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KPVKREPTQDNPPGNPSIVIIGAGFAGITLALRLKRAGFDRVLIVEKGDGVGGVWRENTYPGAACDVPSQ LYSISSAPNPRWGRRYAEQGDILAYLRRVADESGLLSLLRTKTEIAKAAFDERTNTWRLTTTTSQELECD VVISAVGQLSRPSVPDIPGISGFAGPSFHSANWDHDLNLSGKRLAVVGTGASSVQFVPVVAAGAEHLDVF QRSAPWVLPKFDRQYGGRHHQLLRKLPILRLSERLMIWTIFEFLALALVDAKPVARVLGVIALRHLGRQV SDARLRSHLTPDYAPGCKRILFSSDYYPALARPNVLLVTDDIQAVEPGGIRTVNGDFHAADVIIYGTGFS ATEFLSPMEVYGRSDRKLSDVWADGAHAYYGLSVPEFPNFLMMYGPNTNVGSGSIVYMLESQARHIVRLM KVLRAHPGSVIEVRADVEKRFNDRLSRRLDRSVWTMCTSWYRSARGSISTNWPSPTFLYRLRARRPKRRA YVLSRPAPANSSRRGTPEPANTHLADMPYAPSGADSVD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4605 | - | - | 100% (529) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4103 | - | e-105 | 41.91% (482) | cyclohexanone monooxygenase |
| M. gilvum PYR-GCK | Mflv_4608 | - | 8e-98 | 37.10% (496) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 6e-97 | 38.03% (518) | monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 7e-97 | 38.03% (518) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 5e-28 | 25.05% (479) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2077 | - | 1e-164 | 54.78% (502) | monooxygenase |
| M. marinum M | MMAR_3136 | - | 1e-163 | 56.28% (478) | monooxygenase |
| M. avium 104 | MAV_5241 | - | 1e-115 | 45.68% (486) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 1e-109 | 42.86% (483) | monooxygenase |
| M. thermoresistible (build 8) | TH_3452 | - | 1e-107 | 41.53% (496) | PUTATIVE lipolytic enzyme |
| M. ulcerans Agy99 | MUL_4873 | - | 1e-104 | 42.37% (498) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 1e-104 | 40.20% (490) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2077|M.abscessus_ATCC_1997 ------------------------MSSNFATACRAYDPSIVIIGAGFAGV
MMAR_3136|M.marinum_M ------------------------MTGGFARDPRGHDPSIVIIGAGVAGI
Mflv_4605|M.gilvum_PYR-GCK ---------------------MKPVKREPTQDNPPGNPSIVIIGAGFAGI
MAV_5241|M.avium_104 MTETVGPARAKPVMSR-KAKWLYAIGRVRAATRRRRGPKVAIIGAGFGGL
MUL_4873|M.ulcerans_Agy99 -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
TH_3452|M.thermoresistible__bu ---------------------------------MARNLSVGIIGAGPGGI
Mvan_2243|M.vanbaalenii_PYR-1 -----------------------------MTTSMAKTFSVAIIGAGPGGL
Mb3075c|M.bovis_AF2122/97 ---------------MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGL
Rv3049c|M.tuberculosis_H37Rv ---------------MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGL
MSMEG_4451|M.smegmatis_MC2_155 ---------------------MSAPASSTPTLPASVHT--LVVGAGFAGL
MLBr_00065|M.leprae_Br4923 ----------------------------MVVMAETEYLDVVIVGAGISGV
::*:* .*:
MAB_2077|M.abscessus_ATCC_1997 AMAHRLKKDG-FTNFTILEKAADIGGVWRDNTYPGAACDVPSALYSLSYK
MMAR_3136|M.marinum_M AMAHQLKRDG-FTNFTMVEKAADIGGVWRDNTYPGAACDVPSALYSLSDK
Mflv_4605|M.gilvum_PYR-GCK TLALRLKRAG-FDRVLIVEKGDGVGGVWRENTYPGAACDVPSQLYSISSA
MAV_5241|M.avium_104 GAAVALRRAG-IDDLVIIEAADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MUL_4873|M.ulcerans_Agy99 AAAVALRGAG-IDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
TH_3452|M.thermoresistible__bu ALGIFLRRAG-FTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFE
Mvan_2243|M.vanbaalenii_PYR-1 ALGIFLRKAG-FTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
Mb3075c|M.bovis_AF2122/97 GMAIALQKQG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFE
Rv3049c|M.tuberculosis_H37Rv GMAIALQKQG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFE
MSMEG_4451|M.smegmatis_MC2_155 AAAAAVLREDPRADLLIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFA
MLBr_00065|M.leprae_Br4923 SAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFR
. : :.: :**.* *** .* .
