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MSAPASSTPTLPASVHTLVVGAGFAGLAAAAAVLREDPRADLLIIERADEVGGTWRDNTYPGCACDVPTS LYSFSFAPSAKWSHTFARQPEIHRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRTSLGMVTATV LVAATGALSTPKLPDVPGLDRFGGTVFHSATWNHDHDLTDERVAVVGTGASAVQFVPEIADRTAHLTVFQ RTPAWVLPRLDRTLGRLERALYRRIPLSQRLVRGMVYIYREGYLALLAHLTWLLPLLEIIAKTQLRRQVP DPALRRALTPDFRIGCKRILLTNDWLPTLARDDVEVVTTALTEVTETGVRDGTGRLHDVDTIIFATGFTP TEPPVAHQLTGVTGTTLAAHWAGSPSAHLGITVPGFPNLFLMYGPNTNLGHSSIVYMLESQAAYLAAALR VMRAEGLASIDVRPDAERTYNEWINDALTNTVWNSGGCSSWYLDSRGRNSVMWPTFTFRFRARTRSFDVI NYDTLRTRQQIRGVEQRCESQLADADREILAGQIRLAGEDESVTPSTLRTVRRDQRYMTRGRIHAEVADL LDRTVAMNGE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4451 | - | - | 100% (570) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2310 | - | e-111 | 40.90% (489) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1030 | - | e-111 | 40.90% (489) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 1e-113 | 42.51% (501) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4287 | - | 1e-110 | 41.20% (500) | putative monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 1e-113 | 42.51% (501) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-26 | 25.82% (395) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_3920c | - | 1e-115 | 42.98% (484) | monooxygenase |
| M. marinum M | MMAR_1644 | - | 1e-111 | 42.08% (480) | monooxygenase |
| M. avium 104 | MAV_3915 | - | 1e-111 | 42.98% (477) | flavin-containing monooxygenase FMO |
| M. thermoresistible (build 8) | TH_4080 | - | 1e-116 | 42.77% (491) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1880 | - | 1e-110 | 41.67% (480) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2059 | - | 1e-105 | 39.68% (499) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3075c|M.bovis_AF2122/97 ---MSIADTAAKPSTP----SPANQPPVRTRAVIIGTGFSGLGMAIALQK
Rv3049c|M.tuberculosis_H37Rv ---MSIADTAAKPSTP----SPANQPPVRTRAVIIGTGFSGLGMAIALQK
MMAR_1644|M.marinum_M MTDVVIPSTETTASGE----PQAPTPPVKTRAVIIGTGFSGLGMAIALQK
MUL_1880|M.ulcerans_Agy99 MTDVVIPSTETTASGE----PQAPTPPVKTRAVIIGTGFSGLGMAIALQK
MAV_3915|M.avium_104 MTDVVT-HTETAPTPA----AKAAKP-VHTRAVIIGTGFSGLGMAIALQK
TH_4080|M.thermoresistible__bu ---MTVTEPSADITPA----NTPTQPPVRTRALIVGTGFSGLGMAIALQR
Mflv_4287|M.gilvum_PYR-GCK -------MTVAESADT----TAPPQTPVRTRTLIIGSGFSGLGMAIELQR
Mvan_2059|M.vanbaalenii_PYR-1 -------MTVAEQADL----TSAGQTPVRTRALIIGSGFSGLGMGIELQR
MAB_3920c|M.abscessus_ATCC_199 ---MTVTETSHEEQRPDTVGDGGSSEPIRIRALIVGTGFSGIGAGIALQK
MSMEG_4451|M.smegmatis_MC2_155 -------MSAPASSTP--------TLPASVHTLVVGAGFAGLAAAAAVLR
MLBr_00065|M.leprae_Br4923 -------MVVMAETEY-------------LDVVIVGAGISGVSAAWHLQD
.:::*:*::*:. . :
Mb3075c|M.bovis_AF2122/97 QG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHL
Rv3049c|M.tuberculosis_H37Rv QG--VDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHL
