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VRYDGRHVVVTGCASGIGAQAARLLRDLGARVTGLDVRAPEDVSALTDFISVDLADQDSVRAAAAAVDGA VDALFNVAGVSSGIGDPLLVLRINFLGMRQFTESLLDRMPAGGAVTNVSSLAASAYRENAHVTAGLLATR SVDEGLRWCADHPEALADGGYRQSKEAIILYGMQRVTDLGARGIRVNCTAPGVTETPILDQLRSAYGQQY LDSFTAPLGRVSTPEEQAAVLVFLGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2405 | - | - | 100% (271) | 3-alpha-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4338 | - | 1e-31 | 34.26% (251) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4508 | - | 1e-21 | 32.18% (261) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 5e-17 | 27.86% (262) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2857c | - | 5e-17 | 27.86% (262) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-17 | 29.13% (254) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 3e-14 | 28.20% (266) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4773 | - | 6e-81 | 58.62% (261) | dehydrogenase/reductase |
| M. avium 104 | MAV_0882 | - | 5e-86 | 62.45% (261) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 1e-108 | 75.10% (257) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3914 | - | 9e-46 | 40.91% (264) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_0344 | - | 4e-78 | 57.47% (261) | 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | 1e-107 | 77.60% (250) | 3-alpha-hydroxysteroid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_4680c|M.abscessus_ATCC_199 -----------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Mflv_2405|M.gilvum_PYR-GCK ----------------MRYDGRHVVVTGCASGIGAQAARLLRDLGARVTG
Mvan_4241|M.vanbaalenii_PYR-1 ------------------------------------MAHQLGSLGARVTG
MSMEG_4862|M.smegmatis_MC2_155 ---------MAALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTG
MMAR_4773|M.marinum_M ---------MAQIEQLWRYDGRRAVVTGCASGIGERAVHQLTGLGAQVVG
MUL_0344|M.ulcerans_Agy99 ---------MAQIEQLWRYDGRRAVVTGCASGIGERAVHRLTGLGAQVVG
MAV_0882|M.avium_104 ---------MAEIDALWRYDGRRAVVTGCASGIGEQVVRQLGQLGADVIG
TH_3914|M.thermoresistible__bu ---------------MSEFTNRRYVVTGAASGIGDATARKLLAAGAEVTS
: * :
MLBr_01807|M.leprae_Br4923 T--------HRASVVPDWFFGVECDVT-DNDAIGAAFKAVEEHQGPVEVL
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELGDAARFTHLDVT-DAEQWRELIDTTLAGFGTITGL
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSG--LFVPTDVC-DEDAVNGLFDGAAETYGRIDIA
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSG--LFVPTDVC-DEDAVNGLFDGAAETYGRIDIA
Mflv_2405|M.gilvum_PYR-GCK LDVRAPEDVSALTDFISVDLADQDSVRAAAAAVDGAVDALFNVAGVSSGI
Mvan_4241|M.vanbaalenii_PYR-1 LDLREPDAQSAIQDFVQLDLAEPRSVDAAAAAVDGRVDALFNVAGVSSGI
MSMEG_4862|M.smegmatis_MC2_155 LDLRAPDSGAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGVSSGI
MMAR_4773|M.marinum_M LDQRQP--GYEISEFHQIDLADPGSIGRAVEAIGGPVDALFNIAGVSSGI
MUL_0344|M.ulcerans_Agy99 LDQRQP--GYEISEFHQIDLADPGSIDRAVEAIGGPVDALFNIAGVSSGI
MAV_0882|M.avium_104 LDQRRP--GCALGEFHEVDLADPESIDRAAAGIDGPVDALFNIAGVSSGI
TH_3914|M.thermoresistible__bu MDRNPP--SAPVSRHIEVDLANPRSIDAAVEQLEGSYDGLMNIAGIP-GT
.: . *
MLBr_01807|M.leprae_Br4923 VANAGITS--DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFG
MAB_4680c|M.abscessus_ATCC_199 VNNAGISS--AAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGCG
Mb2882c|M.bovis_AF2122/97 FNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKG
Rv2857c|M.tuberculosis_H37Rv FNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKG
Mflv_2405|M.gilvum_PYR-GCK GDPLLVLRINFLGMRQFTESLLDRMPAGGAVTNVSSLAASAYRENAHVTA
Mvan_4241|M.vanbaalenii_PYR-1 KDPLLVMRINFLGMRQFTEALIARMPEGSSITNVSSLAASAYLENAATTA
MSMEG_4862|M.smegmatis_MC2_155 GDPLLVVRINFLGTRQFTEALVDRIADGGSITSVSSLAASAYRENRAVTA
MMAR_4773|M.marinum_M GDPLLVVTINFLGLRQLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVA
MUL_0344|M.ulcerans_Agy99 GDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVA
MAV_0882|M.avium_104 GNPPLVVTVNFLGTRQLTEALIPKMVAGSSIVSVSSLAAAGYREHLRQVA
TH_3914|M.thermoresistible__bu APGETVLAVNSLAVRHLTEAFLDRLNSGGTVTTVSSTAGFGWPERLEAIR
: : .
