For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGGFARDPRGHDPSIVIIGAGVAGIAMAHQLKRDGFTNFTMVEKAADIGGVWRDNTYPGAACDVPSALYS LSDKPNTRWSRRYAEQPEILQYLRRLVLADGMDLHLRTRTEVVEMTFDEQAGRWRLVTGSSETIWCDVVI SAVGQLSRPHTPNIAGEDTFEGPRFHSARWDHSVSLRGKEVAVIGTGASAIQFVPRIAHEAQRVTLYQRT APWILPKWDSRYGRLHQQLIKVLPLWLRLERFAVWLIFEVLAVTLVDAKPLSRILGAVARYHLHRQVADP MLRRQLTPSDAPGCKRVLFSNDYYPAIANGEVSLVTNAVAKLCDKGVVTDDGVLHRADVVIYGTGFRATD FLAPMRVRGWGGVTLDEVWGTQAHAYLGITVPMFPNLFLLYGPNTNVGSGSIIYMIESQVRYVGALIKIL ASDPGRTVDVRPDIEQSYNTRLSRRLRRSVWALCASWYTTSSGAIPTNWPGPTFAYRILTRKPRSHDYLF RHVERLQLDGPSENRARLRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3136 | - | - | 100% (511) | monooxygenase |
| M. marinum M | MMAR_0403 | - | e-106 | 41.06% (492) | monooxygenase |
| M. marinum M | MMAR_0240 | - | e-102 | 42.39% (486) | monoooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 8e-97 | 39.00% (482) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4605 | - | 1e-163 | 56.28% (478) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3049c | - | 8e-97 | 39.00% (482) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 7e-26 | 24.88% (402) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2077 | - | 0.0 | 76.39% (504) | monooxygenase |
| M. avium 104 | MAV_5119 | - | 1e-105 | 41.96% (479) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 1e-108 | 42.86% (469) | monooxygenase |
| M. thermoresistible (build 8) | TH_3452 | - | 1e-104 | 40.79% (478) | PUTATIVE lipolytic enzyme |
| M. ulcerans Agy99 | MUL_1053 | - | 1e-101 | 39.84% (492) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 5e-96 | 37.22% (497) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3075c|M.bovis_AF2122/97 MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQG--VDF
Rv3049c|M.tuberculosis_H37Rv MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQG--VDF
MSMEG_4451|M.smegmatis_MC2_155 ------MSAPASSTPTLPASVHT--LVVGAGFAGLAAAAAVLREDPRADL
MMAR_3136|M.marinum_M ---------MTGGFARDPRGHDPSIVIIGAGVAGIAMAHQLKRDG-FTNF
MAB_2077|M.abscessus_ATCC_1997 ---------MSSNFATACRAYDPSIVIIGAGFAGVAMAHRLKKDG-FTNF
Mflv_4605|M.gilvum_PYR-GCK ------MKPVKREPTQDNPPGNPSIVIIGAGFAGITLALRLKRAG-FDRV
MAV_5119|M.avium_104 --------------MPADPMSELSIGIIGAGPGGLALGILLSQAG-FDDF
MUL_1053|M.ulcerans_Agy99 ------------------MTSPLSVGIIGAGPGGLALGILLKNRG-FENF
TH_3452|M.thermoresistible__bu ------------------MARNLSVGIIGAGPGGIALGIFLRRAG-FTDF
Mvan_2243|M.vanbaalenii_PYR-1 --------------MTTSMAKTFSVAIIGAGPGGLALGIFLRKAG-FTDF
MLBr_00065|M.leprae_Br4923 -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
::*:* .*: . :
Mb3075c|M.bovis_AF2122/97 VILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEI
Rv3049c|M.tuberculosis_H37Rv VILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEI
MSMEG_4451|M.smegmatis_MC2_155 LIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHTFARQPEI
MMAR_3136|M.marinum_M TMVEKAADIGGVWRDNTYPGAACDVPSALYSLSDKPNTRWSRRYAEQPEI
MAB_2077|M.abscessus_ATCC_1997 TILEKAADIGGVWRDNTYPGAACDVPSALYSLSYKPNPRWSRRYAEQPEI
Mflv_4605|M.gilvum_PYR-GCK LIVEKGDGVGGVWRENTYPGAACDVPSQLYSISSAPNPRWGRRYAEQGDI
MAV_5119|M.avium_104 TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQPEI
MUL_1053|M.ulcerans_Agy99 NIFDRESDVGGTWRINTYPGLACDVKSHLYSYSFDLNPGWSGLWSGQPEI
TH_3452|M.thermoresistible__bu TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFELNSEWTRLWPAQPEI
Mvan_2243|M.vanbaalenii_PYR-1 TIFDREDGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRMWSGQEEI
MLBr_00065|M.leprae_Br4923 VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKP-I
:.:: :**.* *** .* . . *
Mb3075c|M.bovis_AF2122/97 LGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---ADGREYVA
Rv3049c|M.tuberculosis_H37Rv LGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---ADGREYVA
MSMEG_4451|M.smegmatis_MC2_155 HRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRT---SLG-MVTA
MMAR_3136|M.marinum_M LQYLRRLVLADGMDLHLRTRTEVVEMTFDEQAGRWRLVT---GSSETIWC
MAB_2077|M.abscessus_ATCC_1997 LKYLQQLVESGGLAAHLRTQTEVVAMTFDDQLGRWTLVT---NSNETITC
Mflv_4605|M.gilvum_PYR-GCK LAYLRRVADESGLLSLLRTKTEIAKAAFDERTNTWRLTT---TTSQELEC
MAV_5119|M.avium_104 LDYFQRCADKYGLGPHLRLGTEIRSAHWDADTQRWRLTT---ASGHRHHF
MUL_1053|M.ulcerans_Agy99 LAYFQRCADRYELRPHLRLGTEIRSARWESQTRQWTLST---ADGEQHQF
TH_3452|M.thermoresistible__bu LRYFERCAQRHRLGPHLRLNTEITSARWNPTSRQWMLTT---GAGEQHNF
Mvan_2243|M.vanbaalenii_PYR-1 LQYFERCAQRYRLPDNLQLNTEIVSARWGSETRTWTLTT---AGGEEHTF
MLBr_00065|M.leprae_Br4923 LEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISC
*: . : : : : * : .
Mb3075c|M.bovis_AF2122/97 QFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIV
Rv3049c|M.tuberculosis_H37Rv QFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIV
MSMEG_4451|M.smegmatis_MC2_155 TVLVAATGALSTPK--LPDVPGLDRFGGTVFHSATWNHDHDLTDERVAVV
MMAR_3136|M.marinum_M DVVISAVGQLSRPH--TPNIAGEDTFEGPRFHSARWDHSVSLRGKEVAVI
MAB_2077|M.abscessus_ATCC_1997 DVVVSAVGQLSLPH--VPVIADADTFQGPRFHSARWDRSVSLRGKQVAVI
Mflv_4605|M.gilvum_PYR-GCK DVVISAVGQLSRPS--VPDIPGISGFAGPSFHSANWDHDLNLSGKRLAVV
MAV_5119|M.avium_104 DVVVSAVGLFTRPL--LPELVEEEPFTGTVMHSARWDHSIPLHGKRIAVL
MUL_1053|M.ulcerans_Agy99 SVVVSVVGIFSRPA--YPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVL
TH_3452|M.thermoresistible__bu DVVVSAVGMFTRPV--MPDLVEEEPFTGTLMHSARWDHGIDLHGKRIAVL
Mvan_2243|M.vanbaalenii_PYR-1 DIVVSAIGLFTQPV--MPDLVDEEPFTGTVMHTARWDHSVDLRDARVAVL
MLBr_00065|M.leprae_Br4923 SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
.:. * * . . * *. :*. * .. .:.::
