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M. avium 104 MAV_5096 (-)

annotation: 3-alpha-hydroxysteroid dehydrogenase
coordinates: 5245983 - 5246774
length: 263

AHFQGKRYVVTGAASGIGNAVAERLLAAGAEVYCLDRNQPAANVTRHIEVDLANPHSIDAAVGQLDGDFD
GLMNVAGIPGTAPADLVLAVNSLAVRHLTELFFDRLKPGGSVTIVSSTAGFGWPHRLDAIRDLLATDTYE
EGAAWFKAHPQQGNAYNFSKEVSTVYTLSMGLAFAEMGFRINAVLPGPVQTPILPDFEESMGKDTLDGLK
NLLGRHADPGDIADVVLFLASDDARWVNGQALAADGGISGAVASGVVPAPEI*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. avium 104MAV_5096--100% (263)3-alpha-hydroxysteroid dehydrogenase
M. avium 104MAV_0882-4e-4540.64% (251) 3-alpha-hydroxysteroid dehydrogenase
M. avium 104MAV_1264-2e-3636.15% (260) oxidoreductase, short chain dehydrogenase/reductase family

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0792-1e-1629.24% (277) short chain dehydrogenase
M. gilvum PYR-GCKMflv_4338-3e-4539.00% (259) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37RvRv0769-1e-1629.24% (277) short chain dehydrogenase
M. leprae Br4923MLBr_01740-1e-1028.45% (232) short chain dehydrogenase
M. abscessus ATCC 19977MAB_0827-6e-1629.15% (271) putative short-chain dehydrogenase/reductase
M. marinum MMMAR_4773-3e-4237.65% (255) dehydrogenase/reductase
M. smegmatis MC2 155MSMEG_4862-2e-3936.61% (254) 3-alpha-hydroxysteroid dehydrogenase
M. thermoresistible (build 8)TH_3914-1e-11677.10% (262) PUTATIVE 3-alpha-hydroxysteroid dehydrogenase
M. ulcerans Agy99MUL_0344-1e-4438.82% (255) 3-alpha-hydroxysteroid dehydrogenase
M. vanbaalenii PYR-1Mvan_2008-9e-5243.03% (251) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb0792|M.bovis_AF2122/97            --------------------------------MFDSKVAIVTGAAQGIGQ
Rv0769|M.tuberculosis_H37Rv         --------------------------------MFDSKVAIVTGAAQGIGQ
MAB_0827|M.abscessus_ATCC_1997      -----------------------------MTSPLKSRRAFVTGGSRGIGA
MAV_5096|M.avium_104                ------------------------------MAHFQGKRYVVTGAASGIGN
TH_3914|M.thermoresistible__bu      ------------------------------MSEFTNRRYVVTGAASGIGD
Mflv_4338|M.gilvum_PYR-GCK          MTRMGGKTVITTVEITRLVVPTMEGYQEGSAMSAEGRRVVVVGAGSGIGA
Mvan_2008|M.vanbaalenii_PYR-1       -------------------------------MQVEKRRIVVVGAGSGIGA
MMAR_4773|M.marinum_M               ------------------------MAQIEQLWRYDGRRAVVTGCASGIGE
MUL_0344|M.ulcerans_Agy99           ------------------------MAQIEQLWRYDGRRAVVTGCASGIGE
MSMEG_4862|M.smegmatis_MC2_155      ------------------------MAALDALVRYDGRHVVVTGCSSGIGA
MLBr_01740|M.leprae_Br4923          --------------------------MVKTAQYFVGKRCFVTGAASGIGR
                                                                        :  .*.* . *** 