MMAR_1644|M.marinum_M QG--VDFVILEKSDDVGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWRNP
MUL_1880|M.ulcerans_Agy99 QG--VDFVILEKSDDVGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWRNP
MAV_3915|M.avium_104 QG--VGFVILEKADDIGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWKNP
TH_4080|M.thermoresistible__bu RG--IDFLMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHL
Mflv_4287|M.gilvum_PYR-GCK RG--VDFLILEKSDEIGGTWRDNTYPGCACDIPSHMYSFSFEPKADWSHM
Mvan_2059|M.vanbaalenii_PYR-1 RG--VDFLILEKADEIGGTWRDNTYPGCACDIPSHMYSFSFEPKPDWTHM
MAB_3920c|M.abscessus_ATCC_199 MG--VPFHILEKAGEMGGTWRDNTYPGAACDVPTHLYSFSFEPRSTWDRL
MSMEG_4451|M.smegmatis_MC2_155 EDPRADLLIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHT
MLBr_00065|M.leprae_Br4923 RCPNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAI
::*: :**** *** .* .* * * .
Mb3075c|M.bovis_AF2122/97 FSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---A
Rv3049c|M.tuberculosis_H37Rv FSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---A
MMAR_1644|M.marinum_M FSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFT---S
MUL_1880|M.ulcerans_Agy99 FSYQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFT---S
MAV_3915|M.avium_104 FSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFT---T
TH_4080|M.thermoresistible__bu FSYQDEIQEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFT---A
Mflv_4287|M.gilvum_PYR-GCK WSFQPEIQEYLLGVTAKYGLRRYIEFGAHVDRAHWDDAEMRWHVFT---K
Mvan_2059|M.vanbaalenii_PYR-1 WSFQPEIQDYLLGVTAKYGLRRYVEFGAHVDRALWDDDEMRWHVHT---K
MAB_3920c|M.abscessus_ATCC_199 FSQQPEIFDYLKEVGAKYGLYRHVTFNTRVTRGYWDEDEYRWHVFT---D
MSMEG_4451|M.smegmatis_MC2_155 FARQPEIHRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRT---S
MLBr_00065|M.leprae_Br4923 ADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNG
* *: . *: ::: . : . *.. * ** * .
Mb3075c|M.bovis_AF2122/97 DGREYVAQFLISGAGALHIPS--FPEIAGRDEFAGP---AFHSAQWDHSI
Rv3049c|M.tuberculosis_H37Rv DGREYVAQFLISGAGALHIPS--FPEIAGRDEFAGP---AFHSAQWDHSI
MMAR_1644|M.marinum_M DGREYVAQFLISGAGALHIPS--LPEIEGREEFAGP---AFHSAEWDHSV
MUL_1880|M.ulcerans_Agy99 DGREYVAQFLISGAGALHIPS--SPEIEGREEFAGP---AFHSAEWDHSV
MAV_3915|M.avium_104 DGREYVAQFLISGAGALHIPS--LPDIEGRDEFAGP---AFHSAEWDHTV
TH_4080|M.thermoresistible__bu DGREYIAQFLISCAGALHIPS--IPDFPGRDQFAGP---AFHSAQWDHSV
Mflv_4287|M.gilvum_PYR-GCK DGREFIAQFLVSGAGGLHIPL--IPEFEGYDDFLASGRAAFHSAQWDHSV
Mvan_2059|M.vanbaalenii_PYR-1 DGREFIAQFLISGAGGLHIPL--IPEFDGYDEYLAAGRVAFHSAQWDHDV
MAB_3920c|M.abscessus_ATCC_199 GGQEYICQFLISGVGALHIPS--IPEIEGLDRFEGP---VFHSAQWNHDY
MSMEG_4451|M.smegmatis_MC2_155 LG-MVTATVLVAATGALSTPK--LPDVPGLDRFGGT---VFHSATWNHDH
MLBr_00065|M.leprae_Br4923 TPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGP---IIHPQHWPEDL
. .*. * * . * : : .. :*. * .
