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SSTIVAPSVDATPIQDLAGKTAIITGGSKGIGAATVARFVRGGARVVTSGRSTPGPLPDGVEYVVADVAT VDGVEHLARRAQQILGDIDIVVNNAGATTLSLGGVLGITDADWRKDLDINFLAAVRLNAALLPAMYTRGA GSIVNVSSTVILSPPAPMLHYATAKAALATYTTGLAAEAGPRGVRVNTVTPGNVTSPGADAIRQAIVDSG GADAPAAGGTPIPLGRKGEASDIAEAIAFLVSDRAAWITATNLVIDGGQIQAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0943 | - | - | 100% (264) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1235 | - | 7e-29 | 33.46% (254) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 9e-29 | 31.20% (250) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 8e-30 | 37.45% (251) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 9e-30 | 37.45% (251) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-23 | 28.96% (259) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 9e-28 | 38.74% (253) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 6e-30 | 32.30% (257) | short chain dehydrogenase |
| M. avium 104 | MAV_3655 | fabG | 3e-30 | 37.25% (255) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_0283 | - | 2e-42 | 39.13% (253) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3708 | - | 5e-30 | 34.39% (253) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 2e-29 | 31.91% (257) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5918 | - | 1e-116 | 80.15% (262) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0943|M.gilvum_PYR-GCK -MSSTIVAPSVDATPIQDLAGKTAIITGGSKGIGAATVARFVRGGARVVT
Mvan_5918|M.vanbaalenii_PYR-1 -MNSAIVAPEVPTAPIHDLTGKNAVITGGSKGIGAATVARFVAGGARVVT
MSMEG_0283|M.smegmatis_MC2_155 ------------MSNQRPLEGRRALVTGGTKGAGAAVVRTLRASGAHVTA
Mb2788c|M.bovis_AF2122/97 -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Rv2766c|M.tuberculosis_H37Rv -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
MAV_3655|M.avium_104 -------------MTSQDLTGRTAIITGASRGIGLAIAQQLAAAGANVVL
TH_3708|M.thermoresistible__bu --------MTPDPLAAFRLDGKVALVTGGSRGLGFEMARAFAGAGADVII
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0827|M.abscessus_ATCC_1997 MTSPLK--------------SRRAFVTGGSRGIGAGIVRRLAEDGARVVF
MMAR_4765|M.marinum_M MVDELAG--------------KIAIVTGGASGIGRATVARFIAEGARVVI
MUL_0336|M.ulcerans_Agy99 MVDELAG--------------KIAIVTGGASGIGRATVARFIAEGARVVI
: .:**. * * . : * *
Mflv_0943|M.gilvum_PYR-GCK SGRSTPGPLPDGVEYV----------VADVATVDGVEHLARRAQQILGDI
Mvan_5918|M.vanbaalenii_PYR-1 SGRSQPDSLPTGVEYV----------VADVATLDGVDLLARRAREILGDI
MSMEG_0283|M.smegmatis_MC2_155 VAR-RPG--GDADEFV----------AADVMSEAGIAEIATHVRATGG-V
Mb2788c|M.bovis_AF2122/97 TARRQEAADEAAAQVG----DRALGVGAHAVDEDAARRCVDLTLERFGSV
Rv2766c|M.tuberculosis_H37Rv TARRQEAADEAAAQVG----DRALGVGAHAVDEDAARRCVDLTLERFGSV
MAV_3655|M.avium_104 TARKQEAADEAAAQVG----PQALGVGAHAVDEDAARQCVQLTLERFGSV
TH_3708|M.thermoresistible__bu SSRDEESCRRAAEEIGRTFAVRAVPMPCHVGRWAELDALADRALATFGHV
MLBr_01807|M.leprae_Br4923 THRASVVP------------DWFFGVECDVTDNDAIGAAFKAVEEHQGPV
MAB_0827|M.abscessus_ATCC_1997 TYSSSVQQAADVVDDINEDGGWARAVKADVADPDQLGAAIGQAAEELGGL
MMAR_4765|M.marinum_M ADVEEERGES----LAAALGADAMFCRTDVSQPEQVAAVVAAAVENFGGL
MUL_0336|M.ulcerans_Agy99 ADVEEERGES----LAAALGADAMFCRTDVSQPEQVAAVVAAAVDNFGGL
.. . * :
Mflv_0943|M.gilvum_PYR-GCK DIVVNNAGATTLSLGGVLGITDADWRKDLDINFLAAVRLNAALLPAMYTR
Mvan_5918|M.vanbaalenii_PYR-1 DIIVNNAGATVPHLGGVLDIEDAEWVNDLNINFLAAVRLNAALLPALYAR
MSMEG_0283|M.smegmatis_MC2_155 HILVHVAGGSSSPAGGFAALSEQDWIDELNLNLLSAVRLDRAVAPMMIEA
Mb2788c|M.bovis_AF2122/97 DILINNAG-TNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGE
Rv2766c|M.tuberculosis_H37Rv DILINNAG-TNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGE
MAV_3655|M.avium_104 DILVNNAG-TNPAYGPLIEQDHARFAKIFDVNLWAPLLWTSLAVKSWMGE
TH_3708|M.thermoresistible__bu DVLVNNAG-MSPLYDKVADITETMWEKTLAVNLRAPFRLTALLAPAMVDN
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDML--IMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQ
MAB_0827|M.abscessus_ATCC_1997 DILVNNAGILSIGD--VDTATLADFDEIVAVNVRAVFAGIKAASPHLTEG
MMAR_4765|M.marinum_M HVMVNNAGVSGVMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH
MUL_0336|M.ulcerans_Agy99 HVMVNNAGVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH
.::: ** . : . :*. . .
