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TRMGGKTVITTVEITRLVVPTMEGYQEGSAMSAEGRRVVVVGAGSGIGAATAAWFHSRGDHVLAVDARPR SGPFAEWLVCDLRSADEIEGALGRIGHGWDVLAHVAGIPGTADARDVLTVNYLGARLMLDGMLPLMNHGG SMVAVASTAALGWDSNIGLLSGLLDARDTTAVTRWLEAQDPSMAYYLSKQALVLYAKRLSGVAWREYGVR VNTVSPGPTETPILGDFEESMGRDMLDGVRTTIGRHGTVDDMTPAIGFLSSPEARWINGQDIHVDGGFTA ALVHPMPERAQV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4338 | - | - | 100% (293) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2405 | - | 1e-31 | 34.26% (251) | 3-alpha-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0943 | - | 5e-17 | 29.21% (267) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 1e-13 | 27.00% (263) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 1e-13 | 27.00% (263) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-07 | 27.27% (264) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0691 | - | 2e-17 | 28.52% (270) | short chain dehydrogenase |
| M. marinum M | MMAR_4773 | - | 4e-32 | 33.20% (253) | dehydrogenase/reductase |
| M. avium 104 | MAV_5096 | - | 3e-45 | 39.00% (259) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 5e-30 | 33.20% (253) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_2988 | - | 7e-92 | 62.79% (258) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0344 | - | 2e-32 | 33.20% (253) | 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2008 | - | 3e-87 | 62.02% (258) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
TH_2988|M.thermoresistible__bu -------------------------------MGAEP-----------RRI
Mvan_2008|M.vanbaalenii_PYR-1 -------------------------------MQVEK-----------RRI
Mflv_4338|M.gilvum_PYR-GCK MTRMGGKTVITTVEITRLVVPTMEGYQEGSAMSAEG-----------RRV
MAV_5096|M.avium_104 ------------------------------MAHFQG-----------KRY
MMAR_4773|M.marinum_M ------------------------MAQIEQLWRYDG-----------RRA
MUL_0344|M.ulcerans_Agy99 ------------------------MAQIEQLWRYDG-----------RRA
MSMEG_4862|M.smegmatis_MC2_155 ------------------------MAALDALVRYDG-----------RHV
Mb2882c|M.bovis_AF2122/97 --------------------------MMDLSQRLAG-----------RVA
Rv2857c|M.tuberculosis_H37Rv --------------------------MMDLSQRLAG-----------RVA
MLBr_01807|M.leprae_Br4923 --------------------------MTDAAAKVSAAPGRGKPAFVSRSI
MAB_0691|M.abscessus_ATCC_1997 --------------------------MPDEVVVVIG---------VGGMG
TH_2988|M.thermoresistible__bu VVVGAGSGIGAATAAHFHNRGEHVVA----VDIKPN--DTPAARHVRCDL
Mvan_2008|M.vanbaalenii_PYR-1 VVVGAGSGIGAAVAAHFHDNGDHVLA----VDLRPN--DTPAAAHAQCDL
Mflv_4338|M.gilvum_PYR-GCK VVVGAGSGIGAATAAWFHSRGDHVLA----VDARPR--SGPFAEWLVCDL
MAV_5096|M.avium_104 VVTGAASGIGNAVAERLLAAGAEVYC----LDRNQP--AANVTRHIEVDL
MMAR_4773|M.marinum_M VVTGCASGIGERAVHQLTGLGAQVVG----LDQRQP--GYEISEFHQIDL
MUL_0344|M.ulcerans_Agy99 VVTGCASGIGERAVHRLTGLGAQVVG----LDQRQP--GYEISEFHQIDL
MSMEG_4862|M.smegmatis_MC2_155 VVTGCSSGIGAKVTDQLRCLGARVTG----LDLRAPDSGAGPDAFREMDL
Mb2882c|M.bovis_AF2122/97 VITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGAAADELSGLFVPTDV
Rv2857c|M.tuberculosis_H37Rv VITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGAAADELSGLFVPTDV
MLBr_01807|M.leprae_Br4923 LVTGGNRGIGLAVARRLVADGHRVAV----THRASVVPDWFFG--VECDV
MAB_0691|M.abscessus_ATCC_1997 RVIARRQGIGKALLLADHNEQALQAV----VDELKADGHNVIGQRVDVSS
: . *** . .
