLLRLDGTTLEVEAVSVLTVWEGKPAYQVIFRDLTTQKAAE
Mflv_0112|M.gilvum_PYR-GCK -----ADGVLIRTGWAILAVGSLGWAARWALGSWPTVRESAALVVFVDVM
Mvan_0796|M.vanbaalenii_PYR-1 -----ADDTVFRLGWAVVAVGSLAWAARWAFLPWPTARESAVLVGCVDVL
MAB_3940c|M.abscessus_ATCC_199 -----PRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLREAVAFVAFADIG
MAV_1995|M.avium_104 -----FFPGLTLTVSVLAGMVGLGMAVLWLHG-WPTRRQSVVFALTGSVA
MSMEG_2774|M.smegmatis_MC2_155 -----PAGAL-RYVPLGATACGVLMSVWWWRRKWPSRNQSWLVVGIGTVG
TH_3406|M.thermoresistible__bu -----PQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQSRVVSLAAGLA
Mb1389c|M.bovis_AF2122/97 -----LGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADAD
Rv1354c|M.tuberculosis_H37Rv -----LGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADAD
MLBr_01419|M.leprae_Br4923 ETLRFQAALVNHVSDAIIATTSTGMVTSWNPAAEAIYRRSASDVLGMPIG
. * .
Mflv_0112|M.gilvum_PYR-GCK MTVSALLFG------------------------DPTLAMSGIPILLCAGG
Mvan_0796|M.vanbaalenii_PYR-1 MTLSALLFG------------------------DPNLAMSGIPILLCAGG
MAB_3940c|M.abscessus_ATCC_199 IAVACWQDS------------------------DPLAGLVGTVLFTPVGA
MAV_1995|M.avium_104 IGAGCLWQT------------------------EPLVGLMACSALSVTGG
MSMEG_2774|M.smegmatis_MC2_155 IAVTLSSMS------------------------DPTVGLLSSSVFSLVTT
TH_3406|M.thermoresistible__bu IAVFAFTLP------------------------DPSAGLVWTAAFAVLAG
Mb1389c|M.bovis_AF2122/97 PVFALCEHA------------------------KEPLVFRPE---PATED
Rv1354c|M.tuberculosis_H37Rv PVFALCEHA------------------------KEPLVFRPE---PATED
MLBr_01419|M.leprae_Br4923 EAVGAPLDPGAIITEGGVLSTTQYASDGMALAVRVSAAVMENGFVLVCSD
.
Mflv_0112|M.gilvum_PYR-GCK YVVFFHGPRLHLVHIAWCTASVVGIAIWLAVSDPVFGPQLAVSR----AI
Mvan_0796|M.vanbaalenii_PYR-1 YVVFFHGPRLHLAHIAWCTVSVVGIAVWLAASTPDYGVQVAVSR----AV
MAB_3940c|M.abscessus_ATCC_199 YVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVK----VT
MAV_1995|M.avium_104 YNAFFHTAKFMGLNFGLAGAIGALQAARLAASG---QAMLAFTG----YF
MSMEG_2774|M.smegmatis_MC2_155 YSAFLHSRRVLVLSWIASGLTVGFLAIRVAFTS----IPMALSG----AL
TH_3406|M.thermoresistible__bu YVALFHSARYATFTVLFAAITAGVLSFELAKTAG---VAAAVCG----FV
Mb1389c|M.bovis_AF2122/97 YQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEA----EL
Rv1354c|M.tuberculosis_H37Rv YQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEA----EL
MLBr_01419|M.leprae_Br4923 YTALLRVERRFQTVVALLEEGVIVLDGDGYVESVNPAALRILGVSDRSAL
* :: :
Mflv_0112|M.gilvum_PYR-GCK IALAVTVCVLPALQFGFWLLQDSS--------------------------
Mvan_0796|M.vanbaalenii_PYR-1 IALLVTVCILPALQFGFWLLQGSS--------------------------
MAB_3940c|M.abscessus_ATCC_199 SMLLVVVLIPAVIQFGIAVVRWDA--------------------------
MAV_1995|M.avium_104 LVLELNVIVPLSIQIVVRALWLDL--------------------------
MSMEG_2774|M.smegmatis_MC2_155 VSGLVIATTSMLCRMAIRLLDAGN--------------------------
TH_3406|M.thermoresistible__bu FITVVTFAVVCACNLLVGLLDVDV--------------------------
Mb1389c|M.bovis_AF2122/97 NALMTIATLFAQVQARVAAEARLR--------------------------
Rv1354c|M.tuberculosis_H37Rv NALMTIATLFAQVQARVAAEARLR--------------------------
MLBr_01419|M.leprae_Br4923 DDPVRRAATLPMYDAQGRLLDHGRGAVREFLRTGTPKTGFIVGIDRPSDG
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------MQS--LTDPLTE
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------KQS--LTDPLTE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------LAA--QRDPLTG
MAV_1995|M.avium_104 --------------------------------------LRA--NRDPLTG
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------VQHPNEIDRLTG
TH_3406|M.thermoresistible__bu --------------------------------------LDA--DIEPLTG
Mb1389c|M.bovis_AF2122/97 --------------------------------------YLA--DHDDLTG
Rv1354c|M.tuberculosis_H37Rv --------------------------------------YLA--DHDDLTG
MLBr_01419|M.leprae_Br4923 TRVWLSVNSRSLNPVDPEDATLLISFTDVTAERQASQYLAHQAAHDTLTG
: **
Mflv_0112|M.gilvum_PYR-GCK LTNRRGLAVSVKRLN------TDARADATLCALLIDVDRFKSVNDTFGHA