Mb3075c|M.bovis_AF2122/97 DLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELP
Rv3049c|M.tuberculosis_H37Rv DLTGKRVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELP
MMAR_1644|M.marinum_M DLTGKRVAIIGTGASAIQIVPEIVEQ-VGELQLYQRTPPWVVPRSNPEIP
MUL_1880|M.ulcerans_Agy99 DLTGKRVAIIGAGASAIQIVPEIVEQ-VGELQLYQRTPPWVVPRSNPEIP
MAV_3915|M.avium_104 DLTGKRVAVIGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRSNPEIP
TH_4080|M.thermoresistible__bu DLTGKRVAVIGTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELP
Mflv_4287|M.gilvum_PYR-GCK DIAGKKVAVIGTGASAIQIVPEIVED-VAELQLYQRTPAWVMPRPNNPIP
Mvan_2059|M.vanbaalenii_PYR-1 DITGKKVAVIGTGASAIQIVPEIVKD-VDELQLYQRTPAWVMPRPNNPIP
MAB_3920c|M.abscessus_ATCC_199 DLTGKKVAVIGTGASAIQFVPEIVGK-VGELKLFQRTPPWVLPRTNVEFG
MSMEG_4451|M.smegmatis_MC2_155 DLTDERVAVVGTGASAVQFVPEIADR-TAHLTVFQRTPAWVLPRLDRTLG
MLBr_00065|M.leprae_Br4923 DYAAKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKI
* : :.:.::*:**:*: :** : . .: : **:*.:::.:
Mb3075c|M.bovis_AF2122/97 VSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNI
Rv3049c|M.tuberculosis_H37Rv VSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNI
MMAR_1644|M.marinum_M PALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYAKYNI
MUL_1880|M.ulcerans_Agy99 PALRRAMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYAKYNI
MAV_3915|M.avium_104 PAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAYAKYNI
TH_4080|M.thermoresistible__bu AWLRRALENIPGLRLALRGGIYALQEALAVGMTKYPGMLRIGHLLGKWNI
Mflv_4287|M.gilvum_PYR-GCK EGMQRAFATVPGTRAAMRAGIYWIHETVGFAMTKQPKLLKIGELLGKWNI
Mvan_2059|M.vanbaalenii_PYR-1 EGLQRVFTNVPGTRAAMRAGIYWLHEAVGFAMTKQPRLLKLGELAGKWNI
MAB_3920c|M.abscessus_ATCC_199 ALAKRAFAGVPGLRALFRSGMYFGAEAGAYAMNRRPALLKGIELLGRAYI
MSMEG_4451|M.smegmatis_MC2_155 RLERALYRRIPLSQRLVRGMVYIYREGYLALLAHLTWLLPLLEIIAKTQL
MLBr_00065|M.leprae_Br4923 AARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWP--QRMRNILLGHVA
* . : . .
