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TETVGPARAKPVMSRKAKWLYAIGRVRAATRRRRGPKVAIIGAGFGGLGAAVALRRAGIDDLVIIEAADG VGGTWRRNTYPGAACDIQSHLYSFSFAPNASWSRTYARQPEILAYLESVADAFDLRRHLMLDTTVRSLRW NPHTAAWDCRIDRGGHPATLSADVVVCAVGLFGAAKLPDIDGLAGFAGPVLHTAQWDHDLDLAGRTVAVI GTGASGVQLVPELAGTAGHVTVFQRTPPWMVPKDDRPYSATELARFKRNPLALRRTRWQIWKFQHDNTAT FADDPVVTARSRIATSFLDRTVADESLRRALTPDYPFRCKRVLLGDDYYRALQRDNVELVTDPIARIGRM SVITASGAEIEADVIVLATGFETSRYLSGIEVVGAGGRRLHEHWGEEPSAYLGVAVSGFPNFFMLYGPNT NQGGNSIVYILEAGARLVASAVSRLARRGGFLEVRPEAEKRFNDRLSADLERTIWTRCDSYFRSPTGRIV TQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVGAAQEF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5241 | - | - | 100% (531) | monooxygenase |
| M. avium 104 | MAV_5119 | - | e-116 | 45.59% (476) | lipolytic enzyme |
| M. avium 104 | MAV_1795 | - | 4e-95 | 39.92% (476) | flavin-binding monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 3e-89 | 38.51% (496) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4103 | - | 1e-116 | 44.18% (498) | cyclohexanone monooxygenase |
| M. tuberculosis H37Rv | Rv0892 | - | 3e-89 | 38.51% (496) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 2e-38 | 29.12% (388) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2077 | - | 8e-99 | 40.16% (488) | monooxygenase |
| M. marinum M | MMAR_0240 | - | 0.0 | 76.32% (511) | monoooxygenase |
| M. smegmatis MC2 155 | MSMEG_2567 | - | 1e-118 | 45.05% (495) | monooxygenase |
| M. thermoresistible (build 8) | TH_3452 | - | 1e-118 | 45.16% (496) | PUTATIVE lipolytic enzyme |
| M. ulcerans Agy99 | MUL_4873 | - | 0.0 | 76.23% (509) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 1e-113 | 44.54% (476) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 --------------------------------MTGRCPTVAVVGAGMSGM
Rv0892|M.tuberculosis_H37Rv --------------------------------MTGRCPTVAVVGAGMSGM
MMAR_0240|M.marinum_M -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MUL_4873|M.ulcerans_Agy99 -------------MTRPAARLRYFAGRLRAATRRGRPPRVVIIGAGFGGI
MAV_5241|M.avium_104 MTETVGPARAKPVMSR-KAKWLYAIGRVRAATRRRRGPKVAIIGAGFGGL
Mflv_4103|M.gilvum_PYR-GCK ---------------------------------MAKSLSVGIIGAGPGGL
Mvan_2243|M.vanbaalenii_PYR-1 -----------------------------MTTSMAKTFSVAIIGAGPGGL
MSMEG_2567|M.smegmatis_MC2_155 ------------------------------MSADRMSMSIGIIGAGPGGL
TH_3452|M.thermoresistible__bu ---------------------------------MARNLSVGIIGAGPGGI
MAB_2077|M.abscessus_ATCC_1997 ------------------------MSSNFATACRAYDPSIVIIGAGFAGV
MLBr_00065|M.leprae_Br4923 ----------------------------MVVMAETEYLDVVIVGAGISGV
: ::*** .*:
Mb0916|M.bovis_AF2122/97 CVAITLLS-AGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFA
Rv0892|M.tuberculosis_H37Rv CVAITLLS-AGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFA
MMAR_0240|M.marinum_M AAAVALRG-AGIDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MUL_4873|M.ulcerans_Agy99 AAAVALRG-AGIDDLVIIEGADGVGGTWRRNTYPGAACDIQSHLYSFSFA
MAV_5241|M.avium_104 GAAVALRR-AGIDDLVIIEAADGVGGTWRRNTYPGAACDIQSHLYSFSFA
Mflv_4103|M.gilvum_PYR-GCK ALGIFLRR-AGFDDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
Mvan_2243|M.vanbaalenii_PYR-1 ALGIFLRK-AGFTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
MSMEG_2567|M.smegmatis_MC2_155 ALGIFLKK-AGFRDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFD
TH_3452|M.thermoresistible__bu ALGIFLRR-AGFTDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFE
MAB_2077|M.abscessus_ATCC_1997 AMAHRLKK-DGFTNFTILEKAADIGGVWRDNTYPGAACDVPSALYSLSYK
MLBr_00065|M.leprae_Br4923 SAAWHLQDRCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFR
. * . * : .:**.* *** .* :
Mb0916|M.bovis_AF2122/97 KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGR--W
Rv0892|M.tuberculosis_H37Rv KNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGR--W
MMAR_0240|M.marinum_M PNKFWTRTYARQPEILAYLESVVDDFDLRRHLMLSARVRSIRWDEDTWRW
MUL_4873|M.ulcerans_Agy99 ANKFWSRTYARQPEILAYLESVVDDFDLRRHLMLSAMVRSIRWDEDTWGW
MAV_5241|M.avium_104 PNASWSRTYARQPEILAYLESVADAFDLRRHLMLDTTVRSLRWNPHTAAW
Mflv_4103|M.gilvum_PYR-GCK LNAHWSRLWSGQKEILEYFERCAQRYRLQEKLRCNTEIVSARWVPSERRW
Mvan_2243|M.vanbaalenii_PYR-1 LNAHWSRMWSGQEEILQYFERCAQRYRLPDNLQLNTEIVSARWGSETRTW
MSMEG_2567|M.smegmatis_MC2_155 LNADWTRLWSSQPEILAYFERCAQRHQLESHLVLGTEITSARWDTDG--W
TH_3452|M.thermoresistible__bu LNSEWTRLWPAQPEILRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQW
MAB_2077|M.abscessus_ATCC_1997 PNPRWSRRYAEQPEILKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRW
MLBr_00065|M.leprae_Br4923 PWTKCQAIADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRW
* *:. . : : : . : *
Mb0916|M.bovis_AF2122/97 VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSAR
Rv0892|M.tuberculosis_H37Rv VLRTDSG---TESTVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSAR
MMAR_0240|M.marinum_M VCQVDRAGGTATLTADVVVCATGLFGPRK--LPDIAGLTDFGGTLMHTAG
MUL_4873|M.ulcerans_Agy99 VCQVDRAGGTAILTADVVVCATGLFGPRK--LPDIAGLTDFGGTLMHTAG
MAV_5241|M.avium_104 DCRIDRGGHPATLSADVVVCAVGLFGAAK--LPDIDGLAGFAGPVLHTAQ
Mflv_4103|M.gilvum_PYR-GCK RLRTSTG---AEHSFDVVVSAVGMFTQPV--MPDLVEEEPFTGTVMHTAR
Mvan_2243|M.vanbaalenii_PYR-1 TLTTAGG---EEHTFDIVVSAIGLFTQPV--MPDLVDEEPFTGTVMHTAR
MSMEG_2567|M.smegmatis_MC2_155 VLTTSGG---DEQRFDFVVSAVGLFTQPL--LPDLVEEEPFTGTVLHTAR
TH_3452|M.thermoresistible__bu MLTTGAG---EQHNFDVVVSAVGMFTRPV--MPDLVEEEPFTGTLMHSAR
MAB_2077|M.abscessus_ATCC_1997 TLVTNSN---ETITCDVVVSAVGQLSLPH--VPVIADADTFQGPRFHSAR
MLBr_00065|M.leprae_Br4923 TVQVENNGTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQH
..:. . * * : * *. :*.
