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TRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGIAAAVALRGAGIDDLVIIEGADGVGGTWRRNTYPG AACDIQSHLYSFSFAANKFWSRTYARQPEILAYLESVVDDFDLRRHLMLSAMVRSIRWDEDTWGWVCQVD RAGGTAILTADVVVCATGLFGPRKLPDIAGLTDFGGTLMHTAGWDHRVDLTGKRVAVIGTGASGVQVVPE LAKLAGRLTVFQRTPPWMVPKDDRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ IATSFLERVVADERLRRALTPGYPFRCKRVLLGDDFYRALQHAHVELVTDPIERVTETSVVTTAGQGVDV DAVVLATGFETSRYLSGIEVIGTGGQSLHERWGDDPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILE AGARLVASAASRLARRGGYLDVRPEAERRYNDEISADLERTIWTQCQSYFRSPSGRIVTQWPYTELEYAR RTWRIRPRDWLHHKGVSPAAQRGGPGSAASAETEIDDPADQLAGNQIGVGVVDAVERVALGDHRVQE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4873 | - | - | 100% (558) | monooxygenase |
| M. ulcerans Agy99 | MUL_1053 | - | e-112 | 42.71% (501) | monooxygenase |
| M. ulcerans Agy99 | MUL_1880 | - | 9e-87 | 36.03% (494) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 3e-88 | 37.16% (514) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4103 | - | 1e-109 | 42.51% (501) | cyclohexanone monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 3e-88 | 37.16% (514) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 8e-31 | 25.91% (467) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2077 | - | 2e-95 | 39.96% (488) | monooxygenase |
| M. marinum M | MMAR_0240 | - | 0.0 | 97.49% (558) | monoooxygenase |
| M. avium 104 | MAV_5241 | - | 0.0 | 76.23% (509) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2567 | - | 1e-114 | 45.17% (487) | monooxygenase |
| M. thermoresistible (build 8) | TH_3452 | - | 1e-113 | 45.09% (479) | PUTATIVE lipolytic enzyme |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 1e-111 | 43.93% (478) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4873|M.ulcerans_Agy99 -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MMAR_0240|M.marinum_M -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MAV_5241|M.avium_104 MTETVGPARAKPVMSR-KAKWLYAIGRVRAATRRRRGPKVAIIGAGFGGL
Mflv_4103|M.gilvum_PYR-GCK ---------------------------------MAKSLSVGIIGAGPGGL
Mvan_2243|M.vanbaalenii_PYR-1 -----------------------------MTTSMAKTFSVAIIGAGPGGL
MSMEG_2567|M.smegmatis_MC2_155 ------------------------------MSADRMSMSIGIIGAGPGGL
TH_3452|M.thermoresistible__bu ---------------------------------MARNLSVGIIGAGPGGI
Mb3075c|M.bovis_AF2122/97 ---------------MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGL
Rv3049c|M.tuberculosis_H37Rv ---------------MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGL
MAB_2077|M.abscessus_ATCC_1997 --------------------MSSNFATACRAYDP----SIVIIGAGFAGV
MLBr_00065|M.leprae_Br4923 ----------------------------MVVMAETEYLDVVIVGAGISGV
*:*:* .*:
MUL_4873|M.ulcerans_Agy99 AAAVALR-GAGIDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MMAR_0240|M.marinum_M AAAVALR-GAGIDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MAV_5241|M.avium_104 GAAVALR-RAGIDDLVIIEAADGVGGTWRRNTYPGAACDIQSHLYSFSFA
Mflv_4103|M.gilvum_PYR-GCK ALGIFLR-RAGFDDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
Mvan_2243|M.vanbaalenii_PYR-1 ALGIFLR-KAGFTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
MSMEG_2567|M.smegmatis_MC2_155 ALGIFLK-KAGFRDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
TH_3452|M.thermoresistible__bu ALGIFLR-RAGFTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFE
Mb3075c|M.bovis_AF2122/97 GMAIALQ-KQG-VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFE
Rv3049c|M.tuberculosis_H37Rv GMAIALQ-KQG-VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFE
MAB_2077|M.abscessus_ATCC_1997 AMAHRLK-KDGFTNFTILEKAADIGGVWRDNTYPGAACDVPSALYSLSYK
MLBr_00065|M.leprae_Br4923 SAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFR
. . *: . .*:: .:**.* *** .* . :
