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M. thermoresistible (build 8) TH_3452 (-)

annotation: lipolytic enzyme
coordinates: 629562 - 631070
length: 503

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3452--100% (503)lipolytic enzyme
M. thermoresistible (build 8)TH_2696-2e-8034.43% (517) PUTATIVE putative FAD dependent oxidoreductase
M. thermoresistible (build 8)TH_4080-7e-8032.02% (481) PUTATIVE conserved hypothetical protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3075c-1e-8333.47% (481) monooxygenase
M. gilvum PYR-GCKMflv_4103-0.074.30% (502) cyclohexanone monooxygenase
M. tuberculosis H37RvRv3049c-1e-8333.47% (481) monooxygenase
M. leprae Br4923MLBr_00065-3e-3026.21% (435) putative monooxygenase
M. abscessus ATCC 19977MAB_2077-1e-10039.20% (477) monooxygenase
M. marinum MMMAR_0403-0.074.07% (486) monooxygenase
M. avium 104MAV_5119-0.076.15% (499) lipolytic enzyme
M. smegmatis MC2 155MSMEG_2567-0.076.91% (485) monooxygenase
M. ulcerans Agy99MUL_1053-0.073.25% (486) monooxygenase
M. vanbaalenii PYR-1Mvan_2243-0.071.43% (497) cyclohexanone monooxygenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3075c|M.bovis_AF2122/97           MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQ-KQG-VDF
Rv3049c|M.tuberculosis_H37Rv        MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQ-KQG-VDF
MAB_2077|M.abscessus_ATCC_1997      -----MSSNFATACRAYDP----SIVIIGAGFAGVAMAHRLK-KDGFTNF
Mflv_4103|M.gilvum_PYR-GCK          ------------------MAKSLSVGIIGAGPGGLALGIFLR-RAGFDDF
Mvan_2243|M.vanbaalenii_PYR-1       --------------MTTSMAKTFSVAIIGAGPGGLALGIFLR-KAGFTDF
MSMEG_2567|M.smegmatis_MC2_155      ---------------MSADRMSMSIGIIGAGPGGLALGIFLK-KAGFRDF
TH_3452|M.thermoresistible__bu      ------------------MARNLSVGIIGAGPGGIALGIFLR-RAGFTDF
MMAR_0403|M.marinum_M               ------------------MTSPLSVGIIGAGPGGLALGILLK-NRGFENF
MUL_1053|M.ulcerans_Agy99           ------------------MTSPLSVGIIGAGPGGLALGILLK-NRGFENF
MAV_5119|M.avium_104                --------------MPADPMSELSIGIIGAGPGGLALGILLS-QAGFDDF
MLBr_00065|M.leprae_Br4923          -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
                                                              *:*:* .*:. .  *  .    .:

Mb3075c|M.bovis_AF2122/97           VILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEI
Rv3049c|M.tuberculosis_H37Rv        VILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEI
MAB_2077|M.abscessus_ATCC_1997      TILEKAADIGGVWRDNTYPGAACDVPSALYSLSYKPNPRWSRRYAEQPEI
Mflv_4103|M.gilvum_PYR-GCK          TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQKEI
Mvan_2243|M.vanbaalenii_PYR-1       TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRMWSGQEEI
MSMEG_2567|M.smegmatis_MC2_155      TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNADWTRLWSSQPEI
TH_3452|M.thermoresistible__bu      TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFELNSEWTRLWPAQPEI
MMAR_0403|M.marinum_M               TIFDRESDVGGTWRINTYPGLACDVKSHLYSYSFDLNPGWSRLWSGQPEI
MUL_1053|M.ulcerans_Agy99           NIFDRESDVGGTWRINTYPGLACDVKSHLYSYSFDLNPGWSGLWSGQPEI
MAV_5119|M.avium_104                TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQPEI
MLBr_00065|M.leprae_Br4923          VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKP-I
                                     *:::  .:**.*    ***  .*      .  :   .           *

Mb3075c|M.bovis_AF2122/97           LGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGRE-----Y
Rv3049c|M.tuberculosis_H37Rv        LGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGRE-----Y
MAB_2077|M.abscessus_ATCC_1997      LKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRWTLVTNSNET-----I
Mflv_4103|M.gilvum_PYR-GCK          LEYFERCAQRYRLQEKLRCNTEIVSARWVPSERRWRLRTSTGAE-----H
Mvan_2243|M.vanbaalenii_PYR-1       LQYFERCAQRYRLPDNLQLNTEIVSARWGSETRTWTLTTAGGEE-----H
MSMEG_2567|M.smegmatis_MC2_155      LAYFERCAQRHQLESHLVLGTEITSARWDTDG--WVLTTSGGDE-----Q
TH_3452|M.thermoresistible__bu      LRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQWMLTTGAGEQ-----H
MMAR_0403|M.marinum_M               LAYFQRCADRYGLRPHLRLSTEIRSARWESQTRQWTLSTADGEQ-----H
MUL_1053|M.ulcerans_Agy99           LAYFQRCADRYELRPHLRLGTEIRSARWESQTRQWTLSTADGEQ-----H
MAV_5119|M.avium_104                LDYFQRCADKYGLGPHLRLGTEIRSAHWDADTQRWRLTTASGHR-----H
MLBr_00065|M.leprae_Br4923          LEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISC
                                    * *::  .    :   :     :    :      * : .  .        