Mb0916|M.bovis_AF2122/97 WDHTVPLLGRRIAVIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWVLPWP
Rv0892|M.tuberculosis_H37Rv WDHTVPLLGRRIAVIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWVLPWP
MMAR_0240|M.marinum_M WDHRVDLTGKRVAVIGTGASGVQVVPELAKL-AGRLTVFQRTPPWMVPKD
MUL_4873|M.ulcerans_Agy99 WDHRVDLTGKRVAVIGTGASGVQVVPELAKL-AGRLTVFQRTPPWMVPKD
MAV_5241|M.avium_104 WDHDLDLAGRTVAVIGTGASGVQLVPELAGT-AGHVTVFQRTPPWMVPKD
Mflv_4103|M.gilvum_PYR-GCK WDHSVDLRGARVAVLGTGSTAAQLVPEVAKQ-AAAVYSVQRSPTWVLPKP
Mvan_2243|M.vanbaalenii_PYR-1 WDHSVDLRDARVAVLGTGSTAAQLVPEVAKQ-AAKVYSVQRSPTWVLPKP
MSMEG_2567|M.smegmatis_MC2_155 WDHSIPLAGKKIAVLGTGSTAAQLVPELAKV-ADTVYSVQRSPTWILPKP
TH_3452|M.thermoresistible__bu WDHGIDLHGKRIAVLGTGSTASQLIPELAKI-ADRVYSVQRSPTWILPKP
MAB_2077|M.abscessus_ATCC_1997 WDRSVSLRGKQVAVIGTGASAIQFVPHIVQE-AEHVTLYQRTAPWILPKW
MLBr_00065|M.leprae_Br4923 WPEDLDYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQP
* . : :.*:*:*::. .: :. * : **:. :::.
Mb0916|M.bovis_AF2122/97 NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAV
Rv0892|M.tuberculosis_H37Rv NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAV
MMAR_0240|M.marinum_M DRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ-I
MUL_4873|M.ulcerans_Agy99 DRRYTATELRQFRRNPLAIRRTRWQIWKFQHDNTATFADDPVVTSRTQ-I
MAV_5241|M.avium_104 DRPYSATELARFKRNPLALRRTRWQIWKFQHDNTATFADDPVVTARSR-I
Mflv_4103|M.gilvum_PYR-GCK DRPYTDREKWMFAHVPFAKKIYRTRLWLRSESNISVIEHGSDKTQEFKSI
Mvan_2243|M.vanbaalenii_PYR-1 DREYTGREKWMFAHIPLAKKIYRTRLWLRSESNISVIENGSDKTEEFKGI
MSMEG_2567|M.smegmatis_MC2_155 DRPYTDRERWVFAHVPLAKKIYRTRLWLRSESNISVIEHGSDKTQEFRSI
TH_3452|M.thermoresistible__bu DRPYSDRERWVFRHVPFAKRIYRTRLWLRSEANISVIEDGSEKTEEFKAI
MAB_2077|M.abscessus_ATCC_1997 DSRYGVLHDRVSELLPMALRLERFAVWLIFELLAVTLVDAKPLSRVLGAI
MLBr_00065|M.leprae_Br4923 AKDKIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWP--QRMRNIL
. . :
Mb0916|M.bovis_AF2122/97 CRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVT
Rv0892|M.tuberculosis_H37Rv CRASLRR-VRDPRLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVT
MMAR_0240|M.marinum_M ATSFLERVVADERLRRALTPGYPFRCKRVLLG--DDFYRALQHDHVELVT
MUL_4873|M.ulcerans_Agy99 ATSFLERVVADERLRRALTPGYPFRCKRVLLG--DDFYRALQHAHVELVT
MAV_5241|M.avium_104 ATSFLDRTVADESLRRALTPDYPFRCKRVLLG--DDYYRALQRDNVELVT
Mflv_4103|M.gilvum_PYR-GCK ALRTLEATVSDDELRARLTPDHPLGCKRLVFA--TDYLKTLTEPHVDVVS
Mvan_2243|M.vanbaalenii_PYR-1 ALRTLEATVADDELRAKLTPTHPLGCKRLVFA--TDYLQTLTQPHVEVVS
MSMEG_2567|M.smegmatis_MC2_155 ALNMLRSTVTDDELRERLTPDHPLGCKRLVFS--SDFIPTLTRPNVEVVS
TH_3452|M.thermoresistible__bu ALKMLEATVPDEEMRRRLTPDHPLGCKRLVFS--SDYLAALMRPNVEVVS
MAB_2077|M.abscessus_ATCC_1997 ARRHLHRQVASPSLREQLMPSDAPGCKRVLFS--NDYYPAIASDRVSLVP
MLBr_00065|M.leprae_Br4923 LGHVARRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVT
. :: : * :*: : . :: *.:*.