MUL_4873|M.ulcerans_Agy99 ANKFWSRTYARQPEILAYLESVVDDFDLRRHLMLSAMVRSIRWDEDTWGW
MMAR_0240|M.marinum_M PNKFWTRTYARQPEILAYLESVVDDFDLRRHLMLSARVRSIRWDEDTWRW
MAV_5241|M.avium_104 PNASWSRTYARQPEILAYLESVADAFDLRRHLMLDTTVRSLRWNPHTAAW
Mflv_4103|M.gilvum_PYR-GCK LNAHWSRLWSGQKEILEYFERCAQRYRLQEKLRCNTEIVSARWVPSERRW
Mvan_2243|M.vanbaalenii_PYR-1 LNAHWSRMWSGQEEILQYFERCAQRYRLPDNLQLNTEIVSARWGSETRTW
MSMEG_2567|M.smegmatis_MC2_155 LNADWTRLWSSQPEILAYFERCAQRHQLESHLVLGTEITSARWDTDG--W
TH_3452|M.thermoresistible__bu LNSEWTRLWPAQPEILRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQW
Mb3075c|M.bovis_AF2122/97 PKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRW
Rv3049c|M.tuberculosis_H37Rv PKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRW
MAB_2077|M.abscessus_ATCC_1997 PNPRWSRRYAEQPEILKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRW
MLBr_00065|M.leprae_Br4923 PWTKCQAIADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRW
** *:: . : : : : *
MUL_4873|M.ulcerans_Agy99 VCQVDRAGGTAILTADVVVCATGLFGPRK--LPDIAGLTDFGGTLMHTAG
MMAR_0240|M.marinum_M VCQVDRAGGTATLTADVVVCATGLFGPRK--LPDIAGLTDFGGTLMHTAG
MAV_5241|M.avium_104 DCRIDRGGHPATLSADVVVCAVGLFGAAK--LPDIDGLAGFAGPVLHTAQ
Mflv_4103|M.gilvum_PYR-GCK RLRTSTG---AEHSFDVVVSAVGMFTQPV--MPDLVEEEPFTGTVMHTAR
Mvan_2243|M.vanbaalenii_PYR-1 TLTTAGG---EEHTFDIVVSAIGLFTQPV--MPDLVDEEPFTGTVMHTAR
MSMEG_2567|M.smegmatis_MC2_155 VLTTSGG---DEQRFDFVVSAVGLFTQPL--LPDLVEEEPFTGTVLHTAR
TH_3452|M.thermoresistible__bu MLTTGAG---EQHNFDVVVSAVGMFTRPV--MPDLVEEEPFTGTLMHSAR
Mb3075c|M.bovis_AF2122/97 HVFTADG---REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQ
Rv3049c|M.tuberculosis_H37Rv HVFTADG---REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQ
MAB_2077|M.abscessus_ATCC_1997 TLVTNSN---ETITCDVVVSAVGQLSLPH--VPVIADADTFQGPRFHSAR
MLBr_00065|M.leprae_Br4923 TVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQH
..:. * * : * *. :*.
MUL_4873|M.ulcerans_Agy99 WDHRVDLTGKRVAVIGTGASGVQVVPELAKL-AGRLTVFQRTPPWMVPKD
MMAR_0240|M.marinum_M WDHRVDLTGKRVAVIGTGASGVQVVPELAKL-AGRLTVFQRTPPWMVPKD
MAV_5241|M.avium_104 WDHDLDLAGRTVAVIGTGASGVQLVPELAGT-AGHVTVFQRTPPWMVPKD
Mflv_4103|M.gilvum_PYR-GCK WDHSVDLRGARVAVLGTGSTAAQLVPEVAKQ-AAAVYSVQRSPTWVLPKP
Mvan_2243|M.vanbaalenii_PYR-1 WDHSVDLRDARVAVLGTGSTAAQLVPEVAKQ-AAKVYSVQRSPTWVLPKP
MSMEG_2567|M.smegmatis_MC2_155 WDHSIPLAGKKIAVLGTGSTAAQLVPELAKV-ADTVYSVQRSPTWILPKP
TH_3452|M.thermoresistible__bu WDHGIDLHGKRIAVLGTGSTASQLIPELAKI-ADRVYSVQRSPTWILPKP
Mb3075c|M.bovis_AF2122/97 WDHSIDLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRT
Rv3049c|M.tuberculosis_H37Rv WDHSIDLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRT
MAB_2077|M.abscessus_ATCC_1997 WDRSVSLRGKQVAVIGTGASAIQFVPHIVQE-AEHVTLYQRTAPWILPKW
MLBr_00065|M.leprae_Br4923 WPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQP
* . : :.::*:*::. .:* :. . : **:..:::.:
MUL_4873|M.ulcerans_Agy99 DRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ-I
MMAR_0240|M.marinum_M DRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ-I
MAV_5241|M.avium_104 DRPYSATELARFKRNPLALRRTRWQIWKFQHDNTATFADDPVVTARSR-I
Mflv_4103|M.gilvum_PYR-GCK DRPYTDREKWMFAHVPFAKKIYRTRLWLRSESNISVIEHGSDKTQEFKSI
Mvan_2243|M.vanbaalenii_PYR-1 DREYTGREKWMFAHIPLAKKIYRTRLWLRSESNISVIENGSDKTEEFKGI
MSMEG_2567|M.smegmatis_MC2_155 DRPYTDRERWVFAHVPLAKKIYRTRLWLRSESNISVIEHGSDKTQEFRSI
TH_3452|M.thermoresistible__bu DRPYSDRERWVFRHVPFAKRIYRTRLWLRSEANISVIEDGSEKTEEFKAI
Mb3075c|M.bovis_AF2122/97 NEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAY
Rv3049c|M.tuberculosis_H37Rv NEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAY
MAB_2077|M.abscessus_ATCC_1997 DSRYGVLHDRVSELLPMALRLERFAVWLIFELLAVTLVDAKPLSRVLGAI
MLBr_00065|M.leprae_Br4923 AKDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWP---QRMRNI
* .