Mvan_0796|M.vanbaalenii_PYR-1 LTNRRGLAVSMQRLN------EAAPTGADLCALLIDVDGFKRVNDTLGHA
MAB_3940c|M.abscessus_ATCC_199 LLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHG
MAV_1995|M.avium_104 LLNRRACNRAIIGRM------LTGASHMFLAVAMVDLDRFKALNDTHGHA
MSMEG_2774|M.smegmatis_MC2_155 LLNREAFEIQAATMLG----SHSRHDDQYLVILAVGIDDMSLLSDMDGTH
TH_3406|M.thermoresistible__bu LLNRDAFYRSAGHLI-----SRSRDDDRQLVIALINIDNLRLLRDTQGQA
Mb1389c|M.bovis_AF2122/97 LHNRRALLQHLDQRL-------APGQPGPVAALFLDLDRLKAINDYLGHA
Rv1354c|M.tuberculosis_H37Rv LHNRRALLQHLDQRL-------APGQPGPVAALFLDLDRLKAINDYLGHA
MLBr_01419|M.leprae_Br4923 LPNRTSILARIDEQR-----YCGAPDQLLTAVLFIDLDNFKGINDSLGHD
* ** . :.:* : : * *
Mflv_0112|M.gilvum_PYR-GCK VGDDVLIRTARRIRASVPEDAVVVRWGGEEFLVVDRIPGNQAETVAERIR
Mvan_0796|M.vanbaalenii_PYR-1 VGDEVLIRTARRIRQSVRGDAVVVRWGGEEFLVVDRIPAQQAGKVAERIR
MAB_3940c|M.abscessus_ATCC_199 TGDRVLIDVAHALTCGTTGTSVVGRSGGEEFLVVTVCPASAVAEFATRLR
MAV_1995|M.avium_104 AGDEALIAVAGALTAACGDTTVVGRVGGEEFLVADIVTTEQLPGWGQQLC
MSMEG_2774|M.smegmatis_MC2_155 STLHARVAVAQALRETVRHRVPLAHVSDSEFLIADVFKTNDPSPLVERMR
TH_3406|M.thermoresistible__bu AADRARVAIGQTLRENTRHNAFVAHLGQDEFLIADTFSSTDSFPLVERVR
Mb1389c|M.bovis_AF2122/97 AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMS--ADAAQPLA
Rv1354c|M.tuberculosis_H37Rv AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMS--ADAAQPLA
MLBr_01419|M.leprae_Br4923 VGDVVLQTAAQRLRAGLRSRDVVGRFGGDEFVALILGKIT-HTELSKVVD
. : : : . .**: :
Mflv_0112|M.gilvum_PYR-GCK AAVAEPAEPTVTVSIGLATCERADIDLIDVIS---------AADAAMYEA
Mvan_0796|M.vanbaalenii_PYR-1 AAVSAPAQPPVTVSIGLATCTRPDLDLIDVIT---------AADAAMYEA
MAB_3940c|M.abscessus_ATCC_199 QAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMYEA
MAV_1995|M.avium_104 EAVAALDPP---VTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMYEA
MSMEG_2774|M.smegmatis_MC2_155 LAISTTPMR---LTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMNES
TH_3406|M.thermoresistible__bu GAIATTPPR---LTASIGVVSTPMRGLAVCPPETLLDELIAVASATMYEA
Mb1389c|M.bovis_AF2122/97 ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
Rv1354c|M.tuberculosis_H37Rv ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
MLBr_01419|M.leprae_Br4923 RMHAALSEPTYVADAVLHLRASIGVVAIKGDDPRNIGQILRDADTAMYRA
: * : :
Mflv_0112|M.gilvum_PYR-GCK KADGGNKVVITAEAA-----------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 KARGGDRVVVTAGVR-----------------------------------
MAB_3940c|M.abscessus_ATCC_199 KHDGGDQSRILHADDDSEGRYLWRSGA-----------------------
MAV_1995|M.avium_104 KRCGGNQTRHRPAQVST---------------------------------
MSMEG_2774|M.smegmatis_MC2_155 RAAGGNQTISVNYPTPTPNQE-----------------------------
TH_3406|M.thermoresistible__bu RRAGGNQARYRKYPNPTAVTEAHYPEQAADDF------------------
Mb1389c|M.bovis_AF2122/97 KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
Rv1354c|M.tuberculosis_H37Rv KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
MLBr_01419|M.leprae_Br4923 KLSGEGTSYYTDTFNQQPS-------------------------------
: * .
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
Rv1354c|M.tuberculosis_H37Rv GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
Rv1354c|M.tuberculosis_H37Rv SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
Rv1354c|M.tuberculosis_H37Rv TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
Rv1354c|M.tuberculosis_H37Rv IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK -----------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 -----------------------------------------
MAB_3940c|M.abscessus_ATCC_199 -----------------------------------------
MAV_1995|M.avium_104 -----------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 -----------------------------------------
TH_3406|M.thermoresistible__bu -----------------------------------------
Mb1389c|M.bovis_AF2122/97 RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
MLBr_01419|M.leprae_Br4923 -----------------------------------------