Mb0916|M.bovis_AF2122/97 AGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRID
Rv0892|M.tuberculosis_H37Rv AGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRID
MMAR_0240|M.marinum_M DPIERVTETSVVTTAGQAVDVDAVVLATGFETSRYLSGIEVIGTGGQSLH
MUL_4873|M.ulcerans_Agy99 DPIERVTETSVVTTAGQGVDVDAVVLATGFETSRYLSGIEVIGTGGQSLH
MAV_5241|M.avium_104 DPIARIGRMSVITASGAEIEADVIVLATGFETSRYLSGIEVVGAGGRRLH
Mflv_4103|M.gilvum_PYR-GCK SPARALRSRSLVTEDGTELDVDVVLCATGYAAADYLGQIDVRGADDIPLS
Mvan_2243|M.vanbaalenii_PYR-1 SPARSLRSRSLVTEDGTELDVDVVLCATGYAAADYLGQIEVRGADDALLS
MSMEG_2567|M.smegmatis_MC2_155 SPARALRSRSLVTEDGRELDVDIVACATGYAAADYLGQIEVTGEGGIRLH
TH_3452|M.thermoresistible__bu SPARALRGDTLITEDGTERRVDVVVCATGYAAADYLGQIEVVGERQRSLR
MAB_2077|M.abscessus_ATCC_1997 KAIAELCDNGVKTVDGEFRPADVVIYGTGFRATDFLAPMSVRGSRGVSLA
MLBr_00065|M.leprae_Br4923 DAIDRFTSTGIRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLA
. : * .* : .** : : . :
Mb0916|M.bovis_AF2122/97 DVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQW
Rv0892|M.tuberculosis_H37Rv DVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQW
MMAR_0240|M.marinum_M ERWGDDPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGARLVASA
MUL_4873|M.ulcerans_Agy99 ERWGDDPAAYLGAAVGGFPNFFMLYGPNTNQGGNSIVYILEAGARLVASA
MAV_5241|M.avium_104 EHWGEEPSAYLGVAVSGFPNFFMLYGPNTNQGGNSIVYILEAGARLVASA
Mflv_4103|M.gilvum_PYR-GCK QTWRDGAFAYLGMSVPGYPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRA
Mvan_2243|M.vanbaalenii_PYR-1 DTWRDGAFAYLGMAVPGYPNFFMLYGPNTNVGSNSVIFMLEAQAHYIVRA
MSMEG_2567|M.smegmatis_MC2_155 DVWRDGAYAYLGMTVPGFPNFFMLYGPNTNVGSNSVIFVLEAQARYVVRA
TH_3452|M.thermoresistible__bu EVWRDGAYAYLGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQARYVVKA
MAB_2077|M.abscessus_ATCC_1997 EVWKTQAYAYLGITVPMFPNLFLLYGPNTNVGSGSILYMIESQVRHIATL
MLBr_00065|M.leprae_Br4923 QTMS-----YKGMMLSGLPNMIYTVG----YTNASWTLKADLVSEFFCRL
: : : **:: * . . : . .