Mb3075c|M.bovis_AF2122/97           VAQFLISGAGALHIPSFPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIV
Rv3049c|M.tuberculosis_H37Rv        VAQFLISGAGALHIPSFPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIV
MAB_2077|M.abscessus_ATCC_1997      TCDVVVSAVGQLSLPHVPVIADADTFQGPRFHSARWDRSVSLRGKQVAVI
Mflv_4103|M.gilvum_PYR-GCK          SFDVVVSAVGMFTQPVMPDLVEEEPFTGTVMHTARWDHSVDLRGARVAVL
Mvan_2243|M.vanbaalenii_PYR-1       TFDIVVSAIGLFTQPVMPDLVDEEPFTGTVMHTARWDHSVDLRDARVAVL
MSMEG_2567|M.smegmatis_MC2_155      RFDFVVSAVGLFTQPLLPDLVEEEPFTGTVLHTARWDHSIPLAGKKIAVL
TH_3452|M.thermoresistible__bu      NFDVVVSAVGMFTRPVMPDLVEEEPFTGTLMHSARWDHGIDLHGKRIAVL
MMAR_0403|M.marinum_M               QFSVVVSAVGIFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVL
MUL_1053|M.ulcerans_Agy99           QFSVVVSVVGIFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVL
MAV_5119|M.avium_104                HFDVVVSAVGLFTRPLLPELVEEEPFTGTVMHSARWDHSIPLHGKRIAVL
MLBr_00065|M.leprae_Br4923          SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
                                       .: *          * :   : * *. :*. :* ..:     .:.::

Mb3075c|M.bovis_AF2122/97           GTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRRALRTV
Rv3049c|M.tuberculosis_H37Rv        GTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRRALRTV
MAB_2077|M.abscessus_ATCC_1997      GTGASAIQFVPHIVQE-AEHVTLYQRTAPWILPKWDSRYGVLHDRVSELL
Mflv_4103|M.gilvum_PYR-GCK          GTGSTAAQLVPEVAKQ-AAAVYSVQRSPTWVLPKPDRPYTDREKWMFAHV
Mvan_2243|M.vanbaalenii_PYR-1       GTGSTAAQLVPEVAKQ-AAKVYSVQRSPTWVLPKPDREYTGREKWMFAHI
MSMEG_2567|M.smegmatis_MC2_155      GTGSTAAQLVPELAKV-ADTVYSVQRSPTWILPKPDRPYTDRERWVFAHV
TH_3452|M.thermoresistible__bu      GTGSTASQLIPELAKI-ADRVYSVQRSPTWILPKPDRPYSDRERWVFRHV
MMAR_0403|M.marinum_M               GTGSTAAQLVPELAKV-ADRVYSIQRSPTWILPKPDRPYSRWERWVFAHV
MUL_1053|M.ulcerans_Agy99           GTGSTAAQLVPELAKV-ADRVYSIQRSPTWILPKPDRPYSRWERWVFAHV
MAV_5119|M.avium_104                GTGSTASQLIPELAKV-AERVYSVQRSPTWILPKPDRPYTRWERWAFAHL
MLBr_00065|M.leprae_Br4923          GSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPD
                                    *:*::*  ::* :.   .  :   **:..:::.:                

Mb3075c|M.bovis_AF2122/97           PGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKD-REL
Rv3049c|M.tuberculosis_H37Rv        PGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKD-REL
MAB_2077|M.abscessus_ATCC_1997      PMALRLERFAVWLIFELLAVTLVDAKPLSRVLGAIARRHLHRQVAS-PSL
Mflv_4103|M.gilvum_PYR-GCK          PFAKKIYRTRLWLRSESNISVIEHGSDKTQEFKSIALRTLEATVSD-DEL
Mvan_2243|M.vanbaalenii_PYR-1       PLAKKIYRTRLWLRSESNISVIENGSDKTEEFKGIALRTLEATVAD-DEL
MSMEG_2567|M.smegmatis_MC2_155      PLAKKIYRTRLWLRSESNISVIEHGSDKTQEFRSIALNMLRSTVTD-DEL
TH_3452|M.thermoresistible__bu      PFAKRIYRTRLWLRSEANISVIEDGSEKTEEFKAIALKMLEATVPD-EEM
MMAR_0403|M.marinum_M               PFAARLYRTRLWLRSESNISVIEHGSPKTKEFTELALRMLENTVSD-PQL
MUL_1053|M.ulcerans_Agy99           PFAARLYRTRLWLRSESNISVIEHGSPKTKEFTELALRMLENTVSD-PQL
MAV_5119|M.avium_104                PLAKKLYRTRLWLRSESNISVIEHGSEKTGQFTNIALGLLEASVPD-EEL
MLBr_00065|M.leprae_Br4923          KYAYTAVRWKNILRQSALYGACQKWP---QRMRNILLGHVARRLPKGYDV
                                           *       .       .       :       :   : .  .:

Mb3075c|M.bovis_AF2122/97           RRKLTPRYRIGCKRILNSS--TYYPAVADPKTELITDRIDRITHDGIVTA
Rv3049c|M.tuberculosis_H37Rv        RRKLTPRYRIGCKRILNSS--TYYPAVADPKTELITDRIDRITHDGIVTA
MAB_2077|M.abscessus_ATCC_1997      REQLMPSDAPGCKRVLFSN--DYYPAIASDRVSLVPKAIAELCDNGVKTV
Mflv_4103|M.gilvum_PYR-GCK          RARLTPDHPLGCKRLVFAT--DYLKTLTEPHVDVVSSPARALRSRSLVTE
Mvan_2243|M.vanbaalenii_PYR-1       RAKLTPTHPLGCKRLVFAT--DYLQTLTQPHVEVVSSPARSLRSRSLVTE
MSMEG_2567|M.smegmatis_MC2_155      RERLTPDHPLGCKRLVFSS--DFIPTLTRPNVEVVSSPARALRSRSLVTE
TH_3452|M.thermoresistible__bu      RRRLTPDHPLGCKRLVFSS--DYLAALMRPNVEVVSSPARALRGDTLITE
MMAR_0403|M.marinum_M               RRQLTPDHPMGCKRLVFSS--EFLTALARPNVELVTSPARYLRQRSLVTA
MUL_1053|M.ulcerans_Agy99           RRQLTPDHPMGCKRLVFSS--EFLTALTRPNVELVTSPARYLRQRSLVTA
MAV_5119|M.avium_104                RRKLTPDHPMGCKRLVFSS--DYLPALTRPNVEVLTSPARSLRRRSLVTE
MLBr_00065|M.leprae_Br4923          QKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLK
                                    : :: *      :*:          ::    ..::..    :    :   

Mb3075c|M.bovis_AF2122/97           DGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGA
Rv3049c|M.tuberculosis_H37Rv        DGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGA
MAB_2077|M.abscessus_ATCC_1997      DG----EFRPADVVIYGTGFRATDFLAPMSVRGSRGVSLAEVWKTQAY-A
Mflv_4103|M.gilvum_PYR-GCK          DGTE----LDVDVVLCATGYAAADYLGQIDVRGADDIPLSQTWR-DGAFA
Mvan_2243|M.vanbaalenii_PYR-1       DGTE----LDVDVVLCATGYAAADYLGQIEVRGADDALLSDTWR-DGAFA
MSMEG_2567|M.smegmatis_MC2_155      DGRE----LDVDIVACATGYAAADYLGQIEVTGEGGIRLHDVWR-DGAYA
TH_3452|M.thermoresistible__bu      DGTE----RRVDVVVCATGYAAADYLGQIEVVGERQRSLREVWR-DGAYA
MMAR_0403|M.marinum_M               DGAE----YDVDVVVCATGYAAADYLGQLEVLGEDGAGLHEVWR-DGAHA
MUL_1053|M.ulcerans_Agy99           DGAE----YDVDVVVCATGYAAADYLGQLEVLGEDGAGLHEVWR-DGAHA
MAV_5119|M.avium_104                DGTE----REVDLVVCATGYAAADYLGELDVTGEHGVTLREVWR-DGAYA
MLBr_00065|M.leprae_Br4923          SGNE----LRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMS------
                                    .*        .*::  .**         :   .     * :         