MAB_2077|M.abscessus_ATCC_1997 PNPRWSRRYAEQPEILKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRW
MMAR_3136|M.marinum_M PNTRWSRRYAEQPEILQYLRRLVLADGMDLHLRTRTEVVEMTFDEQAGRW
Mflv_4605|M.gilvum_PYR-GCK PNPRWGRRYAEQGDILAYLRRVADESGLLSLLRTKTEIAKAAFDERTNTW
MAV_5241|M.avium_104 PNASWSRTYARQPEILAYLESVADAFDLRRHLMLDTTVRSLRWNPHTAAW
MUL_4873|M.ulcerans_Agy99 ANKFWSRTYARQPEILAYLESVVDDFDLRRHLMLSAMVRSIRWDEDTWGW
TH_3452|M.thermoresistible__bu LNSEWTRLWPAQPEILRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQW
Mvan_2243|M.vanbaalenii_PYR-1 LNAHWSRMWSGQEEILQYFERCAQRYRLPDNLQLNTEIVSARWGSETRTW
Mb3075c|M.bovis_AF2122/97 PKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRW
Rv3049c|M.tuberculosis_H37Rv PKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRW
MSMEG_4451|M.smegmatis_MC2_155 PSAKWSHTFARQPEIHRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRW
MLBr_00065|M.leprae_Br4923 PWTKCQAIADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRW
* *: . : : : :. *
MAB_2077|M.abscessus_ATCC_1997 TLVTNSN---ETITCDVVVSAVGQLSLPH--VPVIADADTFQGPRFHSAR
MMAR_3136|M.marinum_M RLVTGSS---ETIWCDVVISAVGQLSRPH--TPNIAGEDTFEGPRFHSAR
Mflv_4605|M.gilvum_PYR-GCK RLTTTTS---QELECDVVISAVGQLSRPS--VPDIPGISGFAGPSFHSAN
MAV_5241|M.avium_104 DCRIDRGGHPATLSADVVVCAVGLFGAAK--LPDIDGLAGFAGPVLHTAQ
MUL_4873|M.ulcerans_Agy99 VCQVDRAGGTAILTADVVVCATGLFGPRK--LPDIAGLTDFGGTLMHTAG
TH_3452|M.thermoresistible__bu MLTTGAG---EQHNFDVVVSAVGMFTRPV--MPDLVEEEPFTGTLMHSAR
Mvan_2243|M.vanbaalenii_PYR-1 TLTTAGG---EEHTFDIVVSAIGLFTQPV--MPDLVDEEPFTGTVMHTAR
Mb3075c|M.bovis_AF2122/97 HVFTADGR---EYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQ
Rv3049c|M.tuberculosis_H37Rv HVFTADGR---EYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQ
MSMEG_4451|M.smegmatis_MC2_155 RVRTSLG----MVTATVLVAATGALSTPK--LPDVPGLDRFGGTVFHSAT
MLBr_00065|M.leprae_Br4923 TVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQH
.:. * * . * *. :*.