Mb0792|M.bovis_AF2122/97            AYAQALAREGASVVVADIN-ADGAAAVAKQIVADGGTVIHVPVDVSDEDS
Rv0769|M.tuberculosis_H37Rv         AYAQALAREGASVVVADIN-ADGAAAVAKQIVADGGTAIHVPVDVSDEDS
MAB_0827|M.abscessus_ATCC_1997      GIVRRLAEDGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVADPDQ
MAV_5096|M.avium_104                AVAERLLAAGAEVYCLDRNQP--AANVTRHIEVDLANPHSIDAAVGQLDG
TH_3914|M.thermoresistible__bu      ATARKLLAAGAEVTSMDRNPP--SAPVSRHIEVDLANPRSIDAAVEQLEG
Mflv_4338|M.gilvum_PYR-GCK          ATAAWFHSRGDHVLAVDARPR--SGPFAEWLVCDLRSADEIEGALGRIGH
Mvan_2008|M.vanbaalenii_PYR-1       AVAAHFHDNGDHVLAVDLRPN--DTPAAAHAQCDLRDPQSIAGLLDDIGA
MMAR_4773|M.marinum_M               RAVHQLTGLGAQVVGLDQRQP--GYEISEFHQIDLADPGSIGRAVEAIGG
MUL_0344|M.ulcerans_Agy99           RAVHRLTGLGAQVVGLDQRQP--GYEISEFHQIDLADPGSIDRAVEAIGG
MSMEG_4862|M.smegmatis_MC2_155      KVTDQLRCLGARVTGLDLRAPDSGAGPDAFREMDLADPDSVDAAAAAIDG
MLBr_01740|M.leprae_Br4923          ATALRLAAYGAELYLTDRHCDGLAQTVSEARALGAQVPEYRALDISDYDE
                                      .  :   *  :                    .                

Mb0792|M.bovis_AF2122/97            AKAMVDRAVGAFGGIDY--LVNNAAIYGGMKLDLLLTVPLDYYKKFMSVN
Rv0769|M.tuberculosis_H37Rv         AKAMVDRAVGAFGGIDY--LVNNAAIYGGMKLDLLLTVPLDYYKKFMSVN
MAB_0827|M.abscessus_ATCC_1997      LGAAIGQAAEELGGLDI--LVNNAGILS---IGDVDTATLADFDEIVAVN
MAV_5096|M.avium_104                DFDGLMNVAGIP-GTAPADLVLAVNSLAVRHLTELFFDRLKPGGSVTIVS
TH_3914|M.thermoresistible__bu      SYDGLMNIAGIP-GTAPGETVLAVNSLAVRHLTEAFLDRLNSGGTVTTVS
Mflv_4338|M.gilvum_PYR-GCK          GWDVLAHVAGIP-GTADARDVLTVNYLGARLMLDGMLPLMNHGGSMVAVA
Mvan_2008|M.vanbaalenii_PYR-1       DWDVLAHVAGVP-GTAPADDVLTVNYLGMRKMVEGMLPRMRRGGSVVAVA
MMAR_4773|M.marinum_M               PVDALFNIAGVSSGIGDPLLVVTINFLGLRQLTEALLPMMGPGSAIVSVS
MUL_0344|M.ulcerans_Agy99           PVDALFNIAGVSSGIGDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVS
MSMEG_4862|M.smegmatis_MC2_155      PVHALFNVAGVSSGIGDPLLVVRINFLGTRQFTEALVDRIADGGSITSVS
MLBr_01740|M.leprae_Br4923          VAAFGADIHARHPSMDIVMNIAGVSVWG-----TVDRLTHDQWSNVVAIN
                                                 .      :      .                 .  : 

Mb0792|M.bovis_AF2122/97            HDGVLVCTR--AVYKHMAKRGGGAIVN--QSSTAAWLYSNFYGLAKVGVN
Rv0769|M.tuberculosis_H37Rv         HDGVLVCTR--AVYKHMAKRGGGAIVN--QSSTAAWLYSNFYGLAKVGVN
MAB_0827|M.abscessus_ATCC_1997      VRAVFAGIK--AASPHLTEGGRIVTIGSINGDSSPTANLSLYSMTKAAVA
MAV_5096|M.avium_104                STAGFGWPHRLDAIRDLLATDTYEEGAAWFKAHP--QQGNAYNFSKEVST
TH_3914|M.thermoresistible__bu      STAGFGWPERLEAIRDLLATESFEDGARWFKEHP--QQGNAYNFSKEVTT
Mflv_4338|M.gilvum_PYR-GCK          STAALGWDSNIGLLSGLLDARDTTAVTRWLEAQD--PSMAYYLS-KQALV
Mvan_2008|M.vanbaalenii_PYR-1       SIAGIGWEQRLDELSELLAATDPEAVAAWQSRQD--PSYPVYTTSKQAVI
MMAR_4773|M.marinum_M               SLAAAGYREHHRAVAPLVNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVI
MUL_0344|M.ulcerans_Agy99           SLAAAGYREHHRAVAPLLNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVI
MSMEG_4862|M.smegmatis_MC2_155      SLAASAYRENRAVTAGLVSTGSVDEGLRWCAENPDALADGGYRLSKEAII
MLBr_01740|M.leprae_Br4923          LMGPIHIIETFVPAILAAGRGGHLVNVSSAAGLVALPWHAAYSASKYGLR
                                      .                                      *   *    