Mb3075c|M.bovis_AF2122/97           HRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGV
Rv3049c|M.tuberculosis_H37Rv        HRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGV
MAB_2077|M.abscessus_ATCC_1997      YLGITVPMFPNLFLLYGPNTNVGSGSILYMIESQVRHIATLIKAVAAHPG
Mflv_4103|M.gilvum_PYR-GCK          YLGMSVPGYPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRRNR
Mvan_2243|M.vanbaalenii_PYR-1       YLGMAVPGYPNFFMLYGPNTNVGSNSVIFMLEAQAHYIVRALKYMRRKNR
MSMEG_2567|M.smegmatis_MC2_155      YLGMTVPGFPNFFMLYGPNTNVGSNSVIFVLEAQARYVVRALKHLRRRRK
TH_3452|M.thermoresistible__bu      YLGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQARYVVKALKRLRRRDT
MMAR_0403|M.marinum_M               YLGMAVPGFPNFFMLYGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSK
MUL_1053|M.ulcerans_Agy99           YLGMAVPGFPNFFMLCGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSK
MAV_5119|M.avium_104                YLGMAVPGFPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRHRR
MLBr_00065|M.leprae_Br4923          YKGMMLSGLPNMIYTVGYTN----ASWTLKADLVSEFFCRLLNYMNANDF
                                    : *: :.  **::   * ..     *     :   ...   :        

Mb3075c|M.bovis_AF2122/97           QALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYT
Rv3049c|M.tuberculosis_H37Rv        QALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYT
MAB_2077|M.abscessus_ATCC_1997      HAIDVRTESAQRYNTRLRRRLRRSVWAL--CASWYRTSSGEIPTNWPGPT
Mflv_4103|M.gilvum_PYR-GCK          SYIEVRSDVMKRYLDKIDSWMQGTVWLT-RCSNYFRAPNGRVVTQWPRSA
Mvan_2243|M.vanbaalenii_PYR-1       SYIEVRSDVMTRFLERIDTWMQGTVWLT-RCSNYFRAPNGRVVTQWPRSA
MSMEG_2567|M.smegmatis_MC2_155      SYVAVKPEVMAQFIADIDRWMQGTVWLT-RCSSYFRAPNGRVVTQWPRSA
TH_3452|M.thermoresistible__bu      SYIAVRPDTAAAFLAKVDQWMQGKVWST-QCNNYFRAPNGRVVTQWPRSA
MMAR_0403|M.marinum_M               TYIAVRPGVLAEFMAKVDRWMTGTVWTT-ECSNYFRAPNGRVVTQWPRSA
MUL_1053|M.ulcerans_Agy99           TYIAVRPGVLAEFIAKVDRWMTGTVWTT-ECSNYFRAPNGRVVTQWPRSA
MAV_5119|M.avium_104                RYIAVRPAALADFVAKIDRWMVGTVWTT-QCSNYFRAPNGRVVTQWPRSA
MLBr_00065|M.leprae_Br4923          DTVAVEYPGSDVEERPFMDFTPGYVLRS---LDALPKQGSRTPWRLNQNY
                                      :             .       *       .      ..         

Mb3075c|M.bovis_AF2122/97           WQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN---------------
Rv3049c|M.tuberculosis_H37Rv        WQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN---------------
MAB_2077|M.abscessus_ATCC_1997      LVYRLLTRKPHSGDYVLRNVGRLKVGDPAEPSLAD---------------
Mflv_4103|M.gilvum_PYR-GCK          RDFWALTRWFRAGDYVFEAPSA--RETISVGAQAEAER------------
Mvan_2243|M.vanbaalenii_PYR-1       RTFWGLTRRFNPGDYGFDAPSS--RSRIRVGAQTSVKQP-----------
MSMEG_2567|M.smegmatis_MC2_155      RALWAMTRRFRAADYLFSAPVDGQAQVVEVAAHETVG-------------
TH_3452|M.thermoresistible__bu      RAFWAMTRRFRSADYLFEPAPD--MSEVSADARPVASR------------
MMAR_0403|M.marinum_M               RSFWGMTRRFKPADFSFQPAAVFAADGGDRNAGQR---------------
MUL_1053|M.ulcerans_Agy99           RSFWGMTRRFKPADFSFQPAAVFAADGGDRNAGQRWPNPRPSIGWTPCCA
MAV_5119|M.avium_104                RAFWSMTRRFRPADYRFQAPAVRVPAPAS-EADAR---------------
MLBr_00065|M.leprae_Br4923          LRDIRLIRRGKVADEGLLFAKKTTPVTV----------------------
                                           *  . .:  :                                 

Mb3075c|M.bovis_AF2122/97           --------------
Rv3049c|M.tuberculosis_H37Rv        --------------
MAB_2077|M.abscessus_ATCC_1997      --------------
Mflv_4103|M.gilvum_PYR-GCK          --------------
Mvan_2243|M.vanbaalenii_PYR-1       --------------
MSMEG_2567|M.smegmatis_MC2_155      --------------
TH_3452|M.thermoresistible__bu      --------------
MMAR_0403|M.marinum_M               --------------
MUL_1053|M.ulcerans_Agy99           PSRRRESTSPRSRS
MAV_5119|M.avium_104                --------------
MLBr_00065|M.leprae_Br4923          --------------