Mflv_0943|M.gilvum_PYR-GCK GAGSIVNVSSTVILSPPAP-MLHYATAKAALATYTTGLAAEAGPRGVRVN
Mvan_5918|M.vanbaalenii_PYR-1 GKGSIINVSSAVTLSPPSP-MLHYATAKAALATYTTGLAAEAGPRGVRVN
MSMEG_0283|M.smegmatis_MC2_155 GGGVIVHISSIQSRMPLYDGTLGYAAAKAALRTYSKGLANELAPKGIRVN
Mb2788c|M.bovis_AF2122/97 HGGAVVNTASIGGMHQSPA-MGMYNATKAALIHVTKQLALELSPR-IRVN
Rv2766c|M.tuberculosis_H37Rv HGGAVVNTASIGGMHQSPA-MGMYNATKAALIHVTKQLALELSPR-IRVN
MAV_3655|M.avium_104 HGGSIVNTASIGGLHQSPA-MGMYNATKAALIHVTKQLALELSPR-VRVN
TH_3708|M.thermoresistible__bu GGGSVINLSSIGAVRPTAD-IVPYAAAKAGLNAMTAALAKEYGPH-VRVN
MLBr_01807|M.leprae_Br4923 RFGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLARELGSRSITAN
MAB_0827|M.abscessus_ATCC_1997 --GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLAREFGPRGITIN
MMAR_4765|M.marinum_M GGGSIVNLTSIGG-IQAGGGVMTYRASKAAVIQFTKSAAIELAHYEIRVN
MUL_0336|M.ulcerans_Agy99 GGGSIVNLTSIGG-IQAGGGVMTYRASKGAVIQFTKSAAIELAHYEIRVN
* : * * :*..: : * * . : *
Mflv_0943|M.gilvum_PYR-GCK TVTPGNVTS------------PGADAIRQAIVDSG------GADAPAAGG
Mvan_5918|M.vanbaalenii_PYR-1 TLTPGTVGS------------PGADAIRRAIIDGV------GADRPEAGG
MSMEG_0283|M.smegmatis_MC2_155 TVSPGFIRT------------TAAEALIERIAEAGNGTREQALDSLMASL
Mb2788c|M.bovis_AF2122/97 AICPGVVRT------------RLAEALWK--------------DHEDPLA
Rv2766c|M.tuberculosis_H37Rv AICPGVVRT------------RLAEALWK--------------DHEDPLA
MAV_3655|M.avium_104 AIAPGVVRT------------RLAEALWK--------------DHEDPLS
TH_3708|M.thermoresistible__bu AIMPGAFAT------------DVSEYWSA--------------EAVARVV
MLBr_01807|M.leprae_Br4923 VVAPGFIDT------------EMTRAMDSK--------------YQEAAL
MAB_0827|M.abscessus_ATCC_1997 NVQPGPIGT------------DMN-PEDGQ--------------LADILR
MMAR_4765|M.marinum_M AIAPGNIPTPLLASSAAGMDQEQVERFTAQ--------------IRQTMR
MUL_0336|M.ulcerans_Agy99 AIAPGNIPTPLLASSAAGLDQEQVERFTAQ--------------IRQTMR
: ** . :
Mflv_0943|M.gilvum_PYR-GCK TPIPLGRKGEASDIAEAIAFLVSDRAAWITATNLVIDGGQIQAG------
Mvan_5918|M.vanbaalenii_PYR-1 IPIPLGRKGEASDIAEAIAFLASDRAAWITGSNLIVDGGQIQTR------
MSMEG_0283|M.smegmatis_MC2_155 GGIPLGRPAEPDEVAGVVGFLVSDAAASVVGADIVVDGGTVPAI------
Mb2788c|M.bovis_AF2122/97 ATIALGRIGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRA
Rv2766c|M.tuberculosis_H37Rv ATIALGRIGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRA
MAV_3655|M.avium_104 SSIALGRIGEPIDVAAAVAFLVSDAASWITGETLVIDGGTVLGAAQGFRS
TH_3708|M.thermoresistible__bu DQTALGRIGDPREIVGTALYLASDAASFTSGAVITVDGGRD---------
MLBr_01807|M.leprae_Br4923 QAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH------
MAB_0827|M.abscessus_ATCC_1997 PNIAVGRYGQPRDIASLVSYLVSDEAWYITGTAINIDGGFTA--------
MMAR_4765|M.marinum_M EDRPLKREGTPEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR
MUL_0336|M.ulcerans_Agy99 EDRPLKREGTPEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR
.: * . ::. ::..: : . : :***
Mflv_0943|M.gilvum_PYR-GCK ------
Mvan_5918|M.vanbaalenii_PYR-1 ------
MSMEG_0283|M.smegmatis_MC2_155 ------
Mb2788c|M.bovis_AF2122/97 APSTEH
Rv2766c|M.tuberculosis_H37Rv APSTEH
MAV_3655|M.avium_104 APTPS-
TH_3708|M.thermoresistible__bu ------
MLBr_01807|M.leprae_Br4923 ------
MAB_0827|M.abscessus_ATCC_1997 ------
MMAR_4765|M.marinum_M ------
MUL_0336|M.ulcerans_Agy99 ------