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M. gilvum PYR-GCK Mflv_4103 (-)

annotation: cyclohexanone monooxygenase
coordinates: 4354835 - 4356343
length: 502

AKSLSVGIIGAGPGGLALGIFLRRAGFDDFTIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHW
SRLWSGQKEILEYFERCAQRYRLQEKLRCNTEIVSARWVPSERRWRLRTSTGAEHSFDVVVSAVGMFTQP
VMPDLVEEEPFTGTVMHTARWDHSVDLRGARVAVLGTGSTAAQLVPEVAKQAAAVYSVQRSPTWVLPKPD
RPYTDREKWMFAHVPFAKKIYRTRLWLRSESNISVIEHGSDKTQEFKSIALRTLEATVSDDELRARLTPD
HPLGCKRLVFATDYLKTLTEPHVDVVSSPARALRSRSLVTEDGTELDVDVVLCATGYAAADYLGQIDVRG
ADDIPLSQTWRDGAFAYLGMSVPGYPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRRNRSYIE
VRSDVMKRYLDKIDSWMQGTVWLTRCSNYFRAPNGRVVTQWPRSARDFWALTRWFRAGDYVFEAPSARET
ISVGAQAEAER*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4103--100% (502)cyclohexanone monooxygenase
M. gilvum PYR-GCKMflv_4605-e-10541.91% (482) FAD dependent oxidoreductase
M. gilvum PYR-GCKMflv_4608-1e-8734.97% (489) FAD dependent oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1428c-2e-8335.40% (483) monoxygenase
M. tuberculosis H37RvRv1393c-2e-8335.40% (483) monoxygenase
M. leprae Br4923MLBr_00065-1e-3025.23% (444) putative monooxygenase
M. abscessus ATCC 19977MAB_2077-2e-9437.74% (477) monooxygenase
M. marinum MMMAR_0403-0.071.28% (484) monooxygenase
M. avium 104MAV_5119-0.074.85% (485) lipolytic enzyme
M. smegmatis MC2 155MSMEG_2567-0.078.47% (483) monooxygenase
M. thermoresistible (build 8)TH_3452-0.074.30% (502) PUTATIVE lipolytic enzyme
M. ulcerans Agy99MUL_1053-0.070.66% (484) monooxygenase
M. vanbaalenii PYR-1Mvan_2243-0.085.26% (502) cyclohexanone monooxygenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1428c|M.bovis_AF2122/97           ---------MMPDYHALIVGAGFSGIGAAIKLDRAG-FSDYLVVEAGDGV
Rv1393c|M.tuberculosis_H37Rv        ---------MMPDYHALIVGAGFSGIGAAIKLDRAG-FSDYLVVEAGDGV
Mflv_4103|M.gilvum_PYR-GCK          ---------MAKSLSVGIIGAGPGGLALGIFLRRAG-FDDFTIFDREDGV
Mvan_2243|M.vanbaalenii_PYR-1       -----MTTSMAKTFSVAIIGAGPGGLALGIFLRKAG-FTDFTIFDREDGV
MSMEG_2567|M.smegmatis_MC2_155      ------MSADRMSMSIGIIGAGPGGLALGIFLKKAG-FRDFTIFDREDGV
TH_3452|M.thermoresistible__bu      ---------MARNLSVGIIGAGPGGIALGIFLRRAG-FTDFTIFDREDGV
MMAR_0403|M.marinum_M               ---------MTSPLSVGIIGAGPGGLALGILLKNRG-FENFTIFDRESDV
MUL_1053|M.ulcerans_Agy99           ---------MTSPLSVGIIGAGPGGLALGILLKNRG-FENFNIFDRESDV
MAV_5119|M.avium_104                -----MPADPMSELSIGIIGAGPGGLALGILLSQAG-FDDFTIFDREDGV
MAB_2077|M.abscessus_ATCC_1997      MSSNFATACRAYDPSIVIIGAGFAGVAMAHRLKKDG-FTNFTILEKAADI
MLBr_00065|M.leprae_Br4923          ----MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGM
                                                     *:*** .*:. .  *       .: :.:   .:

Mb1428c|M.bovis_AF2122/97           GGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVD
Rv1393c|M.tuberculosis_H37Rv        GGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVD
Mflv_4103|M.gilvum_PYR-GCK          GGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQKEILEYFERCAQ
Mvan_2243|M.vanbaalenii_PYR-1       GGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRMWSGQEEILQYFERCAQ
MSMEG_2567|M.smegmatis_MC2_155      GGTWRINTYPGLACDVKSHLYSYSFDLNADWTRLWSSQPEILAYFERCAQ
TH_3452|M.thermoresistible__bu      GGTWRINTYPGLACDVKSHLYSYSFELNSEWTRLWPAQPEILRYFERCAQ
MMAR_0403|M.marinum_M               GGTWRINTYPGLACDVKSHLYSYSFDLNPGWSRLWSGQPEILAYFQRCAD
MUL_1053|M.ulcerans_Agy99           GGTWRINTYPGLACDVKSHLYSYSFDLNPGWSGLWSGQPEILAYFQRCAD
MAV_5119|M.avium_104                GGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQPEILDYFQRCAD
MAB_2077|M.abscessus_ATCC_1997      GGVWRDNTYPGAACDVPSALYSLSYKPNPRWSRRYAEQPEILKYLQQLVE
MLBr_00065|M.leprae_Br4923          GGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKP-ILEYIKSTAV
                                    **.*    ***   *         :               :  * :  . 

Mb1428c|M.bovis_AF2122/97           KYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE-----ITARFLISAC
Rv1393c|M.tuberculosis_H37Rv        KYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE-----ITARFLISAC
Mflv_4103|M.gilvum_PYR-GCK          RYRLQEKLRCNTEIVSARWVPSERRWRLRTSTGAE-----HSFDVVVSAV
Mvan_2243|M.vanbaalenii_PYR-1       RYRLPDNLQLNTEIVSARWGSETRTWTLTTAGGEE-----HTFDIVVSAI
MSMEG_2567|M.smegmatis_MC2_155      RHQLESHLVLGTEITSARWDTDG--WVLTTSGGDE-----QRFDFVVSAV
TH_3452|M.thermoresistible__bu      RHRLGPHLRLNTEITSARWNPTSRQWMLTTGAGEQ-----HNFDVVVSAV
MMAR_0403|M.marinum_M               RYGLRPHLRLSTEIRSARWESQTRQWTLSTADGEQ-----HQFSVVVSAV
MUL_1053|M.ulcerans_Agy99           RYELRPHLRLGTEIRSARWESQTRQWTLSTADGEQ-----HQFSVVVSVV
MAV_5119|M.avium_104                KYGLGPHLRLGTEIRSAHWDADTQRWRLTTASGHR-----HHFDVVVSAV
MAB_2077|M.abscessus_ATCC_1997      SGGLAAHLRTQTEVVAMTFDDQLGRWTLVTNSNET-----ITCDVVVSAV
MLBr_00065|M.leprae_Br4923          MHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGY
                                       :   :    :: .  :      * : .  .           .: *  

Mb1428c|M.bovis_AF2122/97           GILTVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQV
Rv1393c|M.tuberculosis_H37Rv        GILTVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQV
Mflv_4103|M.gilvum_PYR-GCK          GMFTQPVMPDLVEEEPFTGTVMHTARWDHSVDLRGARVAVLGTGSTAAQL
Mvan_2243|M.vanbaalenii_PYR-1       GLFTQPVMPDLVDEEPFTGTVMHTARWDHSVDLRDARVAVLGTGSTAAQL
MSMEG_2567|M.smegmatis_MC2_155      GLFTQPLLPDLVEEEPFTGTVLHTARWDHSIPLAGKKIAVLGTGSTAAQL
TH_3452|M.thermoresistible__bu      GMFTRPVMPDLVEEEPFTGTLMHSARWDHGIDLHGKRIAVLGTGSTASQL
MMAR_0403|M.marinum_M               GIFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVLGTGSTAAQL
MUL_1053|M.ulcerans_Agy99           GIFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVLGTGSTAAQL
MAV_5119|M.avium_104                GLFTRPLLPELVEEEPFTGTVMHSARWDHSIPLHGKRIAVLGTGSTASQL
MAB_2077|M.abscessus_ATCC_1997      GQLSLPHVPVIADADTFQGPRFHSARWDRSVSLRGKQVAVIGTGASAIQF
MLBr_00065|M.leprae_Br4923          YNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTL
                                            * :   : * *  :*. :* .       .: ::*:*::*  .