Mb3075c|M.bovis_AF2122/97 GTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRRALRTV
Rv3049c|M.tuberculosis_H37Rv GTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRRALRTV
MSMEG_4451|M.smegmatis_MC2_155 GTGASAVQFVPEIADR-TAHLTVFQRTPAWVLPRLDRTLGRLERALYRRI
MMAR_3136|M.marinum_M GTGASAIQFVPRIAHE-AQRVTLYQRTAPWILPKWDSRYGRLHQQLIKVL
MAB_2077|M.abscessus_ATCC_1997 GTGASAIQFVPHIVQE-AEHVTLYQRTAPWILPKWDSRYGVLHDRVSELL
Mflv_4605|M.gilvum_PYR-GCK GTGASSVQFVPVVAAG-AEHLDVFQRSAPWVLPKFDRQYGGRHHQLLRKL
MAV_5119|M.avium_104 GTGSTASQLIPELAKV-AERVYSVQRSPTWILPKPDRPYTRWERWAFAHL
MUL_1053|M.ulcerans_Agy99 GTGSTAAQLVPELAKV-ADRVYSIQRSPTWILPKPDRPYSRWERWVFAHV
TH_3452|M.thermoresistible__bu GTGSTASQLIPELAKI-ADRVYSVQRSPTWILPKPDRPYSDRERWVFRHV
Mvan_2243|M.vanbaalenii_PYR-1 GTGSTAAQLVPEVAKQ-AAKVYSVQRSPTWVLPKPDREYTGREKWMFAHI
MLBr_00065|M.leprae_Br4923 GSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAK--DKIAARLNRWL
*:*::: ::* :. . .: **:..:::.: :
Mb3075c|M.bovis_AF2122/97 PGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKDRELR
Rv3049c|M.tuberculosis_H37Rv PGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKDRELR
MSMEG_4451|M.smegmatis_MC2_155 PLSQRLVRGMVYIYREGYLALLAHLTWLLPLLEIIAKTQLRRQVPDPALR
MMAR_3136|M.marinum_M PLWLRLERFAVWLIFEVLAVTLVDAKPLSRILGAVARYHLHRQVADPMLR
MAB_2077|M.abscessus_ATCC_1997 PMALRLERFAVWLIFELLAVTLVDAKPLSRVLGAIARRHLHRQVASPSLR
Mflv_4605|M.gilvum_PYR-GCK PILRLSERLMIWTIFEFLALALVDAKPVARVLGVIALRHLGRQVSDARLR
MAV_5119|M.avium_104 PLAKKLYRTRLWLRSESNISVIEHGSEKTGQFTNIALGLLEASVPDEELR
MUL_1053|M.ulcerans_Agy99 PFAARLYRTRLWLRSESNISVIEHGSPKTKEFTELALRMLENTVSDPQLR
TH_3452|M.thermoresistible__bu PFAKRIYRTRLWLRSEANISVIEDGSEKTEEFKAIALKMLEATVPDEEMR
Mvan_2243|M.vanbaalenii_PYR-1 PLAKKIYRTRLWLRSESNISVIENGSDKTEEFKGIALRTLEATVADDELR
MLBr_00065|M.leprae_Br4923 PDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQ
* . . ::
Mb3075c|M.bovis_AF2122/97 RKLTPRYRIGCKRILNSS--TYYPAVADPKTELITDRIDRITHDGIVTAD
Rv3049c|M.tuberculosis_H37Rv RKLTPRYRIGCKRILNSS--TYYPAVADPKTELITDRIDRITHDGIVTAD
MSMEG_4451|M.smegmatis_MC2_155 RALTPDFRIGCKRILLTN--DWLPTLARDDVEVVTTALTEVTETGVR--D
MMAR_3136|M.marinum_M RQLTPSDAPGCKRVLFSN--DYYPAIANGEVSLVTNAVAKLCDKGVVTDD
MAB_2077|M.abscessus_ATCC_1997 EQLMPSDAPGCKRVLFSN--DYYPAIASDRVSLVPKAIAELCDNGVKTVD
Mflv_4605|M.gilvum_PYR-GCK SHLTPDYAPGCKRILFSS--DYYPALARPNVLLVTDDIQAVEPGGIRTVN
MAV_5119|M.avium_104 RKLTPDHPMGCKRLVFSS--DYLPALTRPNVEVLTSPARSLRRRSLVTED
MUL_1053|M.ulcerans_Agy99 RQLTPDHPMGCKRLVFSS--EFLTALTRPNVELVTSPARYLRQRSLVTAD
TH_3452|M.thermoresistible__bu RRLTPDHPLGCKRLVFSS--DYLAALMRPNVEVVSSPARALRGDTLITED
Mvan_2243|M.vanbaalenii_PYR-1 AKLTPTHPLGCKRLVFAT--DYLQTLTQPHVEVVSSPARSLRSRSLVTED
MLBr_00065|M.leprae_Br4923 KHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKS
: * :*: :: . ::. . : .