TH_2988|M.thermoresistible__bu RDPADIAGTLDEIGTGWDLLAHVAGVP-GTAAAADVLKINYLGMRLITEG
Mvan_2008|M.vanbaalenii_PYR-1 RDPQSIAGLLDDIGADWDVLAHVAGVP-GTAPADDVLTVNYLGMRKMVEG
Mflv_4338|M.gilvum_PYR-GCK RSADEIEGALGRIGHGWDVLAHVAGIP-GTADARDVLTVNYLGARLMLDG
MAV_5096|M.avium_104 ANPHSIDAAVGQLDGDFDGLMNVAGIP-GTAPADLVLAVNSLAVRHLTEL
MMAR_4773|M.marinum_M ADPGSIGRAVEAIGGPVDALFNIAGVSSGIGDPLLVVTINFLGLRQLTEA
MUL_0344|M.ulcerans_Agy99 ADPGSIDRAVEAIGGPVDALFNIAGVSSGIGDPLLVVTINFLGLRHLTEA
MSMEG_4862|M.smegmatis_MC2_155 ADPDSVDAAAAAIDGPVHALFNVAGVSSGIGDPLLVVRINFLGTRQFTEA
Mb2882c|M.bovis_AF2122/97 CDEDAVNGLFDGAAETYGRIDIAFNNA-GISPPEDNLIEN------TELA
Rv2857c|M.tuberculosis_H37Rv CDEDAVNGLFDGAAETYGRIDIAFNNA-GISPPEDNLIEN------TELA
MLBr_01807|M.leprae_Br4923 TDNDAIGAAFKAVEEHQGPVEVLVANA-GITS--DMLIMR------MSEE
MAB_0691|M.abscessus_ATCC_1997 RASVSGLAQAAAGLGRVAQVAHTAGLSPAQSPTAAILAVDLVGVALVVEE
: . . :
TH_2988|M.thermoresistible__bu MLPRLRQGGAVVAVASTAAVGWEQRTETLAGLLDATDADAVERWQAEQD-
Mvan_2008|M.vanbaalenii_PYR-1 MLPRMRRGGSVVAVASIAGIGWEQRLDELSELLAATDPEAVAAWQSRQD-
Mflv_4338|M.gilvum_PYR-GCK MLPLMNHGGSMVAVASTAALGWDSNIGLLSGLLDARDTTAVTRWLEAQD-
MAV_5096|M.avium_104 FFDRLKPGGSVTIVSSTAGFGWPHRLDAIRDLLATDTYEEGAAWFKAHP-
MMAR_4773|M.marinum_M LLPMMGPGSAIVSVSSLAAAGYREHHRAVAPLVNTTTMVEGIDWCKRHLE
MUL_0344|M.ulcerans_Agy99 LLPMMGPGSAIVSVSSLAAAGYREHHRAVAPLLNTTTMVEGIDWCKRHLE
MSMEG_4862|M.smegmatis_MC2_155 LVDRIADGGSITSVSSLAASAYRENRAVTAGLVSTGSVDEGLRWCAENPD
Mb2882c|M.bovis_AF2122/97 AWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQIS
Rv2857c|M.tuberculosis_H37Rv AWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQIS
MLBr_01807|M.leprae_Br4923 QFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSG-VPGQAN
MAB_0691|M.abscessus_ATCC_1997 FGKIVASGGAGVVIASMAGHMPYELTAEQEQELGTTHAEDLLSLPYVRDI
: . : .