MAB_2077|M.abscessus_ATCC_1997 WDRSVSLRGKQVAVIGTGASAIQFVPHIVQE-AEHVTLYQRTAPWILPKW
MMAR_3136|M.marinum_M WDHSVSLRGKEVAVIGTGASAIQFVPRIAHE-AQRVTLYQRTAPWILPKW
Mflv_4605|M.gilvum_PYR-GCK WDHDLNLSGKRLAVVGTGASSVQFVPVVAAG-AEHLDVFQRSAPWVLPKF
MAV_5241|M.avium_104 WDHDLDLAGRTVAVIGTGASGVQLVPELAGT-AGHVTVFQRTPPWMVPKD
MUL_4873|M.ulcerans_Agy99 WDHRVDLTGKRVAVIGTGASGVQVVPELAKL-AGRLTVFQRTPPWMVPKD
TH_3452|M.thermoresistible__bu WDHGIDLHGKRIAVLGTGSTASQLIPELAKI-ADRVYSVQRSPTWILPKP
Mvan_2243|M.vanbaalenii_PYR-1 WDHSVDLRDARVAVLGTGSTAAQLVPEVAKQ-AAKVYSVQRSPTWVLPKP
Mb3075c|M.bovis_AF2122/97 WDHSIDLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRT
Rv3049c|M.tuberculosis_H37Rv WDHSIDLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRT
MSMEG_4451|M.smegmatis_MC2_155 WNHDHDLTDERVAVVGTGASAVQFVPEIADR-TAHLTVFQRTPAWVLPRL
MLBr_00065|M.leprae_Br4923 WPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQP
* . . :.::*:*::. .:* :. . .: **:..:::.:
MAB_2077|M.abscessus_ATCC_1997 DSRYGVLHDRVSELLPMALRLERFAVWLIFELLAVTLVDAKPLSRVLGAI
MMAR_3136|M.marinum_M DSRYGRLHQQLIKVLPLWLRLERFAVWLIFEVLAVTLVDAKPLSRILGAV
Mflv_4605|M.gilvum_PYR-GCK DRQYGGRHHQLLRKLPILRLSERLMIWTIFEFLALALVDAKPVARVLGVI
MAV_5241|M.avium_104 DRPYSATELARFKRNPLALRRTRWQIWKFQHDNTATFADDPVVTARSR-I
MUL_4873|M.ulcerans_Agy99 DRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ-I
TH_3452|M.thermoresistible__bu DRPYSDRERWVFRHVPFAKRIYRTRLWLRSEANISVIEDGSEKTEEFKAI
Mvan_2243|M.vanbaalenii_PYR-1 DREYTGREKWMFAHIPLAKKIYRTRLWLRSESNISVIENGSDKTEEFKGI
Mb3075c|M.bovis_AF2122/97 NEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAY
Rv3049c|M.tuberculosis_H37Rv NEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAY
MSMEG_4451|M.smegmatis_MC2_155 DRTLGRLERALYRRIPLSQRLVRGMVYIYREGYLALLAHLTWLLPLLEII
MLBr_00065|M.leprae_Br4923 AKDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWP--QRMRNIL
* .
MAB_2077|M.abscessus_ATCC_1997 ARRHLHRQVASPSLREQLMPSDAPGCKRVLFS--NDYYPAIASDRVSLVP
MMAR_3136|M.marinum_M ARYHLHRQVADPMLRRQLTPSDAPGCKRVLFS--NDYYPAIANGEVSLVT
Mflv_4605|M.gilvum_PYR-GCK ALRHLGRQVSDARLRSHLTPDYAPGCKRILFS--SDYYPALARPNVLLVT
MAV_5241|M.avium_104 ATSFLDRTVADESLRRALTPDYPFRCKRVLLG--DDYYRALQRDNVELVT
MUL_4873|M.ulcerans_Agy99 ATSFLERVVADERLRRALTPGYPFRCKRVLLG--DDFYRALQHAHVELVT
TH_3452|M.thermoresistible__bu ALKMLEATVPDEEMRRRLTPDHPLGCKRLVFS--SDYLAALMRPNVEVVS
Mvan_2243|M.vanbaalenii_PYR-1 ALRTLEATVADDELRAKLTPTHPLGCKRLVFA--TDYLQTLTQPHVEVVS
Mb3075c|M.bovis_AF2122/97 AKYNIRRSVKDRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELIT
Rv3049c|M.tuberculosis_H37Rv AKYNIRRSVKDRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELIT
MSMEG_4451|M.smegmatis_MC2_155 AKTQLRRQVPDPALRRALTPDFRIGCKRILLT--NDWLPTLARDDVEVVT
MLBr_00065|M.leprae_Br4923 LGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVT
. :: : * :*: :: . ::.