MLBr_01807|M.leprae_Br4923 RYIFMGSVVGLSG-VPGQAN------YAASKSGLIGMARSLARELGSRSI
MAB_4680c|M.abscessus_ATCC_199 SIVNISSAAGLVG-LALTSG------YGASKWGVRGLSKVAAIELGRERI
Mb2882c|M.bovis_AF2122/97 SIVNTASFVAVMGSATSQIS------YTASKGGVLAMSRELGVQFARQGI
Rv2857c|M.tuberculosis_H37Rv SIVNTASFVAVMGSATSQIS------YTASKGGVLAMSRELGVQFARQGI
Mflv_2405|M.gilvum_PYR-GCK GLLATRSVDEGLRWCADHPEALADGGYRQSKEAIILYGMQRVTDLGARGI
Mvan_4241|M.vanbaalenii_PYR-1 GLLETGSVAEGLQWCADHPEALADGGYRQSKEAIILYGMRRTADLGARGI
MSMEG_4862|M.smegmatis_MC2_155 GLVSTGSVDEGLRWCAENPDALADGGYRLSKEAIILYGMSKAVELGARGI
MMAR_4773|M.marinum_M PLVNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLGARGI
MUL_0344|M.ulcerans_Agy99 PLLNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLGARGI
MAV_0882|M.avium_104 PLLDTATMREGIDWCTSHPEELGTG-YQLSKEALILYTMRSVTPLGARGI
TH_3914|M.thermoresistible__bu DLLATESFEDGARWFKEHP--QQGNAYNFSKEVTTVYTMTMGLTAAQRGI
: : * ** . . *
MLBr_01807|M.leprae_Br4923 TANVVAPGFIDTEMTRAMDSKYQE---AALQAIPLGRIGAVEEIAGAVSF
MAB_4680c|M.abscessus_ATCC_199 RVNSVHPGVIYTPMTAKEGFREGE---GNMPIAAMGRVGNADEVAGAVAY
Mb2882c|M.bovis_AF2122/97 RVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAF
Rv2857c|M.tuberculosis_H37Rv RVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAF
Mflv_2405|M.gilvum_PYR-GCK RVNCTAPGVTETPILDQLRSAYGQQYLDSFTAP-LGRVSTPEEQAAVLVF
Mvan_4241|M.vanbaalenii_PYR-1 RINCSAPGVTETPILDQLRSAYGQQYLDSFTAP-LGRVSTAEEQAAMLIF
MSMEG_4862|M.smegmatis_MC2_155 RVNCTGPGVTDTPILDQLRSAYGQQYLDSFTTP-LGRNSEPDEQAALLVF
MMAR_4773|M.marinum_M RINCTGPGVTETPILDQLTTAYGAEFLDDIAKP-LGRVATPGEQASVLVF
MUL_0344|M.ulcerans_Agy99 RINCTGPGVTETPILDQLTTAYGAEFPDDIAKP-LGRVATPGEQASVLVF
MAV_0882|M.avium_104 RINCTGPGVTETPILDQLRTAYGQGFLDDIPKP-LGRVSRPAEQAAVLLF
TH_3914|M.thermoresistible__bu RINAVLPGPVETPILADFEESMGKDTLDGVKAL-LGRHASPDDIADVVVF
* ** * : . :** . : * : :
MLBr_01807|M.leprae_Br4923 LASEDAGYISGAVIPVDGGLGMGH--------------
MAB_4680c|M.abscessus_ATCC_199 LLSDAASYVTGAELAVDGGWTAGPTLTTITGQ------
Mb2882c|M.bovis_AF2122/97 LASDDASFITASTFLVDGGISSAYVTPL----------
Rv2857c|M.tuberculosis_H37Rv LASDDASFITASTFLVDGGISSAYVTPL----------
Mflv_2405|M.gilvum_PYR-GCK LGSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN
Mvan_4241|M.vanbaalenii_PYR-1 LGSRAAGYLTGQVVWTDGGILAQRISAQMTDIQAAQGS
MSMEG_4862|M.smegmatis_MC2_155 LGSAAASYVTGQVIWADGGIIAQRETALIESTRATQES
MMAR_4773|M.marinum_M LNGHAASYISGQVVWVDGGNVAASIAGELGEGRA----
MUL_0344|M.ulcerans_Agy99 LNGHSASYISGQVVRVDGGNVAASIAGELGEGRA----
MAV_0882|M.avium_104 LNSDAASYISGQVVWVDGGNVGAAIARELEEGRTPWPV
TH_3914|M.thermoresistible__bu LASDAARWINGQAVAVDGGITGAVASGVVPKPEF----
* . * ::.. . .***