Mb3075c|M.bovis_AF2122/97 GTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGAH
Rv3049c|M.tuberculosis_H37Rv GTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGAH
MSMEG_4451|M.smegmatis_MC2_155 GTGR--LHDVDTIIFATGFTPTEPPVAHQLTGVTGTTLAAHWAG-SPSAH
MMAR_3136|M.marinum_M GVLH----RADVVIYGTGFRATDFLAPMRVRGWGGVTLDEVWGT-QAHAY
MAB_2077|M.abscessus_ATCC_1997 GEFR----PADVVIYGTGFRATDFLAPMSVRGSRGVSLAEVWKT-QAYAY
Mflv_4605|M.gilvum_PYR-GCK GDFH----AADVIIYGTGFSATEFLSPMEVYGRSDRKLSDVWAD-GAHAY
MAV_5119|M.avium_104 GTER----EVDLVVCATGYAAADYLGELDVTGEHGVTLREVWRD-GAYAY
MUL_1053|M.ulcerans_Agy99 GAEY----DVDVVVCATGYAAADYLGQLEVLGEDGAGLHEVWRD-GAHAY
TH_3452|M.thermoresistible__bu GTER----RVDVVVCATGYAAADYLGQIEVVGERQRSLREVWRD-GAYAY
Mvan_2243|M.vanbaalenii_PYR-1 GTEL----DVDVVLCATGYAAADYLGQIEVRGADDALLSDTWRD-GAFAY
MLBr_00065|M.leprae_Br4923 GNELR----ADIIVTATGLNLQLFGGAVATVDGQPVDLAQ------TMSY
* .* :: .** . * ::
Mb3075c|M.bovis_AF2122/97 RGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGVQ
Rv3049c|M.tuberculosis_H37Rv RGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGVQ
MSMEG_4451|M.smegmatis_MC2_155 LGITVPGFPNLFLMYGPNTNLGHSSIVYMLESQAAYLAAALRVMRAEGLA
MMAR_3136|M.marinum_M LGITVPMFPNLFLLYGPNTNVGSGSIIYMIESQVRYVGALIKILASDPGR
MAB_2077|M.abscessus_ATCC_1997 LGITVPMFPNLFLLYGPNTNVGSGSILYMIESQVRHIATLIKAVAAHPGH
Mflv_4605|M.gilvum_PYR-GCK YGLSVPEFPNFLMMYGPNTNVGSGSIVYMLESQARHIVRLMKVLRAHPGS
MAV_5119|M.avium_104 LGMAVPGFPNFFMLYGPNTNVGSNSVIFVLEAQARYIVRALKYLRRHRRR
MUL_1053|M.ulcerans_Agy99 LGMAVPGFPNFFMLCGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSKT
TH_3452|M.thermoresistible__bu LGMTVPGFPNFFMLYGPNTNVGSNSVLFILEAQARYVVKALKRLRRRDTS
Mvan_2243|M.vanbaalenii_PYR-1 LGMAVPGYPNFFMLYGPNTNVGSNSVIFMLEAQAHYIVRALKYMRRKNRS
MLBr_00065|M.leprae_Br4923 KGMMLSGLPNMIYTVGYTN----ASWTLKADLVSEFFCRLLNYMNANDFD
*: :. **:: * .. * : .. :
Mb3075c|M.bovis_AF2122/97 ALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYTW
Rv3049c|M.tuberculosis_H37Rv ALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYTW
MSMEG_4451|M.smegmatis_MC2_155 SIDVRPDAERTYNEWINDALTNTVWNSGGCSSWYLDSRGRNSVMWPTFTF
MMAR_3136|M.marinum_M TVDVRPDIEQSYNTRLSRRLRRSVWA--LCASWYTTSSGAIPTNWPGPTF
MAB_2077|M.abscessus_ATCC_1997 AIDVRTESAQRYNTRLRRRLRRSVWA--LCASWYRTSSGEIPTNWPGPTL
Mflv_4605|M.gilvum_PYR-GCK VIEVRADVEKRFNDRLSRRLDRSVWT--MCTSWYRSARGSISTNWPSPTF
MAV_5119|M.avium_104 YIAVRPAALADFVAKIDRWMVGTVWTT-QCSNYFRAPNGRVVTQWPRSAR
MUL_1053|M.ulcerans_Agy99 YIAVRPGVLAEFIAKVDRWMTGTVWTT-ECSNYFRAPNGRVVTQWPRSAR
TH_3452|M.thermoresistible__bu YIAVRPDTAAAFLAKVDQWMQGKVWST-QCNNYFRAPNGRVVTQWPRSAR
Mvan_2243|M.vanbaalenii_PYR-1 YIEVRSDVMTRFLERIDTWMQGTVWLT-RCSNYFRAPNGRVVTQWPRSAR
MLBr_00065|M.leprae_Br4923 TVAVEYPGSDVEERPFMDFTPGYVLRS---LDALPKQGSRTPWRLNQNYL
: . * . .