MUL_4873|M.ulcerans_Agy99 ATSFLERVVAD-ERLRRALTPGYPFRCKRVLLG--DDFYRALQHAHVELV
MMAR_0240|M.marinum_M ATSFLERVVAD-ERLRRALTPGYPFRCKRVLLG--DDFYRALQHDHVELV
MAV_5241|M.avium_104 ATSFLDRTVAD-ESLRRALTPDYPFRCKRVLLG--DDYYRALQRDNVELV
Mflv_4103|M.gilvum_PYR-GCK ALRTLEATVSD-DELRARLTPDHPLGCKRLVFA--TDYLKTLTEPHVDVV
Mvan_2243|M.vanbaalenii_PYR-1 ALRTLEATVAD-DELRAKLTPTHPLGCKRLVFA--TDYLQTLTQPHVEVV
MSMEG_2567|M.smegmatis_MC2_155 ALNMLRSTVTD-DELRERLTPDHPLGCKRLVFS--SDFIPTLTRPNVEVV
TH_3452|M.thermoresistible__bu ALKMLEATVPD-EEMRRRLTPDHPLGCKRLVFS--SDYLAALMRPNVEVV
Mb3075c|M.bovis_AF2122/97 AKYNIRRSVKD-RELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELI
Rv3049c|M.tuberculosis_H37Rv AKYNIRRSVKD-RELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELI
MAB_2077|M.abscessus_ATCC_1997 ARRHLHRQVAS-PSLREQLMPSDAPGCKRVLFS--NDYYPAIASDRVSLV
MLBr_00065|M.leprae_Br4923 LLGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMV
: : . :: : * :*: :: ..::
MUL_4873|M.ulcerans_Agy99 TDPIERVTETSVVTTAGQG----VDVDAVVLATGFETSRYLSGIEVIGTG
MMAR_0240|M.marinum_M TDPIERVTETSVVTTAGQA----VDVDAVVLATGFETSRYLSGIEVIGTG
MAV_5241|M.avium_104 TDPIARIGRMSVITASGAE----IEADVIVLATGFETSRYLSGIEVVGAG
Mflv_4103|M.gilvum_PYR-GCK SSPARALRSRSLVTEDGTE----LDVDVVLCATGYAAADYLGQIDVRGAD
Mvan_2243|M.vanbaalenii_PYR-1 SSPARSLRSRSLVTEDGTE----LDVDVVLCATGYAAADYLGQIEVRGAD
MSMEG_2567|M.smegmatis_MC2_155 SSPARALRSRSLVTEDGRE----LDVDIVACATGYAAADYLGQIEVTGEG
TH_3452|M.thermoresistible__bu SSPARALRGDTLITEDGTE----RRVDVVVCATGYAAADYLGQIEVVGER
Mb3075c|M.bovis_AF2122/97 TDRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRH
Rv3049c|M.tuberculosis_H37Rv TDRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRH
MAB_2077|M.abscessus_ATCC_1997 PKAIAELCDNGVKTVDG----EFRPADVVIYGTGFRATDFLAPMSVRGSR
MLBr_00065|M.leprae_Br4923 TDAIDRFTSTGIRLKSGNE----LRADIIVTATGLNLQLFGGAVATVDGQ
.. . : * .* : .** : .