TH_2988|M.thermoresistible__bu -PAYPVYSSSKQAVILYAKRLAGPAWTKYGVRINTVSPGPVETPI-LPDF
Mvan_2008|M.vanbaalenii_PYR-1 -PSYPVYTTSKQAVILYAKRLAGTALSRYGVRVNTVSPGPVETPI-LADF
Mflv_4338|M.gilvum_PYR-GCK -PSMAYYLS-KQALVLYAKRLSGVAWREYGVRVNTVSPGPTETPI-LGDF
MAV_5096|M.avium_104 -QQGNAYNFSKEVSTVYTLSMG-LAFAEMGFRINAVLPGPVQTPI-LPDF
MMAR_4773|M.marinum_M VLGAG-YQLSKEAVILYTMRSA-VGLGARGIRINCTGPGVTETPI-LDQL
MUL_0344|M.ulcerans_Agy99 VLGAG-YQLSKEAVILYTMRSA-VGLGARGIRINCTGPGVTETPI-LDQL
MSMEG_4862|M.smegmatis_MC2_155 ALADGGYRLSKEAIILYGMSKA-VELGARGIRVNCTGPGVTDTPI-LDQL
Mb2882c|M.bovis_AF2122/97 ------YTASKGGVLAMSRELG-VQFARQGIRVNALCPGPVNTPL-LQEL
Rv2857c|M.tuberculosis_H37Rv ------YTASKGGVLAMSRELG-VQFARQGIRVNALCPGPVNTPL-LQEL
MLBr_01807|M.leprae_Br4923 ------YAASKSGLIGMARSLA-RELGSRSITANVVAPGFIDTEM-TRAM
MAB_0691|M.abscessus_ATCC_1997 EHPAVAYQVSKRANHIRVRFAA-RQWGTRGARINSISPGVVSTPMGHQEL
* * . . * ** .* : :
TH_2988|M.thermoresistible__bu ERTMG-KDILDMVRATVGRHATVDDVVPVIDFLGSPAARWITGQDIHVDA
Mvan_2008|M.vanbaalenii_PYR-1 EQTMG-KEILDMLRDTYGRHGTVDDIVPVIAFLASDAAQWINGQDVHVDS
Mflv_4338|M.gilvum_PYR-GCK EESMG-RDMLDGVRTTIGRHGTVDDMTPAIGFLSSPEARWINGQDIHVDG
MAV_5096|M.avium_104 EESMG-KDTLDGLKNLLGRHADPGDIADVVLFLASDDARWVNGQALAADG
MMAR_4773|M.marinum_M TTAYG-AEFLDDIAKPLGRVATPGEQASVLVFLNGHAASYISGQVVWVDG
MUL_0344|M.ulcerans_Agy99 TTAYG-AEFPDDIAKPLGRVATPGEQASVLVFLNGHSASYISGQVVRVDG
MSMEG_4862|M.smegmatis_MC2_155 RSAYG-QQYLDSFTTPLGRNSEPDEQAALLVFLGSAAASYVTGQVIWADG
Mb2882c|M.bovis_AF2122/97 FAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASFITASTFLVDG
Rv2857c|M.tuberculosis_H37Rv FAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASFITASTFLVDG
MLBr_01807|M.leprae_Br4923 DSKYQEAALQ---AIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDG
MAB_0691|M.abscessus_ATCC_1997 ASETGAITKAMVDGSASRRIGTSDDIAAAAAFLLGPESSYVTGTDLLVDG
* . : . ** . : ::.. . .*.
TH_2988|M.thermoresistible__bu GYITSLTCGIPIEL------
Mvan_2008|M.vanbaalenii_PYR-1 GFVTSMTAGTPIAL------
Mflv_4338|M.gilvum_PYR-GCK GFTAALVHPMPERAQV----
MAV_5096|M.avium_104 GISGAVASGVVPAPEI----
MMAR_4773|M.marinum_M GNVAASIAGELGEGRA----
MUL_0344|M.ulcerans_Agy99 GNVAASIAGELGEGRA----
MSMEG_4862|M.smegmatis_MC2_155 GIIAQRETALIESTRATQES
Mb2882c|M.bovis_AF2122/97 GISSAYVTPL----------
Rv2857c|M.tuberculosis_H37Rv GISSAYVTPL----------
MLBr_01807|M.leprae_Br4923 GLGMGH--------------
MAB_0691|M.abscessus_ATCC_1997 GVIAAVRSGQLFN-------
*