Mb0792|M.bovis_AF2122/97            GLTQQLA-RELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQT-IPL
Rv0769|M.tuberculosis_H37Rv         GLTQQLA-RELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQT-IPL
MAB_0827|M.abscessus_ATCC_1997      GLTRGLA-REFGPRGITINNVQPGPIGTDMN--PEDGQLADILRPN-IAV
MAV_5096|M.avium_104                VYTLSMG-LAFAEMGFRINAVLPGPVQTPILPDFEESMGKDTLDGLKNLL
TH_3914|M.thermoresistible__bu      VYTMTMG-LTAAQRGIRINAVLPGPVETPILADFEESMGKDTLDGVKALL
Mflv_4338|M.gilvum_PYR-GCK          LYAKRLSGVAWREYGVRVNTVSPGPTETPILGDFEESMGRDMLDGVRTTI
Mvan_2008|M.vanbaalenii_PYR-1       LYAKRLAGTALSRYGVRVNTVSPGPVETPILADFEQTMGKEILDMLRDTY
MMAR_4773|M.marinum_M               LYTMRSA-VGLGARGIRINCTGPGVTETPILDQLTTAYGAEFLDDIAKPL
MUL_0344|M.ulcerans_Agy99           LYTMRSA-VGLGARGIRINCTGPGVTETPILDQLTTAYGAEFPDDIAKPL
MSMEG_4862|M.smegmatis_MC2_155      LYGMSKA-VELGARGIRVNCTGPGVTDTPILDQLRSAYGQQYLDSFTTPL
MLBr_01740|M.leprae_Br4923          GLSEVLR-FDLARYRIGVSVVVPGAVRTPLVDTIEIAGVDRQDPRFSRWV
                                                   . :.   **   *                      

Mb0792|M.bovis_AF2122/97            SRMG--------TPEDLVG---------------MCLFLLSDSASWITGQ
Rv0769|M.tuberculosis_H37Rv         SRMG--------TPEDLVG---------------MCLFLLSDSASWITGQ
MAB_0827|M.abscessus_ATCC_1997      GRYG--------QPRDIAS---------------LVSYLVSDEAWYITGT
MAV_5096|M.avium_104                GRHA--------DPGDIAD---------------VVLFLASDDARWVNGQ
TH_3914|M.thermoresistible__bu      GRHA--------SPDDIAD---------------VVVFLASDAARWINGQ
Mflv_4338|M.gilvum_PYR-GCK          GRHG--------TVDDMTP---------------AIGFLSSPEARWINGQ
Mvan_2008|M.vanbaalenii_PYR-1       GRHG--------TVDDIVP---------------VIAFLASDAAQWINGQ
MMAR_4773|M.marinum_M               GRVA--------TPGEQAS---------------VLVFLNGHAASYISGQ
MUL_0344|M.ulcerans_Agy99           GRVA--------TPGEQAS---------------VLVFLNGHSASYISGQ
MSMEG_4862|M.smegmatis_MC2_155      GRNS--------EPDEQAA---------------LLVFLGSAAASYVTGQ
MLBr_01740|M.leprae_Br4923          DRFRGHAVSAERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGV
                                    .*             .                     :     * :  * 

Mb0792|M.bovis_AF2122/97            IFNVDGGQIIRS--------------------------------
Rv0769|M.tuberculosis_H37Rv         IFNVDGGQIIRS--------------------------------
MAB_0827|M.abscessus_ATCC_1997      AINIDGGFTA----------------------------------
MAV_5096|M.avium_104                ALAADGGISGAVASGVVPAPEI----------------------
TH_3914|M.thermoresistible__bu      AVAVDGGITGAVASGVVPKPEF----------------------
Mflv_4338|M.gilvum_PYR-GCK          DIHVDGGFTAALVHPMPERAQV----------------------
Mvan_2008|M.vanbaalenii_PYR-1       DVHVDSGFVTSMTAGTPIAL------------------------
MMAR_4773|M.marinum_M               VVWVDGGNVAASIAGELGEGRA----------------------
MUL_0344|M.ulcerans_Agy99           VVRVDGGNVAASIAGELGEGRA----------------------
MSMEG_4862|M.smegmatis_MC2_155      VIWADGGIIAQRETALIESTRATQES------------------
MLBr_01740|M.leprae_Br4923          VMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN
                                     .   .