MUL_4873|M.ulcerans_Agy99 GQSLHERWGDDPA-AYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGA
MMAR_0240|M.marinum_M GQSLHERWGDDPA-AYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGA
MAV_5241|M.avium_104 GRRLHEHWGEEPS-AYLGVAVSGFPNFFMLYGPNTNQGGNSIVYILEAGA
Mflv_4103|M.gilvum_PYR-GCK DIPLSQTWRDGAF-AYLGMSVPGYPNFFMLYGPNTNVGSNSVIFVLEAQA
Mvan_2243|M.vanbaalenii_PYR-1 DALLSDTWRDGAF-AYLGMAVPGYPNFFMLYGPNTNVGSNSVIFMLEAQA
MSMEG_2567|M.smegmatis_MC2_155 GIRLHDVWRDGAY-AYLGMTVPGFPNFFMLYGPNTNVGSNSVIFVLEAQA
TH_3452|M.thermoresistible__bu QRSLREVWRDGAY-AYLGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQA
Mb3075c|M.bovis_AF2122/97 GEDLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQI
Rv3049c|M.tuberculosis_H37Rv GEDLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQI
MAB_2077|M.abscessus_ATCC_1997 GVSLAEVWKTQAY-AYLGITVPMFPNLFLLYGPNTNVGSGSILYMIESQV
MLBr_00065|M.leprae_Br4923 PVDLAQTMS------YKGMMLSGLPNMIYTVGYTN----ASWTLKADLVS
* : : * : **:: * .. * :
MUL_4873|M.ulcerans_Agy99 RLVASAASRLARRG-GYLDVRPEAERRYNDEISADLERTIW--TQCQSYF
MMAR_0240|M.marinum_M RLVASAVSRLARRG-GYLDVRPEAERRYNDEISTDLERTIW--TQCQSYF
MAV_5241|M.avium_104 RLVASAVSRLARRG-GFLEVRPEAEKRFNDRLSADLERTIW--TRCDSYF
Mflv_4103|M.gilvum_PYR-GCK RYIVRALKYLRRRNRSYIEVRSDVMKRYLDKIDSWMQGTVWL-TRCSNYF
Mvan_2243|M.vanbaalenii_PYR-1 HYIVRALKYMRRKNRSYIEVRSDVMTRFLERIDTWMQGTVWL-TRCSNYF
MSMEG_2567|M.smegmatis_MC2_155 RYVVRALKHLRRRRKSYVAVKPEVMAQFIADIDRWMQGTVWL-TRCSSYF
TH_3452|M.thermoresistible__bu RYVVKALKRLRRRDTSYIAVRPDTAAAFLAKVDQWMQGKVWS-TQCNNYF
Mb3075c|M.bovis_AF2122/97 HYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWY
Rv3049c|M.tuberculosis_H37Rv HYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWY
MAB_2077|M.abscessus_ATCC_1997 RHIATLIKAVAAHPGHAIDVRTESAQRYNTRLRRRLRRSVWAL--CASWY
MLBr_00065|M.leprae_Br4923 EFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLR-----SLD
. . : . : .
MUL_4873|M.ulcerans_Agy99 RSPSGRIVTQWPYTELEYARRTWRIRPRDWLHHKGVSPAAQRGGPGSAAS
MMAR_0240|M.marinum_M RSPSGRIVTQWPYTELEYARRTWRIKPRDWLHHKGVSPAAQRGGAGSAAS
MAV_5241|M.avium_104 RSPTGRIVTQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVG-------
Mflv_4103|M.gilvum_PYR-GCK RAPNGRVVTQWPRSARDFWALTRWFRAGDYVFEAPSA--RETISVGAQAE
Mvan_2243|M.vanbaalenii_PYR-1 RAPNGRVVTQWPRSARTFWGLTRRFNPGDYGFDAPSS--RSRIRVGAQTS
MSMEG_2567|M.smegmatis_MC2_155 RAPNGRVVTQWPRSARALWAMTRRFRAADYLFSAPVDGQAQVVEVAAHET
TH_3452|M.thermoresistible__bu RAPNGRVVTQWPRSARAFWAMTRRFRSADYLFEPAPD--MSEVSADARPV
Mb3075c|M.bovis_AF2122/97 LDEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN
Rv3049c|M.tuberculosis_H37Rv LDEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN
MAB_2077|M.abscessus_ATCC_1997 RTSSGEIPTNWPGPTLVYRLLTRKPHSGDYVLRNVGRLKVGDPAEPSLAD
MLBr_00065|M.leprae_Br4923 ALPKQGSRTPWR-LNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV----
. * . .
MUL_4873|M.ulcerans_Agy99 AETEIDDPADQLAGNQIGVGVVDAVERVALGDHRVQE
MMAR_0240|M.marinum_M AQTEIDHPADQLAGNQIGVGVVDAVERVALGDHLVQE
MAV_5241|M.avium_104 AAQEF--------------------------------
Mflv_4103|M.gilvum_PYR-GCK AER----------------------------------
Mvan_2243|M.vanbaalenii_PYR-1 VKQP---------------------------------
MSMEG_2567|M.smegmatis_MC2_155 VG-----------------------------------
TH_3452|M.thermoresistible__bu ASR----------------------------------
Mb3075c|M.bovis_AF2122/97 -------------------------------------
Rv3049c|M.tuberculosis_H37Rv -------------------------------------
MAB_2077|M.abscessus_ATCC_1997 -------------------------------------
MLBr_00065|M.leprae_Br4923 -------------------------------------