Mb3075c|M.bovis_AF2122/97 QYWLTTRSVNPAEYRFFGIGNGLS------------------------SD
Rv3049c|M.tuberculosis_H37Rv QYWLTTRSVNPAEYRFFGIGNGLS------------------------SD
MSMEG_4451|M.smegmatis_MC2_155 RFRARTRSFDVINYDTLRTRQQIRGVEQRCESQL------------ADAD
MMAR_3136|M.marinum_M AYRILTRKPRSHDYLFRH---VERLQLD--------------------GP
MAB_2077|M.abscessus_ATCC_1997 VYRLLTRKPHSGDYVLRN---VGRLKVG--------------------DP
Mflv_4605|M.gilvum_PYR-GCK LYRLRARRPKRRAYVLSRPAPANSSRRG--------------------TP
MAV_5119|M.avium_104 AFWSMTRRFRPADYRFQAPAVRVP------------------------AP
MUL_1053|M.ulcerans_Agy99 SFWGMTRRFKPADFSFQPAAVFAADGGDRNAGQRWPNPRPSIGWTPCCAP
TH_3452|M.thermoresistible__bu AFWAMTRRFRSADYLFEPAPDMSEVS----------------------AD
Mvan_2243|M.vanbaalenii_PYR-1 TFWGLTRRFNPGDYGFDAPSSRSRIR----------------------VG
MLBr_00065|M.leprae_Br4923 RDIRLIRRGKVADEGLLFAKKTTPVTV-----------------------
*
Mb3075c|M.bovis_AF2122/97 RATVAAAN------------------------------------------
Rv3049c|M.tuberculosis_H37Rv RATVAAAN------------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 REILAGQIRLAGEDESVTPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVA
MMAR_3136|M.marinum_M SENRARLRR-----------------------------------------
MAB_2077|M.abscessus_ATCC_1997 AEP--SLAD-----------------------------------------
Mflv_4605|M.gilvum_PYR-GCK EPANTHLADMPYAPSGADSVD-----------------------------
MAV_5119|M.avium_104 ASEADAR-------------------------------------------
MUL_1053|M.ulcerans_Agy99 SRRRESTSPRSRS-------------------------------------
TH_3452|M.thermoresistible__bu ARPVASR-------------------------------------------
Mvan_2243|M.vanbaalenii_PYR-1 AQTSVKQP------------------------------------------
MLBr_00065|M.leprae_Br4923 --------------------------------------------------
Mb3075c|M.bovis_AF2122/97 ----
Rv3049c|M.tuberculosis_H37Rv ----
MSMEG_4451|M.smegmatis_MC2_155 MNGE
MMAR_3136|M.marinum_M ----
MAB_2077|M.abscessus_ATCC_1997 ----
Mflv_4605|M.gilvum_PYR-GCK ----
MAV_5119|M.avium_104 ----
MUL_1053|M.ulcerans_Agy99 ----
TH_3452|M.thermoresistible__bu ----
Mvan_2243|M.vanbaalenii_PYR-1 ----
MLBr_00065|M.leprae_Br4923 ----