Mb1428c|M.bovis_AF2122/97           IPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-IPGGKAVHRL
Rv1393c|M.tuberculosis_H37Rv        IPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-IPGGKAVHRL
Mflv_4103|M.gilvum_PYR-GCK          VPEVAKQ-AAAVYSVQRSPTWVLPKPDRPYTDREKWMFAHVPFAKKIYRT
Mvan_2243|M.vanbaalenii_PYR-1       VPEVAKQ-AAKVYSVQRSPTWVLPKPDREYTGREKWMFAHIPLAKKIYRT
MSMEG_2567|M.smegmatis_MC2_155      VPELAKV-ADTVYSVQRSPTWILPKPDRPYTDRERWVFAHVPLAKKIYRT
TH_3452|M.thermoresistible__bu      IPELAKI-ADRVYSVQRSPTWILPKPDRPYSDRERWVFRHVPFAKRIYRT
MMAR_0403|M.marinum_M               VPELAKV-ADRVYSIQRSPTWILPKPDRPYSRWERWVFAHVPFAARLYRT
MUL_1053|M.ulcerans_Agy99           VPELAKV-ADRVYSIQRSPTWILPKPDRPYSRWERWVFAHVPFAARLYRT
MAV_5119|M.avium_104                IPELAKV-AERVYSVQRSPTWILPKPDRPYTRWERWAFAHLPLAKKLYRT
MAB_2077|M.abscessus_ATCC_1997      VPHIVQE-AEHVTLYQRTAPWILPKWDSRYGVLHDRVSELLPMALRLERF
MLBr_00065|M.leprae_Br4923          VPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTAVRW
                                    :* :.   .  :   **:. : ..:                  .    * 

Mb1428c|M.bovis_AF2122/97           LSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHD-PVVREQLTP
Rv1393c|M.tuberculosis_H37Rv        LSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHD-PVVREQLTP
Mflv_4103|M.gilvum_PYR-GCK          RLWLRSESNISVIEH---GSDKTQEFKSIALRTLEATVSD-DELRARLTP
Mvan_2243|M.vanbaalenii_PYR-1       RLWLRSESNISVIEN---GSDKTEEFKGIALRTLEATVAD-DELRAKLTP
MSMEG_2567|M.smegmatis_MC2_155      RLWLRSESNISVIEH---GSDKTQEFRSIALNMLRSTVTD-DELRERLTP
TH_3452|M.thermoresistible__bu      RLWLRSEANISVIED---GSEKTEEFKAIALKMLEATVPD-EEMRRRLTP
MMAR_0403|M.marinum_M               RLWLRSESNISVIEH---GSPKTKEFTELALRMLENTVSD-PQLRRQLTP
MUL_1053|M.ulcerans_Agy99           RLWLRSESNISVIEH---GSPKTKEFTELALRMLENTVSD-PQLRRQLTP
MAV_5119|M.avium_104                RLWLRSESNISVIEH---GSEKTGQFTNIALGLLEASVPD-EELRRKLTP
MAB_2077|M.abscessus_ATCC_1997      AVWLIFELLAVTLVD---AKPLSRVLGAIARRHLHRQVAS-PSLREQLMP
MLBr_00065|M.leprae_Br4923          KNILRQSALYGACQK------WPQRMRNILLGHVARRLPKGYDVQKHFGP
                                          .       .       .  :       :   : .   :: :: *

