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AALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTGLDLRAPDSGAGPDAFREMDLADPDSVDAAA AAIDGPVHALFNVAGVSSGIGDPLLVVRINFLGTRQFTEALVDRIADGGSITSVSSLAASAYRENRAVTA GLVSTGSVDEGLRWCAENPDALADGGYRLSKEAIILYGMSKAVELGARGIRVNCTGPGVTDTPILDQLRS AYGQQYLDSFTTPLGRNSEPDEQAALLVFLGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4862 | - | - | 100% (278) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5628 | - | 2e-18 | 31.11% (270) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 3e-18 | 29.67% (273) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 3e-19 | 30.40% (273) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2405 | - | 1e-108 | 75.10% (257) | 3-alpha-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 3e-19 | 30.40% (273) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-16 | 30.83% (253) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2723c | - | 3e-16 | 30.62% (258) | 3-oxoacyl- |
| M. marinum M | MMAR_4773 | - | 1e-82 | 59.54% (262) | dehydrogenase/reductase |
| M. avium 104 | MAV_0882 | - | 1e-87 | 60.44% (273) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3914 | - | 2e-42 | 37.45% (251) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_0344 | - | 2e-79 | 57.63% (262) | 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | 9e-98 | 70.92% (251) | 3-alpha-hydroxysteroid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2405|M.gilvum_PYR-GCK ----------------MRYDGRHVVVTGCASGIGAQAARLLRDLGARVTG
Mvan_4241|M.vanbaalenii_PYR-1 ------------------------------------MAHQLGSLGARVTG
MSMEG_4862|M.smegmatis_MC2_155 MAALDA---------LVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTG
MMAR_4773|M.marinum_M MAQIEQ---------LWRYDGRRAVVTGCASGIGERAVHQLTGLGAQVVG
MUL_0344|M.ulcerans_Agy99 MAQIEQ---------LWRYDGRRAVVTGCASGIGERAVHRLTGLGAQVVG
MAV_0882|M.avium_104 MAEIDA---------LWRYDGRRAVVTGCASGIGEQVVRQLGQLGADVIG
TH_3914|M.thermoresistible__bu ---------------MSEFTNRRYVVTGAASGIGDATARKLLAAGAEVTS
Mb2882c|M.bovis_AF2122/97 MMDLS-----------QRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv MMDLS-----------QRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_2723c|M.abscessus_ATCC_199 MTNA-------------EFVPRSVLVTGGNRGIGLAVAQRLAADGHKVAV
: * :
Mflv_2405|M.gilvum_PYR-GCK ----LDVRAPEDVSALTDFISVDLADQDSVRAAAAAVDGAVDALFNVAGV
Mvan_4241|M.vanbaalenii_PYR-1 ----LDLREPDAQSAIQDFVQLDLAEPRSVDAAAAAVDGRVDALFNVAGV
MSMEG_4862|M.smegmatis_MC2_155 ----LDLRAPDSGAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGV
MMAR_4773|M.marinum_M ----LDQRQP--GYEISEFHQIDLADPGSIGRAVEAIGGPVDALFNIAGV
MUL_0344|M.ulcerans_Agy99 ----LDQRQP--GYEISEFHQIDLADPGSIDRAVEAIGGPVDALFNIAGV
MAV_0882|M.avium_104 ----LDQRRP--GCALGEFHEVDLADPESIDRAAAGIDGPVDALFNIAGV
TH_3914|M.thermoresistible__bu ----MDRNPP--SAPVSRHIEVDLANPRSIDAAVEQLEGSYDGLMNIAGI
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGAA-ETYGRIDIAFN
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSGLFVPTDVCDEDAVNGLFDGAA-ETYGRIDIAFN
MLBr_01807|M.leprae_Br4923 ----THRASVVPDWFFG--VECDVTDNDAIGAAFKAVE-EHQGPVEVLVA
MAB_2723c|M.abscessus_ATCC_199 ----THRGSGAPEGLLG--VQCDITDNDQIDAAFKEVE-EKQGPVEVLVA
. *: : : . .::
Mflv_2405|M.gilvum_PYR-GCK SSGIGDPLLVLRINFLGMRQFTESLLDRMPAGGAVTNVSSLAASAYRENA
Mvan_4241|M.vanbaalenii_PYR-1 SSGIKDPLLVMRINFLGMRQFTEALIARMPEGSSITNVSSLAASAYLENA
MSMEG_4862|M.smegmatis_MC2_155 SSGIGDPLLVVRINFLGTRQFTEALVDRIADGGSITSVSSLAASAYRENR
MMAR_4773|M.marinum_M SSGIGDPLLVVTINFLGLRQLTEALLPMMGPGSAIVSVSSLAAAGYREHH
MUL_0344|M.ulcerans_Agy99 SSGIGDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVSSLAAAGYREHH
MAV_0882|M.avium_104 SSGIGNPPLVVTVNFLGTRQLTEALIPKMVAGSSIVSVSSLAAAGYREHL
TH_3914|M.thermoresistible__bu P-GTAPGETVLAVNSLAVRHLTEAFLDRLNSGGTVTTVSSTAGFGWPERL
Mb2882c|M.bovis_AF2122/97 NAGISPPEDNLIENTE------LAAWQRVQDVNLKSVYLCCRAALRHMVL
Rv2857c|M.tuberculosis_H37Rv NAGISPPEDNLIENTE------LAAWQRVQDVNLKSVYLCCRAALRHMVL
MLBr_01807|M.leprae_Br4923 NAGIT--SDMLIMRMS------EEQFQKVIDVNLTGVFRVAKLASRNMIK
MAB_2723c|M.abscessus_ATCC_199 NAGIT--ADMLIMRMS------EEQFLKVIDANLIGTFRLAKRASRNMIK
* : . : .