Mb0916|M.bovis_AF2122/97 IKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDG-I
Rv0892|M.tuberculosis_H37Rv IKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDG-I
MMAR_0240|M.marinum_M VSRLARRG-GYLDVRPEAERRYNDEISTDLERTIW-TQCQSYFRSPSGRI
MUL_4873|M.ulcerans_Agy99 ASRLARRG-GYLDVRPEAERRYNDEISADLERTIW-TQCQSYFRSPSGRI
MAV_5241|M.avium_104 VSRLARRG-GFLEVRPEAEKRFNDRLSADLERTIW-TRCDSYFRSPTGRI
Mflv_4103|M.gilvum_PYR-GCK LKYLRRRNRSYIEVRSDVMKRYLDKIDSWMQGTVWLTRCSNYFRAPNGRV
Mvan_2243|M.vanbaalenii_PYR-1 LKYMRRKNRSYIEVRSDVMTRFLERIDTWMQGTVWLTRCSNYFRAPNGRV
MSMEG_2567|M.smegmatis_MC2_155 LKHLRRRRKSYVAVKPEVMAQFIADIDRWMQGTVWLTRCSSYFRAPNGRV
TH_3452|M.thermoresistible__bu LKRLRRRDTSYIAVRPDTAAAFLAKVDQWMQGKVWSTQCNNYFRAPNGRV
MAB_2077|M.abscessus_ATCC_1997 IKAVAAHPGHAIDVRTESAQRYNTRLRRRLRRSVW-ALCASWYRTSSGEI
MLBr_00065|M.leprae_Br4923 LNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPW
. : . . : :
Mb0916|M.bovis_AF2122/97 PEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA----------
Rv0892|M.tuberculosis_H37Rv PEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA----------
MMAR_0240|M.marinum_M VTQWPYTELEYARRTWRIKPRDWLHHKGVSPAAQRGGAGSAASAQTEIDH
MUL_4873|M.ulcerans_Agy99 VTQWPYTELEYARRTWRIRPRDWLHHKGVSPAAQRGGPGSAASAETEIDD
MAV_5241|M.avium_104 VTQWPYTELDYARWTWRLRRRDWIHHRCAPGAATVG-------AAQEF--
Mflv_4103|M.gilvum_PYR-GCK VTQWPRSARDFWALTRWFRAGDYVFEAPSA--RETISVGAQAEAER----
Mvan_2243|M.vanbaalenii_PYR-1 VTQWPRSARTFWGLTRRFNPGDYGFDAPSS--RSRIRVGAQTSVKQP---
MSMEG_2567|M.smegmatis_MC2_155 VTQWPRSARALWAMTRRFRAADYLFSAPVDGQAQVVEVAAHETVG-----
TH_3452|M.thermoresistible__bu VTQWPRSARAFWAMTRRFRSADYLFEPAPD--MSEVSADARPVASR----
MAB_2077|M.abscessus_ATCC_1997 PTNWPGPTLVYRLLTRKPHSGDYVLRNVGR--LKVGDPAEPSLAD-----
MLBr_00065|M.leprae_Br4923 RLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV----------------
Mb0916|M.bovis_AF2122/97 ------------------------------
Rv0892|M.tuberculosis_H37Rv ------------------------------
MMAR_0240|M.marinum_M PADQLAGNQIGVGVVDAVERVALGDHLVQE
MUL_4873|M.ulcerans_Agy99 PADQLAGNQIGVGVVDAVERVALGDHRVQE
MAV_5241|M.avium_104 ------------------------------
Mflv_4103|M.gilvum_PYR-GCK ------------------------------
Mvan_2243|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_2567|M.smegmatis_MC2_155 ------------------------------
TH_3452|M.thermoresistible__bu ------------------------------
MAB_2077|M.abscessus_ATCC_1997 ------------------------------
MLBr_00065|M.leprae_Br4923 ------------------------------