Mb1428c|M.bovis_AF2122/97           RYAVGCKRPGFHN--TYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHE
Rv1393c|M.tuberculosis_H37Rv        RYAVGCKRPGFHN--TYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHE
Mflv_4103|M.gilvum_PYR-GCK          DHPLGCKRLVFAT--DYLKTLTEPHVDVVSSPARALRSRSLVTEDGTELD
Mvan_2243|M.vanbaalenii_PYR-1       THPLGCKRLVFAT--DYLQTLTQPHVEVVSSPARSLRSRSLVTEDGTELD
MSMEG_2567|M.smegmatis_MC2_155      DHPLGCKRLVFSS--DFIPTLTRPNVEVVSSPARALRSRSLVTEDGRELD
TH_3452|M.thermoresistible__bu      DHPLGCKRLVFSS--DYLAALMRPNVEVVSSPARALRGDTLITEDGTERR
MMAR_0403|M.marinum_M               DHPMGCKRLVFSS--EFLTALARPNVELVTSPARYLRQRSLVTADGAEYD
MUL_1053|M.ulcerans_Agy99           DHPMGCKRLVFSS--EFLTALTRPNVELVTSPARYLRQRSLVTADGAEYD
MAV_5119|M.avium_104                DHPMGCKRLVFSS--DYLPALTRPNVEVLTSPARSLRRRSLVTEDGTERE
MAB_2077|M.abscessus_ATCC_1997      SDAPGCKRVLFSN--DYYPAIASDRVSLVPKAIAELCDNGVKTVDGEFRP
MLBr_00065|M.leprae_Br4923          HYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELR
                                          :*  :        ::    * ::...   :    :   .*    

Mb1428c|M.bovis_AF2122/97           IDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPG
Rv1393c|M.tuberculosis_H37Rv        IDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPG
Mflv_4103|M.gilvum_PYR-GCK          VDVVLCATGYAAAD--YLGQIDVRGADDIPLSQTWRDG-AFAYLGMSVPG
Mvan_2243|M.vanbaalenii_PYR-1       VDVVLCATGYAAAD--YLGQIEVRGADDALLSDTWRDG-AFAYLGMAVPG
MSMEG_2567|M.smegmatis_MC2_155      VDIVACATGYAAAD--YLGQIEVTGEGGIRLHDVWRDG-AYAYLGMTVPG
TH_3452|M.thermoresistible__bu      VDVVVCATGYAAAD--YLGQIEVVGERQRSLREVWRDG-AYAYLGMTVPG
MMAR_0403|M.marinum_M               VDVVVCATGYAAAD--YLGQLEVLGEDGAGLHEVWRDG-AHAYLGMAVPG
MUL_1053|M.ulcerans_Agy99           VDVVVCATGYAAAD--YLGQLEVLGEDGAGLHEVWRDG-AHAYLGMAVPG
MAV_5119|M.avium_104                VDLVVCATGYAAAD--YLGELDVTGEHGVTLREVWRDG-AYAYLGMAVPG
MAB_2077|M.abscessus_ATCC_1997      ADVVIYGTGFRATD--FLAPMSVRGSRGVSLAEVWKTQ-AYAYLGITVPM
MLBr_00065|M.leprae_Br4923          ADIIVTATGLNLQL--FGGAVATVDGQPVDLAQT------MSYKGMMLSG
                                     *::  .**             . .     *          :* *: :. 

Mb1428c|M.bovis_AF2122/97           YPNFFTVFGPYGYVGS-SYFALIETQAHHIIRCLKRARRTGATRIEVTEE
Rv1393c|M.tuberculosis_H37Rv        YPNFFTVFGPYGYVGS-SYFALIETQAHHIIRCLKRARRTGATRIEVTEE
Mflv_4103|M.gilvum_PYR-GCK          YPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRRNRSYIEVRSD
Mvan_2243|M.vanbaalenii_PYR-1       YPNFFMLYGPNTNVGSNSVIFMLEAQAHYIVRALKYMRRKNRSYIEVRSD
MSMEG_2567|M.smegmatis_MC2_155      FPNFFMLYGPNTNVGSNSVIFVLEAQARYVVRALKHLRRRRKSYVAVKPE
TH_3452|M.thermoresistible__bu      FPNFFMLYGPNTNVGSNSVLFILEAQARYVVKALKRLRRRDTSYIAVRPD
MMAR_0403|M.marinum_M               FPNFFMLYGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSKTYIAVRPG
MUL_1053|M.ulcerans_Agy99           FPNFFMLCGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSKTYIAVRPG
MAV_5119|M.avium_104                FPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRHRRRYIAVRPA
MAB_2077|M.abscessus_ATCC_1997      FPNLFLLYGPNTNVGSGSILYMIESQVRHIATLIKAVAAHPGHAIDVRTE
MLBr_00065|M.leprae_Br4923          LPNMIYTVG----YTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYP
                                     **::   *      . *     :   ...   :          : *   