Mflv_2405|M.gilvum_PYR-GCK HVTAGLLATRSVDEGLRWCADHPEALADGGYRQSKEAIILYGMQRVTDLG
Mvan_4241|M.vanbaalenii_PYR-1 ATTAGLLETGSVAEGLQWCADHPEALADGGYRQSKEAIILYGMRRTADLG
MSMEG_4862|M.smegmatis_MC2_155 AVTAGLVSTGSVDEGLRWCAENPDALADGGYRLSKEAIILYGMSKAVELG
MMAR_4773|M.marinum_M RAVAPLVNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLG
MUL_0344|M.ulcerans_Agy99 RAVAPLLNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLG
MAV_0882|M.avium_104 RQVAPLLDTATMREGIDWCTSHPEELGTG-YQLSKEALILYTMRSVTPLG
TH_3914|M.thermoresistible__bu EAIRDLLATESFEDGARWFKEHP--QQGNAYNFSKEVTTVYTMTMGLTAA
Mb2882c|M.bovis_AF2122/97 AGKGSIVNTASFVAVMGSATSQIS------YTASKGGVLAMSRELGVQFA
Rv2857c|M.tuberculosis_H37Rv AGKGSIVNTASFVAVMGSATSQIS------YTASKGGVLAMSRELGVQFA
MLBr_01807|M.leprae_Br4923 QRFGRYIFMGSVVGLSG-VPGQAN------YAASKSGLIGMARSLARELG
MAB_2723c|M.abscessus_ATCC_199 KRFGRLIFMGSVAGQIG-LPGQAN------YSASKAGLVGMARALTRELG
: :. : * ** .
Mflv_2405|M.gilvum_PYR-GCK ARGIRVNCTAPGVTETPILDQLRSAYGQQYLDS-FTAPLGRVSTPEEQAA
Mvan_4241|M.vanbaalenii_PYR-1 ARGIRINCSAPGVTETPILDQLRSAYGQQYLDS-FTAPLGRVSTAEEQAA
MSMEG_4862|M.smegmatis_MC2_155 ARGIRVNCTGPGVTDTPILDQLRSAYGQQYLDS-FTTPLGRNSEPDEQAA
MMAR_4773|M.marinum_M ARGIRINCTGPGVTETPILDQLTTAYGAEFLDD-IAKPLGRVATPGEQAS
MUL_0344|M.ulcerans_Agy99 ARGIRINCTGPGVTETPILDQLTTAYGAEFPDD-IAKPLGRVATPGEQAS
MAV_0882|M.avium_104 ARGIRINCTGPGVTETPILDQLRTAYGQGFLDD-IPKPLGRVSRPAEQAA
TH_3914|M.thermoresistible__bu QRGIRINAVLPGPVETPILADFEESMGKDTLDG-VKALLGRHASPDDIAD
Mb2882c|M.bovis_AF2122/97 RQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAA
Rv2857c|M.tuberculosis_H37Rv RQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAA
MLBr_01807|M.leprae_Br4923 SRSITANVVAPGFIDTEMTRAMDSKYQEAALQ---AIPLGRIGAVEEIAG
MAB_2723c|M.abscessus_ATCC_199 SRSITANVVAPGFIDTDMTRELGEKHVETALT---AIPMGRIGEPSEVAG
:.* * ** :* : : :** . : *
Mflv_2405|M.gilvum_PYR-GCK VLVFLGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN
Mvan_4241|M.vanbaalenii_PYR-1 MLIFLGSRAAGYLTGQVVWTDGGILAQRISAQMTDIQAAQGS
MSMEG_4862|M.smegmatis_MC2_155 LLVFLGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES
MMAR_4773|M.marinum_M VLVFLNGHAASYISGQVVWVDGGNVAASIAGELGEGRA----
MUL_0344|M.ulcerans_Agy99 VLVFLNGHSASYISGQVVRVDGGNVAASIAGELGEGRA----
MAV_0882|M.avium_104 VLLFLNSDAASYISGQVVWVDGGNVGAAIARELEEGRTPWPV
TH_3914|M.thermoresistible__bu VVVFLASDAARWINGQAVAVDGGITGAVASGVVPKPEF----
Mb2882c|M.bovis_AF2122/97 AVAFLASDDASFITASTFLVDGGISSAYVTPL----------
Rv2857c|M.tuberculosis_H37Rv AVAFLASDDASFITASTFLVDGGISSAYVTPL----------
MLBr_01807|M.leprae_Br4923 AVSFLASEDAGYISGAVIPVDGGLGMGH--------------
MAB_2723c|M.abscessus_ATCC_199 VVSWLASPDAAYVSGAVIPVDGGLGMGH--------------
: :* . * ::.. .. .***