MAB_2077|M.abscessus_ATCC_1997 KAIAELCDNGVKTVDGEFR----PADVVIYGTGFRATDFLAPMSVRGSRG
MMAR_3136|M.marinum_M NAVAKLCDKGVVTDDGVLH----RADVVIYGTGFRATDFLAPMRVRGWGG
Mflv_4605|M.gilvum_PYR-GCK DDIQAVEPGGIRTVNGDFH----AADVIIYGTGFSATEFLSPMEVYGRSD
MAV_5241|M.avium_104 DPIARIGRMSVITASGAEI----EADVIVLATGFETSRYLSGIEVVGAGG
MUL_4873|M.ulcerans_Agy99 DPIERVTETSVVTTAGQGV----DVDAVVLATGFETSRYLSGIEVIGTGG
TH_3452|M.thermoresistible__bu SPARALRGDTLITEDGTER----RVDVVVCATGYAAADYLGQIEVVGERQ
Mvan_2243|M.vanbaalenii_PYR-1 SPARSLRSRSLVTEDGTEL----DVDVVLCATGYAAADYLGQIEVRGADD
Mb3075c|M.bovis_AF2122/97 DRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHG
Rv3049c|M.tuberculosis_H37Rv DRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHG
MSMEG_4451|M.smegmatis_MC2_155 TALTEVTETGVR--DGTGR--LHDVDTIIFATGFTPTEPPVAHQLTGVTG
MLBr_00065|M.leprae_Br4923 DAIDRFTSTGIRLKSGNELR----ADIIVTATGLNLQLFGGAVATVDGQP
. : * .* :: .** .
MAB_2077|M.abscessus_ATCC_1997 VSLAEVWKT-QAYAYLGITVPMFPNLFLLYGPNTNVGSGSILYMIESQVR
MMAR_3136|M.marinum_M VTLDEVWGT-QAHAYLGITVPMFPNLFLLYGPNTNVGSGSIIYMIESQVR
Mflv_4605|M.gilvum_PYR-GCK RKLSDVWAD-GAHAYYGLSVPEFPNFLMMYGPNTNVGSGSIVYMLESQAR
MAV_5241|M.avium_104 RRLHEHWGE-EPSAYLGVAVSGFPNFFMLYGPNTNQGGNSIVYILEAGAR
MUL_4873|M.ulcerans_Agy99 QSLHERWGD-DPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGAR
TH_3452|M.thermoresistible__bu RSLREVWRD-GAYAYLGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQAR
Mvan_2243|M.vanbaalenii_PYR-1 ALLSDTWRD-GAFAYLGMAVPGYPNFFMLYGPNTNVGSNSVIFMLEAQAH
Mb3075c|M.bovis_AF2122/97 EDLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIH
Rv3049c|M.tuberculosis_H37Rv EDLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIH
MSMEG_4451|M.smegmatis_MC2_155 TTLAAHWAG-SPSAHLGITVPGFPNLFLMYGPNTNLGHSSIVYMLESQAA
MLBr_00065|M.leprae_Br4923 VDLAQ------TMSYKGMMLSGLPNMIYTVG----YTNASWTLKADLVSE
* :: * : **:: * * :
MAB_2077|M.abscessus_ATCC_1997 HIATLIKAVAAHPGHAIDVRTESAQRYNTRLRRRLRRSVW--ALCASWYR
MMAR_3136|M.marinum_M YVGALIKILASDPGRTVDVRPDIEQSYNTRLSRRLRRSVW--ALCASWYT
Mflv_4605|M.gilvum_PYR-GCK HIVRLMKVLRAHPGSVIEVRADVEKRFNDRLSRRLDRSVW--TMCTSWYR
MAV_5241|M.avium_104 LVASAVSRLARRG-GFLEVRPEAEKRFNDRLSADLERTIW--TRCDSYFR
MUL_4873|M.ulcerans_Agy99 LVASAASRLARRG-GYLDVRPEAERRYNDEISADLERTIW--TQCQSYFR
TH_3452|M.thermoresistible__bu YVVKALKRLRRRDTSYIAVRPDTAAAFLAKVDQWMQGKVWS-TQCNNYFR
Mvan_2243|M.vanbaalenii_PYR-1 YIVRALKYMRRKNRSYIEVRSDVMTRFLERIDTWMQGTVWL-TRCSNYFR
Mb3075c|M.bovis_AF2122/97 YVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYL
Rv3049c|M.tuberculosis_H37Rv YVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYL
MSMEG_4451|M.smegmatis_MC2_155 YLAAALRVMRAEGLASIDVRPDAERTYNEWINDALTNTVWNSGGCSSWYL
MLBr_00065|M.leprae_Br4923 FFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLR---SLDALP
. : . : . .