Mb1428c|M.bovis_AF2122/97           ANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDVPLRPTTTVEAYWR
Rv1393c|M.tuberculosis_H37Rv        ANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDVPLRPTTTVEAYWR
Mflv_4103|M.gilvum_PYR-GCK          VMKRYLDKIDSWMQGTVWLT----RCSNYFRAPNGRVVTQWPRSARDFWA
Mvan_2243|M.vanbaalenii_PYR-1       VMTRFLERIDTWMQGTVWLT----RCSNYFRAPNGRVVTQWPRSARTFWG
MSMEG_2567|M.smegmatis_MC2_155      VMAQFIADIDRWMQGTVWLT----RCSSYFRAPNGRVVTQWPRSARALWA
TH_3452|M.thermoresistible__bu      TAAAFLAKVDQWMQGKVWST----QCNNYFRAPNGRVVTQWPRSARAFWA
MMAR_0403|M.marinum_M               VLAEFMAKVDRWMTGTVWTT----ECSNYFRAPNGRVVTQWPRSARSFWG
MUL_1053|M.ulcerans_Agy99           VLAEFIAKVDRWMTGTVWTT----ECSNYFRAPNGRVVTQWPRSARSFWG
MAV_5119|M.avium_104                ALADFVAKIDRWMVGTVWTT----QCSNYFRAPNGRVVTQWPRSARAFWS
MAB_2077|M.abscessus_ATCC_1997      SAQRYNTRLRRRLRRSVWA-----LCASWYRTSSGEIPTNWPGPTLVYRL
MLBr_00065|M.leprae_Br4923          GSDVEERPFMDFTPGYVLRS------LDALPKQGSRTPWRLNQNYLRDIR
                                            .       *          .     ..    .          

Mb1428c|M.bovis_AF2122/97           S-RRFDLGDYRISS------------------------------------
Rv1393c|M.tuberculosis_H37Rv        S-RRFDLGDYRISS------------------------------------
Mflv_4103|M.gilvum_PYR-GCK          LTRWFRAGDYVFEAPSA--RETISVGAQAEAER-----------------
Mvan_2243|M.vanbaalenii_PYR-1       LTRRFNPGDYGFDAPSS--RSRIRVGAQTSVKQP----------------
MSMEG_2567|M.smegmatis_MC2_155      MTRRFRAADYLFSAPVDGQAQVVEVAAHETVG------------------
TH_3452|M.thermoresistible__bu      MTRRFRSADYLFEPAPD--MSEVSADARPVASR-----------------
MMAR_0403|M.marinum_M               MTRRFKPADFSFQPAAVFAADGGDRNAGQR--------------------
MUL_1053|M.ulcerans_Agy99           MTRRFKPADFSFQPAAVFAADGGDRNAGQRWPNPRPSIGWTPCCAPSRRR
MAV_5119|M.avium_104                MTRRFRPADYRFQAPAVRVPAPAS-EADAR--------------------
MAB_2077|M.abscessus_ATCC_1997      LTRKPHSGDYVLRNVGR---LKVGDPAEPSLAD-----------------
MLBr_00065|M.leprae_Br4923          LIRRGKVADEGLLFAKKTTPVTV---------------------------
                                      *    .*  :                                      

Mb1428c|M.bovis_AF2122/97           ---------
Rv1393c|M.tuberculosis_H37Rv        ---------
Mflv_4103|M.gilvum_PYR-GCK          ---------
Mvan_2243|M.vanbaalenii_PYR-1       ---------
MSMEG_2567|M.smegmatis_MC2_155      ---------
TH_3452|M.thermoresistible__bu      ---------
MMAR_0403|M.marinum_M               ---------
MUL_1053|M.ulcerans_Agy99           ESTSPRSRS
MAV_5119|M.avium_104                ---------
MAB_2077|M.abscessus_ATCC_1997      ---------
MLBr_00065|M.leprae_Br4923          ---------