For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GAIGRWWRQPDQYDWLSSYMHARGFTRPAQIFMAVIAASGVLVPANALWGPAATSHALLLALGVVAGLAG LAYLVLWLSRWPTRNQSIGFALTICVCIALGSFTAADPAIGLMASAALAVSGGYLAFFHSARLVTANLVV ALAVAAVHVARLAADGQAVLAVSMLFLVVELNAGVPLAIQIMVHALGIDLIKSDRDPLTGLLNRRSFQRA VVAAVLDGQRSGTHLAFAMLDLDRFKVLNDTLGHSAGDDALVSVAQALTANLPDTAIIGRVGGEEFLIAD VIAAAVPEDLGERAREAVTFTPYGLTTSVGTASFAVDALNAGNIVDSMHWLTAQADVAMYSAKRAGGNGV RHHTPARRDEDSPREDAPQRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1665 | - | - | 100% (372) | diguanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4819 | - | 3e-72 | 42.24% (348) | diguanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_2385 | - | 2e-68 | 42.24% (348) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-15 | 31.00% (200) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_1453 | - | 7e-71 | 42.98% (349) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-15 | 31.00% (200) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 4e-14 | 33.33% (177) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-44 | 32.43% (370) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 5e-94 | 51.43% (350) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 8e-26 | 30.16% (368) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 4e-52 | 34.94% (352) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 ------------------------MCNDTATPQLEELVTTVANQLMTVDA
Rv1354c|M.tuberculosis_H37Rv ------------------------MCNDTATPQLEELVTTVANQLMTVDA
Mvan_1665|M.vanbaalenii_PYR-1 ------------MGAIGRWWRQPDQYDWLSSYMHARGFTRPAQIFMAVIA
MAV_1995|M.avium_104 ------------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVG
Mflv_1453|M.gilvum_PYR-GCK MISSSTSKRRRLRPAANRWWNQPDQFDWLSGYLHARGLAPATRRLMAVIS
MSMEG_2774|M.smegmatis_MC2_155 -------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTI
TH_3406|M.thermoresistible__bu -----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASIT
MAB_3940c|M.abscessus_ATCC_199 -MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYA
MLBr_00397|M.leprae_Br4923 --MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATRILGLRA
. :
Mb1389c|M.bovis_AF2122/97 ATSAEVSQRVLAYLVEQL-------GVDVSFLRHNDRDRRATRLVAEWPP
Rv1354c|M.tuberculosis_H37Rv ATSAEVSQRVLAYLVEQL-------GVDVSFLRHNDRDRRATRLVAEWPP
Mvan_1665|M.vanbaalenii_PYR-1 ASGVLVPANALWGPAATS-------HALLLALGVVAG-LAGLAYLVLWLS
MAV_1995|M.avium_104 ASLVLVPANVLWGATPFF-------PGLTLTVSVLAG-MVGLGMAVLWLH
Mflv_1453|M.gilvum_PYR-GCK SALVLMAFGVLG-SRDEH-------PVLTYTVAAAAA-IAGIGYGTLWLR
MSMEG_2774|M.smegmatis_MC2_155 TALAFVPVLMLASPAGPA-------GAL-RYVPLGAT-ACGVLMSVWWWR
TH_3406|M.thermoresistible__bu LILGLMPMVMLAGPAGPQ-------SMPGRLIAVAVT-VTALVITLIWLR
MAB_3940c|M.abscessus_ATCC_199 LIFAAICIAVQFSDTGPR-------SMIGRVIVGLCA-VGSLGWALRWAV
MLBr_00397|M.leprae_Br4923 HDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSG
: :
Mb1389c|M.bovis_AF2122/97 RLNIPDPDPLRLIYFADADPVFALCEHAKEP----LVFRPEPATEDYQRL
Rv1354c|M.tuberculosis_H37Rv RLNIPDPDPLRLIYFADADPVFALCEHAKEP----LVFRPEPATEDYQRL
Mvan_1665|M.vanbaalenii_PYR-1 R--WPTRNQSIGFALTICVCIALGSFTAADPAIGLMASAALAVSGGYLAF
MAV_1995|M.avium_104 G--WPTRRQSVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAF
Mflv_1453|M.gilvum_PYR-GCK R--WPTRRQSLMMGMVGGSMIAVGSGMQTEPVVALMGCTGLVVTGGYLAF
MSMEG_2774|M.smegmatis_MC2_155 RK-WPSRNQSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSAF
TH_3406|M.thermoresistible__bu DR-WPSRNQSRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVAL
MAB_3940c|M.abscessus_ATCC_199 GP-WPSLREAVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSF
MLBr_00397|M.leprae_Br4923 QRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTG
.. :
Mb1389c|M.bovis_AF2122/97 IEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT
Rv1354c|M.tuberculosis_H37Rv IEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT
Mvan_1665|M.vanbaalenii_PYR-1 FHSARLVTANLVVALAVAAVHVARLAAD-GQAVLAVSMLFLVVELNAGVP
MAV_1995|M.avium_104 FHTAKFMGLNFGLAGAIGALQAARLAAS-GQAMLAFTGYFLVLELNVIVP
Mflv_1453|M.gilvum_PYR-GCK FHNTKAVLFNFAVAATVGTYCALRVFETYDDRASALAGLWLIIELNLAVP
MSMEG_2774|M.smegmatis_MC2_155 LHSRRVLVLSWIASGLTVGFLAIRVAFTS-IPMALSG-ALVSGLVIATTS
TH_3406|M.thermoresistible__bu FHSARYATFTVLFAAITAGVLSFELAKTAGVAAAVCG-FVFITVVTFAVV
MAB_3940c|M.abscessus_ATCC_199 FLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVL
MLBr_00397|M.leprae_Br4923 LANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVL
: : . : .
Mb1389c|M.bovis_AF2122/97 LFAQVQAR-VAAEARLRYLADHDDLTGLHNRR-----------ALLQHLD
Rv1354c|M.tuberculosis_H37Rv LFAQVQAR-VAAEARLRYLADHDDLTGLHNRR-----------ALLQHLD
Mvan_1665|M.vanbaalenii_PYR-1 LAIQIMVH-ALGIDLIKS--DRDPLTGLLNRR-----------SFQRAVV
MAV_1995|M.avium_104 LSIQIVVR-ALWLDLLRA--NRDPLTGLLNRR-----------ACNRAII
Mflv_1453|M.gilvum_PYR-GCK LAIQTVVR-TMGADVVRS--DHDALTGLLNRR-----------GFY-ERA
MSMEG_2774|M.smegmatis_MC2_155 MLCRMAIR-LLDAGNVQHPNEIDRLTGLLNRE-----------AFEIQAA
TH_3406|M.thermoresistible__bu CACNLLVG-LLDVDVLDA--DIEPLTGLLNRD-----------AFYRSAG
MAB_3940c|M.abscessus_ATCC_199 IPAVIQFG-IAVVRWDALAAQRDPLTGLLNRRGIYA-------EWQRLYG
MLBr_00397|M.leprae_Br4923 QTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLS
: : * .
Mb1389c|M.bovis_AF2122/97 QRL---APGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Rv1354c|M.tuberculosis_H37Rv QRL---APGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Mvan_1665|M.vanbaalenii_PYR-1 AAV-LDGQRSGTHLAFAMLDLDRFKVLNDTLGHSAGDDALVSVAQALTAN
MAV_1995|M.avium_104 GRM-LTG-ASHMFLAVAMVDLDRFKALNDTHGHAAGDEALIAVAGALTAA
Mflv_1453|M.gilvum_PYR-GCK SSL-LTSPAADSDLIVVMIDLDAFKRLNDTYGHLAGDQALAAVGWALRKA
MSMEG_2774|M.smegmatis_MC2_155 TMLGSHSRHDDQYLVILAVGIDDMSLLSDMDGTHSTLHARVAVAQALRET
TH_3406|M.thermoresistible__bu HLI-SRSRDDDRQLVIALINIDNLRLLRDTQGQAAADRARVAIGQTLREN
MAB_3940c|M.abscessus_ATCC_199 ELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTCG
MLBr_00397|M.leprae_Br4923 ESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQCA
: :
Mb1389c|M.bovis_AF2122/97 LVGESLIARLGGDEFVLIPASPMSADAAQP------LAERLRDQLKDH--
Rv1354c|M.tuberculosis_H37Rv LVGESLIARLGGDEFVLIPASPMSADAAQP------LAERLRDQLKDH--
Mvan_1665|M.vanbaalenii_PYR-1 LPDTAIIGRVGGEEFLIA--DVIAAAVPED------LGERAREAVTFTP-
MAV_1995|M.avium_104 CGDTTVVGRVGGEEFLVA--DIVTTEQLPG------WGQQLCEAVAALD-
Mflv_1453|M.gilvum_PYR-GCK SPGSAVIGRTGGEEFLLI--DILPVAQAEA------LPDELCAAIAALP-
MSMEG_2774|M.smegmatis_MC2_155 VRHRVPLAHVSDSEFLIA--DVFKTNDPSP------LVERMRLAISTTP-
TH_3406|M.thermoresistible__bu TRHNAFVAHLGQDEFLIA--DTFSSTDSFP------LVERVRGAIATTP-
MAB_3940c|M.abscessus_ATCC_199 TTGTSVVGRSGGEEFLVV--TVCPASAVAE------FATRLRQAVTASMP
MLBr_00397|M.leprae_Br4923 VTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGM
: . :.: :
Mb1389c|M.bovis_AF2122/97 --VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSV
Rv1354c|M.tuberculosis_H37Rv --VAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSV
Mvan_1665|M.vanbaalenii_PYR-1 --YGLTTSVGTASFAVDALNAGNIVDSMHWLTAQADVAMYSAKRAGGNGV
MAV_1995|M.avium_104 --PPVTASVGTATLPLRDLVSEYAEHAFHQLVAQADSAMYEAKRCGGNQT
Mflv_1453|M.gilvum_PYR-GCK --HPVTASVGAA--VVRGLPQSDAPAVIEALTRTADATMYEAKRSGGNQA
MSMEG_2774|M.smegmatis_MC2_155 --MRLTASIGTVCSPLAPLASLPAEQVLQELIDVAMRAMNESRAAGGNQT
TH_3406|M.thermoresistible__bu --PRLTASIGVVSTPMRGLAVCPPETLLDELIAVASATMYEARRAGGNQA
MAB_3940c|M.abscessus_ATCC_199 AGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADRAMYEAKHDGGDQS
MLBr_00397|M.leprae_Br4923 TFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVN
: .: : * : .*
Mb1389c|M.bovis_AF2122/97 AIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEA
Rv1354c|M.tuberculosis_H37Rv AIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEA
Mvan_1665|M.vanbaalenii_PYR-1 RHHTPARRDEDSPREDAPQRP-----------------------------
MAV_1995|M.avium_104 RHR-PAQVST----------------------------------------
Mflv_1453|M.gilvum_PYR-GCK LIRRVSPLFQN---------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 ISVNYPTPTPNQE-------------------------------------
TH_3406|M.thermoresistible__bu RYRKYPNPTAVTEAHYPEQAADDF--------------------------
MAB_3940c|M.abscessus_ATCC_199 RILHADDDSEGRYLWRSGA-------------------------------
MLBr_00397|M.leprae_Br4923 GIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGAMP
Mb1389c|M.bovis_AF2122/97 LVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGL
Rv1354c|M.tuberculosis_H37Rv LVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGL
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 WILIVCLFVTILAG--------ILFQFTMFGRWVKAIGGNERVATLAGVP
Mb1389c|M.bovis_AF2122/97 GHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQD
Rv1354c|M.tuberculosis_H37Rv GHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQD
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 TRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGG
Mb1389c|M.bovis_AF2122/97 LHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQ
Rv1354c|M.tuberculosis_H37Rv LHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQ
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 TPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAAAVF
Mb1389c|M.bovis_AF2122/97 LGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGF
Rv1354c|M.tuberculosis_H37Rv LGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGF
Mvan_1665|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
Mflv_1453|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VFLQRRKIGIIK--------------------------------------
Mb1389c|M.bovis_AF2122/97 LFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv LFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Mvan_1665|M.vanbaalenii_PYR-1 ---------------------------------
MAV_1995|M.avium_104 ---------------------------------
Mflv_1453|M.gilvum_PYR-GCK ---------------------------------
MSMEG_2774|M.smegmatis_MC2_155 ---------------------------------
TH_3406|M.thermoresistible__bu ---------------------------------
MAB_3940c|M.abscessus_ATCC_199 ---------------------------------
MLBr_00397|M.leprae_Br4923 ---------------------------------