Mb3075c|M.bovis_AF2122/97 RRSVKDRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELITDRIDR
Rv3049c|M.tuberculosis_H37Rv RRSVKDRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELITDRIDR
MMAR_1644|M.marinum_M RRSVKDRELRRKLTPHYRIGCKRILNS--SSYYPAVANPKTRLITDRIAR
MUL_1880|M.ulcerans_Agy99 RRSVKDRELRRKLTPHYRIGCKRILNS--SSYYPAVANPKTRLITDRIAR
MAV_3915|M.avium_104 RRSVKDKELRRKLTPHYRIGCKRILNS--STYYGAVADPKTELVTDHIAR
TH_4080|M.thermoresistible__bu NRSVKDPQLRAKLTPDYRLGCKRILNS--STYYPAVADPRTEVITESIDR
Mflv_4287|M.gilvum_PYR-GCK RRSVKDPVLRRKLTPDYRAGCKRILNS--DTYYRGIADPRTEVITDRIAR
Mvan_2059|M.vanbaalenii_PYR-1 RRSIKDRELRRKLTPDYRAGCKRILNS--DTYYRGIADPRTEVITDRIAR
MAB_3920c|M.abscessus_ATCC_199 KSQISDPEVRRKVTPDYRAGCKRLLGS--ATYYKAIENRKTELVTEAITR
MSMEG_4451|M.smegmatis_MC2_155 RRQVPDPALRRALTPDFRIGCKRILLT--NDWLPTLARDDVEVVTTALTE
MLBr_00065|M.leprae_Br4923 RRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDR
. . :: . * :. :*: : . ::* : .
Mb3075c|M.bovis_AF2122/97 ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
Rv3049c|M.tuberculosis_H37Rv ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
MMAR_1644|M.marinum_M ITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLVD
MUL_1880|M.ulcerans_Agy99 ITRNGIVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLVD
MAV_3915|M.avium_104 ITPDGIVTADG----THRPVDVIVYATGFHVTDSYTYVQIKGLHGEDLVD
TH_4080|M.thermoresistible__bu ITTDGIVTSDG----TERAVDVIVYATGFHVSDSYKYVQIKGLNGEDIVD
Mflv_4287|M.gilvum_PYR-GCK FTARGIVTADEHGRETEREADVVVFATGFHVTDSYTYVDIKGPGGEDLVD
Mvan_2059|M.vanbaalenii_PYR-1 FSPRGIVTTDEHGRETEREADVVVFATGFHVTDSYTYVDIKGPGGVDLVD
MAB_3920c|M.abscessus_ATCC_199 VTTDGVVTSDG----IERKVDAIIFGTGFHVTDSYKYLDLKGQGGEDLGE
MSMEG_4451|M.smegmatis_MC2_155 VTETGVRDGTG----RLHDVDTIIFATGFTPTEPPVAHQLTGVTGTTLAA
MLBr_00065|M.leprae_Br4923 FTSTGIRLKSG----NELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQ
.: *: .* :: .**: . :
Mb3075c|M.bovis_AF2122/97 RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
Rv3049c|M.tuberculosis_H37Rv RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MMAR_1644|M.marinum_M RWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MUL_1880|M.ulcerans_Agy99 RWNREGIGAHRGIAVADVPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MAV_3915|M.avium_104 RWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIRYVADA
TH_4080|M.thermoresistible__bu RFNREGPMAHRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEA
Mflv_4287|M.gilvum_PYR-GCK RWNREGISALRGITVAGMPNLFFLLGPNTALGHNSVVFMIESQIRYAAKA
Mvan_2059|M.vanbaalenii_PYR-1 RWNREGIAALRGITVADMPNLFFLLGPNTALGHNSVVFMIESQIRYAAKA
MAB_3920c|M.abscessus_ATCC_199 RWSSQGVTAHRGITIAGMPNLFFLLGPNTGLGHNSIVFMIESQIHYVTEA
MSMEG_4451|M.smegmatis_MC2_155 HWAG-SPSAHLGITVPGFPNLFLMYGPNTNLGHSSIVYMLESQAAYLAAA
MLBr_00065|M.leprae_Br4923 ------TMSYKGMMLSGLPNMIYTVG----YTNASWTLKADLVSEFFCRL
: * :...** * : * . : :
Mb3075c|M.bovis_AF2122/97 IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