MAB_2077|M.abscessus_ATCC_1997 TSSGEIPTNWPGPTLVYRLLTRKPHSGDYVLRN---VGRLKVG------D
MMAR_3136|M.marinum_M TSSGAIPTNWPGPTFAYRILTRKPRSHDYLFRH---VERLQLD------G
Mflv_4605|M.gilvum_PYR-GCK SARGSISTNWPSPTFLYRLRARRPKRRAYVLSRPAPANSSRRG------T
MAV_5241|M.avium_104 SPTGRIVTQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVG-------A
MUL_4873|M.ulcerans_Agy99 SPSGRIVTQWPYTELEYARRTWRIRPRDWLHHKGVSPAAQRGGPGSAASA
TH_3452|M.thermoresistible__bu APNGRVVTQWPRSARAFWAMTRRFRSADYLFEPAPDMSEVSAD------A
Mvan_2243|M.vanbaalenii_PYR-1 APNGRVVTQWPRSARTFWGLTRRFNPGDYGFDAPSSRSRIRVG------A
Mb3075c|M.bovis_AF2122/97 DEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLS-----------
Rv3049c|M.tuberculosis_H37Rv DEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLS-----------
MSMEG_4451|M.smegmatis_MC2_155 DSRGRNSVMWPTFTFRFRARTRSFDVINYDTLRTRQQIRGVEQRCESQLA
MLBr_00065|M.leprae_Br4923 KQGSRTPWRLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV--------
.
MAB_2077|M.abscessus_ATCC_1997 PAEP--SLAD----------------------------------------
MMAR_3136|M.marinum_M PSENRARLRR----------------------------------------
Mflv_4605|M.gilvum_PYR-GCK PEPANTHLADMPYAPSGADSVD----------------------------
MAV_5241|M.avium_104 AQEF----------------------------------------------
MUL_4873|M.ulcerans_Agy99 ETEIDDPADQLAGNQIGVGVVDAVERVALGDHRVQE--------------
TH_3452|M.thermoresistible__bu RPVASR--------------------------------------------
Mvan_2243|M.vanbaalenii_PYR-1 QTSVKQP-------------------------------------------
Mb3075c|M.bovis_AF2122/97 -SDRATVAAAN---------------------------------------
Rv3049c|M.tuberculosis_H37Rv -SDRATVAAAN---------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 DADREILAGQIRLAGEDESVTPSTLRTVRRDQRYMTRGRIHAEVADLLDR
MLBr_00065|M.leprae_Br4923 --------------------------------------------------
MAB_2077|M.abscessus_ATCC_1997 -------
MMAR_3136|M.marinum_M -------
Mflv_4605|M.gilvum_PYR-GCK -------
MAV_5241|M.avium_104 -------
MUL_4873|M.ulcerans_Agy99 -------
TH_3452|M.thermoresistible__bu -------
Mvan_2243|M.vanbaalenii_PYR-1 -------
Mb3075c|M.bovis_AF2122/97 -------
Rv3049c|M.tuberculosis_H37Rv -------
MSMEG_4451|M.smegmatis_MC2_155 TVAMNGE
MLBr_00065|M.leprae_Br4923 -------