Rv3049c|M.tuberculosis_H37Rv IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
MMAR_1644|M.marinum_M IAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHGR
MUL_1880|M.ulcerans_Agy99 IAKCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHGR
MAV_3915|M.avium_104 IATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEHGK
TH_4080|M.thermoresistible__bu IKAVDKAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCRSWYLDEHGN
Mflv_4287|M.gilvum_PYR-GCK IAAVEKKGVQCLTPTREAQDAYNDELQDDLRGTVWSTGGCRSWYLDEHGV
Mvan_2059|M.vanbaalenii_PYR-1 IAAVDKAGAQALAPTRAAQDDYNDELQHDLGGTVWSTGGCRSWYLDEHGV
MAB_3920c|M.abscessus_ATCC_199 IKQVDAAYAQALVPTREAQDRFNAEVQRKLQGSVWNSGGCQSWYLDEHGK
MSMEG_4451|M.smegmatis_MC2_155 LRVMRAEGLASIDVRPDAERTYNEWINDALTNTVWNSGGCSSWYLDSRGR
MLBr_00065|M.leprae_Br4923 LNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDA----LPKQG-
: : .. : . * : .. * .:*
Mb3075c|M.bovis_AF2122/97 NTVLWCGYTWQYWLTTRSVNPA------------------EYRFFGIGNG
Rv3049c|M.tuberculosis_H37Rv NTVLWCGYTWQYWLTTRSVNPA------------------EYRFFGIGNG
MMAR_1644|M.marinum_M NTVLWCGYTWQYWLATRSVKPE------------------EYQFFKAG--
MUL_1880|M.ulcerans_Agy99 NTVLWCGYTWQYWLATRSVKPE------------------EYQFFKAG--
MAV_3915|M.avium_104 NTVLWGGYTWEYWRATRAVKPE------------------EYQFYGIG--
TH_4080|M.thermoresistible__bu NRVLWGGFTWQYRLATRTLDPA------------------EYRFWG----
Mflv_4287|M.gilvum_PYR-GCK NRTLWSGMTWQYWLATRRFKES------------------EYTFG-----
Mvan_2059|M.vanbaalenii_PYR-1 NRTLWSGMTWQYWLATRRFNKS------------------EYTFR-----
MAB_3920c|M.abscessus_ATCC_199 NRTLWSGFTFEYWSQTRKVDPS------------------EYEFEGAVRP
MSMEG_4451|M.smegmatis_MC2_155 NSVMWPTFTFRFRARTRSFDVINYDTLRTRQQIRGVEQRCESQLADADRE
MLBr_00065|M.leprae_Br4923 SRTPWR-LNQNYLRDIRLIRRG--------------------KVADEGLL
. . * . .: * . .
Mb3075c|M.bovis_AF2122/97 LSSDRATVAAAN--------------------------------------
Rv3049c|M.tuberculosis_H37Rv LSSDRATVAAAN--------------------------------------
MMAR_1644|M.marinum_M ---AKSSVNG----------------------------------------
MUL_1880|M.ulcerans_Agy99 ---AKSSVNG----------------------------------------
MAV_3915|M.avium_104 ---SRAGV------------------------------------------
TH_4080|M.thermoresistible__bu --------------------------------------------------
Mflv_4287|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2059|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3920c|M.abscessus_ATCC_199 AVRRTIPRADGPRQKSPSMAAQ----------------------------
MSMEG_4451|M.smegmatis_MC2_155 ILAGQIRLAGEDESVTPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVAMN
MLBr_00065|M.leprae_Br4923 FAKKTTPVTV----------------------------------------
Mb3075c|M.bovis_AF2122/97 --
Rv3049c|M.tuberculosis_H37Rv --
MMAR_1644|M.marinum_M --
MUL_1880|M.ulcerans_Agy99 --
MAV_3915|M.avium_104 --
TH_4080|M.thermoresistible__bu --
Mflv_4287|M.gilvum_PYR-GCK --
Mvan_2059|M.vanbaalenii_PYR-1 --
MAB_3920c|M.abscessus_ATCC_199 --
MSMEG_4451|M.smegmatis_MC2_155 GE
MLBr_00065|M.leprae_Br4923 --